Market Signal Briefing

, /PRNewswire/ -- CARsgen Therapeutics Holdings Limited (Stock Code: 2171.HK), a company focused on developing innovative CAR T-cell therapies, announces that the research results of the Phase Ib registrational clinical trial of satricabtagene autoleucel ("satri-cel", CT041) (an autologous CAR T-cell product candidate against protein Claudin18.2) for pancreatic cancer (PC) adjuvant therapy in China (CT041-ST-05, NCT05911217) has been presented in poster session at European Society for Medical Oncology (ESMO) Congress 2025. The poster was titled "Adjuvant Therapy with Claudin18.2-specific CAR T Cells (Satri-cel) in High-Risk Pancreatic Cancer (CT041-ST-05)" (Poster number: 2220P). The trial represents the world's first proof-of-concept (POC) study exploring CAR T-cell therapy for the adjuvant treatment of solid tumors. Professor Xianjun Yu from Fudan University Shanghai Cancer Center serves as the principal investigator.

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dismal prognosis even among patients who undergo surgical resection. Local recurrence and distant metastasis are common, often leading to treatment failure. Elevated carbohydrate antigen 19-9 (CA19-9) levels post resection indicate aggressive tumor biology and higher risk of recurrence. The median interval is approximately 3 months between CA19-9 elevation and radiological recurrence. [1][2] Current standard adjuvant therapies have limited effectiveness for high-risk patients, highlighting the urgent need for novel strategies.

This trial enrolled patients with Claudin18.2 positive PDAC who have undergone curative-intent resection, with abnormal CA19-9 after 3 months adjuvant chemotherapy and no evidence of recurrence. From Sep 15, 2023 to April 11, 2025 (data cut-off date), six patients received satri-cel infusion and completed at least 4 weeks of follow-up.

With a median follow-up of 6.05 months from infusion, only one patient experienced disease recurrence, while others are still under disease free. The median disease-free survival (DFS) and median overall survival (OS) were not reached (NR). The 9-month DFS rate from surgery was 83.3%. Notably, one patient who has completed 52-week follow-up post infusion is still under follow-up without disease recurrence. Moreover, significant decline in CA19-9 levels post infusion was observed in five (83.3%) patients, with reductions ranging from 51.3% to 96.1%.

All patients developed Grade 1 or 2 cytokine release syndrome (CRS) after the first satri-cel infusion. For the second infusion administered in one patient, grade 3 CRS accompanied by hypotension was observed, which was resolved within three days following tocilizumab treatment. All patients experienced gastrointestinal disorders, such as nausea and vomiting, which were all Grade 1 or 2. Only one case of Grade 3 gastritis occurred. No immune effector cell-associated neurotoxicity syndrome (ICANS) was reported.

Dr. Zonghai Li, Founder, Chairman of the Board, Chief Executive Officer, and Chief Scientific Officer of CARsgen Therapeutics, said, "We are pleased to see that satri-cel has shown promising preliminary efficacy with a manageable safety profile in the highly challenging setting of pancreatic cancer adjuvant therapy. For patients at high risk of recurrence after surgical resection of pancreatic cancer, there are currently very few effective treatment options. In this trial, the sustained disease-free survival and marked declines in CA19-9 levels suggest that satri-cel, an innovative cellular immunotherapy, may clear minimal residual disease and potentially alter the disease course for these patients. Furthermore, we are actively advancing clinical trials exploring satri-cel for gastric cancer adjuvant therapy and as a sequential treatment following first-line gastric cancer therapy, with the goal of providing better curative opportunities for a broader patient population."

About Satri-cel
Satri-cel is an autologous CAR T-cell product candidate against the protein Claudin18.2 that has the potential to be the first-in-class globally. Satri-cel targets the treatment of Claudin18.2-positive solid tumors with a primary focus on gastric/gastroesophageal junction adenocarcinoma (G/GEJA) and pancreatic cancer (PC). Initiated trials include investigator-initiated trials (CT041-CG4006, NCT03874897), a confirmatory Phase II clinical trial for advanced G/GEJA in China (CT041-ST-01, NCT04581473), a Phase Ib registrational trial for PC adjuvant therapy in China (CT041-ST-05, NCT05911217), an investigator-initiated trial for satri-cel be used as consolidation treatment following adjuvant therapy in patients with resected G/GEJA (CT041-CG4010, NCT06857786), an investigator-initiated trial for satri-cel as a sequential therapy following first-line treatment in patients with advanced G/GEJA (CT041-CG4011, NCT07179484), and a Phase 1b/2 clinical trial for advanced gastric or pancreatic adenocarcinoma in North America (CT041-ST-02, NCT04404595).

The Center for Drug Evaluation (CDE) of National Medical Products Administration (NMPA) of China has accepted the New Drug Application (NDA) for satri-cel for the treatment of Claudin18.2-positive advanced G/GEJA in patients who have failed at least two prior lines of therapy on June 25, 2025. It has been granted Priority Review in May 2025 and Breakthrough Therapy Designation in March 2025 by the CDE. Satri-cel was granted Regenerative Medicine Advanced Therapy designation by U.S. FDA for the treatment of advanced G/GEJA with Claudin18.2-positive tumors in January 2022. Satri-cel received Orphan Drug designation from the U.S. FDA for the treatment of G/GEJA in September 2020.

About CARsgen Therapeutics Holdings Limited
CARsgen is a biopharmaceutical company focusing on developing innovative CAR T-cell therapies to address the unmet clinical needs including but not limited to hematologic malignancies, solid tumors and autoimmune diseases. CARsgen has established end-to-end capabilities for CAR T-cell research and development covering target discovery, preclinical research, product clinical development, and commercial-scale production. CARsgen has developed novel in-house technologies and a product pipeline with global rights to address challenges faced by existing CAR T-cell therapies. Efforts include improving safety profile, enhancing the efficacy in treating solid tumors, and reducing treatment costs, etc. CARsgen's mission is to be a global biopharmaceutical leader that provides innovative and differentiated cell therapies for patients worldwide and makes cancer and other diseases curable.

Forward-looking Statements
All statements in this press release that are not historical fact or that do not relate to present facts or current conditions are forward-looking statements. Such forward-looking statements express the Group's current views, projections, beliefs and expectations with respect to future events as of the date of this press release. Such forward-looking statements are based on a number of assumptions and factors beyond the Group's control. As a result, they are subject to significant risks and uncertainties, and actual events or results may differ materially from these forward-looking statements and the forward-looking events discussed in this press release might not occur. Such risks and uncertainties include, but are not limited to, those detailed under the heading "Principal Risks and Uncertainties" in our most recent annual report and interim report and other announcements and reports made available on our corporate website, https://www.carsgen.com. No representation or warranty is given as to the achievement or reasonableness of, and no reliance should be placed on, any projections, targets, estimates or forecasts contained in this press release.

References

[1] Pancreatology. 2019 Mar;19(2):302-306.

[2] Sci Rep. 2020 Jan 28;10(1):1332.

SOURCE CARsgen Therapeutics

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Key Takeaways Tesla will report Q3 EPS on Wednesday night. The options market suggests an 8.5% move after EPS.Investors will focus on EV demand, the energy segment, & Optimus timeline.
Tesla Earnings Are Due WednesdayZacks Rank #3 (Hold) stock Tesla ((TSLA - Free Report) ), the worldwide electric vehicle (EV) leader and a dynamic technology innovator, will report third-quarter 2025 earnings after the market close on Wednesday, October 22nd. Though Tesla has been one of the top-performing stocks since its IPO in July 2010 (with a 34,000% return), the stock has taken investors on a wild ride over the past few years. Namely, Tesla has had to weather new tariff policies, a slowing EV market, higher interest rates, and increased competition. Additionally, Tesla and its iconic but controversial CEO, Elon Musk, have faced intense political backlash from both sides of the political aisle. Despite its many challenges, TSLA shares are up a robust 93% over the past six months.

Image Source: Zacks Investment Research

Tesla EPS PreviewBelow are some key details to know ahead of Tesla’s earnings:

Tesla Consensus Analyst EstimatesZacks Consensus Estimates suggest tepid sales growth and negative EPS growth until 2026. Wall Street expects Q3 revenue of $26.45B (+5.05%), with EPS of $0.53 (-26.39%).

Image Source: Zacks Investment Research

Tesla EPS Surprise HistoryTesla has delivered spotty earnings results recently. Despite tempered Tesla analyst expectations, Tesla has missed expectations in six of the past ten quarters.

Image Source: Zacks Investment Research

Meanwhile, Tesla has missed analyst expectations by an average of 3.65% over the past four quarters.

Image Source: Zacks Investment Research

TSLA Expected MoveThe options market implies a potential move of +/- $37.48 or an 8.53% implied move. Tesla has had an average move of +/- 10.53% over the past eight quarters. TSLA shares have been higher the day after EPS 50% of the time over that time.

TSLA Technical ViewAfter breaking out from a low-level base structure in September, TSLA shares are coiling in a classic bull flag pattern. If Tesla exceeds expectations, the stock should make a run at its previous all-time high of $488. Should TSLA miss expectations, the stock is likely to test the confluence of the open price gap and rising 50-day moving average ~$400.

Image Source: TradingView

Tesla EPS: 3 Key Catalysts Tesla’s post-earnings price action will likely be determined by the answer to three critical questions, including:

1.      Has Tesla’s Legacy EV Business Bottomed? Tesla recently produced and announced a record number of vehicle deliveries. However, investors will be listening closely to see what Elon Musk and his team have to say about forward expectations in the wake of the removal of federal EV tax credits, lower interest rates, and the new ‘Model Y’ sales performance.

2.      Will Energy Segment Growth Continue? In the absence of a growing EV business, Tesla Energy has been a bastion of growth. Last year, the segment grew at a robust 67%. Meanwhile, thus far in 2025, energy storage deployments have increased at a triple-digit pace. With the AI boom in full force, Tesla’s energy storage business should benefit as energy-hungry data centers require energy storage solutions like Tesla’s ‘Megapack.’

3.      Will Tesla Meet Timelines for FSD, Robotaxis, and Optimus? Elon Musk is well-known for his aggressive timelines for new products. However, if Musk can convince investors that future product roadmaps are still on track, investors will reward him.

Bottom Line

As Tesla prepares to report Q3 earnings, investors face a familiar mix of excitement and uncertainty. With the stock surging nearly 93% in the past six months, expectations are high – yet tempered by Tesla’s recent mixed track record.

Bitcoin treasury companies are entering a new phase as their Net Asset Values (NAVs) collapse, marking the end of inflated premiums and signaling the rise of a more mature investment environment. According to a new report by 10x Research, the sharp decline in NAVs may not be entirely negative—it could represent a major opportunity for investors and the start of a new era for professional Bitcoin asset managers.

The price performance of Bitcoin over the past two weeks has been a major source of concern, as the coin’s value continues to drift away (about 15% down now) from its all-time high. As the flagship cryptocurrency slows down, the latest on-chain data suggests that a group of investors is exiting the market en masse.

More Short-Term Holders Are Giving Up Their Holdings
In an October 18 post on the X platform, on-chain analyst Darkfost revealed that a significant number of Bitcoin’s short-term investors have started to close their positions and realize their losses.

Darkfost’s analysis was hinged on the Net Realized Profit/Loss metric, which tracks the net amount (in USD) of profits or losses that are realized on-chain. This metric measures the net profit or loss on a daily basis, averaged, in this case, over seven days. It provides insight into whether more investors are selling at losses or with their heads still above water..

According to the crypto pundit, the realized losses of BTC investors have surged to an approximate level as high as $750 million per day, one of the highest levels this current cycle has seen. Interestingly, Darkfost explained that the magnitude of these capitulation events stands easily comparable to those seen during the 2024 summer correction.

Source: @Darkfost_Coc on X
What’s worth noting about this capitulation phase is what may likely follow. According to the analyst, events like this usually precede local bottoms. What this means is that after short-term holders (known as the “weak hands”) have surrendered their holdings to the more-confident long-term holders (the “diamond hands”), the cryptocurrency stands a chance of seeing a price rebound — an expectation in congruence with historical trends.

However, on the more cautious side, Darkfost offered a subtle warning that the dreary opposite could also be the case in a situation where the market stands at an early bearish phase. 

Bitcoin Whales Might Be Accumulating Again
Supporting the positive redistribution theory, a Quicktake post on the CryptoQuant platform by Abramchart offers a glimmer of hope for Bitcoin market participants. Referencing the Inflows To Accumulation Addresses (Dynamic Cohort) metric, the analyst highlighted a significant inflow of more than 26,500 BTC into whale accumulation wallets. 

When large amounts of Bitcoin — such as this magnitude — are moved, it usually signals an underlying institutional or whale accumulation, as coins are typically transferred from exchanges to these wallets for long-term holding. 

Following historical patterns, it is very likely that this accumulation event will precede a continued bullish expansion of the flagship cryptocurrency. As Abramchart explained, this trend all serves as a hint that smart money is “quietly buying the dip.”

As of this writing, Bitcoin holds a valuation of about $106,870, with no significant movement seen over the past 24 hours.

The price of BTC on the daily timeframe | Source: BTCUSDT chart on TradingView
Featured image from iStock, chart from TradingView

Since the start of the year, data shows about 432 Casascius physical bitcoins have been cracked open and redeemed—revealing roughly 1,100 BTC inside, valued at more than $119 million using today's exchange rates.

BNB has stood out in recent weeks as one of the most resilient cryptocurrencies, even as the broader market struggles with volatility. New data from CryptoOnchain reveals that the BNB Smart Chain (BSC) reached a record 3.62 million daily active addresses the highest number in its history.

Bitcoin (BTC) continues to trade under pressure, falling to $103,528 earlier today as global macroeconomic uncertainty weighs on investor sentiment. The decline marks an extension of the recent bearish streak that has erased gains made during the first half of October.

Cardano trades at $0.641, sitting in the “opportunity zone” as signaling strong accumulation potential.CMF remains positive, indicating capital inflows and improving investor confidence despite bearish sentiment.A breakout above $0.661 could push ADA to $0.696 or $0.754, while losing $0.623 risks a drop to $0.608.Cardano (ADA) continues to struggle with bearish pressure after multiple failed recovery attempts. However, the recent decline appears to have opened a window of opportunity for investors. 

As ADA’s price enters a key accumulation range, buyers are showing renewed interest, potentially setting the stage for a rebound.

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Cardano Finds OpportunityThe Market Value to Realized Value (MVRV) ratio shows that Cardano is currently sitting in the opportunity zone. With values ranging between -9% and -19%, this indicator reflects that most ADA holders are experiencing unrealized losses.

Historically, this range often marks a local market bottom where selling typically slows and accumulation begins.

Such a development could be the first sign of a shift in market sentiment. As holders stop selling and investors begin buying at lower prices, the resulting demand could provide ADA with the fuel it needs to stabilize.

Want more token insights like this? Sign up for Editor Harsh Notariya’s Daily Crypto Newsletter here.

Cardano MVRV Ratio. Source: SantimentThe Chaikin Money Flow (CMF) indicator reinforces this potential turnaround. Data shows that Cardano has recorded consistent inflows over the last several days, signaling a return of investor confidence.

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The CMF is currently positioned in the positive zone above the zero line, confirming active capital movement into ADA.

Sustained inflows often precede price recoveries, particularly when coupled with reduced selling pressure. If this trend continues, Cardano could gradually regain momentum in the short term. 

Cardano CMF. Source: TradingViewADA Price Can Bounce BackAt the time of writing, Cardano’s price stands at $0.641, holding above the $0.623 support. The altcoin remains under the $0.661 resistance, where repeated rejections have hindered its upward progress over the past week.

If current conditions persist, ADA could breach $0.661 and aim for $0.696. However, for Cardano to mark a true recovery, it must reach and sustain levels above $0.754. Such a move would confirm renewed market strength and investor optimism.

Cardano Price Analysis. Source: TradingViewConversely, if ADA faces renewed selling, the price could drop below $0.623 and test $0.608. A failure to hold these supports would invalidate the bullish outlook and potentially trigger further downside pressure.

Disclaimer

In line with the Trust Project guidelines, this price analysis article is for informational purposes only and should not be considered financial or investment advice. BeInCrypto is committed to accurate, unbiased reporting, but market conditions are subject to change without notice. Always conduct your own research and consult with a professional before making any financial decisions. Please note that our Terms and Conditions, Privacy Policy, and Disclaimers have been updated.

As we approach the end of October 2025, Bitcoin has displayed an uncharacteristic decline, shedding 5.33% of its value, marking its first decline in October since 2019. Traditionally, the last quarter of the year has been a favorable period for Bitcoin, often seeing increases in its value.

Volatility Shares just ignited the ETF race by filing for a groundbreaking set of 27 highly leveraged products—featuring first-ever 5x exposure to bitcoin, XRP, ether, solana, and top equities—signaling a seismic shift in access to turbocharged crypto and stock trading.

Dogecoin (DOGE) extended its weekly losses on Friday, sliding another 10% to trade near $0.17, its lowest level in over a month. On-chain data revealed that whales sold around 360 million DOGE, worth roughly $74 million, within a single day.

In October 2025, Bull Wallet introduced its self-custodial, bitcoin-only mobile wallet to a global audience, offering a blend of cutting-edge privacy features and cost-efficient payment options. Available on both iOS and Android, this app integrates on-chain bitcoin transactions, Lightning Network functionality, and Liquid support.

Japan’s Financial Services Agency (FSA) is reportedly considering reforms that would allow banks to buy and hold cryptocurrencies such as Bitcoin for investment purposes.

According to a Sunday report from Livedoor, discussions on potential regulatory revisions are expected to kick off at an upcoming meeting of the Financial System Council, an advisory body to the Prime Minister.

Regulators are expected to introduce regulations for managing crypto-related risks, such as wild price swings that could affect a bank’s financial stability. If approved, the FSA will likely impose capital and risk-management requirements before allowing banks to hold digital assets.

The move would mark a significant policy shift, as current supervisory guidelines, updated in 2020, effectively prohibited banks from holding crypto for investment due to volatility risks and potential losses that could affect banks’ financial health.

If successful, the proposed framework would align crypto asset management with traditional instruments like equities and government bonds.

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Japanese Banks May Be Allowed To Operate As Licensed Crypto Exchanges
Japan’s Financial Services Agency is also considering allowing banks to register as licensed “cryptocurrency exchange operators,” enabling them to offer their customers trading and custody services directly. The financial regulator believes the foray of trusted banking institutions could create a safer investment environment for retail investors.

Japan has long been a crypto hub; the now-defunct major Bitcoin exchange Mt. Gox was headquartered in Tokyo, resulting in a large retail market in the country. But an infamous, long-running hack of the platform led to its 2014 closure, with repayments only starting in early 2024.

The crypto market in Japan continues to grow rapidly, with over 12 million crypto accounts registered as of February 2025, which is roughly 3.5 times higher than five years ago.

The development comes as Japan’s three megabanks, including Mitsubishi UFJ Financial Group (MUFG), Sumitomo Mitsui Banking Corp. (SMBC), and Mizuho Bank, have joined forces to issue stablecoins pegged to the Japanese yen and the U.S. dollar amid soaring global interest in tokenized fiat rails.

Veteran trader Peter Brandt has turned bullish on Bitcoin, Ethereum, XRP, and Stellar (XLM), a notable shift from his earlier warnings of steep declines. He had previously called the top for Bitcoin and cautioned that major corrections were likely ahead.

This renewed optimism comes at a turbulent moment for the market. Despite his upbeat outlook, cryptocurrencies have been under pressure, with Bitcoin recently erasing most of its October gains amid a broader sell-off across digital assets.

Peter Brandt, one of the most respected chart analysts in global trading circles, released a series of updated charts this week showing bullish structures across XRP, Bitcoin (BTC), Ethereum (ETH), and Stellar (XLM). 

In a series of posts on X (formerly Twitter), veteran trader Peter Brandt downplayed the recent market pullback, calling it “a minor reaction in the bigger theme of things.” He was referring specifically to XRP’s latest correction, which he views as part of a broader, still-intact trend.

Turning to Bitcoin, Brandt reiterated his long-term optimism. He said that “the bull is still alive and well,” highlighting a key support zone in the chart. According to him, this zone should hold firm unless global economic conditions take a sharp turn for the worse.

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Ethereum, he noted, is consolidating within what he described as a structure “ready to rock and roll.” Brandt suggested that once the coin clears resistance, it could be primed for a strong upward move.

As for Stellar, he likened its recent price behavior to “a bull waking from a nap.” The comment hinted at a possible breakout after a long period of sideways trading.

Following a major weekend crash that erased billions in market value after Trump announced tariffs on China, crypto assets have started to recover.

The put/call ratio has tilted toward calls, while one-week implied volatility skewed slightly positive, suggesting renewed demand for bullish options.

Peter Brandt’s updated charts suggest renewed confidence in the resilience of major cryptocurrencies despite recent market turmoil. His analysis positions Bitcoin, Ethereum, XRP, and Stellar as technically strong assets heading into late 2025.

While near-term volatility remains a factor, the veteran trader’s assessment signals that the structural uptrend across leading crypto assets could still be intact.

XRP institutional holders have moved towards long-term positions since the start of the year.

The assets’ metric swings near the $2 billion mark, driving up its total assets under management (AUM). In the same period, altcoins picked up after a slow start to the year, still hinged on massive traditional capital. 

XRP Records $61 Million Weekly Inflows
A new CoinShares Digital Asset Weekly data shows XRP notched $61.6 million inflows, lowering total monthly outflows. Due to the previous dip and fund flows to Bitcoin (BTC), October started poorly for XRP. However, the asset has gained traction and looks set to soar on the back of the Uptober momentum.

Yearly inflows stand at $1.88 billion as institutional vehicles bag gains in Q4 2025, while total assets under management soared past $2.94 billion. XRP remains an institutional favorite asset based on weekly figures targeting future growth. The asset found these tailwinds after a positive outcome in its case against the Securities and Exchange Commission (SEC) and possible spot ETF approvals in the United States. 

Spot ETFs have ignited crypto bulls toward altcoins like Solana and XRP in recent months following imminent approval speculations. With the regulatory nod, experts opine a surge in XRP price, likened to Bitcoin. The market leader soared above the $80k mark last year and subsequently spiked to $124k. 

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XRP is key to most fund strategies because of its cross-border utility and recent company partnerships. Ripple has struck high-value collaborations in multiple jurisdictions, seen as a major boost this year. At press time, XRP trades at $2.40 with bullish monthly gains and a 350% 12-month increase. Per CoinShares data, assets like Solana and Ethereum picked up $93 million and $338 million, respectively. 

“Year-to-date (YTD) inflows have now surpassed the record inflows last year, totaling US$48.7bn so far in 2025. Weekly volumes on digital asset ETPs were the largest on record at a whopping US$53bn for the week, double the 2025 weekly average, with Friday volumes being the largest daily on record at US$15.3bn. Total assets under management (AuM) following the tariff announcement fell by 7% from last week’s peak to US$242bn.”

Meanwhile, Bitcoin topped the charts as expected with $2.6 billion weekly inflows, taking October gains above $5 billion. Bitcoin’s consistent weekly surge contributed to the growing trend of altcoin inflows.

2 mins mins

Key Points:

Ross Calvin, CEO of Parhelion, plans a 450-foot statue on Alcatraz.Project cost is estimated at $450 million; no confirmed funding yet.No market impact observed; initiative remains in conceptual phase.
Ross Calvin, CEO of Parhelion, plans a 450-foot statue of Prometheus on Alcatraz Island, with a proposal soon to President Trump, costing $450 million.

This initiative signals a bold intersection of Bitcoin entrepreneurship and public art, though it currently lacks seen market impact or verified official funding.

Parhelion Proposes $450 Million Statue on Alcatraz Island
Market reactions remain limited, with no observable impact on crypto tokens or asset prices. Official channels, including Twitter, remain silent, and no notable comments have come from key industry figures such as Arthur Hayes or Vitalik Buterin. Community engagement on social platforms is muted, reflecting a lack of substantial traction so far for Calvin’s monumental vision.

Bitcoin’s current market data as of October 19, 2025, indicates a price of $109,322.98 with a market cap of $2.18 trillion and a dominance of 58.98%. Over the last 24 hours, trading volume reached $43.37 billion. This reflects a 2.38% rise but marks a 4.08% decrease over the past week, based on CoinMarketCap’s reporting.

Currently, there are no direct, attributable quotes from Ross Calvin, CEO of Parhelion, regarding the proposed 450-foot Prometheus statue on Alcatraz Island. All information is derived from organizational websites and secondary reporting without any public statements available from Calvin or Parhelion’s official channels as of October 19, 2025.
Bitcoin Market Steady Amid Monumental Project Proposal
Did you know? Historically, few crypto initiatives transition into federally recognized public art projects, reflecting a novel intersection of blockchain impact with cultural heritage endeavors.

Coincu analysts suggest the Prometheus proposal represents progressive potential in marrying digital assets with tangible societal projects. While it has yet to affect financial markets or provoke governmental responses, the initiative could inspire future crypto-backed civic endeavors once formal backing materializes.

Bitcoin(BTC), daily chart, screenshot on CoinMarketCap at 18:26 UTC on October 19, 2025. Source: CoinMarketCap

Coincu analysts suggest the Prometheus proposal represents progressive potential in marrying digital assets with tangible societal projects. While it has yet to affect financial markets or provoke governmental responses, the initiative could inspire future crypto-backed civic endeavors once formal backing materializes.

DISCLAIMER: The information on this website is provided as general market commentary and does not constitute investment advice. We encourage you to do your own research before investing.

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Key Takeaways
Which crypto tokens were the highest gainers this week?
Bittensor [TAO], Ethena [ENA], Morpho [MORPHO] led the week in gains.

Which crypto tokens lost the most this week?
Artificial Superintelligence Alliance [FET], Zcash [ZEC], Memecore [M] saw significant declines.

Crypto markets struggled to defend key support this week.

Bitcoin [BTC] slipped below the crucial $110k level, dropping around 6% to test a multi-month low near $103k.

The move dragged the broader market lower, with most altcoins retracing to price levels last seen in early August. 

However, in contrast to the previous crash, capital didn’t exit the market entirely. Instead, it rotated into high-utility tokens, which emerged as this week’s standout performers.

Bittensor [TAO] — Peer-to-peer network diverged from the broader market
Bittensor [TAO] topped this week’s gainers chart with a 30% run, hitting an exact five-month high. However, as AMBCrypto noted, TAO wasn’t immune to the broader leverage flush.

The week started strong, with TAO spiking 17% past the $470 mark, but almost all those gains disappeared in the next two days as traders pulled about $48 million from derivatives to deleverage.

This move coincided with the RSI reaching a five-month high, signaling “overbought” conditions following TAO’s 21%+ rally from the previous week. The result? TAO erased nearly 50% of those gains.

Source: TradingView (TAO/USDT)

That said, TAO bulls were quick to stop momentum from flipping into fear.

Spot investors jumped in, accumulating around $14 million, which caused a noticeable spike in outflows and reinforced a solid bid support level. The altcoin climbed more than 10% intraday from its $370 mid-week low.

Given this setup, TAO looks poised to repeat a similar bullish move, with eyes on the $480 ceiling. With a solid bid wall in place, a break past that level is looking increasingly plausible.

Ethena [ENA] — Utility blockchain tested its bullish bias
Ethena [ENA] is closing in on TAO with a 27% rally this week, bouncing back after a bearish bias in the first half of the week. A strong mid-week catalyst propelled it onto the top gainers chart.

Supporting this move, ENA’s founder accumulated 48 million coins (worth around $20 million) over the past three days, coinciding with its rebound off the $0.40 base. Derivatives also reflect a bullish bias in the market.

Given this context, the market is eyeing a potential $1 breakout in the short term, following a successful push above $0.50 (a level ENA hasn’t crossed since Q3) making it a key inflection point for next week’s rally.

Morpho [MORPHO] — DeFi token exhibited a weak follow-through
Morpho [MORPHO] came in third with a relatively modest 10% rally, reflecting a volatile on-chain picture. The week began with a 0.8% gain on day one, testing the $2 resistance.

However, the follow-through didn’t materialize. MORPHO saw three consecutive days of red candles, dropping nearly 10% to $1.60 as news of a $500 million outflow sparked short-lived fear.

However, by the end of the week, the panic eased. MORPHO rebounded and retested the $2 zone, reinforcing bid support. Still, unless a clear breakout occurs, its short-term directional bias remains uncertain.

Other notable winners
Outside the majors, altcoin rockets stole the spotlight this week.

BNB Attestation Service (BAS) led the charge with a 362% surge, followed by XPIN Network (XPIN), which jumped 348%, and Bless (BLESS), rallying 173% to round out the leaderboard.

Weekly losers
Artificial Superintelligence Alliance [FET] —  AI blockchain broke down to a multi-year low
Artificial Superintelligence Alliance [FET] emerged as this week’s biggest loser, losing 30% of its value from its $0.37 open. A quick look at the chart shows a clear bearish tilt.

This week’s red candle adds to four consecutive weeks of weekly losses, putting October’s rally in jeopardy. FET carved out two lower lows, with the latest breaking the $0.50 support level. 

The first occurred when it fell below $0.60 during the mid-September run. Together, these movements paint a bearish technical picture, with bid support absent despite the RSI sitting deep in oversold territory.

Source: TradingView (FET/USDT)

In this context, expecting a solid floor at $0.20 would still be premature.

FET’s fate now clearly hinges on this support level. The timing couldn’t be worse. The ongoing U.S.-China trade tensions keep risk-off sentiment in the AI sector sky-high, making a rebound for FET highly unlikely.

Zcash [ZEC] — Privacy token showed reset rather than capitulation
Zcash [ZEC] emerged as this week’s second-biggest loser with a 20% pullback. Unlike some of its peers, this move looks more like a healthy cooldown rather than a full-blown capitulation.

The pullback follows two weeks of strong inflows that had pushed ZEC to a four-year high of $300, marking a 210%+ rally. This suggests the decline is likely due to market pressure rather than any fundamental weakness.

Technically, the weekly RSI looks overextended. Still, ZEC clawed back nearly 20% of its losses by week’s end, setting $180 as a solid demand zone and signaling a healthy reset with potential for bullish continuation.

MemeCore [M] — Meme-based token retraced to early September levels
MemeCore [M] came in third among this week’s biggest losers, with a relatively modest 8% drawdown. On the chart, however, the technicals point to a bearish setup, leaving the door open for a deeper correction.

The week started with a small 0.69% gain, hinting that bulls might be stepping in around the $2 support. But four days of red candles reinforced the bearish bias, pushing M down to early September levels at $1.95. 

For context, this is the second support break in under a month, indicating that M may face further downside unless it can reclaim the $2 level, which would be key to stabilizing the short-term trend.

Other notable losers
In the broader market, downside volatility hit hard.

DORA (DORA) led the losers with a 67% drop, followed by Paparazzi Token (PAPARAZZI), down 47%, and Portal to Bitcoin (PTB), which slipped 43% as momentum sharply cooled.

Conclusion
This week was a rollercoaster. Big pumps, sharp dips, and nonstop action. As always, stay sharp, do your own research, and trade smart.

According to blockchain sleuth ZachXBT, the $3 million worth of XRP that was recently stolen from US investor Brandon LaRoque has already been laundered through OTC services associated with Huione Guarantee, a massive illicit marketplace in Southeast Asia that is known for handling ill-gotten funds that come from scams, human trafficking, and so on. Prior to that, the funds were consolidated into a single Tron address. 

Losing retirement savings Earlier this week, LaRoque's YouTube video, in which he details the devastating loss, went semi-viral. 

The investor revealed that he had been accumulating XRP for a total of eight years, only to lose all of his 1.2 million tokens to hackers. 

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The victim used an Ellipal wallet, mistakenly thinking that it was a cold wallet. However, it turned out the device was connected to the internet, which made it extremely vulnerable. "I thought I did all the things right," LaRoque said. 

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"About a year ago, I retired. My wife and I retired. We were planning on moving out to Las Vegas and buying a house…I don't know what we're going to do. I guess we're going to go back to work," he lamented in the video. 

Ellipal's response Ellipal stated that it was doing "everything possible" to assist the victim, adding that the massive theft happened due to the seed phrase being imported into the app. 

"One lesson our industry needs to do better with is not confusing with products when you offer both custodial and non-custodial products," ZachXBT said.

No chance of getting XRP back? ZachXBT believes that the odds of the victim getting his money back are rather low since crypto theft victims have limited access to law enforcement in the US. 

The blockchain sleuth claims that victims have to contact competent people in the private sector as soon as possible. At the same time, they should steer clear of predatory recovery firms. 

XRP is standing at $2.41 with a market cap of $144 billion and a 24-hour trading volume of $2.76 billion. The price danced within a range of $2.32 to $2.41, holding steady like a poker-faced pro after a rollercoaster ride.

Hyperliquid founder Jeff Yan has addressed criticism, suggesting the platform prioritizes protocol revenue over trader interests.

Summary

Jeff Yan says ADL saved traders millions during October 10 market crash.
Hyperliquid passed profits to users instead of maximizing protocol revenue.
Founder contrasts DeFi onchain transparency with CEX liquidation secrecy.

He also defended the exchange’s auto-deleveraging mechanism during the October 10 market crash.

Yan stated that ADL actions made users “hundreds of millions of dollars” by closing profitable short positions at favorable prices, while the platform’s liquidity pool passed on potential profits to users rather than maximizing its own returns.

The defense comes amid scrutiny of how decentralized perpetual exchanges handle liquidations during volatile market conditions.

Debunking the FUD that Hyperliquid prioritizes protocol revenue over traders

On 10/10, Hyperliquid ADLs net made users hundreds of millions of dollars by closing profitable short positions at favorable prices. If more positions had been backstop liquidated, HLP could have made…

— jeff.hl (@chameleon_jeff) October 18, 2025

Yan emphasized that if more positions had been backstop liquidated, HLP could have made hundreds of millions more in profit, but would have faced irresponsible risk exposure.

He also called the ADL approach a “win-win” that decreased platform exposure.

ADL formula prioritizes simplicity and user understanding
Yan explained that Hyperliquid’s ADL queue follows a similar formula to most centralized exchanges and incorporates both leverage used and unrealized profit on open positions.

Community feedback suggested more sophisticated ADL mechanisms, such as partially offsetting long and short positions in historically correlated assets.

Yan noted that increased complexity could improve performance but questioned whether the benefits merit the added complications.

The founder stated that research is ongoing into whether substantial improvements justify more complex formulas. However, he emphasized that no other major venues use more advanced logic for ADL queues.

Onchain transparency distinguishes DeFi from CEX practices
On October 13, Yan addressed the overall concerns about liquidation reporting by contrasting Hyperliquid’s fully on-chain operations with centralized exchange practices.

Yan called out centralized exchanges for underreporting user liquidations and cited Binance documentation showing that even when thousands of liquidation orders occur in the same second, only one gets reported.

This could be a 100x underreporting under certain conditions when liquidations happen in bursts.

Yan expressed hope that the industry will recognize transparency and neutrality as important features of the new financial system. He also encouraged other platforms to follow Hyperliquid’s approach to verifiable on-chain operations.

Cover image via U.Today

Disclaimer: The opinions expressed by our writers are their own and do not represent the views of U.Today. The financial and market information provided on U.Today is intended for informational purposes only. U.Today is not liable for any financial losses incurred while trading cryptocurrencies. Conduct your own research by contacting financial experts before making any investment decisions. We believe that all content is accurate as of the date of publication, but certain offers mentioned may no longer be available.

The week is ending bullish for most coins, according to CoinMarketCap.

Top coins by CoinMarketCapSHIB/USDThe price of SHIB has risen by 3.21% over the last 24 hours.

Image by TradingViewOn the hourly chart, the rate of SHIB has fixed above the local resistance of $0.00001011. If bulls can hold the gained initiative, the upward move is likely to continue to the $0.00001030-$0.00001050 range.

Image by TradingViewOn the bigger time frame, the price of SHIB is going up after a false breakout of the support of $0.00000956. However, buyers might need more time to accumulate energy for further growth.

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In this case, sideways trading in the area of $0.000010-$0.00001050 is the more likely scenario.

Image by TradingViewFrom the midterm point of view, the picture is quite the opposite. While the rate is below the $0.00001145 level, sellers are more powerful than buyers. In this regard, there is still a chance to witness a correction.

SHIB is trading at $0.00001017 at press time.

Ripple Labs, the company behind the XRP token, is planning to raise at least $1 billion to buy back XRP. The move shows Ripple's confidence in its token even as the crypto market faces pressure.

Bitcoin (BTC) has always been known for its dramatic price swings, often spiking or crashing with little warning. Yet, despite its volatility, one indicator has consistently served as a reliable guide for long-term accumulation: the 200-week moving average (200 WMA).

A well-known crypto analyst is urging investors to rethink the old trade of gold for Bitcoin, calling current market signals a rare buying window.

According to CryptoQuant author Joao Wedson, a set of bottom signals in the BTC/Gold ratio are flashing, and that could mark a turning point in how the two assets move against each other.

Rare Signals Point Toward Bitcoin
Wedson’s chart shows two tags — one blue and one green — that line up with a normalized oscillator he says is at a low. According to him, the blue tag marks a bottom in the BTC/Gold ratio while the green tag appears when both indicators reach lows together.

When that has happened before, it often came at times of steep Bitcoin drops and big swings in market mood. According to Wedson, today is a “historic opportunity” and that investors should now “trade gold for Bitcoin.”

Historic Opportunity: Trade Gold for Bitcoin. 🟡⮕₿

Bottom signals in the BTC/Gold ratio are extremely rare, and they tend to appear during high-volatility moments and sharp BTC drawdowns.

Well, we’re exactly there right now.

The blue signal marks the current bottom, revealed… pic.twitter.com/cWx2YGxd3t

— Joao Wedson (@joao_wedson) October 18, 2025

Arthur Hayes, the former BitMEX CEO, has echoed a similar view: “We’re exactly there right now,” he said, calling the setup one of the most compelling in recent years. The message from both analysts is clear: look closely at this moment.

Bitcoin Seen At A Deep Value Zone
Other market watchers find Bitcoin trading two standard deviations below its ideal range. This type of reading has in the past lined up with accumulation phases, not market tops.

Based on CoinMarketCap data, BTC was trading near $107,400 at press time and had risen 0.45% in the previous 24 hours. Year-to-date gains stood at 15%, and Bitcoin had gained nearly 55% over the last year.

Those figures were cited to show that the currency has already moved a lot this year, but that some measures still point to cheaper-than-usual levels.

BTCUSD currently trading at $107,545. Chart: TradingView
Institutional Shifts May Be Underway
Wedson specifically urged institutional players who have been buying up gold to rethink allocations. The BTC/Gold ratio has long been used as a gauge of confidence between the two stores of value.

When it hits a bottom, some market cycles have followed with Bitcoin regaining ground quickly and, in some cases, moving toward fresh highs within months. This is the historical pattern his signal is tied to.

Some of the language used by analysts was blunt; the oscillator was described as “basically screaming: time to sell gold and buy Bitcoin,” a phrase that underlines how strong the signal appears to those calling it.

Retail Losses Hit Billions
While the ratio story points to upside, a separate disclosure shows a different risk for ordinary investors. Reports from 10X Research say retail buyers lost around $17 billion after piling into public Bitcoin treasury firms that traded at premiums.

Those companies — including MicroStrategy (now Strategy) and Metaplanet — issued shares and used the cash to buy Bitcoin, but the equity premiums collapsed as Bitcoin’s run slowed.

The report added that investors overpaid by about $20 billion in inflated equity premiums, leaving many with losses while insiders and executives benefited earlier in the move.

Featured image from Unsplash, chart from TradingView

Cover image via U.Today

Disclaimer: The opinions expressed by our writers are their own and do not represent the views of U.Today. The financial and market information provided on U.Today is intended for informational purposes only. U.Today is not liable for any financial losses incurred while trading cryptocurrencies. Conduct your own research by contacting financial experts before making any investment decisions. We believe that all content is accurate as of the date of publication, but certain offers mentioned may no longer be available.

The market is mainly bullish at the end of the week, according to CoinStats.

ADA chart by CoinStatsADA/USDThe rate of Cardano (ADA) has increased by almost 4% since yesterday. Over the last week, the price has fallen by 1.1%.

Image by TradingViewOn the hourly chart, the price of ADA is going up after breaking the local resistance of $0.6462. If the daily candle closes above that mark, traders may see a test of the $0.67-$0.68 range shortly.

Image by TradingViewOn the bigger time frame, the rate of ADA keeps growing after it bounced back from the support of $0.6092. However, the volume remains low, which means there are low chances to witness increased volatility.

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All in all, sideways trading around the current prices is the more likely scenario.

Image by TradingViewFrom the midterm point of view, there are no reversal signals so far. The price is far from the main levels, confirming the absence of bulls' and bears' strength. In this case, traders are unlikely to see a bounce off soon.

ADA is trading at $0.6557 at press time.