Market Signal Briefing

The global cryptocurrency market today is facing a sharp cooldown. The total market capitalization dropped 2.74% in the last 24 hours to settle around $4.16 trillion. Even though trading volumes jumped to $240.649 billion, the overall sentiment has turned cautious. As I see it, this crypto selloff is driven by fading short-term momentum, heavy liquidations, and ETF outflows shaking confidence across digital assets.

That being said, Bitcoin continues to dominate with a 57.6% share, while Ethereum follows at 12.6%. The Altcoin Season Index stands at 53/100, suggesting the market is balanced rather than tilted toward altcoins. The Fear & Greed Index also cooled from yesterday’s 62 to a neutral 55, showing traders are becoming more defensive after days of aggressive buying. Meanwhile, the average RSI across the market sits at a low 42.72, hinting that several coins are nearing oversold zones.

Technical and Sentiment AnalysisWhen I checked the TradingView market cap chart, the price action seemed to struggle at the upper Bollinger Band after a short-lived rally. The latest candles show rejection signs, suggesting a temporary pause or pullback. RSI readings have slipped below 60, and the moving average is trending down, signaling that the crypto market news today points to more consolidation in the near term.

Also, as per CoinMarketCap, the CMC20 Index, which tracks large-cap cryptocurrencies, fell 3.09% to $264.41. This drop confirms that both Bitcoin and altcoins are facing widespread selling pressure.

Liquidation and ETF Flows Intensify SellingA big reason behind today’s decline is the surge in derivatives liquidations. According to Coinglass, almost $687.94 million worth of positions were wiped out in the last 24 hours. It is worth noting that those were mostly long trades accounting for about $532.34M. Bitcoin and Ethereum saw the largest hits, with liquidations of $161.79M and $184.48M, respectively. Major altcoins like BNB, SOL, and XRP also took damage as leverage washed out.

ETF activity added more weight to the selloff. Grayscale’s Bitcoin ETF recorded $28.6 million in net outflows, reversing its previous streak of inflows. Combined with a 22% jump in perpetual futures volume to $540T, these trends show traders are turning defensive. The dip in the Fear & Greed Index and Bitcoin’s failure to hold its $126k high only added fuel to the risk-off move dominating crypto news today.

Bitcoin, Ethereum, XRP, and Top MoversBitcoin led the decline, falling 2.61% in 24 hours to $121,413.99. It’s clear that Bitcoin’s struggle to hold new highs triggered a chain reaction. Where whales booked profits, and automated selling kicked in as exchange inflows crossed $5.7 billion.

The Ethereum price also felt the heat, plunging 5.98% as traders rotated back into Bitcoin ETFs. Breaking below key supports triggered stop-losses, worsening the fall. XRP slipped 4.9% after failing to hold support, while mixed ETF sentiment kept traders uneasy.

Not everything was red, though. Below are the top gainers and top losers.

Top Gainers & Losers:CAKE managed to gain 5.7%, with WBNB and BNB showing modest rebounds between 1.9% and 2%. On the flip side, XPL tanked 17.1%, ENA fell 10.7%, and PENGU dropped 10.2%, underlining how volatile the cryptocurrency market today remains.

FAQsHow much has the crypto market dropped today?

The crypto market cap fell by 2.74% in the last 24 hours, settling at $4.16 trillion.

What’s driving the wave of liquidations and selling pressure?

Roughly $687.94 million in liquidations hit the market as ETF outflows and a surge in derivatives volume increased risk-off sentiment, triggering automated selling and profit-taking.

Which coins have stood out as gainers and losers today?

Top gainers include CAKE with +5.7%, BNB with +2%, and WBNB with +1.9%. Top losers are XPL at -17.1%, ENA at -10.7%, and PENGU at -10.2%.

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Cardano (ADA) is showing renewed momentum after weeks of sideways action, climbing back above its 50-day moving average and putting the $0.94 resistance back in focus. Traders view this level as the next major hurdle to unlock a run at the $1.00 psychological mark.

On the daily chart, ADA has reclaimed its green 50-DMA as support, while RSI has rebounded toward 50, leaving room for further upside if buy volume continues to build. A clean daily close over $0.9 would confirm a trend shift and strengthen the case for a Q4 continuation rally.

ADA's price moving sideways on the daily chart. Source: ADAUSD on Tradingview
Coinbase Sparks Institutional Signal: Cardano (ADA) Reserves Jump 462%
Fueling the bullish narrative, Coinbase’s ADA holdings surged 462% to 9.56 million ADA in recent months, coinciding with rapid growth in Coinbase Wrapped ADA (cbADA) on the Base network.

Total cbADA supply has expanded to 9.53 million from 1.7 million at launch, pointing to rising on-chain utility and custody demand from larger players.

In stark contrast, Coinbase’s XRP reserves dropped 98% (from 970 million to 16.39 million), underscoring a rotation in on-exchange liquidity and user preference toward wrapped Cardano products.

Key Levels and Q4 Outlook: $0.83 Support, $1.00 Magnet
From a technical standpoint, Cardano’s (ADA) structure appears increasingly constructive, with the token reclaiming its 50-day moving average and holding firm within the $0.83–$0.85 support zone, a critical base that continues to attract dip-buying interest. Losing this range could open the door to a deeper pullback toward $0.75, but as long as price remains above it, the setup favors further upside.

On the resistance side, $0.94 remains the key multi-touch ceiling, and a decisive breakout above this level could trigger a move toward $1.00, with extensions possible to $1.06–$1.12.

Meanwhile, a rising RSI and improving market breadth suggest healthy momentum, reinforcing the view that short-term pullbacks are likely to be absorbed by buyers.

Macro factors also support he bull case. With Bitcoin steady near record territory, capital rotation into large-cap altcoins typically strengthens into year-end. Similarly, Cardano’s fundamental backdrop, expanding DeFi, smart-contract adoption, and wrapped-asset growth on Base, supports a higher-low, higher-high structure.

If Cardano prints a decisive daily (or weekly) close above $0.94, technicians will look for a swift push to $1.00 and potentially $1.20 on momentum follow-through.

Cover image from ChatGPT, ADAUSD chart from Tradingview

Estonian-based Bringin has launched its full Bitcoin financial services platform after successful beta testing. The platform offers eurozone users a comprehensive solution to save, store, send, receive, and spend Bitcoin in one simple app, allowing them to 'live the standard.'

Bringin, an Estonia-based Bitcoin financial services platform, has announced the full release of its comprehensive Bitcoin-to-euro solution, following an 18-month beta testing period during which approximately 1,000 early users transacted over €6 million. The platform aims to bridge the gap between Bitcoin self-custody and everyday financial needs for users in the eurozone.

The launch addresses longstanding challenges faced by Bitcoin holders in Europe, particularly the difficulties in converting and spending Bitcoin for daily transactions. Bringin’s solution combines self-custodial Lightning Network functionality with traditional financial services, offering users the ability to manage both Bitcoin and euro transactions within a single application.

Key features of the platform include direct on-ramping to self-custody, Bitcoin-to-euro conversions through on-chain (11 minutes) or Lightning Network (5 seconds) transactions, and personal virtual IBAN accounts for each user. Users can gain access to both virtual and physical Visa debit cards with zero transaction fees, enabling Bitcoin spending anywhere Visa is accepted.

The platform’s integrated approach allows users to handle significant Bitcoin-to-euro conversions exceeding 1 BTC, making it suitable for large purchases such as vehicles or property. The service also simplifies compliance and banking relationships through its dedicated virtual IBAN system, addressing a common pain point for Bitcoin users who frequently face banking restrictions or compliance challenges.

Bringin’s solution is particularly noteworthy for its built-in Lightning Network wallet, eliminating the need for users to manage external wallets. This integration streamlines the Bitcoin experience for both experienced users and newcomers, providing a complete suite of Bitcoin-based financial services within a single application.

The platform’s automatic conversion features enable users to maintain Bitcoin holdings while handling daily expenses through the Visa debit card system. This functionality allows users to effectively “live the standard” while maintaining practical access to the traditional financial system.

“Lightning is the fastest payment network on Earth, and we built Bringin on it from day one,” said Prashanth Chandrashekar, Co-founder & CEO/CTO of Bringin. “Moving seamlessly from self-custody to your bank account makes living on better money possible – money that can’t be inflated away, that you actually control.”

The launch represents a significant step forward in making Bitcoin more practical for everyday use in Europe, combining the benefits of self-custody with the convenience of traditional banking services. The platform is now available for download on both Android and iPhone devices, offering eurozone residents a new way to integrate Bitcoin into their daily financial lives.

This development comes at a time when demand for seamless Bitcoin-to-fiat solutions continues to grow in Europe, particularly among users who prefer to self-custody their Bitcoin while maintaining easy access to the traditional financial system.

Vivek Sen

Vivek has been fascinated by Bitcoin since he discovered it in 2016. He also runs a Bitcoin marketing agency, Bitgrow Lab, and he used to work at a Bitcoin VC fund, Lightning Ventures. He loves growth, marketing, startups, and writing. He is an EU news reporter for Bitcoin Magazine.

Valued at over $675 million, the deal aims to create one of the first public vehicles for institutional investors seeking direct exposure to AVAX, Avalanche's native token. The combined company plans to list on Nasdaq in early 2026, pending regulatory and shareholder approval.

XRP Drops to Fifth Spot as BNB and Tether Overtake in Market RankingsXRP has slipped to the fifth position among the world’s largest cryptocurrencies by market capitalization, following a swift overtaking by Binance Coin (BNB) and Tether (USDT). 

According to the latest data from CoinMarketCap, XRP’s market capitalization currently stands at $170.7 billion, trailing behind Tether’s $177.9 billion and BNB’s $179.6 billion.

This reshuffling in rankings underscores the evolving dynamics within the crypto market, where investor sentiment, utility, and liquidity continue to determine positioning among the top digital assets. 

For XRP, the decline comes amid a period of consolidation following earlier price surges fueled by optimism over Ripple’s ongoing legal clarity and expanding cross-border payment partnerships.

BNB’s rise, on the other hand, highlights the sustained strength of the Binance ecosystem. As the utility token powering the world’s largest cryptocurrency exchange, BNB benefits from continuous use in trading fee discounts, decentralized finance (DeFi) applications, and token burns, mechanisms that consistently support its value. 

Its growing utility within Binance Smart Chain (BSC) projects and DeFi protocols has also contributed to renewed investor confidence.

Meanwhile, Tether’s steady climb reflects the broader market’s reliance on stablecoins for liquidity and trading activity. 

As the largest and most widely used stablecoin, USDT continues to dominate crypto transactions, serving as a bridge between traditional fiat and digital assets. Its consistent market cap growth demonstrates a sustained demand for stability in a volatile market landscape.

For XRP, analysts suggest that the recent dip may be temporary. Despite the setback, XRP remains a top contender with significant institutional adoption and active development of Ripple’s payment solutions across global markets. 

The asset’s long-term outlook may hinge on factors such as increased regulatory acceptance, continued integration into financial systems, and investor confidence following recent legal victories.

Therefore, the shifting rankings among top cryptocurrencies emphasize the competitive and fast-changing nature of the digital asset market. 

While XRP’s drop to fifth place marks a notable moment, its resilience and established use case could position it for a rebound, especially if broader market momentum turns bullish once again.

XRP Poised for Major Rally as Historical Pattern Reemerges, Eyes on $10 ZoneAccording to research analyst Ardizor, XRP may be on the brink of a powerful breakout reminiscent of its November 2024 price pattern, a setup that previously preceded a major surge. 

Ardizor now suggests that history could be repeating itself, with XRP’s chart mirroring key momentum signals and structural formations that once sparked a rapid rally.

Source: ArdizorIn November 2024, XRP underwent a powerful accumulation phase that triggered a breakout to multi-month highs. 

According to Ardizor, the current structure, marked by higher lows, tightening consolidation, and surging volume, mirrors that setup. If history repeats, XRP could be on the verge of a major expansion toward the key $10 level.

Therefore, the current market structure mirrors late 2024’s setup since bullish momentum is building, and XRP’s tightening consolidation, which typically precedes sharp breakouts. If this pattern holds, a decisive move above resistance could propel XRP rapidly toward the $10 mark.

At the time of this writing, XRP was trading at $2.86 per CoinGecko data. 

ConclusionXRP’s drop to fifth place highlights how quickly market dynamics can shift in crypto. The ascent of BNB and Tether underscores the growing dominance of utility and stability-focused assets in steering investor sentiment.

On the other hand, XRP’s trajectory showcases a rare blend of technical déjà vu and strengthening fundamentals. Mirroring the explosive setup of November 2024, the current pattern and improving market conditions have ignited intense investor anticipation. As resistance levels tighten, momentum signals an imminent breakout. 

If Ardizor’s analysis holds true, a rally toward the $10 zone could validate market cycle theory and reaffirm XRP’s standing as one of the most resilient, strategically positioned assets in crypto

TLDR:

Bit Digital holds 122,187 ETH valued at $506M, staking over 80% for consistent yield income.
The firm earned 291 ETH in staking rewards during September, equal to a 3.37% annualized return.
Bit Digital raised $150M through convertible notes to expand its Ethereum holdings.
The company’s Ethereum treasury strategy marks a complete shift from Bitcoin mining to ETH yield focus.

Bit Digital’s newest treasury report signals one thing clearly, the company is all-in on Ethereum. The Nasdaq-listed firm revealed it now holds 122,187 ETH, worth roughly $506 million as of September 30, 2025. 

Most of that stack is earning yield through staking, showing how fast Bit Digital’s strategy has shifted from mining to active crypto asset management.

The company’s September filing paints a clear picture of its evolving treasury model. Instead of relying solely on Bitcoin mining, Bit Digital is now using Ethereum’s proof-of-stake system to generate recurring income. 

The report shows that 81.8% of its ETH holdings, nearly 100,000 coins, were staked during the period.

That allocation earned the firm 291 ETH in rewards, representing a 3.37% annualized yield. With Ethereum’s price closing at $4,145.99 at the end of September, those returns translated into roughly $1.2 million in additional income for the month. 

Bit Digital acquired 653 ETH during the same month, pushing its average cost basis to around $2,643 per coin. That puts the firm’s holdings well above breakeven levels, suggesting its Ethereum position is generating both capital appreciation and yield growth.

Nasdaq-listed Bit Digital, Inc. announced that as of September 30, the company held 122,187 ETH, valued at over $500 million. The total staked ETH amounted to approximately 99,936, representing 81.8% of its total holdings, generating 291 ETH in rewards during the staking period,…

— Wu Blockchain (@WuBlockchain) October 8, 2025

Ethereum Staking Takes Center Stage in Bit Digital Treasury Strategy
According to Bit Digital’s press release, the company’s treasury strategy now revolves around staking. 

The approach treats Ethereum as a productive, income-bearing asset instead of a speculative token. This model allows the firm to earn passive rewards while maintaining long-term exposure to ETH’s market value.

Crypto analytics platform AlvaApp described the move as an “ETH-native pivot,” pointing out that the company has essentially redesigned its treasury for consistent on-chain yield. The analyst added that such positioning could set a precedent for other public firms considering staking as part of their capital strategy.

Bit Digital’s recent $150 million convertible notes offering underscores that point. The company confirmed it plans to deploy those proceeds into further Ethereum purchases. 

The decision aligns with its shift toward yield-driven operations and reduced dependency on volatile Bitcoin mining revenue.

Beyond Ethereum, Bit Digital maintains control of 27 million shares of WhiteFiber (WYFI), equal to about 71.5% of the outstanding stock. The report shows that while the firm is diversifying, Ethereum remains its main engine for growth and yield.

Corporate Staking Trend Builds Momentum
Bit Digital’s latest treasury results mirror a broader movement among institutional players toward Ethereum staking. 

Companies are discovering that proof-of-stake models offer predictable yields with less energy intensity. For firms like Bit Digital, staking provides a scalable way to earn income while staying fully engaged with the crypto ecosystem.

The company’s upcoming appearance at the AIM Summit in Dubai later this month may shed more light on its long-term plans. For now, its strategy reflects a clear confidence in Ethereum’s network stability and earning potential. 

As more corporate treasuries explore staking, Bit Digital’s model could serve as an early example of how blockchain assets are maturing into productive, yield-based investments.

Key NotesTokenized wine bottles enable instant peer-to-peer trading while physical inventory stays secure in Burgundy storage facilities.The platform launches with immediate access to Crurated's existing collection worth over $60 million for strong liquidity.Revolutionary fee structure returns a quarter of all trading commissions directly back to original wine producers.
A new platform named CruTrade has launched a secondary marketplace for fine wine on the Avalanche

AVAX
$28.18

24h volatility:
6.6%

Market cap:
$11.90 B

Vol. 24h:
$1.11 B

blockchain. Announced from London on Oct. 7, 2025, the marketplace allows collectors to trade tokenized bottles of wine peer-to-peer. The platform’s standout feature is a commitment to return 25% of every trading fee to the original wine producers.

CruTrade is built upon the foundation of Crurated, an existing members-only digital wine club. Crurated sources wine directly from producers, then creates a non-fungible token (NFT) for each bottle to certify its origin and track its history on the blockchain.

According to an announcement from AVAX, this system ensures transparent provenance. It allows users to trade the NFTs instantly. At the same time, the physical wine remains secure in Crurated’s specialized storage facility in Burgundy.

A New Model for Wine Resale
The company aims to address a broken system in the secondary wine market. Traditionally, resellers face high fees, logistical challenges, and the risk of bottle spoilage during shipping. For collectors, verifying a wine’s provenance can be difficult, making the market susceptible to fraud. CruTrade bypasses these issues by tokenizing the bottles, enabling secure and efficient trading. This approach is part of a larger movement toward tokenizing real-world assets, reflecting growing RWA market trends across traditional finance.

The marketplace launches with exclusive access to Crurated’s inventory, which is valued at over $60 million. This existing collection provides immediate liquidity and many options for collectors from day one.

John Nahas, Chief Business Officer at Ava Labs, commented on the launch, highlighting its potential to bring more real-world use cases to the blockchain. Integrating the Avalanche network was a strategic choice, leveraging the blockchain’s capabilities for fast and low-cost transactions. This decision reflects growing investor confidence in Avalanche, which has been attracting various projects.

The launch further diversifies Avalanche’s growing ecosystem, which includes projects ranging from gaming to decentralized finance and even national stablecoins. CruTrade offers a compelling example of how blockchain technology can refine established luxury markets by creating a fairer economic model that benefits creators.

Disclaimer: Coinspeaker is committed to providing unbiased and transparent reporting. This article aims to deliver accurate and timely information but should not be taken as financial or investment advice. Since market conditions can change rapidly, we encourage you to verify information on your own and consult with a professional before making any decisions based on this content.

Cryptocurrency News, News

As a Web3 marketing strategist and former CMO of DuckDAO, Zoran Spirkovski translates complex crypto concepts into compelling narratives that drive growth. With a background in crypto journalism, he excels in developing go-to-market strategies for DeFi, L2, and GameFi projects.

Zoran Spirkovski on X

Key NotesBitcoin fell to $120K after a 2.22% daily drop, down 3.75% from its recent peak. Gold hit a record $4,017 per ounce, up 53% year-to-date amid risk aversion.On-chain data shows Bitcoin’s Fund Flow Ratio at historic lows as well.
Bitcoin

BTC
$121 400

24h volatility:
1.9%

Market cap:
$2.42 T

Vol. 24h:
$78.64 B

has retreated to the $120,000 level following a 2.22% drop in the past 24 hours, now trading near $121,000, down 3.75% from its all-time high of $126,000 earlier this week.

The leading digital asset is now cooling off after a strong rally that began in late September. Meanwhile, spot BTC ETFs logged the second-highest inflow since their launch in January 2024.

As reported earlier, these funds brought $1.19 billion in total inflows on Oct. 6, with BlackRock’s iShares Bitcoin Trust (IBIT) leading with $967 million. On Oct. 7, however, the ETFs saw outflows totaling $23.81 million.

$140K before the End of October
Economist Timothy Peterson noted that based on historical simulations using data from the past decade, there remains a 50% probability that Bitcoin could surpass $140,000 before the end of October.

Half of Bitcoin's October gains may have already happened, according to this AI simulation.
There is a 50% chance Bitcoin finishes the month above $140k
But there is a 43% chance Bitcoin finishes below $136k. pic.twitter.com/LPhFr0mry9

— Timothy Peterson (@nsquaredvalue) October 7, 2025

His models, derived from hundreds of simulations using real Bitcoin price data since 2015, suggest that half of the month’s potential gains may have already occurred.

However, he also highlighted a 43% chance that Bitcoin could close below $136,000, underscoring the volatility that continues to define the crypto market.

October has historically been one of Bitcoin’s strongest months, averaging gains of around 20.75% since 2013 according to CoinGlass.

If Bitcoin were to follow the pattern, it would need to gain approximately 14.7% from current levels to reach the $140,000 target.

Gold Surges to Record Highs
While Bitcoin has cooled, traditional safe-haven assets are rallying. Spot gold surged past $4,000 an ounce to reach an all-time high, trading at $4,017.16 per ounce as of the morning on Oct. 8.

Gold just broke $4,000 an ounce for the first time ever.

The US government is shut down, France is in political turmoil, Japan is changing leadership.

When every major power is in chaos, gold is the only thing investors still trust.

(a thread) pic.twitter.com/7LykS30zIu

— StockMarket.News (@_Investinq) October 7, 2025

Also, US gold futures for December delivery rose to $4,040 per ounce. Gold’s performance in 2025 has been exceptional, up 53% year-to-date following a 27% increase in 2024.

Investors have increasingly turned to gold as a hedge against inflation and currency debasement, even as Bitcoin continues to mature as a digital alternative.

On-Chain Data Hints at Weakening Selling Pressure
According to CryptoQuant, Bitcoin’s Fund Flow Ratio, which measures exchange-related activity relative to total transaction volume, has fallen to its lowest level since July 2023.

Bitcoin fund flow ratio | Source: CryptoQuant

The decline suggests that more BTC is being transferred to private wallets for long-term storage, used in DeFi applications, or traded via Over-The-Counter (OTC) channels by institutions rather than being moved for liquidation.

Such behavior typically precedes medium-term bullish reversals, where investors often search for the next best crypto to buy.

Disclaimer: Coinspeaker is committed to providing unbiased and transparent reporting. This article aims to deliver accurate and timely information but should not be taken as financial or investment advice. Since market conditions can change rapidly, we encourage you to verify information on your own and consult with a professional before making any decisions based on this content.

Cryptocurrency News, News

A crypto journalist with over 5 years of experience in the industry, Parth has worked with major media outlets in the crypto and finance world, gathering experience and expertise in the space after surviving bear and bull markets over the years. Parth is also an author of 4 self-published books.

Parth Dubey on LinkedIn

Hyperliquid has listed perpetual futures for the unlaunched Monad (MON) token, allowing traders to speculate ahead of its mainnet debut.

Summary

MON-USD perpetuals are available on Hyperliquid with up to 3x leverage, despite the token not yet launching.
Originally expected on Sept. 30, Monad’s mainnet is still offline as of Oct. 8, currently in the audit phase.
Users can engage with the Monad testnet and ecosystem projects, participate in games, and complete tasks to potentially earn testnet MON allocations.

Decentralized derivatives exchange Hyperliquid has listed perpetual futures contracts for the Monad (MON) token, despite the token itself not yet having launched. According to Hyperliquid’s announcement, the listing came “by community request,” and traders can now long or short MON-USD hyperps with up to 3x leverage.

As for the actual token launch, multiple industry outlets had pointed to Sept. 30 as the expected date for the Monad token and mainnet launch. However, as of Oct, 8, the TGE is yet to occur, and the mainnet remains offline.

Given the late-July announcement from Monad’s co-founder, it appears the project is currently in the audit phase—the final step before mainnet deployment. Historical patterns from comparable Layer-1 networks such as Aptos, Sui, and Solana indicate that the audit-to-mainnet timeline typically spans around four months. If Monad’s audit indeed began in late July, the project’s mainnet launch may not arrive until November or later.

While this extends the waiting period, it also provides more time for users to deepen their engagement with the ecosystem and potentially influence their future airdrop eligibility. This can be done through Monad testnet, which went live in February.

Specific examples of engagement include interacting with ecosystem projects such as Kintsu, Magma, FastLane, Opinion Labs, aPriori, and Kuru, playing games like 2048, and using various testnet DApps. Users who hold a Full Access role on Discord may receive 5 MON on the testnet. Those holding at least 0.01 ETH on Ethereum Mainnet with an outgoing transaction may receive 2 MON, while all other testnet participants receive a smaller allocation of 0.05 MON.

LONDON, UK / ACCESS Newswire / October 8, 2025 / Orosur Mining Inc (TSXV:OMI)(AIM:OMI), the mineral explorer and developer with current operations in Columbia, Argentina and Nigeria, announces that Louis Castro, Executive Chairman and Brad George, Chief Executive Officer, will be holding a live Investor Webinar Q&A session via the Investor Meet Company platform on 15th October 2025 at 5.00 pm (UK local time). The presentation is open to all existing and potential shareholders.

SANTA CLARA, Calif., Oct. 08, 2025 (GLOBE NEWSWIRE) -- SoundHound AI, Inc. (Nasdaq: SOUN), a global leader in voice and conversational AI, and Apivia Courtage, part of AEMA Group, one of the world’s largest mutual and cooperative insurers, today announced that they are innovating together to bring agentic AI to Apivia Courtage’s contact centers via SoundHound’s Amelia 7 AI agent platform.

Apivia Courtage will be deploying Amelia 7, one of the first truly agentic AI platforms on the market, as a key part of the company’s digital transformation strategy. The move builds on a successful relationship between the two companies, which already saw SoundHound’s Amelia platform drive a 20% productivity increase at the insurer’s contact center.

Since 2023, the partnership between the two companies has sought to introduce advanced AI agents to support Apivia Courtage’s existing team and deliver innovation that improves customer service. So far, SoundHound’s AI Agents have handled thousands of calls on topics related to medical expense reimbursement ​​and information on insurance guarantee levels. As a result, the company has been able to focus its human teams on bringing more value and time to their relationships with brokers and clients.

Now Amelia 7’s advanced agentic capabilities will enable Apivia Courtage to handle inbound customer queries with fleets of AI agents that can reason, act, and perform complex tasks based on multiple intents. This will allow customers to seamlessly “self-serve” without the need to escalate to a human agent.

Key features of Amelia 7 for Apivia Courtage include:

Verifying the identity of customers using a one-time password as part of a humanlike interactionAnswering contract related questionsUpdating personal information, such as a postal address or phone numberCalculating the financial impact of updates to an insurance contractSending a quote to the customer or schedule a meeting with a human advisor Apivia Courtage is pioneering the use of this technology in the insurance industry, and will be showing the pilot demo to delegates at Reavie in Cannes, France this year, between October 8-10. The company undertook a thorough evaluation of SoundHound’s agentic AI – which is powered by large language models – using strict benchmarks to ensure it was robust and concluded that it was ready to be customer facing.

"Thanks to Amelia 7 Agentic AI, we are deploying a multi-service platform to ensure our clients have seamless and innovative experiences,” said Emmanuelle Nguyen, CEO of Apivia Courtage. “At the same time, we are empowering our teams to focus on their expertise and create added value."

Thanks to the platform’s Agentic+ framework, businesses in the insurance industry and beyond can leverage the reasoning and planning skills of LLMs in combination with more traditional deterministic flows, and human escalation as required. Amelia’s AI agents also operate across channels (e.g. chat, text, voice, etc), and utilize SoundHound’s advanced speech recognition – which has low latency, exceptional natural language understanding, and includes enterprise tuning for optimal responses. This allows customers to speak naturally and be understood.

“This deployment of Amelia 7 will put Apivia Courtage at the leading edge of AI for customer service,” said Gérald Audenis, Head of Operations, Europe at SoundHound AI. “The insurance industry as a whole really stands to benefit from this wave of innovation and platforms like Amelia 7 that drive value for businesses while delivering a faster, more efficient service to their customers.”

Learn more about SoundHound AI’s Amelia 7 platform here.

About SoundHound AI
SoundHound AI (Nasdaq: SOUN), a global leader in voice and conversational AI, delivers solutions that allow businesses to offer superior experiences to their customers. Built on proprietary technology, SoundHound’s voice AI delivers best-in-class speed and accuracy in numerous languages to product creators and service providers across retail, financial services, healthcare, automotive, smart devices, and restaurants. The company’s various groundbreaking AI-driven products include Smart Answering, Smart Ordering, Dynamic Drive-Thru, and the Amelia Platform, which powers AI Agents for enterprise. In addition, SoundHound Chat AI, a powerful voice assistant with integrated Generative AI, and Autonomics, a category-leading operations platform that automates IT processes, have enabled SoundHound to power millions of products and services, and process billions of interactions each year for world class businesses.

Media Contact
Gianna Arantes
(201) 815-9852
[email protected]

A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/e30e6864-faa4-4ce2-9578-b96a231de676

BASINGSTOKE, United Kingdom, Oct. 08, 2025 (GLOBE NEWSWIRE) -- Juniper Research is excited to announce the winners of the Future Digital Awards for Fintech & Payments 2025.

Now in their 10th year, these awards celebrate the standout players transforming digital payments, banking, and fraud prevention; drawing on Juniper Research’s two decades of expertise advising the industry’s leading innovators.

The winners are:

Fintech Leadership

Fintech & Payments Startup of the Year

DailyPay (Platinum)
Fintech Leader of the Year

Chrissy Wagner – Senior Vice President, Go-to-Market at FIS (Platinum)
Banking Innovation

Banking Innovation of the Year

Huawei Mobile Finance Solution (Platinum)
Banking-as-a-Service Innovation

Edenred Payment Solutions: BaaS Support for Tide (Platinum)Grasshopper BaaS Platform (Gold) Open Banking Innovation

Prometeo Borderless Banking (Platinum)LoanTube (Gold) AI in Banking Innovation

Amdocs Agentic AI Platform (Platinum)G+D Convego Card Designer (Gold) Fraud & Security Innovation

AML Innovation

Tookitaki FinCense (Platinum)Fourthline AML Solutions (Gold) KYC Innovation

Trulioo Global Identity Platform (Platinum)LexisNexis Due Diligence Product Suite (Gold) Fraud & Security Innovation of the Year

Mitek Systems Digital Fraud Defender (Platinum)
AI in Fraud Prevention Innovation

LexisNexis Emailage Adaptive (Platinum)Fi911 DisputeLab (Gold) Banking Fraud Prevention

G+D Netcetera BIN Attack Score (Platinum)Experian First-Party Fraud Scores (Gold) Identity Verification Innovation

Mitek Systems Digital Fraud Defender (Platinum)Trulioo Global Identity Platform (Gold) eCommerce Fraud Prevention

Nethone, a Mangopay Solution (Platinum)Riskified: AI-led Fraud Prevention & Risk Intelligence Platform (Gold) Best Network Tokenisation Solution

VGS Card Management Platform (Platinum)Thales eCommerce Token Platform (Gold) Payment Innovation

Best B2B Payment Platform

Thunes Business Payments (Platinum)FIS Automated Finance (Gold) Payment Innovation of the Year

Alipay Tap! (Platinum)
Best Cross-border Payments Platform

Thunes Direct Global Network (Platinum)M-DAQ Global ASEAN Payments Hub (Gold) Best A2A Payments Platform

Token.io A2A Payment Infrastructure (Platinum)Brite Payments: Brite Instant Payments & Instant Payouts (Gold) Best Modern Card Issuing Platform 

Thales D1 (Platinum)G+D Convego Instant Issuance (Gold) Omnichannel Payments Platform of the Year 

Worldpay (Platinum)
Best Mobile Money Offering

Easypaisa (Platinum)M-PESA Ziidi Mobile Money Fund, Empowered by Huawei (Gold) Best Digital Wallet Platform 

Comviva mobiquity Pay (Platinum)MobiFin (Gold) Soft POS Innovation

Stone TapTon (Platinum)Soft Space Fasstap (Gold) Sustainability in Payment Cards 

Thales PVC-Free Payment Card (Platinum)
Virtual Card Innovation

payabl. Virtual Business Cards (Platinum)HSBC Virtual Card Solution (Gold) Digital Currency Innovation 

FV Bank Stablecoin Direct Deposit & Payments (Platinum)Athena Bitcoin Network & App (Gold) FV Bank Secures Platinum Award for Digital Currency Innovation

"We greatly appreciate this recognition from Juniper Research as Platinum Winner in the Digital Currency Innovation category. Our goal at FV Bank has always been to build banking services that reflect how the financial system is evolving, where traditional accounts and payments work seamlessly alongside digital asset custody and settlement. This award affirms that the approach of combining both under one regulated platform is resonating with the industry." - Miles Paschini, CEO of FV Bank

Mitek Triumphs with Double Fraud & Security and Identity Verification Innovation Wins

“AI-generated deepfakes and injection attacks are eroding trust in digital identity,” said Adam Bacia, VP of Product Marketing at Mitek. “Our commitment is simple: help businesses protect real customers with multi-layered defences built for this new era of fraud. These awards from Juniper Research reinforce the urgency of our mission and the importance of the multi-layered approach we’ve taken to fighting this kind of sophisticated fraud. We’re delighted to take home these top honours in recognition of our innovation and leadership.”

Thunes Celebrates Dual Platinum Awards for B2B and Cross-border Payments

Chloe Mayenobe, President and COO of Thunes, said: “Announcing these two Platinum Awards is a proud moment for Thunes. They demonstrate the strength of both our Network and our solutions, and our commitment to reshaping the way money moves globally. None of this would have been possible without the dedication of our incredible team and the trust of our Members around the world. We thank them for their support and partnership as we continue to deliver faster, more transparent and more efficient ways to pay and be paid. This recognition from Juniper Research validates the impact we are making on payments worldwide.”

About the Future Digital Awards

Judged by Juniper Research’s expert analysts, the Future Digital Awards recognise the companies and individuals driving innovation and success across fintech, telecoms, and smart cities. Visit the website to explore past winners and register for upcoming awards; including the Telco Innovation Awards 2026, which close on 24th October 2025.

About Juniper Research

Juniper Research is a global tech strategist firm providing research, data, and forecasting across the fintech, telecoms, and IoT sectors. For over 20 years, Juniper Research has delivered actionable insights that help industry leaders navigate disruption, seize opportunities, and make confident strategic decisions. www.juniperresearch.com

Press Contact

Sam Smith, Press Relations

[email protected]

Stellantis Makes New Appointments to the Leadership Team As It Pursues Its Path to Recovery  

AMSTERDAM, October 8, 2025 – Building on the positive momentum established in recent months and ahead of the upcoming 2026 presentation of its updated strategy, Stellantis N.V. today announces the following new appointments to its Stellantis Leadership Team (SLT).

Emanuele Cappellano is appointed Head of Enlarged Europe and European Brands, in addition to his current role leading Stellantis Pro One. Jean-Philippe Imparato will now focus full-time on driving performance improvements at Maserati, as CEO, and Stellantis & You, reporting to Cappellano.

Herlander Zola, currently Head of Commercial Operations Brazil and South America Light Commercial Vehicles, is appointed Head of the South America region, succeeding Cappellano.

Samir Cherfan joins the SLT, maintaining his responsibilities as Head of Middle East & Africa and Micromobility.

Grégoire Olivier, currently Head of China Strategy, is appointed Head of the China and Asia-Pacific region and SLT member.

Francesco Ciancia will rejoin Stellantis from Mercedes-Benz as Global Head of Manufacturing on November 1 (click here for the dedicated announcement). On that date, Arnaud Deboeuf will leave the Company to pursue other opportunities.

Ralph Gilles joins the SLT as Global Head of Design.

Philippe de Rovira, formerly Head of the joint Asia-Pacific, Middle East and Africa region, leaves Stellantis to pursue new career endeavors, as made public in July.

“With these new appointments we are promoting exceptional talent from inside and out to leadership roles as we prepare our business for future success. We are also sharpening our regional focus by allocating specific responsibility for our Asia-Pacific and Middle East & Africa organizations at the SLT level,” said CEO Antonio Filosa.

“We are delighted we will continue to benefit from Jean-Philippe’s expertise in his new role. Our thanks go to Arnaud and Philippe for their contributions over the years and we wish them the best in their future endeavors,” added Filosa.

Below is the updated composition of the Stellantis Leadership Team (SLT):

Antonio Filosa, CEO and North America & American Brands.

Emanuele Cappellano, Enlarged Europe, European Brands & Stellantis Pro One.

Herlander Zola, South America.

Samir Cherfan, Middle East & Africa and Micromobility.

Grégoire Olivier, China and Asia-Pacific.

Davide Mele, Product Planning.

Ned Curic, Product Development & Technology.

Sébastien Jacquet, Quality.

Monica Genovese, Purchasing.

Scott Thiele, Supply Chain.

Francesco Ciancia, Manufacturing (starting on November 1st).

Joao Laranjo, Chief Financial Officer.

Xavier Chéreau, Human Resources.

Clara Ingen-Housz, Corporate Affairs & Communications.

Ralph Gilles, Design.

Biographies and photos of the SLT members are available at: https://www.stellantis.com/en/company/governance/stellantis-leadership-team

# # #

About Stellantis

Stellantis N.V. (NYSE: STLA / Euronext Milan: STLAM / Euronext Paris: STLAP) is a leading global automaker, dedicated to giving its customers the freedom to choose the way they move, embracing the latest technologies and creating value for all its stakeholders. Its unique portfolio of iconic and innovative brands includes Abarth, Alfa Romeo, Chrysler, Citroën, Dodge, DS Automobiles, FIAT, Jeep®, Lancia, Maserati, Opel, Peugeot, Ram, Vauxhall, Free2move and Leasys. For more information, visit www.stellantis.com.

@StellantisStellantisStellantisStellantisFor more information, contact:

Fernão SILVEIRA +31 6 43 25 43 41 – [email protected]

Nathalie ROUSSEL +33 6 87 77 41 82 – [email protected]

[email protected]
www.stellantis.com

 

EN-20251008-Stellantis-Makes-New-Appointments-to-Leadership-Team

, /PRNewswire/ -- As the physical AI transformation gains rapid momentum, "The Dialogue on AI & Cyber Governance" kicks off in London, focusing on the pressing theme of "The New Reality of Corporate AI Security." Tuya Smart (NYSE: TUYA, HKEX: 2391), a global AI cloud platform service provider, shared its insights on the latest developments in a keynote address titled "Pioneering AI Security: Lessons from the Frontlines," where it unveiled its cutting-edge practices in AI implementation while analyzing prevailing global AI cybersecurity dynamics.

The forum assembled experts and policy makers in AI, cybersecurity, and IoT from organizations, including Yale Law School; Durham Law School; the Oxford China Policy Lab; the Oxford Martin AI Governance Initiative; the Cambridge Centre for Alternative Finance at the University of Cambridge Judge Business School; and Essex Law School. They examined transformative cybersecurity trends amid the rise of physical AI technologies. Cybersecurity leaders representing institutions, organizations, and enterprises convened to deliberate on developments in AI-centric cyber governance frameworks alongside strategic applications of AI in cybersecurity infrastructure.

Global AI security challenges have escalated. Forum participants engaged in substantive discussions regarding cybersecurity vulnerabilities introduced by AI proliferation, while reaffirming the importance of establishing universal, structured normative frameworks for AI-related security challenges.

As a demonstration of private sector practices, Tuya showcased a portfolio of security initiatives spanning the acquisition of international third-party security certifications, the establishment of the Tuya Security Team, and the deployment of six strategically positioned global data centers that deliver rapid response capabilities and operational stability for customers worldwide. Tuya further presented case studies detailing strategic partnerships with global cloud providers, including AWS and Google Cloud, as well as robust data anonymization measures to ensure privacy protection.

To advance substantive discourse on establishing AI security norms, participants also conducted analyses of the latest governmental AI reports and policy frameworks. In analyzing geopolitical tensions surrounding supply chain security, particularly in the semiconductors and AI sectors, participants placed particular emphasis on the importance of public-private sector collaboration in AI governance. Regarding emerging technology development, rather than emphasizing geopolitical competition and establishing technological barriers, the cross-border nature of AI security necessitates the establishment of collaborative governance mechanisms at the global level.

Tuya presented its recent experience within the AI industry, demonstrating the expansion of intelligent consumption scenarios and smart product ecosystems. "Tuya's dual approach of combining reduced barriers for AI developers with accelerated AI commercialization initiatives enables an open, neutral smart ecosystem, thereby promoting the inclusivity and accessibility of AI technology," a Tuya representative stated.

Participants emphasized throughout discussions that AI development, while presenting cybersecurity challenges, simultaneously serves as a powerful cybersecurity enhancement tool, improving organizational capacity to address cybersecurity issues while utilizing technological capabilities to construct robust protective barriers for continued development.

Tuya also shared its industry-leading practices in promoting secure AI development and innovation through strategic partnerships with ecosystem partners, including universities, engineering communities, maker spaces, incubators, cloud developer communities, as well as cultural and intellectual property developers.

"The Dialogue on AI & Cyber Governance represents a valuable and productive forum for industry stakeholders," stated Xueyao Li, Professor of Shanghai Jiao tong University. "The advancement of AI cyber norms requires mutual understanding of relevant policy frameworks, while enabling policymakers to absorb advanced academic perspectives and proven enterprise operational and management practices, thereby further enhancing AI security regulatory frameworks and promoting the sustainable and robust development of AI technology."

AI cybersecurity transcends the scope of any single enterprise or regional initiative, representing a comprehensive 'community project' that requires global collaboration. The Dialogue on AI & Cyber Governance has established a strong foundation for cross-sector cooperation within the global AI cybersecurity landscape.

SOURCE Tuya Smart

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Lloyds Banking Group PLC (LSE:LLOY), Barclays PLC (LSE:BARC), Close Brothers Group PLC (LSE:CBG) and other motor finance lenders could pay a total of £8.2 billion in compensation, the UK financial watchdog said on Wednesday.

The payout calculation from the Financial Conduct Authority, which represents an average of £700 per individual member of the public affected, is less than even the bottom end of its initial estimate of between £9 billion and £18 billion first given after the Supreme Court decision at the start of August.

Redress payments will be made to people who took motor finance agreements taken out between 6 April 2007 and 1 November 2024. where commission was payable by the lender to the broker.  

Lloyds, one of the biggest motor finance lenders, said in a statement that is it "currently assessing the implications and impact of this consultation in the context of its current provision for this issue and will update the market as and when appropriate".

By Reuters

October 8, 20256:24 AM UTCUpdated ago

A small toy figure and mineral imitation are seen in front of the Lynas Rare Earths logo in this illustration taken November 19, 2021. REUTERS/Dado Ruvic/Illustration Purchase Licensing Rights, opens new tab

Oct 8 (Reuters) - Australia's Lynas Rare Earths

(LYC.AX), opens new tab has partnered with U.S.-based manufacturer Noveon Magnetics to supply rare-earth permanent magnets to defense and commercial sectors in the U.S., the two companies said on Wednesday.

Sign up here.

Reporting by Kumar Tanishk in Bengaluru; Editing by Janane Venkatraman

Our Standards: The Thomson Reuters Trust Principles., opens new tab

Analyst’s Disclosure:I/we have no stock, option or similar derivative position in any of the companies mentioned, and no plans to initiate any such positions within the next 72 hours. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.

Seeking Alpha's Disclosure: Past performance is no guarantee of future results. No recommendation or advice is being given as to whether any investment is suitable for a particular investor. Any views or opinions expressed above may not reflect those of Seeking Alpha as a whole. Seeking Alpha is not a licensed securities dealer, broker or US investment adviser or investment bank. Our analysts are third party authors that include both professional investors and individual investors who may not be licensed or certified by any institute or regulatory body.

Peter Nash

Good morning, ladies and gentlemen, and welcome to today's important meeting of relevant shareholders in relation to the proposed scheme of arrangement that you, as shareholders, will be voting on today, which I'll refer to as the scheme. My name is Peter Nash. I'm the Non-Executive Chairman of Johns Lyng Group Limited, and I will be chairing today's meeting.

With me today are other directors of JLG, namely Scott Didier, Nick Carnell, Alison Terry, Larisa Moran and Peter Dixon. We did have Alex online at one stage, but I think he's been unable to -- that line is not working, so he is not attending this meeting. Lisa Dadswell, Company Secretary of JLG, is an apology for this meeting, but we have Anshul Aggarwal attending in her place. Representatives of JLG's share registry, MUFG Corporate Markets, are also present to assist in the poll process for today's meeting. For the purposes of today's meeting.

For the purpose of today's Meeting, I appoint Jeffrey Wu from MUFG to act as returning officer. Mr. Wu has agreed to act in this capacity. Also in attendance are representatives from Nomura, JPMorgan, who are the financial advisers to JLG and Minter Ellison, the legal advisers to JLG.

Can I please ask that you turn your phones to silent.

It's now coming up 10:30, which is -- and we're at the scheduled commencement time for the relevant shareholder scheme meeting. A quorum is present, and therefore, I declare today's meeting to be open. As you know, today's meeting is being held as a hybrid meeting conducted in 2 parts simultaneously with relevant shareholders and proxies participating both in person and via the online platform.

SummaryHess Midstream LP is upgraded from hold to buy, as valuation now prices in downside risks and offers an attractive entry point.HESM trades below historical P/E and EV/EBITDA averages, with fair value estimates suggesting limited but reasonable upside after the recent selloff.Despite oil price volatility and plateauing Bakken production, HESM's fee-based contracts, growing third-party revenue, strong cash flow, and natural gas growth prospects mitigate risks.Technicals remain bearish, but oversold conditions and improving momentum indicators signal potential for a price rebound in the near term. AlizadaStudios/iStock via Getty Images

It has been nearly three months since my initial coverage on Hess Midstream LP (NYSE:HESM). While fundamentals were okay and opportunities outweighed risks, I felt that its drivers were not enough to justify further upside. And now, it trades at low-to-mid-$30s, the

Analyst’s Disclosure:I/we have no stock, option or similar derivative position in any of the companies mentioned, but may initiate a beneficial Long position through a purchase of the stock, or the purchase of call options or similar derivatives in HESM over the next 72 hours. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.

Seeking Alpha's Disclosure: Past performance is no guarantee of future results. No recommendation or advice is being given as to whether any investment is suitable for a particular investor. Any views or opinions expressed above may not reflect those of Seeking Alpha as a whole. Seeking Alpha is not a licensed securities dealer, broker or US investment adviser or investment bank. Our analysts are third party authors that include both professional investors and individual investors who may not be licensed or certified by any institute or regulatory body.

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Pantheon Resources PLC (AIM:PANR, OTCQX:PTHRF) has successfully completed hydraulic fracture stimulation operations at the Dubhe-1 well on Alaska’s North Slope.

The 25-stage plug-and-perforate programme was finalised over eight days without safety or environmental incidents, the AIM-quoted company said in a statement.

"We are extremely pleased with the success of the operations so far," Pantheon chief development officer Erich Krumanocker said.

"The team did an excellent job executing this large and intricate operation safely and efficiently. The stimulation was performed as planned, increasing our confidence in achieving the objectives of the forthcoming flow testing programme."

Dubhe-1 was previously drilled to a total depth of 15,000 feet, with approximately 5,200 feet of the lateral section entirely within the targeted SMD-B reservoir.

IP Group PLC (LSE:IPO) has announced that one of its portfolio companies, Monolith, is being acquired by Nasdaq-listed CoreWeave, marking another successful sale from its deeptech investments.

The London-listed investment firm, which holds a 12.3% stake in Monolith, said the deal follows recent disposals of other portfolio businesses, Featurespace and Garrison.

Monolith, spun out of Imperial College London, provides artificial intelligence software that helps engineering teams solve complex physics and design challenges.

No financial details of the transaction have been disclosed, and the deal remains subject to customary closing conditions.

Greg Smith, chief executive of IP Group, said: “The sale of Monolith marks another positive exit from our deeptech portfolio.

"We’re delighted with this outcome, which follows the sales of Featurespace and Garrison from our deeptech portfolio.

"As the most experienced and active UK-based, early-stage science investor, this further validates the Group’s model and our expertise in identifying and supporting businesses to successful exits.”

For CoreWeave, the acquisition strengthens its push into industrial and manufacturing sectors.

The US-based cloud computing firm said combining its AI infrastructure with Monolith’s engineering-focused machine learning tools would help companies cut research and development times and improve product design.

Monolith’s software is already used by major manufacturers, including BMW, Nissan and Honeywell, to reduce the need for physical testing and speed up innovation.

Brian Venturo, CoreWeave’s co-founder and chief strategy officer, said the deal would help “enterprises better harness AI to accelerate breakthroughs and bring better products to market faster”.

AlphaMedixTM (212Pb-DOTAMTATE) achieved all primary efficacy endpoints in phase 2 study, demonstrating clinically meaningful benefits in patients with gastroenteropancreatic neuroendocrine tumors

AlphaMedixTM showed prolonged and clinically meaningful benefits across PRRT-naïve and PRRT-exposed patients with unresectable or metastatic GEP-NETs, highlighting the potential of Targeted Alpha Therapy with lead-212 as a new treatment option Results will form the basis of future discussions with health authorities Paris, October 8, 2025. Positive results from the ALPHAMEDIX-02 phase 2 study (clinical study identifier: NCT05153772) showed AlphaMedixTM (212Pb-DOTAMTATE), an investigational somatostatin receptor (SSTR)-Targeted Alpha Therapy using the lead-212 isotope, met all primary efficacy endpoints and showed clinically meaningful overall response rates (ORR) and prolonged clinical benefits in both peptide receptor radionuclide therapy (PRRT)-naïve and PRRT-exposed patients with unresectable or metastatic SSTR positive gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Benefits in key secondary endpoints, including progression-free survival (PFS) and overall survival (OS), were also observed across both cohorts. AlphaMedix™ had a manageable safety profile that was similar across both cohorts.

"The positive results from the ALPHAMEDIX-02 study represent a pivotal movement for the Orano Med 212Pb-based platform and underscore the profound potential of lead-212-based radiopharmaceuticals in addressing critical unmet needs for patients with GEP-NETs. We are very encouraged by AlphaMedix™'s consistent and clinically meaningful activity across both peptide receptor radionuclide therapy (PRRT)-naïve and PRRT-exposed patients,” said Volker Wagner, MD, PhD, Chief Medical Officer at Orano Med. “These data reinforce our belief that delivering highly potent alpha-emitters directly to cancer cells could potentially offer a meaningful new treatment option for people living with GEP-NETs.”

Alpha-emitters are being studied to determine their relative potency and targeted tumor activity compared to current approved therapies. It is believed they could potentially reduce exposure of surrounding healthy tissue due to the short range of alpha particles. In February 2024, AlphaMedix™ was granted Breakthrough Therapy Designation by the US Food and Drug Administration (FDA) for treatment of PRRT-naïve patients with unresectable or metastatic, progressive SSTR-expressing GEP-NETs, recognizing the potential clinical benefits and potential of this lead-212–based therapy.

"The promising ALPHAMEDIX-02 results represent a significant step forward, reinforcing the potential of targeted alpha therapy to deliver precise treatment for GEP-NETs,” said Christopher Corsico, MD, Global Head of Development at Sanofi. “These data, demonstrating clinically meaningful activity and a manageable safety profile, underscore our unrelenting commitment to developing innovative therapies for patients with difficult-to-treat cancers. We look forward to advancing AlphaMedix™ and working with Orano Med and regulators to bring this important treatment to the GEP-NET community as soon as possible.”

The study is ongoing, and the full results will be presented at the 2025 European Society for Medical Oncology (ESMO) Congress. The results will also form the basis of discussions with health authorities. AlphaMedix™ has not been approved by any regulatory authority.

About the ALPHAMEDIX-02 study
ALPHAMEDIX-02 is a phase 2, open-label, multicenter study evaluating the efficacy and safety of AlphaMedix™ (212Pb-DOTAMTATE) in patients with histologically confirmed unresectable or metastatic GEP-NETs, positive somatostatin analogue imaging and at least one site of measurable disease. The study included two cohorts evaluating PRRT-naïve (n=35) and PRRT-exposed (n=26) patients. PRRT-exposed patients had progressive disease after receiving up to four doses of 177Lu-DOTATATE and received their last dose at least six months prior to Day 1. In both cohorts, AlphaMedix™ was administered at 67.6 μCi/kg every eight weeks for up to four cycles (6 mCi maximum per cycle). Primary endpoints included ORR per RECIST1.1 and safety. Secondary endpoints included PFS and OS.

About NETs
NETs are a heterogeneous group of cancers that originate from neuroendocrine cells. These cancers occur mostly in the gastrointestinal tract and pancreas but can also occur in other tissues including the thymus, lung, and other uncommon sites such as the ovaries, heart, and prostate. Most NETs strongly express somatostatin receptors. Despite the global prevalence of NETs increasing each year, it is considered a rare cancer that is estimated to affect approximately 35/100,000 individuals worldwide. In the United States, around 12,000 patients annually are expected to be diagnosed with neuroendocrine tumors, with an average five-year survival rate of 60% at a metastatic stage.

About Orano Med
Orano Med is a subsidiary of the Orano Group. Orano Med is a clinical-stage biotechnology company that develops a new generation of targeted therapies against cancer using the unique properties of lead-212 (212Pb), an alpha-emitting radioisotope and one of the more potent therapeutic payloads against cancer cells known as Targeted Alpha Therapy (TAT). Leveraging its unique and secured access to 212Pb, the company is developing several treatments using 212Pb combined with various targeting agents. Orano Med has 212Pb manufacturing facilities, laboratories, and R&D centers in France and in the US and is currently expanding its GMP-manufacturing capacities for 212Pb radiolabeled pharmaceuticals in North America and Europe.

About Sanofi
Sanofi is an R&D driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. We apply our deep understanding of the immune system to invent medicines and vaccines that treat and protect millions of people around the world, with an innovative pipeline that could benefit millions more. Our team is guided by one purpose: we chase the miracles of science to improve people’s lives; this inspires us to drive progress and deliver positive impact for our people and the communities we serve, by addressing the most urgent healthcare, environmental, and societal challenges of our time.

Sanofi is listed on EURONEXT: SAN and NASDAQ: SNY

Media Relations
Sandrine Guendoul | +33 6 25 09 14 25 | [email protected]
Evan Berland | +1 215 432 0234 | [email protected]  
Léo Le Bourhis | +33 6 75 06 43 81 | [email protected]  
Victor Rouault | +33 6 70 93 71 40 | [email protected]
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Investor Relations
Thomas Kudsk Larsen | +44 7545 513 693 | [email protected]  
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Orano Med
Sophie Letournel | +33 6 38 44 34 11| [email protected]
Orano Press Office | +33 (0)1 34 96 12 15| [email protected]

Sanofi forward-looking statements
This press release contains forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995, as amended. Forward-looking statements are statements that are not historical facts. These statements include projections and estimates and their underlying assumptions, statements regarding plans, objectives, intentions, and expectations with respect to future financial results, events, operations, services, product development and potential, and statements regarding future performance. Forward-looking statements are generally identified by the words “expects”, “anticipates”, “believes”, “intends”, “estimates”, “plans” and similar expressions. Although Sanofi’s management believes that the expectations reflected in such forward-looking statements are reasonable, investors are cautioned that forward-looking information and statements are subject to various risks and uncertainties, many of which are difficult to predict and generally beyond the control of Sanofi, that could cause actual results and developments to differ materially from those expressed in, or implied or projected by, the forward-looking information and statements. These risks and uncertainties include among other things, the uncertainties inherent in research and development, future clinical data and analysis, including post marketing, decisions by regulatory authorities, such as the FDA or the EMA, regarding whether and when to approve any drug, device or biological application that may be filed for any such product candidates as well as their decisions regarding labelling and other matters that could affect the availability or commercial potential of such product candidates, the fact that product candidates if approved may not be commercially successful, the future approval and commercial success of therapeutic alternatives, Sanofi’s ability to benefit from external growth opportunities, to complete related transactions and/or obtain regulatory clearances, risks associated with intellectual property and any related pending or future litigation and the ultimate outcome of such litigation,  trends in exchange rates and prevailing interest rates, volatile economic and market conditions, cost containment initiatives and subsequent changes thereto, and the impact that global crises may have on us, our customers, suppliers, vendors, and other business partners, and the financial condition of any one of them, as well as on our employees and on the global economy as a whole. The risks and uncertainties also include the uncertainties discussed or identified in the public filings with the SEC and the AMF made by Sanofi, including those listed under “Risk Factors” and “Cautionary Statement Regarding Forward-Looking Statements” in Sanofi’s annual report on Form 20-F for the year ended December 31, 2024. Other than as required by applicable law, Sanofi does not undertake any obligation to update or revise any forward-looking information or statements.

All trademarks mentioned in this press release are the property of the Sanofi group except for Orano Med and AlphaMedix™.

Press_Release

HP CEO Enrique Lores discusses the use of AI in company technology on 'The Claman Countdown.' #fox #media #breakingnews #us #usa #new #news #breaking #foxbusiness #theclamancountdown #hp #hewlettpackard #enriquelores #ai #artificialintelligence #technology #consumer #innovation #business #ceo #interview #future #digital #technews #aitech #corporate #computing

Analyst’s Disclosure:I/we have a beneficial long position in the shares of BABA either through stock ownership, options, or other derivatives. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.

Seeking Alpha's Disclosure: Past performance is no guarantee of future results. No recommendation or advice is being given as to whether any investment is suitable for a particular investor. Any views or opinions expressed above may not reflect those of Seeking Alpha as a whole. Seeking Alpha is not a licensed securities dealer, broker or US investment adviser or investment bank. Our analysts are third party authors that include both professional investors and individual investors who may not be licensed or certified by any institute or regulatory body.

The logo of ABB is pictured at the Global Industries exhibition in Villepinte near Paris, France, March 26, 2024. REUTERS/Benoit Tessier Purchase Licensing Rights, opens new tab

ZURICH, Oct 8 (Reuters) - Swiss engineering group ABB

(ABBN.S), opens new tab on Wednesday said it has agreed to sell its robotics business to SoftBank Group

(9984.T), opens new tab in a deal that values the business at $5.38 billion.

The deal means ABB has abandoned its original decision to spin off and separately list the industrial automation business, which competes with Japan's Fanuc

(6954.T), opens new tab, Yaskawa

(6506.T), opens new tab and Germany's Kuka in making factory robots.

Sign up here.

The transaction is expected to close in mid-to-late 2026 and generate cash proceeds of roughly $5.3 billion from the divestment, ABB said.

It said the money will be used towards its long-term capital allocation principals, which include investing in organic growth, acquisitions and returning capital to shareholders through dividends and share buybacks.

The robotics business, which employs 7,000 people, generated sales of $2.3 billion last year, equivalent to 7% of ABB's total revenues, but ABB saw limited crossover with the rest of its business, which is largely focussed on electrification and automation.

Reporting by John Revill, Editing by Miranda Murray

Our Standards: The Thomson Reuters Trust Principles., opens new tab