Finex logo
Finex Intelligence

Market Signal Briefing

Real-time pulse of financial headlines curated from 2 premium feeds.

Last news saved at Jan 2, 07:26 24m ago Cron last ran Jan 2, 07:26 24m ago 2 sources live
Switch language
49,191 Stories ingested Auto-fetched market intel nonstop.
275 Distinct tickers Symbols referenced across the feed
stockne... Trending sources stocknewsapi • cryptonews
Hot tickers
BTC ETH XRP SOL USDT DOGE
Surfacing from current coverage
Details Saved Published Title Source Tickers
2025-12-07 21:49 25d ago
2025-12-07 15:11 25d ago
Better Artificial Intelligence Stock: Palantir Technologies vs. Nvidia stocknewsapi
NVDA PLTR
Palantir and Nvidia have both crushed the market since ChatGPT launched, but which AI titan deserves your money today? The answer might surprise you.

The stock market hasn't been the same since OpenAI unleashed ChatGPT to the public three years ago. As of Dec. 4, the S&P 500 (^GSPC +0.19%) market index has posted a 75% total return since then. The tech-heavy Nasdaq-100 index gained a dividend-adjusted 118% over the same period.

But the kings of artificial intelligence (AI) are soaring far above these not-so-pedestrian returns. AI chip champion Nvidia (NVDA 0.56%) is up more than tenfold and AI platform master Palantir Technologies (PLTR +2.19%) more than doubled Nvidia's stellar gains:

PLTR Total Return Level data by YCharts

But past performance is never a guarantee of future results. What matters to today's investors is a fundamentally different question -- which AI stock is the better investment for new money today?

When AI valuations go orbital
Let's address the elephant in the room, or the rocket ship in the stratosphere directly above Wall Street. Palantir's stock has gone absolutely parabolic in 2025, trading at roughly 109 times trailing revenue. That triple-digit figure is not a typo. For context, even during the dot-com bubble's wildest moments, most high-flyers topped out around 50 times sales.

Nvidia, meanwhile, has seen its valuation actually compress even as its business keeps breaking records. At about 24 times revenue, it's still priced for perfection. However, compared to Palantir, Nvidia's stock price looks almost reasonable.

Mind you, Nvidia is already absolutely massive and it should be harder to keep the hypergrowth going from an annual revenue base of $187 billion. Palantir's trailing-12-month sales look minuscule in comparison, stopping at $3.9 billion. The law of large numbers says that Nvidia's sales growth must slow down at some point. Meanwhile, Palantir's long-term value is limited by its focus on the smaller market of government contracts. The company is pushing into commercial contracts too, but how many businesses need military-style data analytics?

Today's Change

(

-0.56

%) $

-1.03

Current Price

$

182.35

The political cycle wild card
Palantir's recent surge coincides suspiciously with a favorable shift in the federal spending environment. The company's government revenue, while growing at a respectable 40% year over year, suddenly seems poised for acceleration as Washington embraces AI-powered defense and intelligence applications.

But here's the risk nobody's talking about: government contracts follow political cycles. What happens if spending priorities shift after the 2026 midterms? What if the regulatory environment becomes less friendly to aggressive data analytics? Palantir's commercial business is growing faster at 54%, but government contracts still represent nearly half of revenue. That's a lot of exposure to political winds that can change direction every two years (with sharper shifts around the four-year presidential election cycle).

Nvidia faces its own unique challenge -- its biggest customers are becoming its biggest competitors. Amazon, Alphabet, and Microsoft are all developing custom AI chips while still buying billions worth of Nvidia's GPUs. It's like selling weapons to armies that are simultaneously building their own armories. Nvidia can maintain this delicate balance, but it requires constant innovation and careful relationship management.

Today's Change

(

2.19

%) $

3.89

Current Price

$

181.81

"Less overvalued" wins by default
I can't believe I'm writing this, but at current prices, Nvidia is the better buy -- and that's despite my concerns about customer competition and a still-rich valuation. Here's why:

Valuation sanity: OK, "sanity" is a stretch but at 24x sales vs. 109x, Nvidia's premium is at least loosely grounded in financial reality.
Proven moat: CUDA's ecosystem lock-in is real and tested, while Palantir's competitive advantages remain harder to quantify.
Diversification: Nvidia sells to everyone in AI; Palantir's concentration in government and large enterprises limits its addressable target market.
Profit machine: Nvidia's 57% net margin vs. Palantir's 20% shows who's actually printing money today.

But here's the real takeaway: Both stocks are priced for a perfect AI future that may not materialize as smoothly as bulls expect. Palantir needs flawless execution and continued government AI spending to justify its valuation. Nvidia needs to fend off increasingly capable competitors while maintaining its innovation edge. Both might actually succeed in the long run, but it won't be easy.

Image source: Getty Images.

For investors seeking AI exposure today, the smartest move might be looking elsewhere in the ecosystem -- perhaps at the hyperscalers building AI services, semiconductor equipment makers enabling the whole industry, or even "boring" companies successfully implementing AI to improve their operations. Sometimes the best investment isn't choosing between two expensive options -- but finding a completely different third path.

So, if forced to pick between these two AI titans, I'd reluctantly choose Nvidia. But I reduced my Nvidia exposure in 2025, converting some of my AI-boom paper gains into cash profits.

My highest-conviction call in this duel is simple: Neither stock really offers a compelling risk/reward balance for new money at December 2025 prices. The AI revolution is real, but that doesn't mean every AI stock is a buy at any price.

Anders Bylund has positions in Alphabet, Amazon, and Nvidia. The Motley Fool has positions in and recommends Alphabet, Amazon, Microsoft, Nvidia, and Palantir Technologies. The Motley Fool recommends the following options: long January 2026 $395 calls on Microsoft and short January 2026 $405 calls on Microsoft. The Motley Fool has a disclosure policy.
2025-12-07 21:49 25d ago
2025-12-07 15:12 25d ago
Halper Sadeh LLC Encourages Eagle Pharmaceuticals, Inc. Shareholders to Contact the Firm to Discuss Their Rights stocknewsapi
EGRX
-

Shareholders should contact the firm immediately as there may be limited time to enforce your rights.

NEW YORK--(BUSINESS WIRE)--Halper Sadeh LLC, an investor rights law firm, is investigating whether certain officers and directors of Eagle Pharmaceuticals, Inc. (OTCPK: EGRX) breached their fiduciary duties to shareholders.

If you currently own Eagle stock and are a long-term shareholder, you may be able to seek corporate governance reforms, the return of funds back to the company, a court-approved financial incentive award, or other relief and benefits. Please click here to learn more about your legal rights and options or contact Daniel Sadeh or Zachary Halper at (212) 763-0060 or [email protected] or [email protected]. Our firm would handle the action on a contingent fee basis, whereby you would not be responsible for out-of-pocket payment of our legal fees or expenses.

Why Your Participation Matters:

Shareholder involvement can help improve a company’s policies, practices, and oversight mechanisms to create a more transparent, accountable, and effectively managed organization, which can enhance shareholder value.

Halper Sadeh LLC represents investors all over the world who have fallen victim to securities fraud and corporate misconduct. Our attorneys have been instrumental in implementing corporate reforms and recovering millions of dollars on behalf of defrauded investors.

Attorney Advertising. Prior results do not guarantee a similar outcome.

More News From Halper Sadeh LLC

Back to Newsroom
2025-12-07 21:49 25d ago
2025-12-07 15:18 25d ago
SL Green chief expects thriving NYC office market to continue — even under Mamdani stocknewsapi
SLG
The Real Estate Board of New York’s holiday luncheon at the Metropolitan Club capped a festive week for the industry, which included the packed Fried Frank holiday bash at Cipriani 42nd Street two nights earlier.

The mood was celebratory thanks to the thriving office market, where low vacancy will continue falling because there’s little new product in the pipeline.

SL Green chief executive and chairman Marc Holliday shared the stage with superchef Daniel Boulud at the REBNY event which I moderated. After a rousing curtain-raiser by REBNY president Jim Whelan, Holliday praised outgoing Mayor Eric Adams’ accomplishments as a “cheerleader” for the city and his role in promoting rezoning and housing creation.

Realty Check columnist Steve Cuozzo and SL Green chief Marc Holliday at the Real Estate Board of New York’s holiday luncheon last week. NY Post
Asked whether the office market would keep up its on-fire pace, Holliday saw no imminent large threat. He said plans would be announced early next year for 346 Madison Ave., the former Brooks Brothers store site which SL Green recently purchased for future redevelopment.

He highlighted the importance of major amenities at new office towers such as the “immersive events” space at Summit atop One Vanderbilt with food curated by Boulud. Noting that many of today’s towers, not only SL Green’s, boasted such features, he cited the “great job [Vornado chief] Steve Roth has done near Penn Station.”

More From Steve Cuozzo

SL Green chief Marc Holliday suggested a willingness to “work with” Mayor-elect Zohran Mamdani. AP
Holliday suggested a willingness to “work with” Mayor-elect Zohran Mamdani and noted that the commercial market thrived throughout previous administrations with different ideologies.

SL Green’s Marc Holliday, shown in May, said the city’s office market has thrived under mayors with different ideologies. Pacific Press via ZUMA Press
His comment presaged his remarks in SL Green’s investors’ call the next day, when he said, “My early read, based on key early appointments, is that we’ll be able to work with this new administration.”
Boulud celebrated his partnership with SL Green, the city’s largest commercial landlord. Boulud’s Le Pavillon and Joji at One Vanderbilt and La Tete D’or at One Madison are among the city’s most acclaimed new eateries.

“People talk about them wherever we travel,” Boulud said – meaning in other cities where his Dinex Group operates, including a return to London in 2026.

The Real Estate Board of New York’s holiday luncheon at the Metropolitan Club drew 200 attendees.
The 200-strong crowd included developer-landlords Jeff Gural and Jonathan Resnick, dealmakers Paul Massey, Mitti Liebersohn, David Goldstein, Mitch Arkin, Lou D’Avanzo, Tom Bow, Leslie Hummel and retail whiz Joseph Aquino hawking his book “Memoirs of a Watch Salesman.”

Fried Frank real estate chairman Jonathan Mechanic came as well, fresh off hosting his firm’s holiday party 48 hours earlier. That gala event drew the usual who’s-who of Big Apple real estate royalty that included Bill Rudin, Aby Rosen, Jed Walenas, John Cefaly, Mary Ann Tighe, Alexander Durst, and Hal Fetner among the 1,000 plus guests and the most delicious cold shrimp in town.
2025-12-07 21:49 25d ago
2025-12-07 15:20 25d ago
Where Will Quantum Computing Stock Be in 1 Year? stocknewsapi
QUBT
The photonics chipmaker still needs to clear a lot of technical hurdles.

Quantum Computing (QUBT 5.45%), also known as QCI, made the jump from the over-the-counter market to the Nasdaq on July 15, 2021. It opened at $6.60 per share that day, but it eventually sank to a record low of $0.42 on July 1, 2024.

But today, QCI trades at about $12 -- so a $1,000 investment at its all-time low would have grown to nearly $28,600 in just over a year. Let's see why this emerging quantum computing stock is attracting so much attention and where it might be headed over the next year.

Image source: Getty Images.

Understanding the quantum computing market
Standard computers still store zeros and ones separately in binary bits. Quantum computers can store those zeros and ones simultaneously in qubits, which allows them to process more data and certain computing tasks at a much faster rate than their classical counterparts.

But for now, quantum computers are still much larger, pricier, and consume more power than standard computers. They also tend to make more mistakes. That's why they're still mainly used for niche government and research projects instead of mainstream computing applications.

Today's Change

(

-5.45

%) $

-0.74

Current Price

$

12.84

To address those issues, quantum computing companies are trying to make those systems smaller, cheaper, and more power-efficient. Yet there isn't a clear consensus regarding how to achieve those goals.

Most of the early movers in the quantum computing market -- including IBM (IBM 0.02%) and Rigetti Computing (RGTI 6.49%) -- accelerate electrons through "superconducting loops" to process data. These systems are easier to manufacture, but they're big and expensive to operate because they need to be cryogenically refrigerated.

Other companies -- most notably IonQ (IONQ 3.78%) -- "trap" ions and manipulate them with tiny lasers to process that data. These smaller systems don't need to be refrigerated, but they can also be expensive to operate because their delicate lasers need to be constantly recalibrated.

What sets QCI apart from its competitors?
QCI doesn't dabble with electrons and ions. Instead, it develops photonic quantum chips -- which process data by beaming light through chips, fibers, and optical circuits. These chips can function at room temperature and can be easily manufactured by conventional chip fabricators.

In theory, QCI's photonic chips can be cheaper, more scalable, and require less maintenance than trapped ion systems. But for now, they're still more expensive to manufacture, produce more errors, and must be paired with big external optical systems.

QCI opened its first foundry this May and finally started shipping its first chips, but it only generated $484,000 in revenue in the first nine months of 2025. Most of that revenue came from its professional service contracts with commercial and government customers, but it also started to recognize some revenue from its cloud-based Dirac-3 quantum-as-a-service platform this year.

For the full year, analysts expect it to generate $777,000 in revenue with a net loss of nearly $24 million. With a market cap of $2.7 billion, QCI stock trades at 3,481 times this year's sales. By comparison, IonQ and Rigetti trade at 159 times and 1,134 times this year's sales, respectively. All three of these quantum computing stocks are speculative -- but QCI still seems the most overvalued relative to its near-term growth potential.

What are QCI's longer-term catalysts?
QCI is currently planning the construction of its second fab, which it aims to start building within the next three years. In the meantime, it expects to refine its manufacturing processes, ramp up its small-batch production, expand its workforce, and demonstrate its performance capabilities at its first fab.

Yet QCI doesn't expect to mass-produce its chips until its second fab opens. So over the next year, most of its modest revenue will still come from its professional service contracts and cloud-based services. It will also likely need to raise more cash by issuing more debt and secondary offerings. For 2026, analysts expect QCI's revenue to surge 169% to $2.1 million as its net loss widens to $40.5 million.

Where will QCI's stock be in a year?
QCI has a lot of growth potential, but it still has plenty of hurdles to clear. It must scale up its business, reduce its production costs, and prove that its photonics chips are actually cheaper and more scalable than electron or ion-based systems.

It faces an uphill battle against those entrenched players, and it could easily run out of money before it reaches the mass production stage. It also faces competition from smaller photonics companies like Xanadu and PsiQuantum.

QCI's stock might go through some wild swings over the next year, but I don't think those gains will be sustainable. Instead, I believe it will either trade sideways or slip lower unless it demonstrates some big technological breakthroughs or lands some huge new contracts.
2025-12-07 21:49 25d ago
2025-12-07 15:28 25d ago
Gentherm Stock Down 60% Since 2022 — But One Hedge Fund Just Bought 431,072 Shares stocknewsapi
THRM
A battered auto-tech supplier posting record revenue is exactly the kind of mismatch value-hunters watch closely.

On November 14, New York-based Harvey Partners disclosed in an SEC filing that as of September 30, it had bought 431,072 shares of Gentherm (THRM 1.62%), increasing the stake by approximately $18.1 million.

What HappenedAccording to a Securities and Exchange Commission (SEC) filing dated November 14, Harvey Partners boosted its holding in Gentherm by 431,072 shares during the third quarter. The firm’s position as of September 30 stood at about 1 million shares with a market value of $34.9 million.

What Else to KnowThis buy brings the Gentherm stake to 3.1% of Harvey Partners’ reportable U.S. equity AUM, below the top five fund holdings.

Top holdings after the filing: 

NYSE: NPO: $56.3 million (5.1% of AUM)NYSE: BWXT: $53.4 million (4.9% of AUM)NYSE: AZZ: $53 million (4.8% of AUM)NASDAQ: GLDD: $44.4 million (4% of AUM)NASDAQ: ADEA: $43.9 million (4% of AUM)As of Friday, shares of Gentherm were priced at $36.46, down 13% over the past year and well underperforming the S&P 500, which is instead up 13% in the same period.

Company OverviewMetricValuePrice (as of market close Friday)$36.46Market capitalization$1.1 billionRevenue (TTM)$1.5 billionNet income (TTM)$30.6 millionCompany SnapshotGentherm offers thermal management technologies, including climate comfort systems for automotive interiors, battery performance solutions, and patient temperature management systems for medical applications.The company generates revenue primarily through the design, manufacture, and sale of automotive parts and systems to original equipment manufacturers (OEMs), first-tier suppliers, and aftermarket distributors.Its main customer base consists of global automotive OEMs, seat manufacturers, and healthcare providers across North America, Europe, and Asia.Gentherm is a leading supplier of thermal management solutions, serving the global automotive and medical sectors. The company leverages advanced proprietary technologies to provide climate comfort and battery performance products, supporting innovation in vehicle electrification and passenger comfort. Gentherm's diversified product portfolio and established relationships with major OEMs underpin its competitive position in the auto parts industry.

Foolish TakeDespite a bruising multiyear selloff, a move into a deeply discounted name like Gentherm signals that Harvey Partners may see the beginnings of a turnaround forming. The company just posted record quarterly revenue and strong operating cash flow, suggesting that operational footing is firmer than the stock chart implies—a dynamic long-term investors often look for when sentiment disconnects from fundamentals.

Harvey Partners’ third-quarter purchase brought its Gentherm holdings to roughly 1 million shares valued at $34.9 million, lifting the position to 3.1% of reportable assets. That keeps it below the fund’s top weightings but is still pretty meaningful.

Gentherm’s third-quarter report strengthened the case. Revenue rose 4% year over year to a record $386.9 million, buoyed by 8.6% growth in automotive climate and comfort solutions. Adjusted EBITDA ticked up to $49 million, margins remained healthy at 12.7%, and the company generated $87.8 million in year-to-date operating cash flow (up from $73.1 million in the prior year). Management also secured $745 million in new automotive awards, keeping it on pace for more than $2 billion this year—a sign its core technologies continue to win share even as material costs pressure gross margins.

Glossary13F AUM: The total value of U.S. equity securities reported by an institutional investment manager on SEC Form 13F.
Enterprise value to EBITDA ratio: A valuation metric comparing a company's total value to its earnings before interest, taxes, depreciation, and amortization.
Forward price/earnings ratio: A valuation metric using forecasted earnings to assess how much investors are paying per dollar of future profit.
Original equipment manufacturers (OEMs): Companies that produce parts or equipment that may be marketed by another manufacturer, often in the automotive industry.
Aftermarket distributors: Businesses that sell replacement parts, accessories, or equipment for vehicles after the original sale.
Trailing twelve months (TTM): The 12-month period ending with the most recent quarterly report.
Fund AUM: The total market value of assets managed by an investment fund.
Position: The amount of a particular security or investment held by an individual or institution.
Stake: The ownership interest or share held in a company by an investor or fund.
Climate comfort systems: Technologies designed to regulate temperature for passenger comfort in vehicle interiors.
Battery performance solutions: Products or technologies aimed at improving battery efficiency, lifespan, or reliability, especially in automotive applications.
First-tier suppliers: Companies that supply parts or systems directly to original equipment manufacturers (OEMs), especially in the automotive sector.

Jonathan Ponciano has no position in any of the stocks mentioned. The Motley Fool has positions in and recommends Azz and BWX Technologies. The Motley Fool has a disclosure policy.
2025-12-07 21:49 25d ago
2025-12-07 15:30 25d ago
Why One Fund Just Bet $64 Million on a Healthcare Stock Down 63% This Past Year stocknewsapi
ACHC
This hedge fund just made a bold bet on a behavioral-health giant in the middle of a reset—here’s what they may be seeing.

On November 14, New York City-based Engine Capital Management disclosed a new position in Acadia Healthcare (ACHC +5.74%), acquiring 2.6 million shares valued at $64 million.

What HappenedAccording to a Securities and Exchange Commission (SEC) filing dated November 14, Engine Capital Management initiated a new position in Acadia Healthcare, acquiring nearly 2.6 million shares. The stake was valued at $64 million at the end of the third quarter. This transaction brought the fund’s total reported U.S. equity positions to 27.

What Else to KnowEngine Capital’s new position in ACHC represents 7.6% of its reportable assets under management as of September 30.

Top holdings after the filing: 

NYSE: AVTR: $246.1 million (29.2% of AUM)NYSE: NATL: $94.7 million (11.2% of AUM)NASDAQ: LNW: $80.9 million (9.6% of AUM)NASDAQ: ACHC: $64.0 million (7.6% of AUM)NASDAQ: OFIX: $62.3 million (7.4% of AUM)As of Friday, shares of Acadia Healthcare were priced at $15.47, down 63% over the past year and far underperforming the S&P 500, which is up 13% in the same period.

Company OverviewMetricValueRevenue (TTM)$3.3 billionNet income (TTM)$107.4 millionMarket capitalization$1.4 billionPrice (as of market close Friday)$15.47Company SnapshotAcadia Healthcare operates hundreds of behavioral healthcare facilities across the United States and Puerto Rico.The company focuses on inpatient psychiatric hospitals, specialty treatment facilities, residential treatment centers, and outpatient clinics.It serves a diverse patient base seeking mental health and addiction treatment services.Acadia Healthcare is a leading provider of behavioral healthcare services, leveraging its broad network to address a wide range of mental health and addiction needs. Its scale and specialized care offerings position it as a key player in the behavioral health sector.

Foolish TakeA sharp move into Acadia Healthcare matters because it shows a fund leaning into a sector facing short-term turbulence but long-term demand tailwinds. Behavioral health remains one of the few healthcare categories with structurally rising need, and Acadia’s recent results hint at stabilization even as near-term profitability is under pressure. For long-term investors, this kind of contrarian build-up can signal that current valuation weakness may not reflect the company’s full earnings power once volumes recover and expansion projects mature.

Engine Capital’s new $64 million position comes as Acadia reported 4.4% year-over-year revenue growth to $851.6 million and continued momentum in same-facility admissions, up 3.3%. But the company also lowered full-year revenue, EBITDA, and EPS guidance amid payor scrutiny, Medicaid softness, and higher liability costs. Adjusted EBITDA fell to $173 million from $194 million a year earlier.

Still, management is cutting 2026 capex by at least $300 million and pushing toward positive free cash flow—moves that could materially improve returns once bed additions start contributing. So what might be worth taking away? Demand is durable, margins are fixable, and the stock’s 63% drop over 12 months may have already priced in much of the pain.

GlossaryAssets under management (AUM): The total market value of investments managed by a fund or investment firm.

Reportable U.S. equity assets: U.S. stock holdings that an investment manager must disclose in regulatory filings.

Position: The amount of a particular security or asset held by an investor or fund.

Stake: The ownership interest or share held in a company by an investor or fund.

Holding: A security or asset owned within an investment portfolio.

Initiated a new position: When an investor or fund buys shares of a company for the first time.

Behavioral healthcare services: Medical services focused on treating mental health and substance use disorders.

Inpatient psychiatric hospitals: Facilities where patients stay overnight for intensive mental health treatment.

Residential treatment centers: Live-in healthcare facilities providing therapy and support for behavioral or addiction issues.

Outpatient clinics: Healthcare centers where patients receive treatment without staying overnight.

Market capitalization: The total value of a company's outstanding shares, calculated as share price times shares outstanding.

TTM: The 12-month period ending with the most recent quarterly report.
2025-12-07 21:49 25d ago
2025-12-07 15:46 25d ago
Netflix co-CEO reportedly discussed Warner Bros. deal with Trump stocknewsapi
NFLX WBD
Will Netflix’s $82.7 billion deal to acquire Warner Bros. get approval from federal regulators?

While Paramount was assumed to be the frontrunner to acquire the storied movie studio thanks to CEO David Ellison’s connections to the Trump administration, new reporting in Bloomberg and The Hollywood Reporter suggests that Netflix co-CEO Ted Sarandos met with President Donald Trump to discuss a potential deal in November.

Trump reportedly told Sarandos that Warner Bros. should sell to the highest bidder, and the Netflix executive seems to have left the meeting convinced that the president would not immediately oppose the acquisition.

Bloomberg also reports that Warner Bros. CEO David Zaslav was reluctant to sell the company and surprised when Paramount began to explore an acquisition — if nothing else, he’d expected Ellison to wait until the studio completed a planned split of its movie and streaming businesses from its cable networks.

Ultimately, Warner Bros. said it would consider other bids, leading to a competitive process that Netflix won — although Paramount could still keep its hat in the ring with a hostile bid.
2025-12-07 21:49 25d ago
2025-12-07 16:00 25d ago
S&P 500: Sell Strength (Technical Analysis) stocknewsapi
IVV SPLG SPXL SPY SSO UPRO VOO
Analyst’s Disclosure:I/we have a beneficial long position in the shares of VOO either through stock ownership, options, or other derivatives. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.

Seeking Alpha's Disclosure: Past performance is no guarantee of future results. No recommendation or advice is being given as to whether any investment is suitable for a particular investor. Any views or opinions expressed above may not reflect those of Seeking Alpha as a whole. Seeking Alpha is not a licensed securities dealer, broker or US investment adviser or investment bank. Our analysts are third party authors that include both professional investors and individual investors who may not be licensed or certified by any institute or regulatory body.
2025-12-07 21:49 25d ago
2025-12-07 16:00 25d ago
Wave Life Sciences to Announce Interim Data from the Phase 1 INLIGHT Trial of WVE-007 (INHBE) for Obesity on Monday, December 8, 2025 stocknewsapi
WVE
December 07, 2025 16:00 ET

 | Source:

Wave Life Sciences USA, Inc.

CAMBRIDGE, Mass., Dec. 07, 2025 (GLOBE NEWSWIRE) -- Wave Life Sciences Ltd. (Nasdaq: WVE), a clinical-stage biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health, will announce interim data from the ongoing Phase 1 INLIGHT clinical trial evaluating WVE-007, an investigational INHBE GalNAc-siRNA using Wave’s proprietary SpiNA design, for the treatment of obesity on Monday, December 8, 2025. A press release announcing the interim data will be issued at 7:30 a.m. ET, followed by an investor conference call and webcast at 8:30 a.m. ET.

A webcast of the conference call can be accessed by visiting “Investor Events” on the investor relations section of the Wave Life Sciences website: https://ir.wavelifesciences.com/events-publications/events. Following the live event, an archived version of the webcast will be available on the Wave Life Sciences website.

About WVE-007
WVE-007 is an investigational GalNAc-siRNA that utilizes Wave’s best-in-class proprietary oligonucleotide chemistry and the company’s Stereopure interfering Nucleic Acid (SpiNA) next generation siRNA design. WVE-007 is designed to silence INHBE mRNA, an obesity target with strong evidence from human genetics. Individuals who have a protective loss-of-function variant in one copy of the INHBE gene have a healthier body composition and cardiometabolic profile, including less visceral fat and lower risk of type 2 diabetes or cardiovascular disease. In preclinical models, INHBE GalNAc-siRNA led to adipocyte shrinkage, fewer pro-inflammatory macrophages, less fibrosis, and improved insulin sensitivity in visceral adipose tissue, supporting potential for metabolic improvement. As an add-on to semaglutide, Wave’s GalNAc-siRNA doubled weight loss in mice and prevented weight regain upon cessation of semaglutide.

About the INLIGHT Clinical Trial
INLIGHT is an ongoing, first-in-human clinical trial (3:1 active: placebo) evaluating WVE-007 in adults living with overweight or obesity and assesses safety, tolerability, pharmacokinetics, Activin E, body weight and composition, and biomarkers of metabolic health. INLIGHT is currently ongoing at multiple trial sites, including in the US.

About Wave Life Sciences
Wave Life Sciences (Nasdaq: WVE) is a biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health. Wave’s RNA medicines platform, PRISM®, combines multiple modalities, chemistry innovation and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and common disorders. Its toolkit of RNA-targeting modalities includes editing, splicing, RNA interference, and antisense silencing, providing Wave with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology. Wave’s diversified pipeline includes clinical programs in obesity, alpha-1 antitrypsin deficiency, Duchenne muscular dystrophy, and Huntington’s disease, as well as several preclinical programs utilizing the company’s broad RNA therapeutics toolkit. Driven by the calling to “Reimagine Possible,” Wave is leading the charge toward a world in which human potential is no longer hindered by the burden of disease. Wave is headquartered in Cambridge, MA. For more information on Wave’s science, pipeline and people, please visit www.wavelifesciences.com and follow Wave on X and LinkedIn.

Contact:
Kate Rausch
VP, Corporate Affairs and Investor Relations
+1 617-949-4827

Investors:
James Salierno
Director, Investor Relations
+1 617-949-4043
[email protected]

Media:
Katie Sullivan
Senior Director, Corporate Communications
+1 617-949-2936
[email protected]
2025-12-07 21:49 25d ago
2025-12-07 16:00 25d ago
Why One Fund Dumped Its Entire $15 Million Stake as This Defense Stock Posted $47 Billion in Backlog stocknewsapi
AMTM
Why would a fund step away from a stock that’s quietly building one of the strongest backlogs in federal contracting?

On November 14, New York City-based Engine Capital Management disclosed that it sold out its entire position in Amentum Holdings (AMTM 1.26%), a move representing an estimated $15 million change in value.

What HappenedAccording to its SEC filing dated November 14, Engine Capital Management, LP reported a complete sale of its Amentum Holdings position during the third quarter. The fund eliminated 635,255 shares, an estimated $15 million transaction based on quarterly average pricing.

What Else to KnowTop holdings after the filing: 

NYSE: AVTR: $246.1 million (29.2% of AUM)NYSE: NATL: $94.7 million (11.2% of AUM)NASDAQ: LNW: $80.9 million (9.6% of AUM)NASDAQ: ACHC: $64.0 million (7.6% of AUM)NASDAQ: OFIX: $62.3 million (7.4% of AUM)As of Friday, shares of Amentum Holdings were priced at $28.88, up 26% over the past year and outperforming the S&P 500, which is up 13% in the same period.

Company OverviewMetricValuePrice (as of market close Friday)$28.88Market capitalization$7 billionRevenue (TTM)$14.4 billionNet income (TTM)$66 millionCompany SnapshotAmentum Holdings provides mission-critical services including test, training, and operations for missile defense, IT and engineering for defense and space, environmental remediation, and advanced cyber and intelligence solutions.The company generates revenue through long-term government and commercial contracts, focusing on technology-driven consulting, systems integration, and technical services.It serves U.S. government agencies, defense and intelligence clients, and energy sector organizations as primary customers.Amentum Holdings is a leading provider of technical and mission support services to government and commercial clients, with a focus on aerospace, defense, and intelligence sectors. The company leverages its scale and expertise in critical mission solutions and advanced cyber capabilities to address complex national security and infrastructure needs. It combines its deep technical know-how with a robust contract portfolio, positioning itself as a key partner for clients requiring high-reliability, technology-driven solutions.

Foolish TakeAmentum’s recent rally underscores why understanding a full exit like this matters for long-term investors: When a fund divests following a stretch of strengthening fundamentals, it can signal a shift in portfolio strategy rather than a judgment on the business itself. The company just delivered a standout fourth quarter, posting $3.9 billion in revenue, $300 million in adjusted EBITDA, and $261 million in free cash flow, all while expanding backlog to a massive $47.1 billion and reducing its net leverage.

For investors, Amentum’s multi-year contract visibility, strong cash generation, and fiscal year 2026 guidance calling for up to $14.3 billion in revenue and as much as $575 million in free cash flow offer notable long-term appeal. The business is tied to mission-critical spending across defense, space, nuclear, and digital infrastructure—areas less sensitive to economic cycles. While the stock remains volatile since its public-market debut last September, the underlying growth trajectory appears intact.

Glossary13F reportable assets: Investment holdings that institutional investment managers must disclose quarterly to the Securities and Exchange Commission (SEC) if above a certain threshold.

Assets under management (AUM): The total market value of all investments managed by a fund or investment firm.

Stake: The ownership interest or investment a fund or individual holds in a particular company.

Quarterly average pricing: The average price of a security over a specific quarter, used for estimating transaction values.

Mission-critical services: Essential services that are vital to the core operations or security of an organization or client.

Systems integration: The process of combining different technology systems and software to function as a coordinated whole.

Technical services: Specialized support involving engineering, IT, or scientific expertise provided to clients.

Contract portfolio: The collection of active contracts a company holds with its clients, often indicating business stability and future revenue.

TTM: The 12-month period ending with the most recent quarterly report.
2025-12-07 21:49 25d ago
2025-12-07 16:00 25d ago
Victory Fighting League CEO on Climbing MMA Popularity, TKO Rally stocknewsapi
TKO
Victory Fighting League CEO, Dan Anderson, talks about his New York-based company and the rise of MMA as a sport. He points to TKO Group (TKO) muscling a strong 2025 rally as a leading signal to consumer interest.
2025-12-07 21:49 25d ago
2025-12-07 16:05 25d ago
MRX DEADLINE TOMORROW: ROSEN, TRUSTED INVESTOR COUNSEL, Encourages Marex Group plc Investors with Losses in Excess of $100K to Secure Counsel Before Important December 8 Deadline in Securities Class Action - MRX stocknewsapi
MRX
December 07, 2025 4:05 PM EST | Source: The Rosen Law Firm PA
New York, New York--(Newsfile Corp. - December 7, 2025) - WHY: Rosen Law Firm, a global investor rights law firm, reminds purchasers of securities of Marex Group plc (NASDAQ: MRX) between May 16, 2024 and August 5, 2025, both dates inclusive (the "Class Period"), of the important December 8, 2025 lead plaintiff deadline.

SO WHAT: If you purchased Marex securities during the Class Period you may be entitled to compensation without payment of any out of pocket fees or costs through a contingency fee arrangement.

WHAT TO DO NEXT: To join the Marex class action, go to https://rosenlegal.com/submit-form/?case_id=43100 or call Phillip Kim, Esq. toll-free at 866-767-3653 or email [email protected] for information on the class action. If you wish to serve as lead plaintiff, you must move the Court no later than December 8, 2025. A lead plaintiff is a representative party acting on behalf of other class members in directing the litigation.

WHY ROSEN LAW: We encourage investors to select qualified counsel with a track record of success in leadership roles. Often, firms issuing notices do not have comparable experience, resources, or any meaningful peer recognition. Many of these firms do not actually litigate securities class actions, but are merely middlemen that refer clients or partner with law firms that actually litigate the cases. Be wise in selecting counsel. The Rosen Law Firm represents investors throughout the globe, concentrating its practice in securities class actions and shareholder derivative litigation. Rosen Law Firm has achieved, at that time, the largest ever securities class action settlement against a Chinese Company. Rosen Law Firm was Ranked No. 1 by ISS Securities Class Action Services for number of securities class action settlements in 2017. The firm has been ranked in the top 4 each year since 2013 and has recovered hundreds of millions of dollars for investors. In 2019 alone the firm secured over $438 million for investors. In 2020, founding partner Laurence Rosen was named by law360 as a Titan of Plaintiffs' Bar. Many of the firm's attorneys have been recognized by Lawdragon and Super Lawyers.

DETAILS OF THE CASE: According to the lawsuit, during the Class Period, defendants made materially false and/or misleading statements and/or failed to disclose that: (1) Marex sold over-the-counter financial instruments to itself; (2) Marex had inconsistencies in its financial statements between its subsidiaries and related parties, including as to intercompany receivables and loans; (3) as a result of the foregoing, Marex's financial statements could not be relied upon; and (4) as a result of the foregoing, defendants' positive statements about Marex's business, operations, and prospects were materially misleading and/or lacked a reasonable basis. When the true details entered the market, the lawsuit claims that investors suffered damages.

To join the Marex class action, go to https://rosenlegal.com/submit-form/?case_id=43100 or call Phillip Kim, Esq. toll-free at 866-767-3653 or email [email protected] for information on the class action.

No Class Has Been Certified. Until a class is certified, you are not represented by counsel unless you retain one. You may select counsel of your choice. You may also remain an absent class member and do nothing at this point. An investor's ability to share in any potential future recovery is not dependent upon serving as lead plaintiff.

Follow us for updates on LinkedIn: https://www.linkedin.com/company/the-rosen-law-firm, on Twitter: https://twitter.com/rosen_firm or on Facebook: https://www.facebook.com/rosenlawfirm/.

Attorney Advertising. Prior results do not guarantee a similar outcome.

-------------------------------

To view the source version of this press release, please visit https://www.newsfilecorp.com/release/277075
2025-12-07 21:49 25d ago
2025-12-07 16:22 25d ago
ROSEN, RECOGNIZED INVESTOR COUNSEL, Encourages StubHub Holdings, Inc. Investors to Secure Counsel Before Important Deadline in Securities Class Action - STUB stocknewsapi
STUB
December 07, 2025 4:22 PM EST | Source: The Rosen Law Firm PA
New York, New York--(Newsfile Corp. - December 7, 2025) - WHY: Rosen Law Firm, a global investor rights law firm, reminds purchasers of common stock of StubHub Holdings, Inc. (NYSE: STUB) pursuant and/or traceable to the Registration Statement issued in connection with StubHub's September 2025 initial public offering (the "IPO"), of the important January 23, 2026 lead plaintiff deadline.

SO WHAT: If you purchased StubHub common stock you may be entitled to compensation without payment of any out of pocket fees or costs through a contingency fee arrangement.

WHAT TO DO NEXT: To join the StubHub class action, go to https://rosenlegal.com/submit-form/?case_id=48412 or call Phillip Kim, Esq. at 866-767-3653 or email [email protected] for more information. A class action lawsuit has already been filed. If you wish to serve as lead plaintiff, you must move the Court no later than January 23, 2026. A lead plaintiff is a representative party acting on behalf of other class members in directing the litigation.

WHY ROSEN LAW: We encourage investors to select qualified counsel with a track record of success in leadership roles. Often, firms issuing notices do not have comparable experience, resources, or any meaningful peer recognition. Many of these firms do not actually litigate securities class actions, but are merely middlemen that refer clients or partner with law firms that actually litigate the cases. Be wise in selecting counsel. The Rosen Law Firm represents investors throughout the globe, concentrating its practice in securities class actions and shareholder derivative litigation. Rosen Law Firm achieved, at that time, the largest ever securities class action settlement against a Chinese Company. Rosen Law Firm was Ranked No. 1 by ISS Securities Class Action Services for number of securities class action settlements in 2017. The firm has been ranked in the top 4 each year since 2013 and has recovered hundreds of millions of dollars for investors. In 2019 alone the firm secured over $438 million for investors. In 2020, founding partner Laurence Rosen was named by law360 as a Titan of Plaintiffs' Bar. Many of the firm's attorneys have been recognized by Lawdragon and Super Lawyers.

DETAILS OF THE CASE: According to the lawsuit, the Registration Statement was materially false and misleading and omitted to state that: (1) StubHub was experiencing changes in the timing of payments to vendors; (2) those changes had a significant adverse impact on free cash flow, including trailing twelve months ("TTM") free cash flow; (3) as a result, StubHub's free cash flow reports were materially misleading, and that; (4) as a result of the foregoing, defendants' positive statements about StubHub's business, operations, and prospects were materially misleading and/or lacked a reasonable basis. When the true details entered the market, the lawsuit claims that investors suffered damages.

To join the StubHub class action, go to https://rosenlegal.com/submit-form/?case_id=48412 or call Phillip Kim, Esq. at 866-767-3653 or email [email protected] for more information.

No Class Has Been Certified. Until a class is certified, you are not represented by counsel unless you retain one. You may select counsel of your choice. You may also remain an absent class member and do nothing at this point. An investor's ability to share in any potential future recovery is not dependent upon serving as lead plaintiff.

Follow us for updates on LinkedIn: https://www.linkedin.com/company/the-rosen-law-firm, on Twitter: https://twitter.com/rosen_firm or on Facebook: https://www.facebook.com/rosenlawfirm/.

Attorney Advertising. Prior results do not guarantee a similar outcome.

-------------------------------

To view the source version of this press release, please visit https://www.newsfilecorp.com/release/277154
2025-12-07 21:49 25d ago
2025-12-07 16:27 25d ago
MLTX DEADLINE ALERT: ROSEN, A LEADING INVESTOR RIGHTS LAW FIRM, Encourages MoonLake Immunotherapeutics Investors with Losses in Excess of $100K to Secure Counsel Before Important December 15 Deadline in Securities Class Action - MLTX stocknewsapi
MLTX
December 07, 2025 4:27 PM EST | Source: The Rosen Law Firm PA
New York, New York--(Newsfile Corp. - December 7, 2025) - WHY: Rosen Law Firm, a global investor rights law firm, reminds purchasers of common stock of MoonLake Immunotherapeutics (NASDAQ: MLTX) between March 10, 2024 and September 29, 2025, both dates inclusive (the "Class Period"), of the important December 15, 2025 lead plaintiff deadline.

SO WHAT: If you purchased MoonLake common stock during the Class Period you may be entitled to compensation without payment of any out of pocket fees or costs through a contingency fee arrangement.

WHAT TO DO NEXT: To join the MoonLake class action, go to https://rosenlegal.com/submit-form/?case_id=45681 or call Phillip Kim, Esq. toll-free at 866-767-3653 or email [email protected] for information on the class action. If you wish to serve as lead plaintiff, you must move the Court no later than December 15, 2025. A lead plaintiff is a representative party acting on behalf of other class members in directing the litigation.

WHY ROSEN LAW: We encourage investors to select qualified counsel with a track record of success in leadership roles. Often, firms issuing notices do not have comparable experience, resources, or any meaningful peer recognition. Many of these firms do not actually litigate securities class actions, but are merely middlemen that refer clients or partner with law firms that actually litigate the cases. Be wise in selecting counsel. The Rosen Law Firm represents investors throughout the globe, concentrating its practice in securities class actions and shareholder derivative litigation. Rosen Law Firm has achieved, at that time, the largest ever securities class action settlement against a Chinese Company. Rosen Law Firm was Ranked No. 1 by ISS Securities Class Action Services for number of securities class action settlements in 2017. The firm has been ranked in the top 4 each year since 2013 and has recovered hundreds of millions of dollars for investors. In 2019 alone the firm secured over $438 million for investors. In 2020, founding partner Laurence Rosen was named by law360 as a Titan of Plaintiffs' Bar. Many of the firm's attorneys have been recognized by Lawdragon and Super Lawyers.

DETAILS OF THE CASE: According to the complaint, throughout the Class Period, defendants made false and/or misleading statements, as well as failed to disclose material facts, regarding the distinction between the Nanobodies and monoclonal antibodies, including that: (1) SLK and BIMZELX share the same molecular targets (the inflammatory cytokines IL-17A and IL-17F); (2) SLK's distinct Nanobody structure would not confer a superior clinical benefit over the traditional monoclonal structure of BIMZELX; (3) SLK's distinct Nanobody structure supposed tissue penetration would not translate to clinical efficacy; and (4) based on the foregoing, defendants lacked a reasonable basis for their positive statements regarding SLK's purported superiority to monoclonal antibodies. When the true details entered the market, the lawsuit claims that investors suffered damages.

To join the MoonLake class action, go to https://rosenlegal.com/submit-form/?case_id=45681 or call Phillip Kim, Esq. toll-free at 866-767-3653 or email [email protected] for information on the class action.

No Class Has Been Certified. Until a class is certified, you are not represented by counsel unless you retain one. You may select counsel of your choice. You may also remain an absent class member and do nothing at this point. An investor's ability to share in any potential future recovery is not dependent upon serving as lead plaintiff.

Follow us for updates on LinkedIn: https://www.linkedin.com/company/the-rosen-law-firm, on Twitter: https://twitter.com/rosen_firm or on Facebook: https://www.facebook.com/rosenlawfirm/.

Attorney Advertising. Prior results do not guarantee a similar outcome.

-------------------------------

To view the source version of this press release, please visit https://www.newsfilecorp.com/release/277082
2025-12-07 21:49 25d ago
2025-12-07 16:30 25d ago
Lyell Immunopharma Presents New Clinical Data from Ongoing Trial of Ronde-Cel Showing High Rates of Durable Complete Responses in Patients with Large B-cell Lymphoma at the 67th ASH Annual Meeting and Exposition stocknewsapi
LYEL
93% overall response and 76% complete response rates with median progression-free survival of 18 months in patients with large B-cell lymphoma in the 3L+ setting83% overall response and 61% complete response rates in cohort comprised predominantly of patients with primary refractory large B-cell lymphoma in the 2L settingManageable safety profile appropriate for outpatient administration; no high-grade CRS and ≤ 5% of patients with Grade ≥ 3 ICANS following dexamethasone prophylaxisLyell management will host an investor webcast with presenting author and ronde-cel investigator Sarah M. Larson, MD, Associate Professor at the David Geffen School of Medicine, University of California, Los Angeles, at 8:30 AM ET on Monday, December 8th SOUTH SAN FRANCISCO, Calif., Dec. 07, 2025 (GLOBE NEWSWIRE) -- Lyell Immunopharma, Inc. (Nasdaq: LYEL), a clinical-stage company advancing a pipeline of next-generation chimeric antigen receptor (CAR) T-cell therapies for patients with cancer, today announced new clinical and translational data from the ongoing clinical trial of rondecabtagene autoleucel (ronde-cel, also known as LYL314) in patients with large B-cell lymphoma (LBCL), which were presented today in two oral presentations at the 67th American Society of Hematology (ASH) Annual Meeting and Exposition. As of the data cutoff date of September 5, 2025, ronde-cel continued to demonstrate robust clinical responses with a manageable safety profile appropriate for outpatient administration. A 93% overall response rate, a 76% complete response rate, and median progression-free survival of 18 months were reported for patients with relapsed and/or refractory (R/R) LBCL in the third- or later-line (3L+) setting. Patients evaluated in the second-line (2L) setting (94% with difficult-to-treat primary refractory disease) achieved an 83% overall response rate and a 61% complete response rate, and 70% of patients with a complete response remained in complete response at 6 months or longer.

Ronde-cel is an autologous dual-targeting CD19/CD20 CAR T-cell product candidate in pivotal development for patients with R/R LBCL. Ronde-cel CAR T cells are designed to have enhanced antitumor activity through a proprietary manufacturing process that enriches for CD62L-positive cells to produce a CAR T-cell product with a higher proportion of naïve and central memory T cells. The United States Food and Drug Administration (FDA) has granted ronde-cel Regenerative Medicine Advanced Therapy (RMAT) designation for the treatment of patients with R/R LBCL in the 3L+ and 2L settings.

“These data from the ongoing clinical trial showing high rates of durable complete responses along with a manageable safety profile in patients with high-risk large B-cell lymphoma represent the potential of ronde-cel to improve patient outcomes,” commented Sarah M. Larson, MD, Associate Professor, Department of Medicine, Medical Director, Immune Effector Cell Therapy Program, Division of Hematology/Oncology, David Geffen School of Medicine at UCLA. “The two pivotal trials underway, including the first-of-its kind head-to-head CAR T-cell trial, are expected to provide a comprehensive and robust evaluation of the potential for ronde-cel to demonstrate differentiated benefit over approved CD19 CAR T-cell therapies.”

Sixty-nine CAR T-cell naïve patients with R/R LBCL received ronde-cel as of the data cutoff date for the presentation. The efficacy evaluable population, defined as those patients with Day 84 assessments or prior disease progression or death, consisted of 47 patients (29 in the 3L+ and 18 in the 2L settings). Imaging assessments were performed locally by the sites. Patient demographics and baseline disease characteristics were consistent with a high-risk, heavily pre-treated patient population, particularly as compared to historical trials of CD19 CAR T-cell products: median ages of 64 and 65 years with 20% (9/45) and 21% (5/24) of patients being 75 years or older in the 3L+ and 2L settings, respectively; and primary refractory disease in 49% (22/45) and 92% (22/24) of patients in the 3L+ and 2L settings, respectively.

Patients Evaluated in the 3L+ Setting

There were 29 efficacy-evaluable 3L+ patients with R/R LBCL (diffuse large B-cell lymphoma, primary mediastinal B-cell lymphoma, Grade 3B follicular lymphoma, or transformed follicular lymphoma) with a median follow up time of 12 months as of the data cutoff date. In these patients:

The overall response rate was 93% (27/29 patients), with 76% (22/29) of patients achieving a complete response72% (13/18) of patients with complete response remained in complete response at 6 months or longerMedian progression-free survival was 18 months
Patients Evaluated in the 2L Setting

There were 18 efficacy-evaluable patients enrolled in the 2L setting with a median follow-up time of 9 months as of the data cutoff date. Of these efficacy-evaluable patients, 94% had primary refractory disease. In these patients:

The overall response rate was 83% (15/18 patients), with 61% (11/18) achieving a complete response70% (7/10) of patients with complete response remained in complete response at 6 months or longerThe median duration of complete response was not reached
Safety Data

In 69 patients, including patients from both the 3L+ and the 2L cohorts, a manageable safety profile appropriate for outpatient administration was observed. No Grade 3 or greater cytokine release syndrome (CRS) was observed in any patient. Twenty-five of the 69 patients received protocol-directed dexamethasone prophylaxis (10 mg/day for 3 days). One case (4%) of Grade 3 or greater ICANS was reported in a patient with high disease burden; no case of Grade 2 ICANS was reported.

In all 69 patients, as of the data cutoff date, low rates of Grade 1 (32%) or Grade 2 (29%) CRS were reported; ICANS rates were reported as follows: Grade 1 (9%), Grade 2 (3%), and Grade 3 or greater (12%) of patients. The median time to complete resolution of all reports of ICANS was 4 days. Cell pharmacodynamic data demonstrated robust CAR T-cell expansion and persistence that were similar in patients with or without dexamethasone prophylaxis. No deaths were determined to be related to ronde-cel administration.

Pivotal Clinical Trials

Lyell has initiated two pivotal clinical trials of ronde-cel: PiNACLE – H2H and PiNACLE.

PiNACLE – H2H is a Phase 3 head-to-head CAR T-cell therapy randomized controlled clinical trial of ronde-cel versus investigator’s choice of either lisocabtagene maraleucel (liso-cel) or axicabtagene ciloleucel (axi-cel) in patients with R/R LBCL receiving treatment in the 2L setting. Patients randomized to ronde-cel will be treated with a dose of 100 x 106 CAR T cells; patients in the control arm will be treated as per the product label. The primary endpoint of the trial is event-free survival and the trial is expected to enroll approximately 200 patients per arm (N = 400) with R/R LBCL, including diffuse large B-cell lymphoma, primary mediastinal B-cell lymphoma, high grade B-cell lymphoma, Grade 3B follicular lymphoma, or transformed follicular or transformed mantle cell lymphoma who have not previously received CAR T-cell therapy. Patients may be treated with ronde-cel in either the inpatient or outpatient setting. More information about the PiNACLE – H2H trial can be found on clinicaltrials.gov (NCT07188558) here.

PiNACLE is a single-arm trial of ronde-cel that is enrolling up to 120 patients receiving treatment in the 3L+ setting. This registration trial is a seamless expansion of the 3L+ cohort from the Phase 1/2 trial. The dose is 100 x 106 CAR+ cells and the primary endpoint is overall response rate. Patients may be treated with ronde-cel in either the inpatient or outpatient setting. More information about the PiNACLE trial can be found on clinicaltrials.gov (NCT05826535) here.

Ronde-cel Translational Data

Translational data from the ongoing Phase 1/2 clinical trial showed that ronde-cel manufactured with CD62L enrichment achieved robust expansion and high expression of memory-related genes after infusion in patients with LBCL. An evaluation of ronde-cel and published data for CD19 CAR T-cell products demonstrated that ronde-cel had a higher proportion of CD62L-positive T cells with a higher proportion of memory-cell phenotype prior to infusion (ronde-cel, N = 34; axi-cel, N = 110 and tisagenlecleucel (tisa-cel), N = 31). In addition, ronde-cel had up to a three-fold higher expansion in patients after infusion compared to the expansion of approved CD19 CAR T-cell products. The product memory-cell phenotype was positively correlated with expansion. Peripheral blood samples collected from patients one month after infusion (N = 9) also had a higher proportion of CAR T cells with a memory phenotype compared to cells from axi-cel-treated patients (N = 4). Ronde-cel CAR-positive T cells collected from patients one (N = 7) and two months (N = 3) after infusion demonstrated sustained capacity to proliferate, kill tumor cells over 72 hours, and secrete cytokines (N = 3).

The clinical data were highlighted in an oral presentation by Sarah M. Larson, MD, Associate Professor, Department of Medicine, Medical Director, Immune Effector Cell Therapy Program, Division of Hematology/Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA. Translational data were presented in a separate oral presentation by Akil Merchant, MD, Associate Professor and Co-Director of the Lymphoma Program at the Samuel Oschin Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA.

Conference Call Details

Lyell’s management will host an investor conference call and webcast to review these data at 8:30 AM ET on Monday, December 8th. The webcast registration link can be accessed here. A replay of the event and presentation materials will be available on the Investor page of the Lyell Website following the end of the event.

About Rondecabtagene Autoleucel (Ronde-cel)

Rondecabtagene autoleucel (ronde-cel, also known as LYL314) is a next-generation dual-targeting CD19/CD20 CAR T-cell product candidate designed to increase complete response rates and prolong the duration of the responses as compared to the approved CD19 targeted CAR T-cell therapies for the treatment of R/R LBCL.

Ronde-cel is designed with an ‘OR’ logic gate to target B cells that express either CD19, CD20 or both, each with full potency. Ronde-cel is manufactured to produce a CAR T-cell product with higher proportions of naïve and central memory T cells through a proprietary process that enriches for CD62L-expressing cells. This manufacturing process is designed to generate CAR T cells with enhanced antitumor activity.

Ronde-cel has received RMAT designation from the FDA for the treatment of patients with R/R LBCL in the 3L+ and 2L settings, as well as Fast Track Designation for the treatment of patients with R/R LBCL in the 3L+ setting.

About Lyell

Lyell is a clinical stage company advancing a pipeline of next-generation CAR T-cell therapies for patients with hematologic malignancies and solid tumors. To realize the potential of cell therapy for cancer, Lyell utilizes a suite of technologies to arm CAR T cells with enhancements needed to drive durable tumor cytotoxicity and achieve consistent and long-lasting clinical responses, including the ability to resist exhaustion, maintain qualities of durable stemness, and function in the hostile tumor microenvironment. Lyell’s LyFE Manufacturing Center™ has commercial launch capability and can manufacture more than 1,200 CAR T-cell doses at full capacity. To learn more, please visit www.lyell.com.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements expressed or implied in this press release include, but are not limited to, statements regarding: the potential clinical benefits and therapeutic potential of ronde-cel; Lyell’s expectations around the progress of the PiNACLE and PiNACLE H2H trials, including expectations around enrollment; the sufficiency of the capacity of LyFE to manufacture drug supply through potential commercial launch; and other statements that are not historical fact. These statements are based on Lyell’s current plans, objectives, estimates, expectations and intentions, are not guarantees of future performance and inherently involve significant risks and uncertainties. Actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of these risks and uncertainties, which include, but are not limited to, risks and uncertainties related to: interim results of a clinical trial as of the data cutoff are not necessarily indicative of final results and one or more of the clinical and safety outcomes may materially change as patient enrollment continues, following more comprehensive reviews of the data, as follow-up on the outcome of any particular patient continues and as more patient or final data becomes available; Lyell’s limited experience as a company in enrolling and conducting clinical trials, and lack of experience in completing clinical trials; the nonclinical profiles of Lyell’s product candidates or technology not translating in clinical trials; the potential for results from clinical trials to differ from nonclinical, early clinical, preliminary or expected results; significant adverse events, toxicities or other undesirable side effects associated with Lyell’s product candidates, including the risk that the ultimate safety profile of ronde-cel may not support outpatient administration; the translational data presented above is not based on a head-to-head trial and differences exist between trial designs and subject characteristics, and caution should be exercised when comparing data across trials; Lyell’s ability to submit planned Investigational New Drug Applications or initiate or progress clinical trials on the anticipated timelines, if at all; RMAT and Fast Track designations may not actually lead to faster development, regulatory review or approval process, and do not assure ultimate FDA approval; the significant uncertainty associated with Lyell’s product candidates ever receiving any regulatory approvals; Lyell’s ability to obtain, maintain or protect intellectual property rights related to its product candidates; the complexity of manufacturing cellular therapies and Lyell’s ability to manufacture and supply its product candidates for its clinical trials; implementation of Lyell’s strategic plans for its business and product candidates; Lyell’s realization of the expected benefits of its strategic plans for its business and product candidates, including the license of its product candidate LYL273; the potential reduction of Lyell’s cash resources and fluctuations in Lyell’s operating results and financial condition as a result of Lyell’s milestone, royalty and success payment obligations; the sufficiency of Lyell’s capital resources and need for additional capital to achieve its goals; the effects of macroeconomic conditions, including the effects of disruption between the U.S. and its trading partners due to tariffs or other policies, and any geopolitical instability; potential changes to U.S. drug pricing, including the potential for “most-favored nations” pricing limitations; other risks, including general economic conditions and regulatory developments, not within our control; and other risks, including those described under the heading “Risk Factors” in Lyell’s Annual Report on Form 10‑K for the fiscal year ended December 31, 2024, filed with the Securities Exchange Commission (SEC) on March 11, 2025, and Lyell’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2025, filed with the SEC on November 12, 2025. Forward-looking statements contained in this press release are made as of this date, and Lyell undertakes no duty to update such information except as required under applicable law.

Contact:

Ellen Rose
Senior Vice President, Communications and Investor Relations
[email protected]
2025-12-07 21:49 25d ago
2025-12-07 16:30 25d ago
Lynozyfic™ (linvoseltamab) Monotherapy in Newly Diagnosed Multiple Myeloma (NDMM) Shows Impressive Responses, Supporting Rationale as a Potential Foundation in Frontline Treatment stocknewsapi
REGN
All three dose groups (50 mg, 100 mg and 200 mg) showed impressive monotherapy efficacy, with VGPR+ (very good partial response or better) of ≥70% despite limited follow-up; evidence shows that these responses are expected to deepen over time

Across all dose groups, 95% (19 of 20 patients) of all evaluable VGPR+ patients achieved minimal residual disease negative status

Data featured in an ASH oral presentation; LINKER-MM4 is the first clinical trial to evaluate a BCMAxCD3 bispecific monotherapy in NDMM and is part of a broad clinical development program evaluating Lynozyfic-based regimens in earlier lines of treatment

Regeneron to host virtual ‘Regeneron Roundtable’ investor event to discuss its multiple myeloma development program on Wednesday, December 10 at 8:30 a.m. ET 

TARRYTOWN, N.Y., Dec. 07, 2025 (GLOBE NEWSWIRE) -- Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) today announced encouraging data from the Phase 1/2 LINKER-MM4 trial evaluating Lynozyfic™ (linvoseltamab) in adults with newly diagnosed multiple myeloma (NDMM) who were transplant eligible or ineligible were shared in an oral presentation at the American Society of Hematology (ASH) Annual Meeting. These data build on results from a broad clinical development program evaluating Lynozyfic in early lines of treatment, including precursor conditions, as monotherapy and in combination with standard-of-care or novel agents.

“The treatment of newly diagnosed multiple myeloma often relies on complicated combinations of quadruplet or triplet regimens, each with its own toxicities, in order to achieve rapid and durable responses, which can be incredibly burdensome for these patients,” said Robert Orlowski, M.D., Ph.D., Deputy Chair, Professor of Medicine, and Director of Translational Myeloma Research in the Departments of Lymphoma/Myeloma and Experimental Therapeutics at The University of Texas MD Anderson Cancer Center and the lead investigator for the LINKER-MM4 trial. “As the first to evaluate a BCMAxCD3 bispecific monotherapy in this setting, LINKER-MM4 seeks to understand whether frontline intervention with a single agent can deliver strong efficacy, enabling the simplification and potentially greater tolerability of these regimens. Lynozyfic monotherapy is already achieving MRD negativity rates comparable to quadruplet regimens but earlier in the treatment course, and these compelling results are expected to deepen with longer follow up. These results underscore Lynozyfic’s potential as a foundational component of frontline treatment regimens for multiple myeloma – or even a monotherapy regimen – for both transplant-eligible and transplant-ineligible patients.”

LINKER-MM4 is an ongoing, open-label Phase 1/2 trial investigating Lynozyfic in adults with NDMM. During a Phase 1A (dose escalation) cohort, patients were treated with a step-up dosing regimen followed by 50 mg, 100 mg or 200 mg doses of Lynozyfic. The lowest (50 mg) and highest (200 mg) tolerated doses were selected for further evaluation in the Phase 1B (dose-expansion) cohort. Among the 45 treated patients in both Phase 1A and 1B, 28 were transplant eligible, and 17 were transplant ineligible.

Across all dose levels (n=45), there was a 1.2 months median time to onset of response (range: 1-4.5 months). All three dose groups (50 mg, 100 mg and 200 mg) showed impressive efficacy, with a VGPR+ (very good partial response or better) of ≥70% with limited follow-up. Evidence shows that these responses are expected to deepen over time. Across all dose groups, 95% (19 of 20 patients) of all minimum residual disease (MRD) evaluable VGPR+ patients achieved MRD negative status at 10-5 sensitivity.

Across all dose levels, the most common treatment-emergent adverse events (TEAEs) were cytokine release syndrome (CRS; all Grade 1: 44%) and neutropenia (any Grade: 38%; Grade 3/4: 33%). Among other adverse events of special interest, one patient in the 50 mg cohort experienced Grade 1 immune effector cell-associated neurotoxicity syndrome (ICANS). Infections occurred in 84% of patients (Grade 1/2: 51%; Grade 3: 33%) with the majority occurring within the first three months of treatment and the rate of infections decreased over time. There were no ≥Grade 4 infections, Grade 5 TEAEs or dose-limiting toxicities. Ten patients elected to undergo an autologous stem cell transplant, all of whom had an acceptable CD34+ stem cell yield post-induction (range: 2.5-11.5 x 106/kg).

A broad clinical development program investigating Lynozyfic in early stages of the disease is underway. This includes the Phase 2 portion of the LINKER-MM4 trial evaluating Lynozyfic at the recommended 200 mg dose, as well as LINKER-MM6 (EMN39), a trial evaluating a combination of daratumumab, lenalidomide and dexamethasone (DRd) followed by Lynozyfic monotherapy compared with continued DRd in transplant-ineligible NDMM.

The use of Lynozyfic described above is investigational, and its safety and efficacy has not been evaluated by any regulatory authority for this indication.

About the ‘Regeneron Roundtable’ Investor Event 
Regeneron will host a virtual investor event to discuss its multiple myeloma program on Wednesday, December 10 at 8:30 a.m. ET. This is the next webcast in a new investor event series called the ‘Regeneron Roundtable,’ intended to highlight programs from the company’s innovative investigational pipeline.

  Links to the webcast and to register via telephone may be accessed from the ‘Investors and Media’ page of Regeneron’s website at 

https://investor.regeneron.com/events-and-presentations. Upon registration, all telephone participants will receive a confirmation email detailing how to join the conference call, including the dial-in number along with a unique passcode and registrant ID that can be used to access the call. A replay of the conference call and webcast will be archived on the company’s website for at least 30 days. 

About Multiple Myeloma
As the second most common blood cancer, there are over 187,000 new cases of MM diagnosed globally every year, with more than 36,000 diagnosed and 12,000 deaths anticipated in the U.S. in 2025. The disease is characterized by the proliferation of cancerous plasma cells (MM cells) that crowd out healthy blood cells in the bone marrow, infiltrate other tissues and cause potentially life-threatening organ injury. Despite treatment advances, MM is not curable, and while current treatments are able to slow progression of the cancer, most patients will ultimately experience cancer progression and require additional therapies.

About Lynozyfic
Lynozyfic was invented using Regeneron’s VelocImmune® technology and is a fully human BCMAxCD3 bispecific antibody designed to bridge B-cell maturation antigen (BCMA) on MM cells with CD3-expressing T cells to facilitate T-cell activation and cancer-cell killing. Lynozyfic is approved to treat certain adults with R/R MM: in the U.S. after four lines of therapy and in the European Union after at least three prior therapies.

In the U.S., the generic name for Lynozyfic in its approved indications is linvoseltamab-gcpt, with gcpt as the suffix designated in accordance with Nonproprietary Naming of Biological Products Guidance for Industry issued by the U.S. FDA. Outside of the U.S., the generic name of Lynozyfic in its approved indications is linvoseltamab.

Lynozyfic is being investigated in a broad clinical development program exploring its use as a monotherapy as well as in combination regimens across different lines of therapy in MM, including earlier lines of treatment, as well as plasma cell precursor disorders. These potential uses are investigational, and their safety and efficacy have not been evaluated by any regulatory authority.  

In addition to LINKER-MM4, ongoing trials include:

LINKER-MM1: Phase 1/2 dose-escalation and dose-expansion trial evaluating the safety, tolerability, dose-limiting toxicities and anti-tumor activity of Lynozyfic monotherapy in R/R MMLINKER-MM2: Phase 1b, open-label trial evaluating Lynozyfic in combination with other cancer treatments in patients with R/R MMLINKER-MM3: Phase 3 confirmatory trial evaluating Lynozyfic monotherapy compared to the combination of elotuzumab, pomalidomide and dexamethasone in R/R MMLINKER-MM5: Phase 3 trial evaluating Lynozyfic monotherapy or in combination with carfilzomib compared to standard of care combination regimens in patients with R/R MMLINKER-MM6 (EMN39): Phase 3 trial, in collaboration with the European Myeloma Network, evaluating daratumumab, lenalidomide and dexamethasone induction followed by Lynozyfic monotherapy compared to continued daratumumab, lenalidomide, and dexamethasone in NDMM who are transplant-ineligiblePhase 1 trial evaluating Lynozyfic in combination with a Regeneron CD38xCD28 costimulatory bispecific in R/R MMLINKER-SMM1: Phase 2 trial evaluating Lynozyfic monotherapy in high-risk smoldering MMLINKER-MGUS1: Phase 2 dose-ranging trial evaluating Lynozyfic monotherapy in high-risk monoclonal gammopathy of unknown significance and non-high-risk SMMLINKER-AL2: Phase 1/2 trial evaluating Lynozyfic monotherapy in R/R systemic light chain amyloidosis 
For more information on Regeneron’s clinical trials in blood cancer, visit the clinical trials website, or contact via [email protected] or 844-734-6643.

IMPORTANT SAFETY INFORMATION FOR U.S. PATIENTS

What is the most important information I should know about LYNOZYFIC?
LYNOZYFIC may cause serious or life-threatening side effects, including Cytokine Release Syndrome (CRS) and infusion-related reactions (IRR), or neurologic problems.

Cytokine Release Syndrome (CRS) and infusion related reactions (IRR). CRS is common during treatment with LYNOZYFIC and can also be serious or life-threatening. Tell your healthcare provider or get medical help right away if you develop any signs or symptoms of CRS or IRR, including:

fever of 100.4ºF (38ºC) or higher fast heartbeat chills or shaking dizziness or light-headedness trouble breathing   Neurologic problems. LYNOZYFIC can cause neurologic problems that can be serious or life-threatening. Tell your healthcare provider or get medical help right away if you develop any signs or symptoms of neurologic problems, including:

headacheagitation, trouble staying awake, confusion or disorientation, seeing or hearing things that are not real (hallucinations)trouble speaking, writing, thinking, remembering things, paying attention, or understanding thingsproblems walking, muscle weakness, shaking (tremors), loss of balance, or muscle spasmsnumbness and tingling (feeling like “pins and needles”)burning, throbbing, or stabbing painchanges in your handwritingseizures Due to the risk of CRS and neurologic problems, you will receive LYNOZYFIC on a “step-up dosing schedule” and should be hospitalized for 24 hours after the first and second “step-up” doses.

During the “step-up dosing schedule”: For your first dose, you will receive a smaller “step-up” dose of LYNOZYFIC on Day 1 of your treatment.For your second dose, you will receive a larger “step-up” dose of LYNOZYFIC, which is usually given on Day 8 of your treatment.For your third dose, you will receive the first treatment dose of LYNOZYFIC, which is usually given on Day 15 of your treatment.Your healthcare provider may repeat one or both of the “step-up” doses depending on side effects or if your treatment is delayed.Before the “step-up” doses and the first two treatment doses of LYNOZYFIC, you will receive medicines to help reduce your risk of CRS and IRR. Your healthcare provider will decide if you need to receive medicine to help reduce your risk of side effects with future doses. LYNOZYFIC is available only through the LYNOZYFIC Risk Evaluation and Mitigation Strategy (REMS) due to the risk of side effects of CRS and neurologic problems. You will receive a Patient Wallet Card from your healthcare provider. Carry the LYNOZYFIC Patient Wallet Card with you at all times and show it to all of your healthcare providers. The LYNOZYFIC Patient Wallet Card lists signs and symptoms of CRS and neurologic problems. Get medical help right away if you develop any of the signs and symptoms listed on the LYNOZYFIC Patient Wallet Card. You may need to be treated in a hospital.

Your healthcare provider will monitor you for signs and symptoms of CRS and neurologic problems during treatment with LYNOZYFIC, as well as other side effects, and may treat you in a hospital if needed. Your healthcare provider may temporarily stop or completely stop your treatment with LYNOZYFIC if you develop CRS, neurologic problems, or any other severe side effects.

If you have any questions about LYNOZYFIC, ask your healthcare provider.

Before receiving LYNOZYFIC, tell your healthcare provider about all of your medical conditions, including if you:

have an infection.are pregnant or plan to become pregnant. LYNOZYFIC may harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think that you may be pregnant during treatment with LYNOZYFIC.
Females who are able to become pregnant: Your healthcare provider should do a pregnancy test before you start treatment with LYNOZYFIC.You should use an effective form of birth control (contraception) during treatment with LYNOZYFIC and for 3 months after your last dose of LYNOZYFIC.are breastfeeding or plan to breastfeed. It is not known whether LYNOZYFIC passes into your breast milk. Do not breastfeed during treatment with LYNOZYFIC and for 3 months after your last dose of LYNOZYFIC.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How will I receive LYNOZYFIC?

LYNOZYFIC will be given to you by your healthcare provider by infusion through a needle placed in a vein (intravenous infusion).After the “step-up dosing schedule”, the treatment dose of LYNOZYFIC is usually given 1 time each week for 11 doses, and then 1 time every other week for 5 doses. After these doses and based on how your disease responds, your healthcare provider will decide if you are able to receive LYNOZYFIC less often (every 4 weeks) or will continue to have every other week treatment.Your healthcare provider will decide how long you will receive treatment with LYNOZYFIC.If you miss any appointments, call your healthcare provider as soon as possible to reschedule your appointment. It is important for you to be monitored closely for side effects during treatment with LYNOZYFIC. What should I avoid while receiving LYNOZYFIC?
Do not drive, or operate heavy or potentially dangerous machinery, or do other dangerous activities for 48 hours after completing each of your “step-up” doses or at any time during treatment with LYNOZYFIC if you develop new neurologic symptoms, until the symptoms go away.

What are the possible side effects of LYNOZYFIC?
LYNOZYFIC may cause serious side effects, including:

Infections. LYNOZYFIC can cause bacterial, viral, or fungal infections that are serious, life-threatening, or that may lead to death. Upper respiratory tract infections and pneumonia are common during treatment with LYNOZYFIC. Your healthcare provider will monitor you for signs and symptoms of infection before and during treatment with LYNOZYFIC.Your healthcare provider may prescribe medicines for you to help prevent infections and treat you as needed if you develop an infection during treatment with LYNOZYFIC.Tell your healthcare provider right away if you develop any signs or symptoms of infection during treatment with LYNOZYFIC, including: fever of 100.4 °F (38 °C) or higherchillscoughshortness of breathchest painsore throatpain during urinationfeeling weak or generally unwell Decreased white blood cell counts. Decreased white blood cell counts are common during treatment with LYNOZYFIC and can also be severe. Fever can happen with low white blood cell counts and may be a sign that you have an infection. Your healthcare provider will check your blood cell counts before you start treatment and during treatment with LYNOZYFIC, and will treat you as needed.Liver problems. LYNOZYFIC can cause increased liver enzymes and bilirubin in your blood. These increases can happen with or without you also having CRS. Your healthcare provider will do blood tests to check your liver before starting and during treatment with LYNOZYFIC. Tell your healthcare provider if you develop any of the following signs or symptoms of liver problems: tirednessloss of appetitepain in your right upper stomach-area (abdomen)dark urine yellowing of your skin or the white part of your eyes The most common side effects of LYNOZYFIC include:

muscle and bone pain nausea cough headache diarrheatiredness or weakness shortness of breath The most common severe abnormal blood test results with LYNOZYFIC include: low white blood cell counts and low red blood cell counts.

These are not all of the possible side effects of LYNOZYFIC.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Please see full Prescribing Information, including Boxed WARNING, and Medication Guide for LYNOZYFIC.

What is LYNOZYFIC?
LYNOZYFIC is a prescription medicine used to treat adults with multiple myeloma who:

have already received at least 4 treatment regimens, including a proteasome inhibitor, an immunomodulatory agent and an anti-CD38 monoclonal antibody to treat their multiple myeloma, andtheir cancer has come back or did not respond to prior treatment. It is not known if LYNOZYFIC is safe and effective in children.

About Regeneron in Hematology 
At Regeneron, we’re applying more than three decades of biology expertise with our proprietary VelociSuite® technologies to develop medicines for patients with diverse blood cancers and rare blood disorders.

Our blood cancer research is focused on bispecific antibodies that are being investigated both as monotherapies and in various combinations and emerging therapeutic modalities. Together, they provide us with unique combinatorial flexibility to develop customized and potentially synergistic cancer treatments.

Our research and collaborations to develop potential treatments for rare blood disorders include explorations in antibody medicine, gene editing and gene-knockout technologies, and investigational RNA-approaches focused on depleting abnormal proteins or blocking disease-causing cellular signaling. 

About Regeneron's VelocImmune Technology  
Regeneron's VelocImmune technology utilizes a proprietary genetically engineered mouse platform endowed with a genetically humanized immune system to produce optimized fully human antibodies. When Regeneron's co-Founder, President and Chief Scientific Officer George D. Yancopoulos was a graduate student with his mentor Frederick W. Alt in 1985, they were the first to envision making such a genetically humanized mouse, and Regeneron has spent decades inventing and developing VelocImmune and related VelociSuite technologies. Dr. Yancopoulos and his team have used VelocImmune technology to create a substantial proportion of all original, FDA-approved or authorized fully human monoclonal antibodies. This includes Dupixent® (dupilumab), Libtayo® (cemiplimab-rwlc), Praluent® (alirocumab), Kevzara® (sarilumab), Evkeeza® (evinacumab-dgnb), Inmazeb® (atoltivimab, maftivimab and odesivimab-ebgn) and Veopoz® (pozelimab-bbfg). In addition, REGEN-COV® (casirivimab and imdevimab) had been authorized by the FDA during the COVID-19 pandemic until 2024.

  About Regeneron  
Regeneron (NASDAQ: REGN) is a leading biotechnology company that invents, develops and commercializes life-transforming medicines for people with serious diseases. Founded and led by physician-scientists, our unique ability to repeatedly and consistently translate science into medicine has led to numerous approved treatments and product candidates in development, most of which were homegrown in our laboratories. Our medicines and pipeline are designed to help patients with eye diseases, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, neurological diseases, hematologic conditions, infectious diseases, and rare diseases.

Regeneron pushes the boundaries of scientific discovery and accelerates drug development using our proprietary technologies, such as VelociSuite, which produces optimized fully human antibodies and new classes of bispecific antibodies. We are shaping the next frontier of medicine with data-powered insights from the Regeneron Genetics Center® and pioneering genetic medicine platforms, enabling us to identify innovative targets and complementary approaches to potentially treat or cure diseases.

For more information, please visit www.Regeneron.com or follow Regeneron on LinkedIn, Instagram, Facebook or X.

Forward-Looking Statements and Use of Digital Media 
This press release includes forward-looking statements that involve risks and uncertainties relating to future events and the future performance of Regeneron Pharmaceuticals, Inc. (“Regeneron” or the “Company”), and actual events or results may differ materially from these forward-looking statements. Words such as “anticipate,” “expect,” “intend,” “plan,” “believe,” “seek,” “estimate,” variations of such words, and similar expressions are intended to identify such forward-looking statements, although not all forward-looking statements contain these identifying words. These statements concern, and these risks and uncertainties include, among others, the nature, timing, and possible success and therapeutic applications of products marketed or otherwise commercialized by Regeneron and/or its collaborators or licensees (collectively, “Regeneron’s Products”) and product candidates being developed by Regeneron and/or its collaborators or licensees (collectively, “Regeneron’s Product Candidates”) and research and clinical programs now underway or planned, including without limitation Lynozyfic™ (linvoseltamab-gcpt); the likelihood, timing, and scope of possible regulatory approval and commercial launch of Regeneron’s Product Candidates and new indications for Regeneron’s Products, such as Lynozyfic as a monotherapy and/or in combination with standard-of-care agents across different lines of therapy in multiple myeloma (“MM”) and plasma cell precursor disorders, including the treatment of adults with newly diagnosed MM as discussed in this press release; uncertainty of the utilization, market acceptance, and commercial success of Regeneron’s Products (such as Lynozyfic) and Regeneron’s Product Candidates and the impact of studies (whether conducted by Regeneron or others and whether mandated or voluntary), including the studies discussed or referenced in this press release, on any of the foregoing or any potential regulatory approval of Regeneron’s Products and Regeneron’s Product Candidates; the ability of Regeneron’s collaborators, licensees, suppliers, or other third parties (as applicable) to perform manufacturing, filling, finishing, packaging, labeling, distribution, and other steps related to Regeneron’s Products and Regeneron’s Product Candidates; the ability of Regeneron to manage supply chains for multiple products and product candidates and risks associated with tariffs and other trade restrictions; safety issues resulting from the administration of Regeneron’s Products (such as Lynozyfic) and Regeneron’s Product Candidates in patients, including serious complications or side effects in connection with the use of Regeneron’s Products and Regeneron’s Product Candidates in clinical trials; determinations by regulatory and administrative governmental authorities which may delay or restrict Regeneron’s ability to continue to develop or commercialize Regeneron’s Products and Regeneron’s Product Candidates; ongoing regulatory obligations and oversight impacting Regeneron’s Products, research and clinical programs, and business, including those relating to patient privacy; the availability and extent of reimbursement or copay assistance for Regeneron’s Products from third-party payors and other third parties, including private payor healthcare and insurance programs, health maintenance organizations, pharmacy benefit management companies, and government programs such as Medicare and Medicaid; coverage and reimbursement determinations by such payors and other third parties and new policies and procedures adopted by such payors and other third parties; changes to drug pricing regulations and requirements and Regeneron’s pricing strategy; other changes in laws, regulations, and policies affecting the healthcare industry; competing drugs and product candidates that may be superior to, or more cost effective than, Regeneron’s Products and Regeneron’s Product Candidates (including biosimilar versions of Regeneron’s Products); the extent to which the results from the research and development programs conducted by Regeneron and/or its collaborators or licensees may be replicated in other studies and/or lead to advancement of product candidates to clinical trials, therapeutic applications, or regulatory approval; unanticipated expenses; the costs of developing, producing, and selling products; the ability of Regeneron to meet any of its financial projections or guidance and changes to the assumptions underlying those projections or guidance; the potential for any license, collaboration, or supply agreement, including Regeneron’s agreements with Sanofi and Bayer (or their respective affiliated companies, as applicable), to be cancelled or terminated; the impact of public health outbreaks, epidemics, or pandemics on Regeneron's business; and risks associated with litigation and other proceedings and government investigations relating to the Company and/or its operations (including the pending civil proceedings initiated or joined by the U.S. Department of Justice and the U.S. Attorney's Office for the District of Massachusetts), risks associated with intellectual property of other parties and pending or future litigation relating thereto (including without limitation the patent litigation and other related proceedings relating to EYLEA® (aflibercept) Injection), the ultimate outcome of any such proceedings and investigations, and the impact any of the foregoing may have on Regeneron’s business, prospects, operating results, and financial condition. A more complete description of these and other material risks can be found in Regeneron’s filings with the U.S. Securities and Exchange Commission, including its Form 10-K for the year ended December 31, 2024 and its Form 10-Q for the quarterly period ended September 30, 2025. Any forward-looking statements are made based on management’s current beliefs and judgment, and the reader is cautioned not to rely on any forward-looking statements made by Regeneron. Regeneron does not undertake any obligation to update (publicly or otherwise) any forward-looking statement, including without limitation any financial projection or guidance, whether as a result of new information, future events, or otherwise.

Regeneron uses its media and investor relations website and social media outlets to publish important information about the Company, including information that may be deemed material to investors. Financial and other information about Regeneron is routinely posted and is accessible on Regeneron's media and investor relations website (https://investor.regeneron.com) and its LinkedIn page (https://www.linkedin.com/company/regeneron-pharmaceuticals).
2025-12-07 21:49 25d ago
2025-12-07 16:30 25d ago
Lilly's Jaypirca (pirtobrutinib) met its primary endpoint in first-of-its-kind, head-to-head Phase 3 study versus Imbruvica (ibrutinib) stocknewsapi
LLY
In addition to meeting the primary endpoint of non-inferiority for overall response rate (ORR) in the BRUIN CLL-314 study, pirtobrutinib achieved a numerically higher ORR of 87.0% compared to 78.5% for ibrutinib in the intent-to-treat (ITT) population

Progression-free survival data were immature but trended in favor of pirtobrutinib with a 43% reduction of the risk of disease progression or death in the ITT population, and the treatment-naïve subgroup, which had the longest follow up, showed a 76% reduction

These data will be simultaneously published in the Journal of Clinical Oncology and presented at the 2025 American Society of Hematology Annual Meeting and Exposition, as well as featured as part of the meeting's press program

, /PRNewswire/ -- Eli Lilly and Company (NYSE: LLY) today announced results from the Phase 3 BRUIN CLL-314 clinical trial evaluating Jaypirca (pirtobrutinib), a non-covalent (reversible) Bruton tyrosine kinase (BTK) inhibitor, versus Imbruvica (ibrutinib), a covalent BTK inhibitor, in patients with chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) who were treatment-naïve or were BTK inhibitor-naïve. Pirtobrutinib met its primary endpoint of non-inferiority on overall response rate (ORR) compared to ibrutinib (87.0% [95% CI, 82.90-90.44] versus 78.5% [95% CI, 73.73-82.85]; p<0.0001) in the intent-to-treat (ITT) population. Pirtobrutinib also had numerically higher ORR rates and, while immature, progression-free survival (PFS) was also trending in favor of pirtobrutinib compared to ibrutinib across all populations, including a 76% reduction in the risk of disease progression or death (HR=0.239 [95% CI, 0.098-0.586]) in treatment-naïve patients, the subgroup with the longest follow-up.

These data will be highlighted at the 67th American Society of Hematology (ASH) Annual Meeting and Exposition taking place in Orlando, Florida and simultaneously published in the Journal of Clinical Oncology. 

"These data from BRUIN CLL-314 are both novel and clinically significant, demonstrating an improved overall response rate and a favorable trend in progression-free survival outcomes with pirtobrutinib compared to ibrutinib across all populations, including treatment-naïve patients where covalent BTK inhibitors are a cornerstone of treatment," said Jennifer A. Woyach, M.D., professor, hematologist-oncologist, and Director of the Division of Hematology at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute. "BRUIN CLL-314 is the first randomized study to compare covalent and non-covalent BTK inhibitors and to directly compare any BTK inhibitors in the treatment-naïve setting, offering findings that are important for advancing the field and patient care. These efficacy results, along with pirtobrutinib's safety profile, offer strong evidence on the role of pirtobrutinib earlier in the treatment course for patients with CLL or SLL."

The BRUIN CLL-314 study enrolled 662 patients who were randomized to receive pirtobrutinib (n=331) or ibrutinib (n=331), with the ITT population consisting of 225 treatment-naïve and 437 relapsed/refractory patients. The efficacy results utilize a June 10, 2025, data cutoff date.

The study achieved its primary endpoint demonstrating that pirtobrutinib was statistically non-inferior to ibrutinib in independent review committee (IRC)-assessed ORR for the ITT population, and results numerically favored pirtobrutinib (87.0% [95% CI, 82.90-90.44] versus 78.5% [95% CI, 73.73-82.85]; nominal p = 0.0035). Additionally, ORR consistently favored pirtobrutinib versus ibrutinib across all populations evaluated, including relapsed/refractory and treatment-naïve, as well as across pre-specified subgroups such as patients with and without 17p deletions, IGHV status and complex karyotype.  

PFS, a key secondary endpoint, was not yet mature at this analysis but was trending in favor of pirtobrutinib compared to ibrutinib in the ITT (HR=0.569 [95% CI, 0.388-0.834]), relapsed/refractory (HR=0.729 [95% CI, 0.471-1.128]), and treatment-naïve (HR=0.239 [95% CI, 0.098-0.586]) populations, with a median follow-up of 22.0 months, 18.4 months, and 22.5 months, respectively. Among all subgroups, the largest PFS effect size was observed in the treatment-naïve subgroup, which had the longest follow-up at this data cut, with a 76% reduction in the risk of disease progression or death. A formal PFS analysis testing for superiority is planned at a future analysis. There was no detriment in overall survival (OS) (HR=0.961 [95% CI, 0.55-1.69]) for the ITT population. 

The overall safety profile for patients treated with pirtobrutinib in BRUIN CLL-314 was similar to previously reported trials, and the most common treatment-emergent adverse events were similar between arms. Most adverse events (AE) of interest were lower with pirtobrutinib compared to ibrutinib, including atrial fibrillation/flutter (2.4% versus 13.5%) and hypertension (10.6% versus 15.1%). Fewer AE-related dose reductions (7.9% versus 18.2%) and discontinuations (9.4% versus 10.8%) were seen with pirtobrutinib versus ibrutinib.  

"We are excited to share these compelling new findings for pirtobrutinib with the scientific community at ASH and in the Journal of Clinical Oncology," said Jacob Van Naarden, executive vice president and president, Lilly Oncology. "These data build on additional results from the BRUIN development program and the recent FDA approval for pirtobrutinib in the post-covalent BTK inhibitor setting to reinforce the medicine's potential to deliver meaningful benefit for people living with CLL or SLL across various disease settings."

As part of the Late-Breaking Abstract Session on Dec. 9, Lilly will also share results from the Phase 3 BRUIN CLL-313 study of pirtobrutinib versus chemoimmunotherapy in patients with treatment-naïve CLL/SLL without del(17p). These data were also selected to be highlighted as part of the ASH Annual Meeting press program session on Dec. 8.

Lilly is studying Jaypirca in CLL/SLL in multiple Phase 3 studies. Details on the trials can be found by visiting clinicaltrials.gov.

About BRUIN CLL-314  
BRUIN CLL-314 is a Phase 3, randomized, open-label study of Jaypirca (pirtobrutinib) versus Imbruvica (ibrutinib) in patients with CLL/SLL who were either treatment-naïve, or who were previously treated and were BTK inhibitor-naïve. The trial planned to enroll 650 patients who were randomized 1:1 to receive pirtobrutinib (200 mg orally, once daily) or ibrutinib (420 mg orally, once daily). The primary endpoint is ORR as assessed by blinded IRC. Secondary endpoints include investigator and IRC-assessed PFS, duration of response (DoR) and event-free survival (EFS), and time to next treatment (TTNT), OS, safety and tolerability, and patient-reported outcomes (PRO). 

About Jaypirca (pirtobrutinib) 
Jaypirca (pirtobrutinib, formerly known as LOXO-305) (pronounced jay-pihr-kaa) is a highly selective (300 times more selective for BTK versus 98% of other kinases tested in preclinical studies), non-covalent (reversible) inhibitor of the enzyme BTK.1 BTK is a validated molecular target found across numerous B-cell leukemias and lymphomas including mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL).2,3 Jaypirca is a U.S. FDA-approved oral prescription medicine, 100 mg or 50 mg tablets taken as a once-daily 200 mg dose with or without food until disease progression or unacceptable toxicity.

About Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are forms of slow-growing non-Hodgkin lymphoma that develop from white blood cells known as lymphocytes.4 CLL is one of the most common types of leukemia in adults.4 In the U.S., CLL accounts for about one-quarter of the new cases of leukemia and there will be approximately 23,690 new cases of CLL diagnosed this year.4,5  SLL is identical to CLL from a pathologic and immunophenotypic standpoint, with the main difference between them being the location of the cancer cells.4 In CLL, the cancer cells are present in the blood, and in SLL, the cancer cells are found in the lymph nodes.4

INDICATIONS FOR JAYPIRCA (pirtobrutinib)
Jaypirca is indicated for the treatment of

Adult patients with relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) who have previously been treated with a covalent BTK inhibitor.
Adult patients with relapsed or refractory (R/R) mantle cell lymphoma (MCL) after at least two lines of systemic therapy, including a BTK inhibitor. This indication is approved under accelerated approval based on response rate. Continued approval for this indication may be contingent upon verification and description of clinical trial benefit in a confirmatory trial. 

IMPORTANT SAFETY INFORMATION FOR JAYPIRCA (pirtobrutinib)

Infections: Fatal and serious infections (including bacterial, viral, fungal) and opportunistic infections occurred in Jaypirca-treated patients. Across clinical trials, Grade ≥3 infections occurred (25%), most commonly pneumonia (20%); fatal infections (5%), sepsis (6%), and febrile neutropenia (3.8%) occurred. In patients with CLL/SLL, Grade ≥3 infections occurred (32%), with fatal infections occurring in 8%. Opportunistic infections included Pneumocystis jirovecii pneumonia and fungal infection. Consider prophylaxis, including vaccinations and antimicrobial prophylaxis, in patients at increased risk for infection, including opportunistic infections. Monitor for signs and symptoms, evaluate, and treat. Based on severity, reduce dose, temporarily withhold, or permanently discontinue Jaypirca.

Hemorrhage: Fatal and serious hemorrhage has occurred with Jaypirca. Across clinical trials, major hemorrhage (Grade ≥3 bleeding or any central nervous system bleeding) occurred (2.6%), including gastrointestinal hemorrhage; fatal hemorrhage occurred (0.3%). Bleeding of any grade, excluding bruising and petechiae, occurred (16%). Major hemorrhage occurred when taking Jaypirca with (2.0%) and without (0.6%) antithrombotic agents. Consider risks/benefits of co-administering antithrombotic agents with Jaypirca. Monitor for signs of bleeding. Based on severity, reduce dose, temporarily withhold, or permanently discontinue Jaypirca. Consider withholding Jaypirca 3-7 days pre- and post-surgery based on surgery type and bleeding risk.

Cytopenias: Jaypirca can cause cytopenias, including neutropenia, thrombocytopenia, and anemia. Across clinical trials, Grade 3 or 4 cytopenias, including decreased neutrophils (27%), decreased platelets (13%), and decreased hemoglobin (11%), developed. Grade 4 decreased neutrophils (15%) and Grade 4 decreased platelets (6%) developed. Monitor complete blood counts regularly. Based on severity, reduce dose, temporarily withhold, or permanently discontinue Jaypirca.

Cardiac Arrhythmias: Cardiac arrhythmias occurred in patients taking Jaypirca. Across clinical trials, atrial fibrillation or flutter were reported in 3.4% of Jaypirca treated patients, with Grade 3 or 4 atrial fibrillation or flutter in 1.6%. Other serious cardiac arrhythmias such as supraventricular tachycardia and cardiac arrest occurred (0.4%). Cardiac risk factors such as hypertension or previous arrhythmias may increase risk. Monitor and manage signs and symptoms of arrhythmias (e.g., palpitations, dizziness, syncope, dyspnea). Based on severity, reduce dose, temporarily withhold, or permanently discontinue Jaypirca.

Second Primary Malignancies: Across clinical trials, second primary malignancies, including non-skin carcinomas, developed in 9% of Jaypirca-treated patients, most frequently non-melanoma skin cancer (4.4%). Other second primary malignancies included solid tumors (including genitourinary and breast cancers) and melanoma. Advise patients to use sun protection and monitor for development of second primary malignancies.

Hepatotoxicity, Including Drug-Induced Liver Injury (DILI): Hepatotoxicity, including severe, life-threatening, and potentially fatal cases of DILI, has occurred in patients treated with BTK inhibitors, including Jaypirca. Evaluate bilirubin and transaminases at baseline and throughout Jaypirca treatment. For patients who develop abnormal liver tests after Jaypirca, monitor more frequently for liver test abnormalities and clinical signs and symptoms of hepatic toxicity. If DILI is suspected, withhold Jaypirca. If DILI is confirmed, discontinue Jaypirca.

Embryo-Fetal Toxicity: Jaypirca can cause fetal harm. Administration of pirtobrutinib to pregnant rats caused embryo-fetal toxicity, including embryo-fetal mortality and malformations at maternal exposures (AUC) approximately 3-times the recommended 200 mg/day dose. Advise pregnant women of fetal risk and females of reproductive potential to use effective contraception during treatment and for one week after last dose.

Adverse Reactions (ARs) in Patients Who Received Jaypirca

The most common (≥30%) ARs in the pooled safety population of patients with hematologic malignancies (n=704) were decreased neutrophil count (54%), decreased hemoglobin (43%), decreased leukocytes (32%), fatigue (31%), decreased platelets (31%), decreased lymphocyte count (31%), calcium decreased (30%).

Mantle Cell Lymphoma

Serious ARs occurred in 38% of patients, with pneumonia (14%), COVID-19 (4.7%), musculoskeletal pain (3.9%), hemorrhage (2.3%), pleural effusion (2.3%), and sepsis (2.3%) occurring in ≥2% of patients. Fatal ARs within 28 days of last dose occurred in 7% of patients, most commonly due to infections (4.7%), including COVID-19 (3.1% of all patients).

Dose Modifications and Discontinuations Due to ARs: Dose reductions in 4.7%, treatment interruption in 32%, and permanent discontinuation of Jaypirca in 9% of patients. Permanent discontinuation in >1% of patients included pneumonia.

Most common ARs (≥15%) and Select Laboratory Abnormalities (≥10%) (all Grades %; Grade 3-4 %): hemoglobin decreased (42; 9), platelet count decreased (39; 14), neutrophil count decreased (36; 16), lymphocyte count decreased (32; 15), creatinine increased (30; 1.6), fatigue (29; 1.6), musculoskeletal pain (27; 3.9), calcium decreased (19; 1.6), diarrhea (19; -), edema (18; 0.8), dyspnea (17; 2.3), AST increased (17; 1.6), pneumonia (16; 14), bruising (16; -), potassium decreased (13; 1.6), sodium decreased (13; -), lipase increased (12; 4.4), ALT increased (11; 1.6), potassium increased (11; 0.8), alkaline phosphatase increased (11; -). Grade 4 laboratory abnormalities in >5% of patients included neutrophils decreased (10), platelets decreased (7), lymphocytes decreased (6).

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma from Single-Arm and Randomized Controlled Clinical Trials

Serious ARs occurred in 47-56% of patients across clinical trials. Serious ARs in ≥5% of patients in the single-arm trial were pneumonia (18%), COVID-19 (9%), sepsis (7%), febrile neutropenia (7%). Serious ARs in ≥3% of patients in the randomized controlled trial were pneumonia (21%), COVID-19 (5%), sepsis (3.4%). Fatal ARs within 28-30 days of last Jaypirca dose occurred in 8-11% of patients, most commonly due to infections (7-10%), including sepsis (5%), COVID-19 (2.7-5%), and pneumonia (3.4%).

Dose Modifications and Discontinuations Due to ARs: Dose reductions in 3.6-10%, treatment interruption in 42-51%, and permanent discontinuation of Jaypirca in 9-17% of patients. Permanent discontinuation in >1% of patients included second primary malignancy, pneumonia, COVID-19, neutropenia, sepsis, anemia, and cardiac arrythmias.

Most common ARs and Select Laboratory Abnormalities (≥20%) (all Grades %, Grade 3-4 %)--in a randomized controlled trial: neutrophil count decreased (54; 26), hemoglobin decreased (45; 10), platelet count decreased (37; 17), pneumonia (28; 16), ALT increased (25; 1.8), creatinine increased (25; -), calcium decreased (23; 0.9), sodium decreased (22; 0.9), bilirubin increased (21; 0.9), upper respiratory tract infections (21; 0.9); in a single-arm trial: neutrophil count decreased (63; 45), hemoglobin decreased (48; 19), calcium decreased (40; 2.8), fatigue (36; 2.7), bruising (36; -), cough (33; -), musculoskeletal pain (32; 0.9), platelet count decreased (30; 15), sodium decreased (30; -), COVID-19 (28; 7), pneumonia (27; 16), diarrhea (26; -), abdominal pain (25; 2.7), lymphocyte count decreased (23; 8), ALT increased (23; 2.8), AST increased (23; 1.9), creatinine increased (23; -), dyspnea (22; 2.7), hemorrhage (22; 2.7), lipase increased (21; 7), alkaline phosphatase increased (21; -), edema (21; -), nausea (21; -), pyrexia (20; 2.7), headache (20; 0.9). Grade 4 laboratory abnormalities in >5% of patients included neutrophils decreased (23).

Drug Interactions

Strong CYP3A Inhibitors: Concomitant use increased pirtobrutinib systemic exposure, which may increase risk of Jaypirca ARs. Avoid using strong CYP3A inhibitors with Jaypirca. If concomitant use is unavoidable, reduce Jaypirca dose according to approved labeling.

Strong or Moderate CYP3A Inducers: Concomitant use decreased pirtobrutinib systemic exposure, which may reduce Jaypirca efficacy. Avoid using Jaypirca with strong or moderate CYP3A inducers. If concomitant use with moderate CYP3A inducers is unavoidable, increase Jaypirca dose according to approved labeling.

Sensitive CYP2C8, CYP2C19, CYP3A, P-gp, or BCRP Substrates: Use with Jaypirca increased their plasma concentrations, which may increase risk of ARs related to these substrates for drugs sensitive to minimal concentration changes. Follow recommendations for these sensitive substrates in their approved labeling.

Use in Specific Populations

Pregnancy and Lactation: Due to potential for Jaypirca to cause fetal harm, verify pregnancy status in females of reproductive potential prior to starting Jaypirca. Presence of pirtobrutinib in human milk is unknown. Advise women to use effective contraception and to not breastfeed while taking Jaypirca and for one week after last dose.

Geriatric Use: In the pooled safety population of patients with hematologic malignancies, patients aged ≥65 years experienced higher rates of Grade ≥3 ARs and serious ARs compared to patients <65 years of age.

Renal Impairment: Because severe renal impairment increases pirtobrutinib exposure, reduce Jaypirca dose in these patients according to approved labeling.

PT HCP ISI MCL_CLL Q42025

Please see Prescribing Information and Patient Information for Jaypirca.

About Lilly                                      
Lilly is a medicine company turning science into healing to make life better for people around the world. We've been pioneering life-changing discoveries for nearly 150 years, and today our medicines help tens of millions of people across the globe. Harnessing the power of biotechnology, chemistry and genetic medicine, our scientists are urgently advancing new discoveries to solve some of the world's most significant health challenges: redefining diabetes care; treating obesity and curtailing its most devastating long-term effects; advancing the fight against Alzheimer's disease; providing solutions to some of the most debilitating immune system disorders; and transforming the most difficult-to-treat cancers into manageable diseases. With each step toward a healthier world, we're motivated by one thing: making life better for millions more people. That includes delivering innovative clinical trials that reflect the diversity of our world and working to ensure our medicines are accessible and affordable. To learn more, visit Lilly.com and Lilly.com/news, or follow us on Facebook, Instagram, and LinkedIn. P-LLY

© Lilly USA, LLC 2025. ALL RIGHTS RESERVED.

Trademarks and Trade Names
All trademarks or trade names referred to in this press release are the property of the company, or, to the extent trademarks or trade names belonging to other companies are referenced in this press release, the property of their respective owners. Solely for convenience, the trademarks and trade names in this press release are referred to without the ® and ™ symbols, but such references should not be construed as any indicator that the company or, to the extent applicable, their respective owners will not assert, to the fullest extent under applicable law, the company's or their rights thereto. We do not intend the use or display of other companies' trademarks and trade names to imply a relationship with, or endorsement or sponsorship of us by, any other companies.

Cautionary Statement Regarding Forward-Looking Statements
This press release contains forward-looking statements (as that term is defined in the Private Securities Litigation Reform Act of 1995) about Jaypirca as a treatment for adults with relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) who have been previously treated with a covalent BTK inhibitor and as a treatment for adult patients with relapsed or refractory mantle cell lymphoma (MCL) after at least two lines of systemic therapy, including a BTK inhibitor, and reflects Lilly's current beliefs and expectations. However, as with any pharmaceutical product, there are substantial risks and uncertainties in the process of drug research, development, and commercialization. Among other things, there is no guarantee that planned or ongoing studies will be completed as planned, that future study results will be consistent with study results to date, or that Jaypirca will receive additional regulatory approvals. For further discussion of these and other risks and uncertainties that could cause actual results to differ from Lilly's expectations, see Lilly's Form 10-K and Form 10-Q filings with the United States Securities and Exchange Commission. Except as required by law, Lilly undertakes no duty to update forward-looking statements to reflect events after the date of this release.

Endnotes & References

Mato AR, Shah NN, Jurczak W, et al. Pirtobrutinib in relapsed or refractory B-cell malignancies (BRUIN): a phase 1/2 study. Lancet. 2021;397(10277):892-901. doi:10.1016/S0140-6736(21)00224-5
Hanel W, Epperla N. Emerging therapies in mantle cell lymphoma. J Hematol Oncol. 2020;13(1):79. Published 2020 Jun 17. doi:10.1186/s13045-020-00914-1
Gu D, Tang H, Wu J, Li J, Miao Y. Targeting Bruton tyrosine kinase using non-covalent inhibitors in B cell malignancies. J Hematol Oncol. 2021;14(1):40. Published 2021 Mar 6. doi:10.1186/s13045-021-01049-7
Mukkamalla SKR, Taneja A, Malipeddi D, et al. Chronic Lymphocytic Leukemia. [Updated Feb 18, 2023]. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470433/
NCI SEER Program [NIH]. Cancer Stat Facts: Leukemia—Chronic Lymphocytic Leukemia (CLL). Accessed on September 3, 2025. https://seer.cancer.gov/statfacts/html/clyl.html

SOURCE Eli Lilly and Company
2025-12-07 21:49 25d ago
2025-12-07 16:39 25d ago
Rosen Law Firm Encourages agilon health, inc. Investors to Inquire About Securities Class Action Investigation - AGL stocknewsapi
AGL
, /PRNewswire/ -- 

Why: Rosen Law Firm, a global investor rights law firm, continues to investigate potential securities claims on behalf of shareholders of agilon health, inc. (NYSE: AGL) resulting from allegations that agilon health may have issued materially misleading business information to the investing public.

So What: If you purchased agilon health securities you may be entitled to compensation without payment of any out of pocket fees or costs through a contingency fee arrangement. The Rosen Law Firm is preparing a class action seeking recovery of investor losses.

What to do next: To join the prospective class action, go to https://rosenlegal.com/submit-form/?case_id=46039 https://rosenlegal.com/submit-form/?case_id=39889or call Phillip Kim, Esq. toll-free at 866-767-3653 or email [email protected] for information on the class action.

What is this about: On August 4, 2025, agilon health issued a press release entitled "agilon health Reports Second Quarter 2025 Results." Commenting on the results, agilon health's Executive Chair stated that "as we progressed through this transition year, it's become clear that the industry headwinds are more acute than previously expected[.]" Further, the release announced that the company was "suspending its previously issued full-year 2025 financial guidance and related assumptions."

On this news, agilon health's stock fell 51.5% on August 5, 2025.

Why Rosen Law: We encourage investors to select qualified counsel with a track record of success in leadership roles. Often, firms issuing notices do not have comparable experience, resources, or any meaningful peer recognition. Many of these firms do not actually litigate securities class actions.  Be wise in selecting counsel. The Rosen Law Firm represents investors throughout the globe, concentrating its practice in securities class actions and shareholder derivative litigation. Rosen Law Firm achieved, at that time, the largest ever securities class action settlement against a Chinese Company. Rosen Law Firm was Ranked No. 1 by ISS Securities Class Action Services for number of securities class action settlements in 2017. The firm has been ranked in the top 4 each year since 2013 and has recovered hundreds of millions of dollars for investors. In 2019 alone the firm secured over $438 million for investors. In 2020, founding partner Laurence Rosen was named by law360 as a Titan of Plaintiffs' Bar. Many of the firm's attorneys have been recognized by Lawdragon and Super Lawyers.

Follow us for updates on LinkedIn: https://www.linkedin.com/company/the-rosen-law-firm, on Twitter: https://twitter.com/rosen_firm or on Facebook: https://www.facebook.com/rosenlawfirm/.

Attorney Advertising. Prior results do not guarantee a similar outcome.

Contact Information:

      Laurence Rosen, Esq.
      Phillip Kim, Esq.
      The Rosen Law Firm, P.A.
      275 Madison Avenue, 40th Floor
      New York, NY 10016
      Tel: (212) 686-1060
      Toll Free: (866) 767-3653
      Fax: (212) 202-3827
      [email protected]
      www.rosenlegal.com

SOURCE THE ROSEN LAW FIRM, P. A.
2025-12-07 20:49 25d ago
2025-12-07 13:05 25d ago
Jupiter Lend Clarifies Earlier ‘Zero Contagion' Statement Was Not Accurate cryptonews
JUP
19h05 ▪
5
min read ▪ by
Ifeoluwa O.

Summarize this article with:

Jupiter Exchange is working to clear the air after concerns emerged around its lending protocol. Kash Dhanda, the platform’s chief operating officer, acknowledged that earlier communications overstated the safety of Jupiter Lend’s vaults. Previous posts had suggested there was zero risk of contagion, a claim that was later removed. Dhanda admitted this messaging missed the mark and stressed the need to provide clearer, more accurate information about the risks involved.

In Brief

Jupiter COO Kash Dhanda clarified that earlier statements claiming zero contagion in Jupiter Lend vaults were not accurate and the misleading posts have been removed.
He explained that while the vaults use rehypothecation, each vault has its own configurations and limits, which the team considers a form of isolation.
Kamino co-founder Marius Ciubotariu pointed out that the Jupiter Lend migration tool was blocked because users had been misled about the protocol’s design and the risks involved.

Jupiter Clarifies Vault Risks and Isolation
Before Dhanda issued his clarification, Jupiter had shared social posts describing the vaults as operating with “isolated risk,” even suggesting that this setup prevented any interaction between pairs. One post went further, claiming the design eliminated the possibility of contagion entirely. The message drew criticism and was eventually removed, prompting a broader review of how the protocol’s mechanics were being communicated.

In a video lasting a little over three minutes, Dhanda acknowledged the error in the video and stated that the posts had been removed to prevent the incorrect message from spreading, adding that the vaults do carry a limited level of contagion risk, rather than none.

In hindsight, we should have issued a correction right when we deleted it. But so it goes. The point is, what we should have said is that there is a very limited risk of contagion because that is actually accurate.

Kash Dhanda
Fluid co-founder Samyak Jain added context, explaining that Jupiter Lend employs rehypothecation. He noted that the vaults are still isolated, stating that “each vault has its own configs, caps, liquidation threshold, liquidation penalty, etc and there’s surely rehypo for better capital optimization.”

Jupiter Lend Faces Criticism Over Vault Structure
However, Kamino co-founder Marius Ciubotariu voiced concern that this setup could mislead users. He stated that the Jupiter Lend migration tool had been blocked because their “users have been misled about the protocol design and the risks they are taking.”  Ciubotariu argued that while the platform had long indicated the vaults would prevent one asset from impacting another, the system operates differently in practice. 

The Kamino co-founder explained that when a user supplies SOL and borrows USDC, the deposited SOL can be lent to loopers like JupSOL and INF, exposing the user to the risks associated with those positions. In his view, this results in fully interconnected risk across assets, which contradicts the way the product has been presented.

Dhanda, however, maintained in the video that the protocol does use rehypothecation but still keeps the vaults isolated. He said the structure should be seen as isolated because of how each vault is configured.

Resistance and Support in Protocol Design
The word “isolation” appeared to be at the center of disagreement between Jupiter Lend executives and Marius Ciubotariu:

Dhanda and Jain maintain that the vaults are isolated because each operates with its own configuration, including loan-to-value ratios, limits on assets, and rules for liquidations, which provide resistance and allow liquidity to flow through rehypothecation
Ciubotariu countered that this setup falls short of true isolation, arguing that in both traditional and decentralized finance, users need to know if collateral can be reused and how that affects contagion risk
He emphasized that describing pair-specific configurations as isolated is misleading and could give users a false sense of security

Meanwhile, in comments shared with The Block, Ciubotariu noted that he would consider reopening the migration tool once Jupiter stops presenting the system in a way that gives users and the wider Solana community an inaccurate picture, as well as updates the tool to allow movement in both directions.

Early Performance and Safety Debate
Jupiter Lend was introduced in August with loan-to-value ratios reaching up to 90%. Dhanda pointed out the protocol’s performance during the market drop on October 10, noting that its ability to avoid any bad debt demonstrated it could handle pressure even as a relatively new platform.

However, Ciubotariu disagreed, pointing out that the protocol had only been active for a month with limited positions exposed to real market stress. He noted that Jupiter Lend would need years of testing under tougher conditions before making claims about safety or resilience.

Maximize your Cointribune experience with our "Read to Earn" program! For every article you read, earn points and access exclusive rewards. Sign up now and start earning benefits.

Join the program

A

A

Lien copié

Ifeoluwa O.

Ifeoluwa specializes in Web3 writing and marketing, with over 5 years of experience creating insightful and strategic content. Beyond this, he trades crypto and is skilled at conducting technical, fundamental, and on-chain analyses.

DISCLAIMER

The views, thoughts, and opinions expressed in this article belong solely to the author, and should not be taken as investment advice. Do your own research before taking any investment decisions.
2025-12-07 20:49 25d ago
2025-12-07 13:05 25d ago
Jupiter Admits Inaccuracy in Loan Vault Risk Claims cryptonews
JUP
2 mins mins

Key Points:

Jupiter’s inaccurate risk claims corrected, raising transparency concerns.Jupiter Lend vaults involve rehypothecation, despite initial claims.Kamino raises issues with Jupiter’s risk model clarity.
Jupiter Exchange COO Kash Dhanda acknowledged inaccuracies in the company’s marketing of Jupiter Lend’s vaults, admitting to community concerns about asset rehypothecation, during a video statement on X.

This admission impacts transparency in DeFi protocols, highlighting the controversy over risk models and collateral use, which sparked debates within the Solana DeFi community.

Jupiter Corrects Vault Risk Claims Amid Community Backlash
Jupiter Exchange’s recent clarification regarding Jupiter Lend vaults’ risk model has heightened scrutiny within the crypto community. COO Kash Dhanda admitted past claims of “zero contagion risk” were incorrect. The company now confirms the presence of asset rehypothecation, altering previous narratives about vault isolation. This shift in narrative has prompted Kamino Finance to block migration tools for Jupiter Lend, citing unreliable risk assessments. Concerns over accurate risk communication remain a focal point in evaluating DeFi protocols.

Kamino Finance’s co-founder Marius Ciubotariu publicly criticized Jupiter’s initial risk presentation, arguing that asset rehypothecation disputes the isolated vault narrative. This criticism highlights broader industry tensions over DeFi transparency.

Solana Market Moves Amid DeFi Risk Disclosure
Did you know? The acknowledgment of inaccurate risk claims by Jupiter Exchange echoes a pattern seen in past DeFi communications, where misrepresented risk leads to scrutiny and market distrust.

According to CoinMarketCap, Solana’s current price is $134.90, with a market cap of $75.63 billion. It holds a 2.44% market dominance. Over the past 24 hours, the trading volume reached $3.23 billion, showing a 38.06% increase. Recent price movement includes a 1.44% rise within 24 hours but a decline of 16.24% over 30 days.

Solana(SOL), daily chart, screenshot on CoinMarketCap at 18:01 UTC on December 7, 2025. Source: CoinMarketCap

Coincu research team indicates potential regulatory implications for DeFi protocols in maintaining clear risk models. Enhanced transparency is crucial to ensuring investor trust and avoiding market volatility due to misinformation or insufficiencies in risk communication.

DISCLAIMER: The information on this website is provided as general market commentary and does not constitute investment advice. We encourage you to do your own research before investing.

Rate this post
2025-12-07 20:49 25d ago
2025-12-07 13:09 25d ago
Binance PoR Shows BTC Pile-Up, Rising Over-Reserves, and Bitcoin Rally Signals cryptonews
BTC
Binance’s latest Proof of Reserves reveals a major shift in user positioning, where Bitcoin balances are climbing, while ETH and USDT fall.

At the same time, Binance’s stablecoin over-reserves hit six-month highs, strengthening liquidity during ongoing market volatility.

Sponsored

Bitcoin Accumulation Jumps as User Behavior ShiftsBinance users increased their Bitcoin balances by 4% month-over-month, reaching 617,620 BTC, according to the exchange’s 37th Proof of Reserves snapshot. That’s an addition of 23,768 BTC since November 1.

The exchange utilizes Merkle trees and zk-SNARKs to enable users to verify their balances without disclosing personal information. Current reserve ratios include:

BTC: 102.11%
ETH: 100%
USDT: 109.16%
USDC: 137.7%
BNB: 112.32%
This system offers real-time transparency, unlike traditional audits, which are episodic and rely on third-party trust.

As of November 30, Binance reserves were hovering near $120 billion, with USDT (ERC-20) reaching a record $42.8 billion. Despite volatility, Binance remains the second-largest holder of global Bitcoin reserves.

CONFIRMED: #Binance Now Holds $120B in Reserves 🚀

Source Crypto Quant 👇

On-chain data shows Binance total reserves holding near ATHs (around $120 billion) and USDT (ERC20) reserves reaching a record $42.8 billion despite recent market volatility.

The exchange also remains… pic.twitter.com/xy8ZIY5siV

— Altcoin Daily (@AltcoinDaily) November 29, 2025
Sponsored

General sentiment on X (Twitter) is that this trend is bullish for Bitcoin, with users stacking the pioneer crypto as ETH and stablecoin balances decline.

User Ethereum holdings dropped 1.32% to 4.04 million ETH (-54,257 ETH), while USDT balances slipped 1.24% to 34.3 billion USDT (-430 million USDT).

Binance Asset Reserves. Source: Wu BlockchainThe pattern suggests rebalancing rather than a broad withdrawal, with users migrating into Bitcoin during periods of uncertainty.

Sponsored

Stablecoin Over-Reserves Hit Six-Month HighsAnalyst AB Kuai Dong highlighted a sharp rise in Binance’s stablecoin buffers:

USDT over-reserve ratio: 109.16% (up from 101.52% in June)
USDC over-reserve ratio: 137.7%
Overall platform over-reserves: 12.32% above user funds
BNB over-reserve ratio: 112.32%, highest among major assets
He added that rising over-reserves “enhance the platform’s risk resistance capabilities,” especially for stablecoins. The Binance exchange reiterated that all user assets remain backed 1:1.

The consistent build-up, from June to December, signals stronger liquidity management. It also aligns with regulatory expectations that reserves remain fully available for redemptions rather than internal trading.

Sponsored

Signals for Possible Future Moves?CryptoQuant noted that Binance’s Bitcoin reserve ratio recently touched its lowest level since 2018. This condition has historically preceded powerful Bitcoin rallies due to reduced sell-side liquidity.

“History shows that hitting such lows often precedes powerful Bitcoin rallies, simply because the liquidity required to fuel a price surge is now fully available on the exchange,” wrote CryptoQuant analysts.

Yet, recent market data shows that Bitcoin is leaving exchanges globally, even as Binance balances rise. This suggests that Binance is gaining market share from competitors rather than reversing the broader trend toward self-custody.

The combination of rising Bitcoin accumulation, expanding stablecoin over-reserves, and historically low reserve ratios creates a mixed but potentially constructive setup.

If macro conditions stabilize, Binance’s strengthened liquidity and growing buffers position the exchange to support higher trading activity in a future rally phase.
2025-12-07 20:49 25d ago
2025-12-07 13:10 25d ago
Jupiter Faces Scrutiny Over Misleading Vault Claims Amid Crypto Industry Concerns cryptonews
JUP
On December 6, 2025, the co-founder of Kamino, a competing lending platform, publicly challenged Jupiter’s assertions regarding their “isolated vaults” and responded by disabling a migration feature. The dispute highlights increasing tensions within the decentralized finance (DeFi) sector, as platforms vie to assure users of their security and reliability.

Jupiter’s executive team recently admitted that their previous statements about the “zero contagion” nature of their isolated vaults were not entirely accurate. This admission came in the wake of criticism from Kamino and other industry observers, who argued that Jupiter’s marketing created misconceptions about the safety of their product. The term “zero contagion” was intended to suggest that the isolated vaults could safeguard user assets from risks affecting the broader system. However, this characterization was later deemed misleading, as the inherent complexities and interconnectedness of DeFi platforms make absolute isolation challenging to achieve.

Kamino’s co-founder expressed frustration with Jupiter’s communication strategy, emphasizing that by overstating the security of their vaults, Jupiter not only misled users but also potentially undermined trust in decentralized finance innovations. This incident underscores the growing need for transparency and accountability in the rapidly evolving crypto ecosystem, where investors often rely heavily on technical claims to guide their decisions.

The crypto market’s expansion has been marked by both tremendous opportunities and significant risks. As of 2023, DeFi had grown to manage billions in assets, with the rise of novel financial products pushing the boundaries of traditional finance. However, this growth has also attracted scrutiny from regulators and industry insiders concerned about systemic risks and the potential for large-scale financial disruption.

The situation with Jupiter reflects broader challenges facing DeFi projects. The complexity and novelty of these financial products inherently carry risks that can be difficult for average investors to fully understand. The promise of high returns often overshadows the underlying vulnerabilities, leading to a delicate balance between innovation and security.

In response to the backlash, Jupiter has committed to revisiting their promotional materials and refining their messaging to more accurately reflect the features and limitations of their isolated vaults. This includes a pledge to work closely with third-party auditors and enhance security protocols. Their willingness to acknowledge and address these issues is a positive step towards regaining user trust.

Nonetheless, the incident raises questions about the oversight and regulation of DeFi platforms. Unlike traditional financial institutions, which are subject to stringent regulatory scrutiny, many DeFi operators operate in a largely unregulated environment. This lack of oversight can lead to scenarios where platforms make bold claims without sufficient evidence or accountability.

The rival platform, Kamino, has capitalized on the situation by emphasizing its own security protocols and transparency in its operations. By halting the migration tool, Kamino signaled its disapproval of Jupiter’s practices, aiming to position itself as a more trustworthy alternative in the competitive DeFi landscape. Kamino’s actions highlight the importance of peer accountability in the absence of external regulatory pressures.

In the broader context of financial markets, the DeFi sector’s rapid growth resembles the early days of the internet, where innovation outpaced regulation. Just as the dot-com bubble burst was followed by a wave of regulatory interventions and more sustainable growth, it is possible that DeFi will undergo similar transformations. For the sector to mature, industry leaders need to collaborate with regulators to establish standards that protect investors while fostering innovation.

A potential risk facing Jupiter and similar platforms is the erosion of user confidence. In decentralized systems, trust is a critical component of success, and losing it can lead to a rapid outflow of capital. If users perceive a platform as unreliable, they may move their assets to competitors, which could destabilize the platform’s financial structure. Therefore, maintaining a reputation for integrity and transparency is essential for survival in the competitive DeFi market.

Looking forward, the crypto community must balance the lure of cutting-edge financial technology with a commitment to accuracy and responsibility. As platforms like Jupiter navigate these challenges, they can draw lessons from traditional financial sectors, where transparency and customer protection are paramount.

Ultimately, the path forward for Jupiter and its peers hinges on their ability to innovate responsibly. By embracing transparency and engaging in honest dialogue with users and competitors, they can help pave the way for a more secure and reliable DeFi ecosystem. This approach will not only benefit individual platforms but also contribute to the overall credibility and sustainability of decentralized finance as a whole.

Post Views: 14
2025-12-07 20:49 25d ago
2025-12-07 13:17 25d ago
UK Locks In Ethereum Property Rights as Futures Bets Rebuild cryptonews
ETH
Ethereum sits in the spotlight today as the UK writes digital assets like ETH directly into property law while derivatives traders quietly rebuild leverage after October’s wipeout. Together, the legal shift and the rise in open interest show how Ethereum’s role keeps deepening both in traditional courts and on crypto futures markets.

UK passes law that directly strengthens ETH property rightsDigital assets such as Bitcoin and Ethereum now have explicit recognition as personal property in England, Wales and Northern Ireland after the Property (Digital Assets etc) Act 2025 received Royal Assent and came into force on Dec. 2.

The Act states that a “thing,” including something digital or electronic, is not prevented from being the object of personal property rights just because it is neither a “thing in possession” nor a “thing in action,” the two traditional categories in English law. In effect, lawmakers have opened the door for a third category of personal property to cover assets like crypto-tokens and non-fungible tokens.

The UK government says the change confirms that digital assets can be recognised as personal property and gives stronger protection to victims of digital theft and fraud, who can now rely on a clearer statutory basis when they go to court.Courts will be able to apply existing property law tools more directly to crypto, including freezing, tracing and recovery of misappropriated coins, and to handle digital asset balances more cleanly in insolvency or exchange failure cases.

At the same time, legal analysts say the Act removes uncertainty for banks, custodians and funds that want to hold or use crypto under English-law structures. With digital assets now recognised as objects of property rights in statute, it becomes easier to document security interests and collateral arrangements over ETH and other tokens in secured lending and structured finance transactions.

The legislation applies across England, Wales and Northern Ireland and took effect immediately on the day it was passed, following recommendations from the Law Commission’s 2023 digital assets report.

ETH open interest climbs again after October crashMeanwhile, Ethereum futures open interest has been rebuilding since the violent wipeout on Oct. 10, leaving derivatives traders more exposed again, according to chart data shared by analyst Ted (@TedPillows). The ETHUSDT perpetual contract on Binance Futures now shows steadily rising positioning even as spot price trades well below its early-autumn levels.

Ethereum Futures Open Interest Rebuilds. Source: TedPillows

The accompanying chart tracks Ethereum’s daily candles on Binance Futures alongside aggregated open interest in coins from analytics platform Velo. It shows leverage collapsing in mid-October, when open interest dropped sharply, then grinding higher through November and into early December as traders slowly added new positions.

Ted said he expects much of this rebuilt open interest to “be wiped out in the coming months,” arguing that market makers may push Ethereum into a choppy trading range to flush out leveraged longs and shorts. In that scenario, open interest could fall again as positions are forced to close, even if spot price does not revisit the October crash levels.
2025-12-07 20:49 25d ago
2025-12-07 13:30 25d ago
Vladimir Putin Said Nothing Could Ban Bitcoin A Year Ago: Here's How Moscow Has Used Crypto Since Then To Overcome US Sanctions cryptonews
BTC
Russian President Vladimir Putin asserted only a year ago that no power can ban Bitcoin (CRYPTO: BTC) regardless of what happens to the dollar. While many saw it as a message to the West on international sanctions, the country has taken targeted steps to open its economy to the world’s largest cryptocurrency.

Bitcoin Will Continue To Grow, Said PutinDuring an investment conference in Moscow on Dec. 4, 2024, Putin argued that the influence of the dollar on the global economy was waning, paving the way for the growth of other instruments.

“For instance – Bitcoin. Who can prohibit its use? No one,” Putin said. “Or the use of other electronic ways of settlement. No one can ban the use of them.”

Putin added that the new instruments would “continue developing” regardless of what happens to the dollar.

Crypto To Bypass Russia’s Trade DisruptionsShortly after these comments, Russia’s Finance Minister Anton Siluanov revealed that Russian companies have started using Bitcoin and other cryptocurrencies for cross-border transactions, described as a response to trade disruptions from sanctions imposed after the Ukraine war.

The minister said that it was possible to use the Bitcoin mined in Russia in foreign trade.

It’s worth noting that Putin greenlighted Bitcoin mining in the country earlier that year. He previously rejected the central bank's proposal to ban cryptocurrencies in 2022, arguing that the country possesses "competitive advantages" in the field of mining.

See Also: Ex-SEC Chair Gary Gensler Warns Crypto Remains ‘Speculative, Volatile’

Bank Of Russia’s Plan To Broaden Crypto AccessIn accordance with Putin’s directives, the central bank proposed in March of this year to allow a limited number of “highly qualified” Russian investors to purchase and sell cryptocurrencies under a new three-year experimental legal regime.

The bank maintained that it still doesn’t see cryptocurrency as a means of payment and proposed a ban on all cryptocurrency transactions between Russian residents outside the experimental regime.

However, recent developments suggest attempts to expand cryptocurrency access for Russians. Bank of Russia First Deputy Governor Vladimir Chistyukhin said that rules should be eased beyond the “extremely narrow” category of qualified investors, given the sanctions in place, according to a Cryptopolitan report.

How Big Is Russia’s Bitcoin Mining Industry?Maxim Oreshkin, the Deputy Chief of Staff of the Presidential Executive Office, said earlier this week that cryptocurrency mining generates “enormous sums” and must be factored into Russia’s balance of payments, according to a report by Vedomosti, the country’s leading business newspaper.

There is no publicly available official figure for how much Bitcoin the Russian government holds. Although, calculations from Russia’s National Cryptomining Association showed that 54,000 BTC were mined in 2023 alone.

Price Action: At the time of writing, BTC was exchanging hands at $$91,968.59, up 1.35% in the last 24 hours, according to data from Benzinga Pro.

Photo Courtesy: miss.cabul on Shutterstock.com

Read Next: 

If You’re Expecting A Bitcoin Bear Market In 2026, You Have It Wrong, Grayscale Says
Market News and Data brought to you by Benzinga APIs

© 2025 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.
2025-12-07 20:49 25d ago
2025-12-07 13:43 25d ago
Bitcoin Teeters on the Edge of $90K, Raising Questions About Market Stability cryptonews
BTC
On December 7, 2025, Bitcoin’s price fluctuated between $88,990 and $89,473, tantalizingly close to the coveted $90,000 threshold. As traders speculate on its future trajectory, the cryptocurrency holds a market capitalization of $1.78 trillion, coupled with a 24-hour trading volume of $21.62 billion. Despite its dominant position, the market mood underscores a cautious sentiment, indicating potential turbulence ahead.

The cryptocurrency world has long been characterized by its volatility, and Bitcoin’s latest price action is no exception. Hovering just below $90,000, this level represents a significant psychological barrier for investors. A breach of this threshold could reinforce bullish sentiment and potentially trigger a wave of buying; conversely, failure to surpass it might embolden bearish investors to drive prices lower. The stakes are high as both camps prepare for the next decisive move.

Historically, Bitcoin’s price has been susceptible to rapid fluctuations, often driven by market speculation, regulatory news, and macroeconomic factors. The cryptocurrency’s meteoric rise from its inception to its recent highs has been nothing short of extraordinary, drawing parallels with other historic asset bubbles. Despite these comparisons, Bitcoin has consistently defied predictions of its demise, maintaining its status as the leading digital currency.

The current market dynamics can be attributed to a mix of factors. On the one hand, increasing institutional interest and adoption have provided strong support for Bitcoin’s valuation. Major financial institutions have expanded their cryptocurrency offerings, and more countries are contemplating regulatory frameworks to integrate digital currencies into their financial systems. However, this increased visibility also brings heightened regulatory scrutiny, which can impact market confidence.

In recent months, several influential voices in the financial world have voiced concerns about the sustainability of Bitcoin’s valuation. Critics argue that the absence of intrinsic value and the speculative nature of cryptocurrency trading poses significant risks to investors. They warn that a sharp correction could lead to substantial financial losses for those who entered the market at higher price points.

Conversely, Bitcoin proponents argue that the digital currency represents a revolutionary shift in how value is stored and transferred. They highlight its potential as a hedge against inflation and a decentralized alternative to traditional financial systems. As global economic uncertainties persist, some investors view Bitcoin as a digital gold, offering diversification away from conventional assets.

Beyond the trade-offs between bulls and bears, the broader cryptocurrency market continues to evolve at a breakneck pace. Emerging technologies, such as decentralized finance (DeFi) and non-fungible tokens (NFTs), are reshaping the landscape, creating new opportunities and challenges. These innovations contribute to the overall market dynamism, attracting a new wave of participants eager to capitalize on the next big trend.

Despite the excitement surrounding Bitcoin, several risks loom on the horizon. The environmental impact of Bitcoin mining remains a contentious issue, as the energy-intensive process contributes to significant carbon emissions. This has prompted calls for more sustainable practices and could influence regulatory policies in the future. Additionally, cybersecurity threats, such as hacking and fraud, continue to pose challenges to the integrity of cryptocurrency exchanges and wallets.

The path forward for Bitcoin is fraught with uncertainty. While the potential for upside remains considerable, the possibility of downside risk cannot be ignored. Investors must navigate these complexities, balancing optimism with caution as they consider their positions in this volatile asset class. As Bitcoin approaches the $90,000 mark, the world watches closely, waiting to see whether it will surge past this milestone or retreat under the weight of its own volatility.

In the broader context of global finance, the rise of cryptocurrencies represents a paradigm shift that traditional financial institutions must contend with. The integration of digital currencies into the mainstream financial system is no longer a question of if, but when. Stakeholders across the board are tasked with adapting to this new reality, ensuring that the benefits of innovation are harnessed while mitigating potential risks.

As Bitcoin teeters on the brink of a new price echelon, the implications extend beyond immediate gains or losses. The outcome of this pivotal moment could influence investor sentiment and market trends for months to come. Only time will tell whether Bitcoin’s ascent continues unimpeded or whether it faces a formidable resistance that sends it back below the threshold. In any case, the narrative of Bitcoin as a barometer for the cryptocurrency market remains unchanged, captivating the attention of both enthusiasts and skeptics alike.

Post Views: 17
2025-12-07 20:49 25d ago
2025-12-07 14:00 25d ago
Crypto market's weekly winners and losers – MYX, LINK, CC, ZEC cryptonews
CC LINK MYX ZEC
This week, high-caps fell below key levels. Here's a look at how some of your favorite coins fared.
2025-12-07 20:49 25d ago
2025-12-07 14:00 25d ago
Bitcoin's December Downturn Sparks Concerns in Derivatives Market cryptonews
BTC
On Sunday, Bitcoin’s value fell below $88,000, casting doubts on the anticipated year-end rally often referred to as the “Santa Rally.” This sudden decline has sent ripples through the derivatives market, leading traders and analysts to reassess their strategies during what is traditionally a bullish period. The unexpected drop in Bitcoin’s price has caused significant fluctuations in open interest across major trading platforms, stirring uncertainty among investors.

Bitcoin’s recent performance contradicts the typical December trend, which many investors look forward to as a period of gains driven by seasonal market optimism. In recent years, the cryptocurrency market has frequently experienced a surge at the end of the year as institutional investors finalize their annual strategies and retail investors seize the opportunity to enter or expand their positions. However, this year seems to buck the trend, raising questions about the underlying dynamics at play.

The derivatives market, crucial for gauging investor sentiment and market direction, has shown signs of stress in response to Bitcoin’s decline. Open interest, a measure of the total number of outstanding derivative contracts, has exhibited volatility, reflecting traders’ uncertainty. This fluctuation suggests that investors are re-evaluating their positions, potentially leading to further market instability as changes in open interest can amplify price movements.

Historically, Bitcoin’s price movements have been volatile, with significant swings influencing global market sentiment. December has often been seen as a time of optimism, with the term “Santa Rally” symbolizing a period when prices tend to rise. This year, however, the cryptocurrency landscape appears more complicated, with various factors contributing to the current downturn.

Several elements are potentially impacting Bitcoin’s price behavior this December. Macro-economic conditions, such as interest rate hikes by central banks, have added pressure on risky assets like Bitcoin. Additionally, regulatory crackdowns in key markets and heightened scrutiny over digital currencies have created a more challenging environment for growth. Bitcoin’s price swings can also be attributed to shifts in investor attitudes, with some opting for safer investments amidst global economic uncertainties.

The role of derivatives in this scenario is pivotal. These financial instruments, which include futures and options, allow investors to hedge against price fluctuations or speculate on future movements. While derivatives can enhance liquidity and price discovery, they also introduce complexities and potential risks. The current instability in open interest suggests that traders are either closing positions to mitigate risk or opening new ones to capitalize on expected volatility, contributing to market unpredictability.

Adding to the complexity, the broader cryptocurrency market has also shown mixed signals. Other major cryptocurrencies, such as Ethereum and Binance Coin, have faced their own challenges, with price adjustments reflecting broader market sentiments. The interconnected nature of these digital assets means that a substantial movement in Bitcoin often influences the performance of other cryptocurrencies, affecting the overall market stability.

Looking back, Bitcoin has experienced several significant downturns, often followed by strong recoveries. Despite the current uncertainty, past patterns suggest that the crypto market’s inherent volatility could eventually lead to a rebound. However, the timing and magnitude of such recoveries are difficult to predict, leaving investors in a state of cautious anticipation.

A mitigating factor that could influence Bitcoin’s trajectory is the continued institutional interest in digital assets. Despite current fluctuations, many financial institutions remain engaged in the cryptocurrency sector, exploring blockchain technology applications and investing in digital assets. This sustained interest could provide a stabilizing force, reinforcing confidence in Bitcoin’s long-term prospects.

Yet, risk factors persist. A key concern is the potential for regulatory changes that could impact market dynamics. As governments worldwide continue to develop frameworks for cryptocurrency regulation, any unexpected policy shifts could disrupt market stability. Additionally, the decentralized nature of cryptocurrencies means they are susceptible to security breaches and hacking incidents, which could erode investor trust.

In contrast, the technology underlying Bitcoin and other cryptocurrencies, particularly blockchain, continues to evolve. Innovations in this space may unlock new use cases and efficiencies, potentially attracting new investors and driving market growth. Moreover, the expansion of decentralized finance (DeFi) and non-fungible tokens (NFTs) demonstrates the diverse applications within the crypto ecosystem, which could bolster Bitcoin’s value proposition.

Despite the current downturn, Bitcoin remains a focal point in the financial world, symbolizing both the potential and the challenges of digital currencies. Its price movements are closely watched by a wide array of stakeholders, from individual investors to multinational corporations. As the market navigates this uncertain period, the interplay between regulatory developments, technological advancements, and investor behavior will be critical in shaping Bitcoin’s future trajectory.

In conclusion, Bitcoin’s decline below $88,000 this December has unsettled the derivatives market, raising important questions about the factors influencing its price. While some view this as a temporary setback, others perceive it as a sign of deeper market shifts. Ultimately, the path forward for Bitcoin will likely depend on a combination of external economic factors, regulatory developments, and the ongoing evolution of the cryptocurrency landscape. As always, investors must remain vigilant and informed, balancing the potential rewards against the inherent risks of this fast-paced market.

Post Views: 17
2025-12-07 20:49 25d ago
2025-12-07 14:01 25d ago
Ethereum's $18 Billion Burn: The Complex Equation of Supply and Demand cryptonews
ETH
As of December 7, 2025, Ethereum has incinerated over six million ETH through transaction fees since the London upgrade on August 5, 2021, equivalent to more than $18 billion at current exchange rates. Despite this massive burn, Ethereum’s overall supply continues to grow, presenting a paradox in the realm of cryptocurrency economics.

The London hard fork introduced a significant change to Ethereum’s monetary policy through the implementation of EIP-1559, a protocol aiming to stabilize transaction fees and enhance user experience. By converting a portion of transaction fees into a base fee that gets ‘burned’ or removed from circulation, it was anticipated that Ethereum’s supply might decrease, driving up its price due to scarcity principles. However, the Ethereum network’s supply has paradoxically increased, driven by factors that extend beyond the mere destruction of ETH.

Ethereum’s capacity to burn over six million ETH has been driven by its role as a leading decentralized finance (DeFi) platform. As DeFi applications continue to expand, the demand for Ethereum’s network has surged. This demand fuels transactions, consequently increasing the amount of ETH burned. Yet, as the network burns ETH, it also incentivizes miners through ‘block rewards,’ a process where new coins are created and distributed to miners for validating transactions. This continuous minting of new ETH has contributed to the overall increase in supply, counterbalancing the effects of burning.

In the broader context of cryptocurrency ecosystems, Ethereum’s burning mechanism aims to address some of the inflationary pressures that affect many digital currencies. Unlike Bitcoin, which has a capped supply of 21 million coins, Ethereum does not have a maximum supply limit. This lack of a cap means that without mechanisms like burning, Ethereum’s supply could theoretically expand indefinitely, potentially diminishing its value over time. By strategically burning a portion of fees, Ethereum attempts to navigate the delicate balance between maintaining a robust network and sustaining value for its holders.

The Ethereum network operates as the backbone of numerous blockchain applications, including smart contracts and non-fungible tokens (NFTs). The intrinsic value and utility of these applications drive transaction volumes, which are critical to ETH’s burning mechanism. Since the London upgrade, the network has seen a significant increase in adoption, which has fueled both growth and the complexity of its economic model.

However, Ethereum’s supply dynamics are not without their risks and challenges. One potential risk is the network’s transition to Ethereum 2.0, a proof-of-stake model designed to improve security and scalability. This transition could significantly alter the supply-demand landscape. As Ethereum shifts from proof-of-work to proof-of-stake, validators will replace miners, earning rewards for their commitment rather than computational power. The change could influence how ETH is issued and burned, impacting overall supply and possibly altering market perceptions.

Moreover, the cryptocurrency market is subject to regulatory scrutiny and evolving policies, which can affect Ethereum’s economic model. Regulatory changes in major markets could influence how cryptocurrencies like Ethereum are traded, held, and used, potentially impacting demand and supply. The ongoing debate around digital currency regulation underscores the importance of proactive governance in the crypto space.

Ethereum’s journey since the London hard fork illustrates the intricate balance of supply and demand within a rapidly evolving financial ecosystem. Despite burning significant amounts of ETH, the network’s growth and the continuous creation of new ETH through mining have maintained a steady supply increase. This scenario highlights the complexity of managing a decentralized currency system where various economic forces interact.

The digital currency market remains highly volatile, and Ethereum’s supply and demand dynamics are a reflection of this volatility. While the burning of ETH aims to introduce deflationary pressure, the simultaneous creation of new ETH through rewards presents a balancing act. Investors and participants in the Ethereum ecosystem must navigate this complexity, understanding the broader market conditions and economic principles at play.

In summary, the burning of over six million ETH underscores both the potential and the challenges of Ethereum’s economic model. By implementing mechanisms like EIP-1559, Ethereum attempts to balance network growth with value preservation. Yet, the supply increase suggests that burning alone is not a panacea for inflationary pressures. As Ethereum continues to evolve, its economic dynamics will be closely watched by investors, developers, and regulators alike, as they look to understand and harness the potential of this leading cryptocurrency.

Post Views: 12
2025-12-07 20:49 25d ago
2025-12-07 14:05 25d ago
Social Sentiment Turns Bearish For XRP cryptonews
XRP
20h05 ▪
4
min read ▪ by
Luc Jose A.

Summarize this article with:

XRP is going through a rare moment of tension. While institutional investors continue to pour in via spot ETFs, social sentiment around the asset plunges sharply into extreme fear territory. This striking contrast between capital inflows and market panic feeds uncertainty. At the crossroads of fragile technical signals and a possible rebound, XRP becomes one of the most watched assets in the crypto ecosystem.

In brief

XRP is going through a tension phase marked by a 7.4 % drop over the week.
Social sentiment around the asset plunges into extreme fear territory, according to Santiment data.
A technical rebound attempt at $2.07 failed, revealing persistent market weakness.
A TD Sequential reversal signal appears on the weekly chart, revealing a possible rebound.

A degraded technical climate for XRP
Pressure on XRP intensified this week, with a weekly performance down by -7.4 %, in the context of the ongoing downtrend observed since the beginning of the month.

The technical rebound attempt was aborted despite a notable spike in activity. XRP briefly crossed $2.05, reaching $2.07 on volume up 68 % compared to the average. This movement, although promising in appearance, was fully retraced in the following hours, revealing a lack of bullish conviction in the market.

Here are the key elements of this technical deterioration :

Failure to break above $2.05 : despite a volume of 44.99 million dollars, the bullish attempt was not followed through, and sellers quickly regained control ;

An immediate resistance between $2.04 and $2.05 : this zone is identified as a distribution level, where each rebound is actively sold ;

Momentum declining across multiple timeframes : technical oscillators confirm a persistent downtrend, with no signs of bullish divergence at this stage ;

A fragile support zone at $2.030 : analysts emphasize the importance of this technical pivot, under threat of a move back to $2.020 – $2.025, or even the psychological level of $2.00.

The current dynamic shows a clear dominance of sellers in the short term. The technical context seems to indicate that, for now, the bulls neither have the strength nor the volume to reverse the trend.

Optimistic signals despite extreme fear
Despite this degraded technical climate, some underlying signals suggest a possible reversal. Social sentiment around XRP, measured by the Santiment platform, reached an extreme fear level comparable to lows observed in October.

Indeed, this is the highest level of bearish comments in over five weeks. Yet, these extreme levels have often been followed by short-term rebounds. That was the case on November 21, when a similar configuration preceded a notable bullish move. Moreover, a TD Sequential reversal signal appeared on the weekly chart, indicating a potential start of long-term stabilization.

At the same time, massive inflows into XRP ETFs in the United States testify to robust institutional momentum. $906 million of net inflows have been recorded since the product launches, with no days of outflows. On-chain data confirms this dichotomy. While XRP holders over a 6 to 12 month period reduce their exposure (from 26.18 % to 21.65 %), long positions held via ETFs continue to quietly increase.

The XRP price moves within a zone of high uncertainty. While technical signals suggest a possible rebound, sentiment is still dominated by fear. The fragile balance between recovery and continuation of the decline could quickly shift, depending on market reactions in the coming days.

Maximize your Cointribune experience with our "Read to Earn" program! For every article you read, earn points and access exclusive rewards. Sign up now and start earning benefits.

Join the program

A

A

Lien copié

Luc Jose A.

Diplômé de Sciences Po Toulouse et titulaire d'une certification consultant blockchain délivrée par Alyra, j'ai rejoint l'aventure Cointribune en 2019.
Convaincu du potentiel de la blockchain pour transformer de nombreux secteurs de l'économie, j'ai pris l'engagement de sensibiliser et d'informer le grand public sur cet écosystème en constante évolution. Mon objectif est de permettre à chacun de mieux comprendre la blockchain et de saisir les opportunités qu'elle offre. Je m'efforce chaque jour de fournir une analyse objective de l'actualité, de décrypter les tendances du marché, de relayer les dernières innovations technologiques et de mettre en perspective les enjeux économiques et sociétaux de cette révolution en marche.

DISCLAIMER

The views, thoughts, and opinions expressed in this article belong solely to the author, and should not be taken as investment advice. Do your own research before taking any investment decisions.
2025-12-07 20:49 25d ago
2025-12-07 14:05 25d ago
Bitget Launches POWERUSDT Perpetual Contract with 20x Leverage cryptonews
BGB
3 mins mins

Key Points:

Bitget launches POWERUSDT perpetual contract on December 6, 2025Leverage options range from 1 to 20, with trading bots supportedEvent marks expansion in Bitget’s U-Index perpetual offerings
On December 6, 2025, Bitget launched the POWERUSDT perpetual contract, introducing leverage options ranging from 1 to 20, and activated trading bots, according to their official announcement.

This move underscores Bitget’s ongoing expansion of U-Index-based derivatives, potentially influencing market dynamics for synthetic assets while highlighting advanced trading tools available on the platform.

Bitget Expands U-Index Offerings with POWERUSDT Launch
Bitget announced the POWERUSDT perpetual contract’s initiation, offering leverage from 1 to 20 times. Gracy Chen, CEO of Bitget, highlighted this product as part of Bitget’s broader strategy to expand its U-Index-based offerings. Both the perpetual contract and its corresponding trading bot became active on December 6, 2025, further enriching Bitget’s derivative market tools.

Incorporating this contract deepens Bitget’s commitment to providing diversified trading instruments. It broadens traders’ and investors’ capabilities for exposure to synthetic derivatives, structured to mirror real-world asset indices. With varying leverage options, traders can adjust their risk profiles to suit market conditions. This addition also introduces potential for fluctuating financial exposures via automated trading bots for this contract’s management.

Bitget has launched POWERUSDT for futures trading with a maximum leverage of 20, along with support for futures trading bots, on December 6, 2025 (UTC+8).Market reactions from leading experts in the cryptocurrency ecosystem appeared muted, with no significant public comments from notable figures in crypto communities. The general feedback from industry circles focused on Bitget’s strategic continuity in expanding derivative offerings with standardized features.

Price Impact and Future Market Potential
Did you know? Power Protocol’s launch of POWERUSDT follows a consistent precedent set by Bitget, notably its BSUUSDT launch earlier on December 4, 2025, highlighting a methodical pattern in expanding U-Index offerings.

Power Protocol’s token, POWER, currently trades at $0.20, with a market cap of approximately $42.67 million. Over the past 24 hours, its trading volume reached around $65.97 million, experiencing an 11.75% decline. Remarkably, the token saw a 150.95% increase over the past month, indicating heightened market interest. All figures are sourced from CoinMarketCap.

Power Protocol(POWER), daily chart, screenshot on CoinMarketCap at 18:58 UTC on December 7, 2025. Source: CoinMarketCap

Insights from the Coincu research team suggest this ongoing expansion by Bitget into U-Index offerings could shape future trends in synthetic asset derivatives. Past launches hint at regulatory stability, assuming no new legal challenges arise, thus fostering continued innovative financial product developments within Bitget’s ecosystem.

DISCLAIMER: The information on this website is provided as general market commentary and does not constitute investment advice. We encourage you to do your own research before investing.

Rate this post
2025-12-07 20:49 25d ago
2025-12-07 14:10 25d ago
3 Reasons to Buy Ethereum Before January 2026 cryptonews
ETH
Ethereum could be once again on the path to the $5,000 price level. Here's why.

Following a brief stumble after summer, Ethereum (ETH +3.27%) is showing signs of a recovery. While it's still down nearly 7% for the year, Ethereum has finally stabilized around the $3,000 to $3,100 price level.

Three important catalysts have the potential to propel Ethereum in 2026. If you've been debating whether or not to add some Ethereum to your crypto portfolio, here's what you need to watch.

New blockchain upgrade
If there's one thing Ethereum does well, it's new blockchain upgrades. Unlike other cryptocurrencies, Ethereum actually has a long-term strategic roadmap that outlines when and how new blockchain upgrades will occur.

Image source: Getty Images.

In 2022, Ethereum completed The Merge, transforming from a proof-of-work blockchain into a proof-of-stake blockchain. In 2023, the Shapella upgrade occurred. In 2024, there was the Dencun upgrade. And in May of this year, there was the Pectra upgrade.

Coming in December is the new Fusaka upgrade. This is being heralded as the biggest Ethereum blockchain upgrade in years. It's easily the biggest since The Merge. Without delving too deeply into the technical details, Fusaka aims to enhance the Ethereum blockchain's speed, efficiency, and cost-effectiveness. That should result in a surge of new blockchain activity.

New regulatory changes
Another big catalyst involves the improving regulatory environment for crypto. The Trump administration promised a pro-crypto regime, and that's exactly what it has delivered in 2025.

Ethereum is now part of a new digital asset stockpile created by the Treasury Department in March. There is also a new regulatory framework for stablecoins (i.e., cryptocurrencies that are pegged 1:1 to the value of the U.S. dollar). Next up is a comprehensive piece of legislation that outlines the regulation of digital assets within the U.S. marketplace.

But the really big news may be a new approach to staking, which was once a popular way for investors to earn passive income on their cryptocurrency investments. However, after a SEC crackdown on staking in 2023, it has largely faded from public view.

But that could be changing soon. Both the Treasury Department and the IRS are working on new rules for staking, particularly as they relate to the creation of new investment products. The biggest impact will be on proof-of-stake blockchains such as Ethereum.

As a result, major Wall Street firms are now mulling the introduction of new staking-enabled Ethereum products, including new staking-enabled exchange-traded funds (ETFs). This should help to build long-term demand for Ethereum, sending its price higher.

Macroeconomic tailwinds
It's been difficult this year to make sense of what's really happening with the U.S. economy. Is it growing or not? Is inflation on the rise or not? And are tariffs helping or hurting?

Today's Change

(

3.27

%) $

99.34

Current Price

$

3137.92

As a result, cryptocurrencies such as Ethereum have tended to rise and fall with each new development in this unfolding economic drama. In April, for example, cryptocurrencies plummeted as soon as the new worldwide tariffs were unveiled at the White House. At the same time, even the vaguest hint of a new Fed rate cut can send digital assets soaring.

The good news is that the economic situation appears to be stabilizing as we head into 2026. New rate cuts are on the imminent horizon, and liquidity continues to be pumped into the system. A new Fed chairman, too, might be more amenable to a pro-growth economic agenda for crypto.

All of this activity can be safely lumped under the heading "macroeconomic tailwinds." Long story short -- the White House appears to have its eye on the prices of major cryptocurrencies such as Bitcoin and Ethereum, and isn't going to let the market decline too far without getting involved.

Is Ethereum now on a path to $5,000?
The all-time high for Ethereum is $4,954, which it hit in late August. To simplify the math, let's just call this $5,000.

The conventional wisdom now is that Ethereum is once again on a path to regain the $5,000 price level. It's not clear how long this will take, but according to Tom Lee of Fundstrat, Ethereum could be coasting to a price of $9,000 by the end of next year.

So, if you've been on the fence about Ethereum, now might be the time to buy the dip. If you wait too much longer, you might miss out on a splendid opportunity to buy the world's second-largest cryptocurrency on the cheap.
2025-12-07 20:49 25d ago
2025-12-07 14:14 25d ago
Bitcoin Whipsaws as $1.39 Billion Whale Dump Triggers Coordinated Sell-Off cryptonews
BTC
Bitcoin’s Sunday price action turned chaotic after a wave of whale-driven sell orders triggered a rapid $2,000 drop, mass liquidations, and an equally aggressive rebound.

The moves wiped out both long and short traders within hours, raising fresh concerns about low-liquidity manipulation and order book fragility at a time when Bitcoin continues hovering above $91,000.

Sponsored

Sponsored

$1.39 Billion in Bitcoin Dumped Within One HourSeveral analysts reported a what appeared to be coordinated sell-offs, where more than 15,565 BTC, worth roughly $1.39 billion, hit the market in a single hour.

“Here is why the market just nuked: whale dumped 4,551 BTC, Coinbase dumped 2,613 BTC, Wintermute dumped 2,581 BTC, Binance dumped 2,044 BTC, BitMEX dumped 1,932 BTC, Fidelity dumped 1,844 BTC. A total of 15,565 BTC worth $1.39 billion was dumped in one hour! This was a full-scale coordinated sell-off,” wrote analyst Wimar in a post.

The sudden surge in supply hitting the market simultaneously accelerated Bitcoin’s decline from $89,700 to $87,700, setting the stage for a cascade of liquidations.

$171 Million in Liquidations as Longs and Shorts Get WipedThe sharp initial drop wiped out $171 million worth of BTC longs, caught off guard as the Bitcoin price fell $2,000 in minutes before rebounding with equal force. As of this writing, the Bitcoin price is $91,494.

Bitcoin (BTC) Price Performance. Source: TradingViewAlong with this quick recovery, almost $14 million in short positions were liquidated in the past hour and over $91 million in the past four hours.

Sponsored

Sponsored

“This is another example of manipulation on the low-liquidity weekend to wipe out both leveraged longs and shorts,” Bull Theory said.

Data from Coinglass confirms the scale of the damage. Over the past 24 hours, 121,628 traders were liquidated, resulting in total liquidations of $346.67 million.

Crypto Liquidations. Source: CoinglassTraders Call It “Engineered Liquidity Collection”Market commentators say this wasn’t normal volatility, with Marto arguing that the sequence was not accidental.

Sponsored

Sponsored

“People keep calling this volatility. It’s not. It’s engineered liquidity collection. When the order book is weak, whales swing the price like a door hinge and cash in on both sides,” he wrote.

Others pointed to the speed of the recovery, with Lenny, a trader known for tracking liquidity flows, remarking about the whipsaw.

“Honestly, that BTC dip to 89k got absorbed fast. That’s not noise,” Lenny chimed.

The quick absorption suggests strong spot demand remains intact even as aggressive leverage flushes continue at weekend lows.

Sponsored

Sponsored

Can Bitcoin Maintain $90,000?The Bitcoin price is recovering its weekend losses but still showing signs of heavy intraday stress. The dual liquidations demonstrate how thin order books on weekends continue to be a target for large players capable of moving billions of dollars in minutes.

Spot demand may stabilize price action into the upcoming week, especially as liquidity normalizes and derivatives markets reset.

With over $300 million in liquidations behind it, Bitcoin enters the next trading sessions with cleared leverage, but also heightened sensitivity to further whale-driven moves.

Meanwhile, data shows that $1 billion in short positions are at risk of liquidation if the Bitcoin price pumps to $93,000.

Notably, the $93,000 threshold stands barely 2% above current levels.
2025-12-07 20:49 25d ago
2025-12-07 14:21 25d ago
Crypto markets sets odds of XRP hitting a record high by December 31, 2025 cryptonews
XRP
As the year winds down, prediction markets suggest there is only a slim chance that XRP will hit a record high by December 31.

According to data retrieved by Finbold on December 7, traders on Polymarket currently price the likelihood at just 3%. 

Since the trade went live, those odds have plunged more than 60%, marking one of the sharpest declines from the elevated levels seen in September and October.

XRR odds of new record high by Dec 31. Source: Polymarket
The market’s pricing, driven by Polymarket’s crypto-using participants who stake real funds on event outcomes, has trended sharply downward throughout the final quarter. 

The data shows sentiment weakening from early September, sliding through November, and settling close to zero in December.

As of press time, traders had wagered more than $170,000 on the question, with resolution set for January 1, 2026.

Notably, sentiment surrounding a possible record high has deteriorated in recent sessions in line with the broader market tone. To this end, XRP has posted notable losses in recent weeks, reflecting the wider downturn and the threat of losing the $2 support.

XRP price analysis
However, the asset is showing short-term strength amid a sharp capital inflow. As of press time, XRP was trading at $2.10, up over 3% in the past 24 hours, although still down 4.6% on the week.

XRP seven-day price chart. Source: Finbold
This renewed momentum follows an influx of roughly $6 billion into XRP within hours as the broader cryptocurrency market staged a recovery led by Bitcoin (BTC). The next target for XRP remains reclaiming the $2.15 level on its path toward $2.50.
2025-12-07 20:49 25d ago
2025-12-07 14:31 25d ago
French Bank BPCE Rolls Out BTC, ETH, SOL, USDC Trading to Millions in France cryptonews
BTC ETH SOL USDC
BPCE launches in-app trading for BTC, ETH, SOL, and USDC, marking a major shift as European banks race to meet rising retail crypto demand.

Izabela Anna2 min read

7 December 2025, 07:31 PM

France’s banking landscape is shifting as BPCE begins offering direct crypto purchases to a segment of its retail customers. The group now enables access to Bitcoin, Ether, Solana, and USDC through its regional networks. The launch signals a major step by a traditional financial institution entering an increasingly competitive digital asset sector. 

Early Rollout Targets Two Million CustomersBPCE introduced the service within four regional entities, including Banque Populaire Île-de-France and Caisse d’Épargne Provence-Alpes-Côte d’Azur. These entities represent around two million customers. The group plans to introduce the service across its remaining networks during 2026. However, executives want to monitor performance before accelerating expansion.

Customers can buy or sell supported assets through the Caisse d’Épargne and Banque Populaire apps. Each user creates a dedicated digital asset account that carries a monthly fee of €2.99. Moreover, each transaction includes a 1.5% commission with a €1 minimum. Hexarq, BPCE’s crypto subsidiary, manages all related accounts.

European Banks Intensify Their Crypto PushEuropean banks are expanding digital asset services as more consumers seek regulated access. Fintech competition increased pressure on traditional banks. Apps like Revolut, Deblock, Bitstack, and Trade Republic attracted millions of crypto users across Europe. Consequently, major banks now view digital assets as an important retention tool.

Several institutions already moved ahead. BBVA allows Spanish customers to buy, sell, and hold Bitcoin and Ether through its app. Additionally, Santander’s digital unit Openbank added Bitcoin, Ether, Litecoin, Polygon, and Cardano with integrated trading and custody. These developments show rising confidence among banks exploring broader crypto strategies for retail clients.

BPCE Aims to Strengthen Its Retail PositionBPCE sees digital assets as a way to strengthen customer loyalty during rapid fintech disruption. Moreover, the bank expects growing interest as users seek simple crypto access through familiar platforms. 

The phased rollout helps BPCE collect data and refine the service. This approach also prepares the bank for larger demand once digital asset regulations adjust across Europe.

Significantly, the move aligns with a wider trend in European banking that supports regulated access instead of external platforms. BPCE plans to position itself as a reliable and convenient gateway for everyday investors.

ENRICH your inbox with our best storiesDon’t miss out and join our newsletter to get the latest,
well-curated news from the crypto world!

Izabela Anna

Izabela Anna is a knowledgeable freelance journalist, who boasts over five years of experience covering the cryptocurrency market. Her tenure has seen her navigate through the ebbs and flows of multiple market cycles, giving her a deep understanding within. Her journalistic focus lies in dissecting price action dynamics, scrutinizing the on-chain landscape, and providing insights from a technical perspective, making her a trusted voice in the realm of cryptocurrency reporting.

Read more about

Latest Solana (SOL) News Today
2025-12-07 20:49 25d ago
2025-12-07 14:36 25d ago
Jupiter Lend Faces Backlash Over Misleading Risk Claims cryptonews
JUP
2 mins mins

Key Points:

Jupiter Lend addresses concerns over incorrect contagion risk claims.Leadership admits communication failure, affecting trust.Kamino Finance critiques misleading risk models.
Kash Dhanda, COO of Jupiter Exchange, admitted inaccuracies in previous risk claims for Jupiter Lend, after Kamino Finance blocked its migration tool over rehypothecation concerns on Solana.

This revelation highlights potential trust issues within DeFi, impacting Solana’s ecosystem and sparking discussions on risk management and transparency, without affecting immediate financial metrics.

Jupiter Exchange Under Scrutiny for Risk Disclosures
Recently, Kash Dhanda, COO of Jupiter Exchange, admitted that the previous claims of “zero contagion risk” associated with the Jupiter Lend vaults were inaccurate. Kash Dhanda stated, “In hindsight, we should have issued a correction right when we deleted it.” This acknowledgment follows the removal of social media posts that initially promoted this idea.

In response to these developments, Jupiter Exchange is correcting past communication errors to maintain trust within its community. The vaults are confirmed to be risk-isolated but acknowledge existing risks from re-mortgaged assets.

The co-founder of Kamino Finance criticized these statements and blocked Jupiter Lend’s migration tool, citing misleading risk models. This action reflects broader market skepticism about the project’s risk management strategies.

Kamino Blocks Jupiter’s Tool: DeFi Protocols Self-Regulate
Did you know? Kamino Finance’s decision to block Jupiter Lend’s migration tool sets a notable precedent in DeFi, as it demonstrates protocols taking active roles in policing each other’s risk communication and management.

According to CoinMarketCap, Solana’s (SOL) current price stands at $135.37 with a market cap of $75.89 billion. Recent trends show a 24-hour increase of 2.29% while experiencing a 37.19% decline over 90 days, highlighting significant volatility in the market.

Solana(SOL), daily chart, screenshot on CoinMarketCap at 19:29 UTC on December 7, 2025. Source: CoinMarketCap

Experts from Coincu indicate that the miscommunication surrounding contagion risk could drive tighter regulatory scrutiny in the DeFi sector. This incident may influence future technological transparency and risk assessments across similar platforms.

DISCLAIMER: The information on this website is provided as general market commentary and does not constitute investment advice. We encourage you to do your own research before investing.

Rate this post
2025-12-07 20:49 25d ago
2025-12-07 14:43 25d ago
Big Buyers Storm In as Bitcoin's Rebound to $91K Triggers Massive Liquidation Wave cryptonews
BTC
After spending the morning flirting with the dungeon below $88,000, BTC clawed its way upward and blasted to an intraday high of $91,767. Bitcoin's latest rebound didn't just flip the script on weekend traders — it triggered a full-blown liquidation bonfire across the crypto market as deep-pocketed buyers muscled shorts into oblivion.
2025-12-07 20:49 25d ago
2025-12-07 14:52 25d ago
Solana Bottoming? $120–$125 Support Holds as Momentum Returns cryptonews
SOL
TLDR:

Solana sustains the $120–$125 support band, signaling stronger buyer defense after an extended multi-month decline.

RSI bullish divergence and improving momentum suggest the market may be forming an early bottoming structure.

Analysts monitor a gradual climb toward $145–$160 as selling activity slows and price stabilizes above support.

A drop below $120 remains the low-probability scenario unless broader market weakness triggers renewed downside.

Solana bottoming speculation is growing as the asset maintains stability above the closely watched $120–$125 support zone. 

The recent performance shows the market protecting a key demand region while momentum indicators attempt to shift in favor of buyers. These developments come after months of downward pressure that pushed the asset toward levels last tested earlier in the year.

Solana bottoming discussions have intensified due to the narrowing price swings and steady defense of multi-month support. Market participants are now focused on whether this structure evolves into a sustained recovery or remains within a short-term consolidation pattern.

Support Zone Holds as Price Stabilizes
In a recent analysis shared by veteran financial trader Matthew Dixon, Solana’s price action shows clear signs of stabilization. 

He noted that the asset completed a multi-month downtrend and is now stalling around the $125–$135 area, which previously served as an important support band. This defense of the zone has limited selling pressure and created room for buyers to regain positioning.

#Solana has completed a multi-month downtrend after a strong run-up. Recent candles show the price stalling around the $125–$135 zone, which acted as support earlier in the year.

The trend from August to November is clearly down, but the recent weeks show:
Selling momentum… pic.twitter.com/nwd9797qjS

— Matthew Dixon – Veteran Financial Trader (@mdtrade) December 7, 2025

Dixon’s tweet also pointed out that the price has continued to hold above the broader $110–$120 demand region. 

This behavior suggests that the market is not currently forming a bearish continuation pattern. A series of higher lows on the micro timeframe supports the view that accumulation is taking place as sellers gradually lose momentum.

The RSI (14) offers additional evidence, with a visible bullish divergence showing the indicator forming higher lows while the price sets lower lows. 

Although the RSI has yet to move above the neutral 50 level, its steady rise from oversold conditions often aligns with early bottoming phases rather than mid-trend declines.

Momentum Turns Toward a Mild Upward Bias
Dixon outlined several potential paths for Solana, with the most likely scenario pointing to a gradual move toward the $145–$160 range. 

This expectation is based on slowing selling activity and the supportive RSI structure. Traders are watching whether a retest of $135 transitions into a stronger push through the next resistance area at $145.

A secondary scenario involves the market holding within a consolidated band between $120 and $140. 

This outcome may materialize if broader market conditions remain neutral. Such periods often reflect hesitation before a directional move, and Solana’s positioning within long-term support keeps both upward and sideways outcomes in consideration.

The least likely scenario remains a breakdown toward the $110 level. Dixon noted that this would require a decisive close below $120 accompanied by rising volume. 

Broader Bitcoin weakness would likely be the primary catalyst for such a shift. Until that occurs, the current structure continues to support the view that Solana may be forming a bottom while momentum gradually returns.
2025-12-07 20:49 25d ago
2025-12-07 14:55 25d ago
Bitcoin Stabilizes at 86–88K as Binance Futures Leverage Quietly Resets cryptonews
BTC
TLDR:

Binance futures open interest prints turn negative, signaling traders are reducing leveraged exposure during Bitcoin’s pullback.

Funding rates drop sharply, showing long-side aggression easing and derivatives pressure cooling across recent sessions.

Binance Leverage Pulse at 0.198 sits below its 20-day average, indicating stable leverage relative to stablecoin reserves.

A collective reset across OI, funding, and leverage supports Bitcoin’s steady trade within the crucial 86–88K support range.

Bitcoin Stabilizes at 86–88K as the market enters a quieter derivatives phase on Binance, where leverage metrics show a steady reset rather than stress.

The move from 89.6K toward the lower 89K region unfolds during a moment of reduced speculative positioning, giving Bitcoin room to trade within this key support zone. Conditions remain orderly, with traders stepping back from aggressive leverage as the market cools.

This reset is visible across multiple metrics that track behavior on Binance’s futures market. 

Open interest and funding readings both point to a broad step-down in leveraged exposure. The environment is not showing signs of panic or disorder; instead, it reflects controlled positioning as Bitcoin holds its range.

Open Interest and Funding Ease as Market Cools
Open interest readings on the 12-hour window turned negative at –0.18%, –0.24%, and –0.53%. 

These values show traders reducing exposure rather than increasing speculative bets. Such behavior often appears during resets that follow extended upward moves, allowing the market structure to stay stable during pullbacks.

Open Interest and Funding Ease as Market CoolsSource: Cryptoquant
Funding data also moved sharply lower with readings of –69%, –62%, –49%, and –40%. These drops suggest a slowdown in long-leaning positioning across Binance Futures. 

With fewer traders attempting to push the price through leverage, Bitcoin’s move into the 86–88K zone develops in a relatively calm setting.

Crazzyblockk shared these metrics to show that the futures market is cooling at the right time. The absence of rising leverage during this dip supports a more balanced structure. Traders on Binance appear to be waiting rather than preparing for a deeper slide.

Leverage Pulse Shows Controlled Conditions
The Binance Leverage Pulse (ST_ELR) provides another reference point. 

The latest reading at 0.198 sits below the 20-day average of about 0.205. The negative z-score indicates that leverage relative to stablecoin reserves remains contained during this stage.

Source: Cryptoquant
A controlled leverage pulse reduces the risk of forced liquidations, which often accelerate volatility during pullbacks. 

With this metric cooling in tandem with open interest and funding, Bitcoin’s position near the 86–88K range gains a steadier foundation. The market appears to be resetting rather than showing stress signals.

According to Crazzyblockk, Binance’s influence on global Bitcoin sentiment remains central. 

When leverage activity cools across all core indicators, conditions often support a slow rebuilding phase. As long as Bitcoin maintains the 86–88K support zone, this quieter derivatives backdrop may provide space for a more measured recovery.
2025-12-07 20:49 25d ago
2025-12-07 15:06 25d ago
Bitcoin wallets interacting with this specific protocol are now flagged for “high-risk” seizures by compliance algorithms cryptonews
BTC
When European police staged another coordinated sweep against crypto mixers this autumn, most people saw a familiar headline and scrolled on. But every seizure, every frozen server rack, every compressed hard drive pushed into an evidence van has the potential to change how Bitcoin actually moves.

Mixers (tools that allow users to break the traceable chain of custody on public ledgers) have always lived in the grey zone where privacy expectations collide with financial crime rules.

The EU’s new legal architecture turns that grey into a deep red patrolled by Europol, Eurojust, and various national cybercrime units, each empowered to go after services they classify as money-laundering infrastructure.

The result is a slow but steady reconfiguration of Bitcoin’s liquidity in Europe.

The EU’s mixer enforcement blueprintMixers themselves are straightforward in design and controversial in purpose. At their simplest, they’re pools that commingle inputs from many users and return fresh outputs that no longer map cleanly back to the sender; in practice, the good ones run timed delays, randomized output paths, and multi-pool routing to add entropy. Centralized mixers do this on a server they control.

Decentralized variants, like coinjoin protocols like JoinMarket or Whirlpool, use collaborative transaction construction without custody. In enforcement, EU regulators treat centralized mixers as unlicensed money-laundering tools and decentralized ones as risky vectors subject to monitoring rather than takedowns.

The regulatory structure is pretty formal and coordinated. Under the EU’s AML legislative package, including the Anti-Money Laundering Regulation (AMLR) and the Anti-Money Laundering Authority (AMLA), mixers fall squarely under the remit of Europol and national financial intelligence units when they’re suspected of handling illicit proceeds.

Europol’s 2023 and 2024 enforcement bulletins described mixers as “criminal facilitation services” when tied to ransomware or darknet commerce. Eurojust steps in when operators sit across borders: the agency coordinated joint actions in Operation “Cookie Monster” in 2023, which targeted Hydra-linked services and explicitly called out mixer infrastructure as part of the laundering stack.

Member states then handle on-the-ground seizures: Germany’s BKA, the Netherlands’ FIOD, France’s Gendarmerie, and Spain’s Guardia Civil have all executed warrants involving mixer servers over the past three years.

Historic precedent for hard bans exists and is unambiguous. The US sanctioned Tornado Cash in August 2022 under OFAC authority, a move that effectively criminalized using the smart contracts if doing so involved US persons; in August 2023, the FBI and FinCEN issued further guidance warning exchanges and VASPs to block deposits that touched Tornado Cash pools.

Centralized mixers have been shut down in Europe before: Bestmixer.io was dismantled in 2019 in a Dutch-led action with Europol support, marking one of the earliest global mixer takedowns. The pattern since then has been consistent: trace illicit inflows, locate hardware, seize it, and force operators into criminal proceedings.

How enforcement against mixers worksTo understand what enforcement looks like in practice, picture a data center outside Berlin or Rotterdam. Officers arrive with warrants obtained through Eurojust cooperation, isolate racks, image disks, and pull network logs that link transactions to accounts, timestamps, and operator access credentials.

In public statements, Europol described this forensic phase with clinical precision, mentioning server seizures, domain takedowns, and asset freezes, pairing it with arrest actions when operators are identifiable. When Bestmixer was taken down, servers in Luxembourg and the Netherlands were confiscated, and over 27,000 BTC worth of logs were preserved for analysis, according to Europol’s release at the time.

Because most centralized mixers rely on web-facing infrastructure, seizing the servers immediately collapses the service. Decentralized protocols can’t be seized, but they can be pressured through compliance channels.

Exchanges with EU licenses, such as Kraken, Bitstamp, Binance Europe, and Coinbase Europe, are required under AMLR to treat mixer-linked UTXOs as high-risk activity.

That means automated risk engines that flag deposits with KYT (Know-Your-Transaction) scores above preset thresholds. A flagged deposit might trigger an automated freeze, a request for proof-of-source, or a forced withdrawal return.

The side effects spill into DeFi and everyday crypto usage. When centralized venues tighten their rules, users who rely on mixers, some for privacy, some for operational security, some for illicit concealment, pivot to alternative rails. Chain-hopping is becoming more common: privacy seekers move from BTC to XMR, then via bridges to chains with deep liquidity, often hopping back into BTC via non-EU venues.

TRM Labs and Chainalysis have documented these displacement effects after both Tornado Cash sanctions and Europe’s more recent enforcement actions. Liquidity doesn’t vanish when a mixer goes down; it migrates, usually toward jurisdictions with lighter compliance overhead.

For ordinary users, the problem isn’t prosecution but friction. False positives can hit coinjoin participants even when no illicit activity is involved, because the collaborative structure looks “tainted” to risk engines built for centralized mixers. People who use Lightning channels to rebalance funds can face similar issues, as some exchanges treat LN closures as unverifiable returns.

EU member states themselves are unevenly equipped to enforce these rules. Countries like Germany and the Netherlands have established cybercrime units with dedicated blockchain forensics teams, enabling swift, coordinated operations.

Smaller states rely more on Europol intelligence packages and AMLA coordination once the authority becomes operational. Because AMLA will supervise high-risk cross-border crypto activity directly, expect a more coherent compliance regime across the bloc by 2026, with consistent language around mixer-linked inflows and mandatory reporting to FIUs.

The national patchwork we have now is set to become a single grid of enforcement, and BTC privacy liquidity will be the first thing that feels the shift.

What this means for Bitcoin liquidityBitcoin aims to be global, but its liquidity is territorial the moment regulated venues decide what they will or won’t accept.

When EU exchanges receive guidance or implicit pressure to block flows connected to seizures, users shift their activity elsewhere. Liquidity pools thin, spreads widen, and the familiar pathways for moving privacy-sensitive BTC tighten.

In previous takedowns, analysts at Elliptic and Chainalysis observed volume draining from sanctioned hubs into offshore exchanges, P2P markets, and other privacy-focused ecosystems. Europe’s coordinated approach produces the same pattern, only with more internal consistency and more data-sharing between agencies.

For exchanges, the math is simple: the EU wants uniform AML standards, and licensed venues wish to stay licensed. Users can expect more explicit policy pages from European exchanges, more precise definitions of prohibited sources, and automated filters that treat any mixer-associated UTXO as a compliance ticket.

The experience of using these exchanges has the potential to degrade significantly, with users forced to show provenance, avoid cross-contamination between UTXOs, and anticipate delays whenever a transaction touches any kind of collaborative privacy tooling. None of this bans privacy outright, but it forces the practice into narrower corridors.

The long-term effect will definitely be fragmentation. If Europe becomes the region where privacy flows are inherently complex, those flows migrate to friendlier venues in Asia, LATAM, or the US that haven’t yet absorbed similar enforcement models.

Nothing structurally relevant will actually happen to Bitcoin, though. The privacy-sensitive portion of its liquidity will just become more global and less local, more dependent on arbitrage paths and less on straightforward CEX-to-wallet cycles inside the EU.

Privacy tech will continue to evolve, coinjoins hardening, Lightning liquidity deepening, and PayJoin gaining support, but the regulatory superstructure will grow alongside it, building walls around the parts of the system it finds risky.

The EU isn’t and probably won’t be banning mixers with a single sweeping act. Instead, it’s performing a quiet, steady campaign that replaces uncertainty with predictability, and predictability with control. Enforcement arrives through joint actions, FATF-aligned rules, standardized KYT systems, and soon an AML authority that supervises crypto directly.

Most of the consequences will land in liquidity charts, trading desks, and the inboxes of users whose deposits get held up by compliance queues, instead of courtrooms.

The story here isn’t about whether mixers survive, because they always reappear in new forms. It’s about how Europe’s enforcement blueprint will reshape the way Bitcoin moves, settles, and hides its footsteps.
2025-12-07 20:49 25d ago
2025-12-07 15:19 25d ago
Aztec Network raises over $60 million in ETH with community-first token sale, testing new auction model cryptonews
AZTEC ETH
Privacy-focused Ethereum Layer 2 developer Aztec Network closed its public AZTEC token sale Saturday, collecting 19,476 ETH from more than 16,700 participants in what the project claims represents a shift away from insider-dominated token launches.

The sale, which ran from December 2-6 using a novel Continuous Clearing Auction mechanism built with Uniswap Labs, raised approximately $61.3 million at current ether prices. Aztec said half of the capital came from its existing community, such as testnet operators, early users of its now-shuttered Aztec Connect product, and other ecosystem participants, rather than large institutional allocations.

Aztec's token distribution eschewed the airdrop model that has become standard for Layer 2 launches in favor of what it described as a "fair-access" auction. The CCA mechanism started at a floor price corresponding to a $350 million fully diluted valuation, which Aztec said represented a 75% discount to the implied valuation from its equity financing rounds. Per-user caps of 240 ETH were instituted to limit whale concentration.

Uniswap founder Hayden Adams praised the sale in a post on X. "No sniping, bundling, timing games," Adams wrote. "Just slow, fair price discovery ending at 59% above the floor — with literally days to bid earlier and get a better average price."

A Uniswap v4 liquidity pool containing 273 million AZTEC tokens (roughly 2.6% of total supply) will also go live following the token generation event to bootstrap secondary market trading.

AZTEC tokens purchased through the sale will remain non-transferable until at least February 11, 2026. Token holders can then initiate a governance vote to unlock transferability. If no vote passes, tokens will unlock linearly through November 2026. Validators wishing to stake must commit 200,000 AZTEC tokens.

The a16z-backed project had raised $100 million in Series B funding in December 2022, with additional backing from Paradigm and Ethereum co-founder Vitalik Buterin. The company has raised over $119 million in total funding, per The Block Pro's Funding Dashboard. 

Aztec launched its privacy-focused Ethereum Layer 2 network, Ignition Chain, in mid-November. Aztec called Ignition the "first fully decentralized L2 on Ethereum," which will power the firm's vision of a "private world computer."

165 nodes are currently powering the network, according to the project's dashboard. The chain is currently producing blocks but does not yet process user transactions, a deliberate staging approach the team says will allow real economic stress-testing before full functionality launches in early 2026. Nearly 556 million AZTEC tokens have been staked. 

Disclaimer: The Block is an independent media outlet that delivers news, research, and data. As of November 2023, Foresight Ventures is a majority investor of The Block. Foresight Ventures invests in other companies in the crypto space. Crypto exchange Bitget is an anchor LP for Foresight Ventures. The Block continues to operate independently to deliver objective, impactful, and timely information about the crypto industry. Here are our current financial disclosures.

© 2025 The Block. All Rights Reserved. This article is provided for informational purposes only. It is not offered or intended to be used as legal, tax, investment, financial, or other advice.
2025-12-07 20:49 25d ago
2025-12-07 15:30 25d ago
Michael Saylor Teases Bitcoin Rally With Orange Dot Post cryptonews
BTC DOT
3 mins mins

Key Insights:

MicroStrategy now holds 650,000 BTC, valued at $57.8B, with gains of over $9.4 billion.
Saylor’s “Orange Dots” post suggests new Bitcoin buys may be underway during the market dip.
On-chain metrics show miner and holder stress, often seen near bottoms in previous Bitcoin cycles.

Michael Saylor Teases Bitcoin Rally With Orange Dot Post
MicroStrategy now holds 650,000 bitcoins, purchased across 88 separate buys. As of time of writting, the total value of the company’s holdings stands at $57.80 billion. The average cost per bitcoin is $74,436. At current prices, the portfolio is showing a gain of 19.5%, or just over $9.4 billion.

Each orange dot on the chart represents a single purchase. These dots appear across both rising and falling markets. Recent activity shows a new cluster of dots forming during the latest price dip, suggesting more bitcoin may have been added in recent weeks. The buying trend matches past behavior, where MicroStrategy has increased its holdings during periods of price weakness.

Saylor’s Tweet Hints at New Buying Activity
Michael Saylor posted “₿ack to Orange Dots?” on social media, a phrase often linked with the company’s bitcoin purchases. While no new buy has been confirmed, the timing of the message and the chart activity suggest a possible new phase of accumulation.

Source: Michael Saylor/XSource: Michael Saylor/X
The phrase is used by some traders to track MicroStrategy’s entries. This recent post has renewed attention on whether the firm is continuing to buy. Without official confirmation, the question remains open. “₿ack to Orange Dots?” may point to resumed activity, but it is still unclear.

On-Chain Signals Show Market Stress
Bitcoin’s Hash Ribbon chart has turned bearish. This signal appears when the 30-day hash rate moves below the 60-day average. It often reflects mining stress, where lower profit margins push some miners to shut down operations.

Another metric, Short-Term Holder NUPL, has dropped below zero. This means most recent buyers are holding at a loss. The chart reflects a zone of capitulation, a stage where weaker hands tend to sell. These signals have appeared near price bottoms in the past, but there are no guarantees.

🚨 WARNING: Bitcoin is flashing major on-chain stress signals

– BTC Hash Ribbon has flipped bearish
– Short-Term Holder NUPL dropped into negative territory

Miners and short-term holders are capitulating.
Historically, these conditions appear near major bottoms.

Patience. ⏳ pic.twitter.com/GlzeWUdNEz

— Bitcoin Archive (@BitcoinArchive) December 7, 2025

Market Watching for Next Move
MicroStrategy has often made purchases during periods like this. The company has shown a pattern of buying during downturns and holding long-term. If recent orange dots mark new buys, this may be the start of another round.

Market participants are watching closely. If confirmed, new purchases could send a strong message. For now, the post remains a hint — not a statement.

DISCLAIMER: The information on this website is provided as general market commentary and does not constitute investment advice. We encourage you to do your own research before investing.

Rate this post
2025-12-07 20:49 25d ago
2025-12-07 15:36 25d ago
Crypto's other halving: Bittensor's first 4-year cycle seen as ‘maturation' milestone cryptonews
TAO
With Bitcoin now in its fourth quadrennial halving, other decentralized projects have adopted similar supply-cut cycles — and Bittensor is approaching its first since launching in 2021.

Bittensor, a decentralized, open-source machine-learning network built around specialized “subnets” that incentivize marketplaces for AI services, is expected to undergo its inaugural halving on or around Dec. 14. At that point, issuance of its native token, TAO (TAO), will drop to 3,600 per day from the current 7,200.

Grayscale Research analyst William Ogden Moore called the event a “key milestone in the network’s maturation as it progresses toward its 21 million token supply cap,” matching Bitcoin’s (BTC) fixed limit.

TAO follows a supply schedule similar to Bitcoin’s. Source: Grayscale ResearchDigital-asset investors and network participants often view a hard-capped supply as a potential value catalyst: if adoption grows and token demand rises, a finite issuance model can be more appealing than pre-mined tokens or fiat currencies with effectively unlimited supply.

Cointelegraph reported on Bittensor in May during a conversation with DNA Fund’s Chris Miglino, whose AI compute fund is heavily involved in the Bittensor ecosystem.

“The biggest thing that we’re working on in the whole ecosystem is our AI compute fund, where we’ve been entrenched into the TAO ecosystem,” Miglino said.

A dive into Bittensor subnetsGrayscale describes Bittensor’s subnets as a kind of “Y Combinator for decentralized AI networks,” since each operates like a startup building a specialized product or service.

CoinGecko currently lists over 100 Bittensor subnets, with a combined market cap exceeding $850 million. Taostats, which tracks the ecosystem more comprehensively, shows 129 subnets with a total market cap closer to $3 billion.

The growth of Bittensor subnets. Source: CoinGeckoIn either case, subnet valuations have grown significantly since launch, according to Grayscale Research. The largest include Chutes, which provides serverless compute for AI models, and Ridges, a subnet focused on crowdsourcing the development of AI agents.

The expansion underscores growing demand for decentralized AI infrastructure as developers race to build and scale new AI products and applications.

As Miglino told Cointelegraph, decentralized AI may prove to be blockchain’s most significant use case since Bitcoin, driven largely by that demand.

Bittensor subnets are also drawing venture capital. Inference Labs recently closed a $6.3 million round to support Subnet 2, a Bittensor marketplace for inference verification.

Meanwhile, xTao, an infrastructure developer building tools and services for the Bittensor ecosystem, began trading on the TSX Venture Exchange in July as a newly public company.
2025-12-07 20:49 25d ago
2025-12-07 15:41 25d ago
Crypto Adoption Continues Even As Bitcoin Stumbles cryptonews
BTC
Crypto volatility has returned, but has not slowed adoption by institutions
2025-12-07 19:48 25d ago
2025-12-07 12:58 25d ago
Incyte Gets FDA Breakthrough Therapy Fast Track For Rare Blood Cancer Drug stocknewsapi
INCY
Information in Investor’s Business Daily is for informational and educational purposes only and should not be construed as an offer, recommendation, solicitation, or rating to buy or sell securities. The information has been obtained from sources we believe to be reliable, but we make no guarantee as to its accuracy, timeliness, or suitability, including with respect to information that appears in closed captioning. Historical investment performances are no indication or guarantee of future success or performance. Authors/presenters may own the stocks they discuss. We make no representations or warranties regarding the advisability of investing in any particular securities or utilizing any specific investment strategies. Information is subject to change without notice. For information on use of our services, please see our Terms of Use.

*Real-time prices by Nasdaq Last Sale. Real-time quote and/or trade prices are not sourced from all markets. Ownership data provided by LSEG and Estimate data provided by FactSet.

IBD, IBD Digital, IBD Live, IBD Weekly, Investor's Business Daily, Leaderboard, MarketDiem, MarketSurge and other marks are trademarks owned by Investor's Business Daily, LLC.

©2025 Investor’s Business Daily, LLC. All Rights Reserved.
2025-12-07 19:48 25d ago
2025-12-07 13:30 25d ago
What Is One of the Best Tech Stocks to Hold for the Next 10 Years? stocknewsapi
APLD
This data center company is well positioned for substantial growth.

Shares of Applied Digital (APLD +0.13%) have risen 265% year to date, driven by improving growth prospects in the data center market. Applied Digital is a leader in designing and building data centers for artificial intelligence (AI) and cloud services.

The power shortage for new data center build-outs has significantly raised the value of Applied Digital's data center pipeline, which could make recent gains just the beginning of a monster bull run over the next decade.

Let's see what this could all mean for investors considering the stock now.

Image source: Getty Images.

Why invest in this data center stock
While the growing demand for semiconductors has driven significant gains for top chip stocks in the past few years, there is an even greater need for power to run these massive chip clusters inside data centers. Deloitte estimates that AI data centers in the U.S. will consume over 100 gigawatts of power by 2035, potentially straining the power grid.

This limited power availability means that hyperscalers will ultimately need every available watt of data center capacity that Applied Digital can supply. It already has a 15-year, $7 billion deal with CoreWeave, which will provide the hyperscaler with access to 400 megawatts of capacity from Applied Digital's Polaris Forge 1 campus in North Dakota.

Management has stated that it has been in active discussions with other hyperscalers, suggesting that another major deal could be announced soon.

Today's Change

(

0.13

%) $

0.04

Current Price

$

31.18

The company is expanding quickly to address this demand. Its Polaris Forge 2 data center site will offer 300 megawatts of power, with the potential to grow to 1 gigawatt. Management is targeting $1 billion of net operating income over the next five years, which makes its current market capitalization of $8 billion appear undervalued.

Assuming the company executes its plan to construct new data center sites on schedule, there is enormous upside for investors who can patiently hold the stock for the next decade.

John Ballard has no position in any of the stocks mentioned. The Motley Fool has no position in any of the stocks mentioned. The Motley Fool has a disclosure policy.
2025-12-07 19:48 25d ago
2025-12-07 13:30 25d ago
Hedge Fund Buys 622,500 Knowles Shares as Stock Outperforms S&P 500 — Should You? stocknewsapi
KN
One specialty manufacturer is drawing fresh hedge-fund attention—and it isn’t because of consumer gadgets.

On November 14, New York-based Harvey Partners disclosed a new position in Knowles Corporation (KN 0.17%), adding 622,500 shares valued at approximately $14.5 million during the third quarter.

What HappenedAccording to a filing with the Securities and Exchange Commission dated November 14, Harvey Partners established a new position in Knowles Corporation (KN 0.17%). The firm reported a holding of 622,500 shares, amounting to a market value of approximately $14.5 million as of September 30. The position accounts for 1.3% of the fund’s reportable U.S. equity assets.

What Else to KnowTop holdings after the filing: 

NYSE: NPO: $56.3 million (5.1% of AUM)NYSE: BWXT: $53.4 million (4.9% of AUM)NYSE: AZZ: $53 million (4.8% of AUM)NASDAQ: GLDD: $44.4 million (4% of AUM)NASDAQ: ADEA: $43.9 million (4% of AUM)As of Friday, shares of Knowles Corporation were priced at $23.37, up 20% over the past year and well outperforming the S&P 500, which is up 13% in the same period.

Company OverviewMetricValuePrice (as of market close Friday)$23.37Market Capitalization$2 billionRevenue (TTM)$573.5 millionNet Income (TTM)$35.8 millionCompany SnapshotKnowles Corporation offers micro-acoustic microphones, balanced armature speakers, audio processors, high-performance capacitors, and RF solutions across consumer electronics, medtech, defense, electric vehicle, industrial, and communications sectors.The company generates revenue by designing, manufacturing, and selling audio and precision device components to original equipment manufacturers, contract manufacturers, and distributors worldwide.Primary customers include global OEMs in mobile, hearing health, IoT, computing, medical, satellite communications, and industrial markets.Knowles Corporation is a leading provider of advanced micro-acoustic, audio, and precision device solutions with a global footprint and a diversified customer base. The company leverages decades of expertise to serve high-growth markets such as mobile communications, hearing health, and industrial electronics.

Foolish TakeA new position in a volatile name like Knowles matters because it signals where managers see durable demand. In other words, Harvey Partners’ move might suggest confidence that Knowles’ exposure to diversified end-markets—from hearing health to defense and industrial electronics—can support steadier earnings even when consumer hardware cycles soften.

In the third quarter, Harvey Partners initiated a $14.5 million position, making Knowles a modest but intentional addition at 1.3% of reportable assets. And although shares have traded choppily in recent years, Knowles has outperformed the broader market over the past 12 months, rising 20% versus the S&P 500’s 13% gain.

Recent earnings help explain the interest. Third-quarter revenue grew 7% year over year to $152.9 million, while gross margin expanded to 45.7%, and non-GAAP EPS came in at $0.33—above the midpoint of guidance. Management highlighted strong design activity, a healthy backlog, and reiterated expectations for 6% organic revenue growth this year, with fourth-quarter revenue projected to rise another 9% year over year. The company also generated $29 million in operating cash and repurchased $20 million of stock, underscoring improving fundamentals that long-term investors may view as a stabilizing force despite ongoing share volatility.

Glossary13F reportable assets: Assets that institutional investment managers must disclose quarterly to the SEC, showing their U.S. equity holdings.
Assets under management (AUM): The total market value of investments managed on behalf of clients by a fund or firm.
Alpha: A measure of an investment's performance relative to a benchmark, showing value added or subtracted by active management.
Original equipment manufacturer (OEM): A company that produces parts or equipment used in another company's end products.
Micro-acoustic: Technology involving very small audio components, such as miniature microphones and speakers, for electronic devices.
Balanced armature speakers: Small, precise speakers commonly used in hearing aids and in-ear monitors for accurate sound reproduction.
RF solutions: Products or technologies related to radio frequency, used for wireless communication in electronic devices.
Contract manufacturer: A company hired to produce goods on behalf of another company, often at scale and to specific requirements.
TTM: The 12-month period ending with the most recent quarterly report.

Jonathan Ponciano has no position in any of the stocks mentioned. The Motley Fool has positions in and recommends Azz and BWX Technologies. The Motley Fool has a disclosure policy.
2025-12-07 19:48 25d ago
2025-12-07 13:40 25d ago
3 Stocks That Could Create Lasting Generational Wealth stocknewsapi
AXP BRK-A BRK-B GOOG GOOGL
Berkshire Hathaway, American Express, and Alphabet are all solid long-term investments.

As the S&P 500 hovers near its all-time highs, we should recall that Peter Lynch once said, "Everybody in the world is a long-term investor until the market goes down." So when the market inevitably pulls back, you shouldn't panic and forget your own long-term goals.

A simple way to tune out that near-term noise is to invest in evergreen stocks that can create generational wealth for their patient investors. These three blue chip giants fit that description: Berkshire Hathaway (BRK.A +0.14%) (BRK.B +0.19%), American Express (AXP 0.20%), and Alphabet (GOOG +1.08%) (GOOGL +1.15%).

Image source: Getty Images.

Berkshire Hathaway
Berkshire Hathaway was a struggling textile maker before it was taken over by Warren Buffett's fund in 1965. Under Buffett, Berkshire divested its textile business; acquired cash-rich insurance, energy, railroad, retail, and consumer companies; and accumulated a massive portfolio of stocks that now accounts for 29% of its market cap of $1.09 trillion.

Today's Change

(

0.19

%) $

0.95

Current Price

$

504.18

Buffett will retire at the end of this year, but Berkshire is still an evergreen investment for three simple reasons. First, its core insurance subsidiaries (GEICO, Gen Re, Berkshire Hathaway Reinsurance Group, and others) are well insulated from economic downturns because their clients usually won't cancel their policies just to save a few dollars. Berkshire then uses the cash generated by those insurance premiums to invest in additional companies or expand its stock portfolio.

Second, Berkshire has outperformed the S&P 500 ever since Buffett took the helm. Past performance never guarantees future gains, but its scale, diversification, and constant expansion give it a great shot at outperforming the broader market. Lastly, its massive stock portfolio -- which houses blue chip giants like Apple, American Express, Bank of America, and Coca-Cola -- should continue growing and outpacing inflation over the next few decades. Simply put, Berkshire is still one of the simplest ways to profit from the long-term growth of the U.S. economy -- and it could easily generate lasting wealth over the next few generations.

American Express
American Express, Berkshire's second-largest holding, is another evergreen investment. Unlike Visa and Mastercard, which only process payments instead of handling the actual bank accounts, American Express is both a card issuer and a bank. That business model might seem riskier, since it's responsible for any delinquent accounts, but it also forces it to be more selective with its card approvals. That focus on quality over quantity exposes it to fewer at-risk clients and reinforces its reputation as a card for affluent customers.

Today's Change

(

-0.20

%) $

-0.76

Current Price

$

370.39

It's also better insulated from interest swings than stand-alone payment processing companies or banks. When interest rates are higher, its banking business can generate higher net interest income to offset the impact of slower consumer spending on its payment processing business. When those rates decline, higher consumer spending can offset its lower interest income.

That's why American Express' earnings per share (EPS) grew at a steady compound annual growth rate (CAGR) of 10% from 2014 to 2024, even as the pandemic, geopolitical conflicts, inflation, soaring interest rates, and other macro headwinds rattled the global economy. So if you're looking for a reliable stock that can beat the market over the next few decades, American Express checks all the right boxes.

Alphabet
Alphabet, the parent company of Google, was also recently added to Berkshire's portfolio. Its core strengths are obvious: Google is the world's top search engine, Chrome is its most popular web browser, Android is its leading mobile OS, and YouTube is the biggest streaming video platform. Furthermore, Google Cloud is the world's third-largest cloud platform, Gemini is gaining ground against OpenAI's ChatGPT in the generative AI race, and it's invested in the nascent autonomous driving, quantum computing, and AI-powered healthcare markets.

Today's Change

(

1.15

%) $

3.65

Current Price

$

321.27

Alphabet faced plenty of regulatory, competitive, and macro challenges over the past decade. But from 2014 to 2024, it still grew its EPS at a CAGR of 23% as it continued to expand its ecosystem, lock in more advertisers, and upgrade its cloud-based services. It also recently withstood demands from regulators to spin off Chrome and share its data with its industry peers.

Google still generates most of its revenue from ads, but its massive reach helps it hold a near-duopoly with Meta Platforms in the digital ad space across many markets. That higher-margin revenue subsidizes its lower-margin ecosystem-expanding projects.

Google still faces intense competition from OpenAI, which is challenging its core search engine with ChatGPT; ByteDance's TikTok, which is pulling younger viewers away from YouTube; as well as tech giants like Amazon and Microsoft in the cloud platform market. Yet betting against Alphabet has constantly been the wrong move over the past few years -- and the stock could still deliver even bigger market-beating gains over the next few decades.

American Express is an advertising partner of Motley Fool Money. Bank of America is an advertising partner of Motley Fool Money. Leo Sun has positions in Amazon, Apple, Coca-Cola, and Meta Platforms. The Motley Fool has positions in and recommends Alphabet, Amazon, Apple, Berkshire Hathaway, Mastercard, Meta Platforms, Microsoft, and Visa. The Motley Fool recommends the following options: long January 2026 $395 calls on Microsoft and short January 2026 $405 calls on Microsoft. The Motley Fool has a disclosure policy.
2025-12-07 19:48 25d ago
2025-12-07 13:53 25d ago
Looking for Top ETFs? Here's One to Consider Now. stocknewsapi
RDVY
With this ETF, investors don't have to sacrifice growth to access reliable, growing dividends.

Investors shopping for top exchange-traded funds (ETFs) can't be blamed if they're focusing on funds holding equities associated with artificial intelligence (AI) and technology. After all, those have been market-leading segments for an extended period.

Still, investors shouldn't get sidetracked. In the quest to identify some of the top ETFs to buy today, the First Trust Rising Dividend Achievers ETF (RDVY +0.16%) merits consideration. This ETF, which turns 12 years old next month, could be a potent addition to a wide variety of portfolios, but before diving in, investors should examine the fund's plumbing.

This tech-heavy dividend fund is one of the top ETFs to consider today. Image source: Getty Images.

This isn't your grandfather's dividend ETF
Home to $18.21 billion in assets under management (AUM) as of Dec. 1, First Trust Rising Dividend Achievers ETF is among the top 10 in terms of size in the dividend ETF category. More important is this ETF's long-running track record of outperforming peers, often by sizable margins.

RDVY Total Return Level data by YCharts

Knowing how First Trust Rising Dividend Achievers ETF generated that stellar run is important because while past performance isn't a guarantee of future returns, a fund's methodology can give investors a sense of what to expect. In the case of this dividend ETF, it focuses on four primary pillars.

First, member firms must have paid a dividend over the trailing 12 months that is "greater than the dividend paid in the trailing twelve-month period three and five years prior." Second, companies eligible for inclusion must have positive earnings over the past year, and those profits must exceed those notched in the prior three fiscal years.

Other mandates include prospective holdings must have cash-to-debt ratios of at least 50% and they can't have trailing 12-month payout ratios in excess of 65%. For some dividend-paying companies, those are high hurdles to clear, but adhering to those guidelines helps this ETF deliver a quality portfolio while steering investors away from yield traps.

The end product is something many investors may view as enticing, as this ETF allocates almost 27% of its roster to tech stocks. It's not common for dividend ETFs to feature Alphabet and Nvidia among their top six holdings, but this ETF breaks from the pack and it's worked out well for investors, helping make this fund one worth looking into.

Todd Shriber has positions in Alphabet. The Motley Fool has positions in and recommends Alphabet, Nvidia, and Vanguard Dividend Appreciation ETF. The Motley Fool has a disclosure policy.
2025-12-07 19:48 25d ago
2025-12-07 14:00 25d ago
Fed Rate Decision, Oracle, Costco, Broadcom, and More Stocks to Watch stocknewsapi
AVGO COST ORCL
The Federal Open Market Committee is expected to announce a quarter-point interest-rate cut. We'll also see earnings reports from Toll Brothers, AutoZone, Campbell's, and more.
2025-12-07 19:48 25d ago
2025-12-07 14:00 25d ago
Prologis announces redemption of 3.00% Notes due 2026 stocknewsapi
PLD
, /PRNewswire/ -- Prologis, Inc. (NYSE: PLD) announced today that Prologis, L.P. will redeem all of its outstanding 3.00% Notes due June 2, 2026 (CUSIP Number 74340XBB6, ISIN XS1072516690 and Common Code 107251669, the "bonds"), following which the bonds will be delisted from the New York Stock Exchange. The redemption price is estimated to be at a price equal to 102.1% of the principal amount of the bonds outstanding, which includes interest accrued to the redemption date for an aggregate payment of approximately €1,021 per €1,000 in principal amount issued and outstanding as of the redemption date (estimated using a current German government bond rate). Interest on the principal amount shall cease to accrue on and after the redemption date, which is January 9, 2026.

ABOUT PROLOGIS
The world runs on logistics. At Prologis, we don't just lead the industry, we define it. We create the intelligent infrastructure that powers global commerce, seamlessly connecting the digital and physical worlds. From agile supply chains to clean energy solutions, our ecosystems help your business move faster, operate smarter and grow sustainably. With unmatched scale, innovation and expertise, Prologis is a category of one–not just shaping the future of logistics but building what comes next. Learn more at Prologis.com.

FORWARD-LOOKING STATEMENTS
The statements in this document that are not historical facts are forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. These forward-looking statements are based on current expectations, estimates and projections about the industry and markets in which we operate as well as management's beliefs and assumptions. Such statements involve uncertainties that could significantly impact our financial results. Words such as "expects," "anticipates," "intends," "plans," "believes," "seeks," "aims," and "estimates" including variations of such words and similar expressions are intended to identify such forward-looking statements, which generally are not historical in nature. All statements that address performance, events or developments that we expect or anticipate will occur in the future—including statements relating to the expected redemption price and the delisting of the bonds—are forward-looking statements. These statements are not guarantees of future performance and involve certain risks, uncertainties and assumptions that are difficult to predict. Although we believe the expectations reflected in any forward-looking statements are based on reasonable assumptions, we can give no assurance that our expectations will be attained and, therefore, actual outcomes and results may differ materially from what is expressed or forecasted in such forward-looking statements. Some of the factors that may affect outcomes and results include, but are not limited to: (i) international, national, regional and local economic and political climates and conditions; (ii) changes in global financial markets, interest rates and foreign currency exchange rates; (iii) increased or unanticipated competition for our properties; (iv) risks associated with acquisitions, dispositions and development of properties, including the integration of the operations of significant real estate portfolios; (v) maintenance of Real Estate Investment Trust status, tax structuring and changes in income tax laws and rates; (vi) availability of financing and capital, the levels of debt that we maintain and our credit ratings; (vii) risks related to our investments in our co-investment ventures, including our ability to establish new co-investment ventures; (viii) risks of doing business internationally, including currency risks; (ix) environmental uncertainties, including risks of natural disasters; (x) risks related to global pandemics; and (xi) those additional factors discussed in reports filed with the Securities and Exchange Commission by us under the heading "Risk Factors." We undertake no duty to update any forward-looking statements appearing in this document except as may be required by law.

SOURCE Prologis, Inc.