Market Signal Briefing

Key Takeaways Ralph Lauren is driving growth through its iconic brands, product innovation and Next Great Chapter strategy.The company boosts digital performance with personalization, analytics-driven decisions and omnichannel gains.Ralph Lauren sees broad retail momentum, with 13% global DTC comparable sales growth in fiscal Q2 2026.
Ralph Lauren Corporation (RL - Free Report) continues to benefit from its iconic brand portfolio, constant product innovations and disciplined execution of its Next Great Chapter strategy. The company is accelerating its digital transformation by enhancing personalization, strengthening data-driven decision-making and delivering seamless omnichannel experiences.

Ralph Lauren is optimizing distribution, strengthening wholesale partnerships and enhancing its retail network to reinforce its premium positioning. The company has been experiencing significant growth in its digital channels across key regions. Leveraging advanced analytics, RL tailors product recommendations, optimizes pricing and sharpens its regional marketing strategies to drive stronger consumer engagement and profitability.

Ralph Lauren’s Next Great Chapter initiative serves as the foundation of its growth strategy, emphasizing brand elevation, consumer centricity and operational agility. This strategy is designed to create a more balanced global footprint by expanding into high-growth markets, such as Asia, while strengthening its presence in core regions. In second-quarter fiscal 2026, global direct-to-consumer comparable store sales increased 13%, backed by positive retail comps in all regions and channels.

Ralph Lauren’s retail and wholesale operations remain core pillars of its premium lifestyle business, contributing to a balanced and diversified revenue mix. Management is confident that the Next Great Chapter plan will drive sustainable growth, expand market share and reinforce its leadership in the luxury lifestyle space.

RL’s Price Performance, Valuation and EstimatesRalph Lauren’s shares have surged 54.3% year to date against the industry’s 14.9% decline.

Image Source: Zacks Investment Research

From a valuation standpoint, RL is trading at a forward price-to-earnings ratio of 21.77X compared with the industry’s average of 16.22X.

Image Source: Zacks Investment Research

The Zacks Consensus Estimate for RL’s fiscal 2026 and fiscal 2027 earnings per share (EPS) indicates year-over-year growth of 25% and 9.1%, respectively. The company’s EPS estimate for 2025 and 2026 has moved north in the past 30 days.

Image Source: Zacks Investment Research

Ralph Lauren currently carries a Zacks Rank #3 (Hold).

Key Picks in the Consumer Discretionary SpaceCrocs, Inc. (CROX - Free Report) , which is a leading footwear company, currently sports a Zacks Rank #1 (Strong Buy). You can see the complete list of today’s Zacks #1 Rank stocks here.

 CROX delivered a trailing four-quarter earnings surprise of 14.3%, on average. The Zacks Consensus Estimate for Crocs’ current financial-year EPS indicates a decline of 7.9% from the year-ago number.

Guess?, Inc. (GES - Free Report) , which is a designer and marketer of casual apparel and accessories, currently carries a Zacks Rank #2 (Buy).

GES delivered a trailing four-quarter earnings surprise of 45%, on average. The Zacks Consensus Estimate for GES’ current financial-year sales indicates growth of 8% from the year-ago number.

Kontoor Brands, Inc. (KTB - Free Report) , which is an apparel company, currently carries a Zacks Rank of 2.

The Zacks Consensus Estimate for KTB’s current financial-year EPS is expected to rise 12.5% from the corresponding year-ago reported figure. KTB delivered a trailing four-quarter earnings surprise of 14%, on average.

KeyCorp (KEY) Goldman Sachs 2025 U.S. Financial Services Conference December 9, 2025 8:40 AM EST

Company Participants

Christopher Gorman - Chairman, President & CEO

Conference Call Participants

Ryan Nash - Goldman Sachs Group, Inc., Research Division

Presentation

Ryan Nash
Goldman Sachs Group, Inc., Research Division

So up next, we're once again excited to have KeyCorp joining us at the conference. Key's had another strong year, driving return improvement through significant margin expansion and fee growth, which has resulted in best-in-class operating leverage, more recently it began returning additional capital via share repurchase and should be another lever help it achieve its 15% ROTCE return by year-end '27.

Here to tell us more about how they're going to achieve these goals is Chairman and CEO, Chris Gorman. Today's discussion will be a fireside chat. So welcome, Chris.

Christopher Gorman
Chairman, President & CEO

Well, thanks, Ryan, and it's great to be here. I always enjoy coming to your conference.

Question-and-Answer Session

Ryan Nash
Goldman Sachs Group, Inc., Research Division

Absolutely. Appreciate having you here. So maybe just to start off, Chris, as we wrap up 2025 maybe talk a little bit about what are some of the big accomplishments you're most proud of as an organization. And conversely, any areas in retrospect that could have gone a little bit better? And what areas you focus on improving into 2026?

Christopher Gorman
Chairman, President & CEO

Sure. Let me start with 2025, and I'll just give you kind of a brief recap. It was a really important year for us. So in 2025, we celebrated our 200th birthday. And that in and of itself isn't of all that import. But what was important is I was out in the market, probably 50 separate sort of town hall meetings with 300 clients. And I couldn't help but really be energized by how

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nCino, Inc. ( NCNO ) Raymond James TMT & Consumer Conference December 9, 2025 11:20 AM EST Company Participants Gregory D. Orenstein - CFO & Treasurer Conference Call Participants Alexander Sklar - Raymond James & Associates, Inc., Research Division Presentation Alexander Sklar Raymond James & Associates, Inc., Research Division All right.

UNH Stock rebounds after a turbulent 2025, as investors weigh healthcare costs and regulatory risks.

NurPhoto via Getty Images

UnitedHealth’s stock has generally underperformed compared to some rivals over the last year, but how does it stand against competitors in the ever-changing healthcare landscape? An in-depth analysis shows strong profitability, consistent revenue growth, and reasonable valuation support. However, the potential for ongoing outperformance might be constrained if regulatory challenges or new sector issues escalate.

UNH's 6.1% operating margin, the highest among competitors, gains from its high-margin Optum division, even with recent pressures on Medicare utilization.UNH's 10.5% revenue growth, surpassing CVS but trailing behind CNC/MOH, is enhanced by Optum's services and the expansion of government program memberships.UNH stock has declined by 39.4% (1 yr), underperforming peers, and is trading at a P/E of 17.8x due to rising medical costs and uncertainties in regulation and leadership.Here’s how UnitedHealth measures up in terms of size, valuation, and profitability compared to key peers.

comparison

Trefis

For additional information on UnitedHealth, read Buy or Sell UNH Stock. Below, we analyze UNH's growth, margins, and valuation in comparison to peers over the years.

Revenue Growth Comparisonrev comps

Trefis

Operating Margin Comparisonop margin comps

Trefis

PE Ratio ComparisonP/E

Trefis

Still uncertain about UNH stock? Consider a portfolio strategy.

The Best Investors Think In PortfoliosIndividual stocks can fluctuate significantly, but staying invested is essential. A well-constructed portfolio allows you to remain invested, take advantage of upward movements, and cushion losses from single stocks.

The Trefis High Quality (HQ) Portfolio, comprising 30 carefully selected stocks, has a proven history of outperforming its benchmark, which includes all three indices – the S&P 500, S&P mid-cap, and Russell 2000. What accounts for this? Collectively, HQ Portfolio stocks deliver superior returns with reduced risk when compared to the benchmark index; they present a steadier investment experience, as shown in the HQ Portfolio performance metrics.

Google faces a fresh antitrust investigation in Brussels over whether it ripped off copyrighted material to train its artificial intelligence models without properly compensating publishers, the European Commission announced Tuesday.

The European Union’s antitrust cops expressed concern that Google used web publishers’ articles and videos to build its “AI Overviews” search summary feature and “AI Mode” search function without paying them or allowing them to opt out.

The investigation is centered on Google’s handling of articles from news publishers and content creators, as well as videos uploaded to YouTube.

EU Executive Vice-President for Clean, Just and Competitive Transition Teresa Ribera gestures during a press conference on an EU global climate and energy vision at the EU headquarters in Brussels on Oct. 16. AFP via Getty Images
“AI is bringing remarkable innovation and many benefits for people and businesses across Europe, but this progress cannot come at the expense of the principles at the heart of our societies,” EU antitrust chief Teresa Ribera said in a statement.

The investigation could further raise tensions between the EU and the Trump administration, which has been critical of the 27-member bloc’s ongoing campaign of fines and penalties against US tech companies.

A Google spokesperson said the EU’s inquiry “risks stifling innovation in a market that is more competitive than ever.”

“Europeans deserve to benefit from the latest technologies and we will continue to work closely with the news and creative industries as they transition to the AI era,” the spokesperson added.

In September, the EU slapped Google with a $3.4 billion fine after determining it broke competition rules related to advertising technology. President Trump blasted that action as “discriminatory.”

Google CEO Sundar Pichai addresses the crowd during Google’s annual I/O developers conference in Mountain View, Calif., on May 20. (Photo by Camille Cohen / AFP) AFP via Getty Images
Earlier this week, Trump warned Europe to be “very careful” after it imposed a $140 million fine on Elon Musk’s social media platform X for alleged violations of the EU’s content moderation policies.

At the same time, Google and other tech firms remain under intense scrutiny within the US over their AI training practices.

As The Post reported, a group of top conservatives including ex-Trump adviser Steve Bannon recently demanded that the administration reject Big Tech’s argument that its use of copyrighted material is protected by so-called “fair use doctrine.”

Meanwhile, Mark Zuckerberg’s Meta, which is locked in a fierce AI competition with Google, recently announced a new set of licensing deals with top publishers, including CNN and Fox News.

Fox News shares a common owner with News Corp, which publishes The Post.

Minneapolis, MN, Dec. 09, 2025 (GLOBE NEWSWIRE) -- Sezzle Inc. (NASDAQ:SEZL) (Sezzle or Company) // Purpose-driven digital payment platform, Sezzle, today announced it will join the S&P SmallCap index, effective after market close on Friday, December 12, 2025. The S&P SmallCap 600 seeks to measure the small-cap segment of the U.S. equity market. 

“Our inclusion in the S&P SmallCap 600 highlights the progress Sezzle has made and sets the stage for our next phase of growth. It marks another step in strengthening the foundation we’re building on,” said Charlie Youakim, Sezzle Executive Chairman and CEO. 

Contact Information 

Lee Brading, CFA 
Investor Relations 
+651 240 6001 
[email protected]    Erin Foran 
Media Enquiries  
+651 403 2184 
[email protected]    About Sezzle Inc. 
Sezzle is a forward-thinking fintech company committed to financially empowering the next generation. Through its purpose-driven payment platform, Sezzle enhances consumers' purchasing power by offering access to point-of-sale financing options and digital payment services—connecting millions of customers with its global network of merchants. Centered on transparency, inclusivity, and ease of use, Sezzle empowers consumers to manage spending responsibly, take charge of their finances, and achieve lasting financial independence. 

For more information visit sezzle.com. 

Amkor Technology, Inc. (AMKR) Presents at 53rd Annual Nasdaq Investor Conference Transcript

Ascent Industries Co. (ACNT) Presents at IAccess Alpha Virtual Best Ideas Winter Investment Conference 2025 Transcript

Trusted Editorial content, reviewed by leading industry experts and seasoned editors. Ad Disclosure

Renowned analyst Peter Brandt has unveiled a new set of Bitcoin price targets that have quickly sparked discussion across trading communities. His updated technical roadmap comes as BTC shows signs of cooling, prompting traders to reassess its recent price movement. With Bitcoin slipping beneath the structure that supported its multi-month climb, Brandt’s projected corrective zones have become a central focus in the market’s debate over where the asset may be headed next.

Bitcoin Price’s Structural Breakdown Raises The Stakes For Crypto Traders
In a recent post on X, Brandt outlined his latest outlook, highlighting a completed five-leg advance — a classic sequence often linked to trend exhaustion when price stretches too far without meaningful resets. In this case, the formation appears as a rising wedge, a pattern known for producing sharp shifts once its lower boundary is breached. That breach has now happened, marking what Brandt interprets as a structural turning point rather than a panic-driven drop.

Source: Peter Brandt on X
From the breakdown, two corrective regions emerge: near $81,852 and $59,403. These targets are drawn directly from the proportions of Bitcoin’s recently completed structure, giving them a grounded, technical foundation. Brandt frames the pullback as a normalization event, one that fits neatly into Bitcoin’s historical rhythm of expansions followed by methodical cooldowns. Instead of portraying the situation as a threat to long-term strength, the analysis positions the zones as potential resting points where the market could stabilize before setting its next course.

There is also a familiar pattern echoing through the charts — a reminder of late 2021, when sentiment surged ahead of structural reality and the market eventually recalibrated. While conditions today are not identical, the resemblance underscores how expectations and chart formations often move in parallel. In both scenarios, a strong run gave way to a controlled corrective period.

Brandt’s roadmap follows a clear sequence: formation completion, slope-line violation, and defined landing zones. Each step reinforces the next, forming a cohesive narrative that explains why this chart has quickly gained traction among crypto traders monitoring short-term volatility.

Brandt’s Targets Offer Strategic Guidance For Crypto Traders
Bitcoin is currently trading at $90,175, reflecting a 1.9% dip over the past 24 hours alongside a 4.4% gain across the last seven days. The price sits close to the level where the structural break first appeared, amplifying interest in Brandt’s outlined targets. Traders are now assessing whether the asset is preparing for a deeper corrective sweep or simply entering a consolidation phase before another directional move.

Ultimately, Brandt’s targets are intended to guide traders rather than alarm them. They highlight likely equilibrium zones during routine market resets, offering reference points where Bitcoin could stabilize after extended rallies. By framing the analysis this way, traders are encouraged to approach the market with a measured strategy and sharper precision, rather than reacting impulsively to short-term fluctuations.

BTC moves low after recovery | Source: BTCUSD on Tradingview.com
Featured image created with Dall.E, chart from Tradingview.com

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I'm Sandra White, a writer at Bitcoinist, and I provide the latest updates on the world of cryptocurrencies. I believe crypto a gateway to a new order and I have made it my life's mission to help educate as much people as possible.
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XRP trades near $2.05 after a volatile month that shows an 8.75% decline over the last 30 days and a short-term recovery of 2.02% this week. 

Traders now track a tightening symmetrical triangle formation that compresses price action toward a decisive breakout point. The structure shows converging trendlines that guide shrinking volatility, and the setup forms as buyers and sellers test control near a narrow compression zone.

The pattern signals a squeeze where a break from the current level creates a path toward a 16% move. A clean move above the resistance line projects a target near $2.40, which is the distance implied by the width of the formation. Traders monitor this level because the setup forms during a period where sentiment remains mixed across the wider market.

Symmetrical Triangle Shapes Market SentimentThe one-hour XRPUSDT chart shows a clear series of lower highs and higher lows that create the triangular structure. Price swings contract toward the apex as liquidity rotates through short bursts of buying and selling. Traders often treat this pattern as a continuation signal, yet failed breakouts can also appear when broader market conditions shift.

Source: X

The market entered this formation after selling pressure from large holders weighed on the recovery that followed the launch of XRP exchange-traded products. Bitcoin’s drop under $90,000 sparked forced selling across altcoins, and XRP saw a sharp reaction that left the token down 43% from its record peak.

The stall in upside momentum now leaves this triangle pattern as a key area of interest. Market participants track the breakout zone because the trend direction often strengthens once the price exits the tightening structure.Several recent $XRP developments point out and back the 16% bullish move.

Ripple Draws $500 Million From Wall Street InvestorsRipple’s November capital raise introduced a significant development that intersects with the current market environment. Bloomberg reports that the company secured $500 million through a structured deal that gives investors downside protection and defined return mechanics. Citadel Securities, Fortress, Marshall Wace, Brevan Howard-linked entities, Galaxy, and Pantera joined the round, which placed Ripple’s valuation at $40 billion.

The structure of the agreement played a central role. Investors negotiated a right to sell shares back to Ripple after three or four years with a 10% annual return, while a forced repurchase lifts the return to 25% each year. A liquidation-preference clause also ensures priority in the event of a sale or restructuring.

XRP ETFs Near a Major MilestoneU.S. spot XRP ETFs continue to draw inflows that push the products toward a $1 billion threshold. Data from SoSoValue shows $897.35 million in cumulative inflows after a 15-day streak of net buying that stretches across providers such as Canary Capital, Grayscale, Bitwise, and Franklin Templeton.

Market analysts link the strong inflows to the regulatory clarity that followed the conclusion of Ripple’s court case with the U.S. Securities and Exchange Commission in August. The case established that XRP does not fall under securities classification, which opened a path for broader institutional participation. This wave of structured access mirrors the early growth patterns seen during the launch cycles of Bitcoin and Ethereum ETFs.

Institutional and Global Adoption Shapes Long-Term OutlookRipple continues to expand its global presence through RippleNet as banks across regions engage its cross-border payment infrastructure. Institutions in the Middle East, Latin America, Africa, and Southeast Asia integrate Ripple products as demand for faster settlement increases. Countries such as the UAE, Saudi Arabia, Brazil, Nigeria, and Mexico lead adoption through banks and payment firms that use Ripple’s technology for remittances and liquidity flows.

Ripple’s RLUSD stablecoin now sits near a $1.3 billion market cap as multi-chain expansion across the XRP Ledger and Ethereum drives usage. The dual approach creates access to low-cost settlement and deep liquidity pools, which accelerates adoption in both ecosystems.

The combination of rising ETF inflows, structured Wall Street exposure, and expanding global integration now forms the backdrop for XRP’s tightening chart pattern, which approaches a decisive breakout zone that traders continue to watch closely.

Key NotesPNC Bank partners with Coinbase to enable institutional clients to trade Bitcoin directly through their banking platform.The ninth-largest US bank by assets eliminates the need for customers to maintain separate cryptocurrency exchange accounts.This move reflects growing institutional adoption as traditional banks integrate digital assets into their services.
US banking giant PNC Bank has launched direct Bitcoin

BTC
$93 950

24h volatility:
4.5%

Market cap:
$1.88 T

Vol. 24h:
$52.27 B

trading for qualified institutional clients, making it the first major US-based banking firm to do so.

PNC Bank is the ninth-largest US bank by assets as of Q3, 2025. The firm has partnered with Coinbase, the second largest cryptocurrency exchange by volume, to launch its direct trading services.

According to a Nov. 9 press release, approved PNC Private Bank clients can now buy, sell, and hold Bitcoin directly through their accounts on PNC’s digital banking platform via Coinbase’s Crypto-as-a-Service (CaaS) function. This eliminates the need for qualified PNC customers to create and operate a separate exchange account to facilitate bridged cryptocurrency trading.

Today marks a major milestone for institutional crypto adoption.@Coinbase’s Crypto-as-a-Service platform is now powering @PNCBank’s launch of direct bitcoin trading for PNC Private Bank clients – the first to market with such an offering among the major U.S. banks. pic.twitter.com/wwuOIRuBfK

— Coinbase Institutional 🛡️ (@CoinbaseInsto) December 9, 2025

Expanding Fiat-to-Crypto Bridges
PNC Bank announced its intent to begin direct crypto trading back in July during a noteworthy third quarter for the company. According to data from S&P Global, the bank’s parent company, PNC Financial Services Group Inc., recorded the third-highest sequential increase in total assets among US banks for the quarter, with 6.5% growth.

Much of this growth can be attributed to PNC’s acquisition of FirstBank Holding Co. for $4.04 billion which stood as one the largest bank deals announced in 2025.

According to the aforementioned press release, PNC bank clients accessing the platform’s crypto trading services can buy, sell, and hold Bitcoin directly through their accounts. It’s unclear at this time if and when other cryptocurrencies will be added for trading on the service.

PNC’s further expansion into Bitcoin trading comes as traditional finance institutions across the banking industry clamor to integrate digital assets such as cryptocurrency and stablecoins into their platform.

Bank of America, for example, recently advised its clients to allocate up to 4% of their portfolios in cryptocurrency despite recent turbulence in the cryptocurrency market.

Disclaimer: Coinspeaker is committed to providing unbiased and transparent reporting. This article aims to deliver accurate and timely information but should not be taken as financial or investment advice. Since market conditions can change rapidly, we encourage you to verify information on your own and consult with a professional before making any decisions based on this content.

Coinbase News, Cryptocurrency News, News

Tristan is a technology journalist and editorial leader with 8 years of experience covering science, deep tech, finance, politics, and business. Before joining Coinspeaker, he wrote for Cointelegraph and TNW.

Tristan Greene on X

By

PYMNTS
 | 
December 9, 2025

 | 

PNC Bank now enables eligible clients of its PNC Private Bank to buy, hold and sell bitcoin directly through its digital banking system.

These direct spot bitcoin trading capabilities are powered by Coinbase’s Crypto-as-a-Service (CaaS) infrastructure, the companies said in a Tuesday (Dec. 9) press release.

The capabilities mark the first offering launched as part of the partnership between PNC and Coinbase that was announced in July, according to the release.

In future phases of the rollout of this offering, PNC plans to add enhanced features and services and to expand access to more client segments, per the release.

“As client interest in digital assets continues to grow, our responsibility is to offer secure and well-designed options that fit within the broader context of their financial lives,” PNC Chairman and CEO William S. Demchak said in the release.

Brett Tejpaul, co-CEO of Coinbase Institutional, said in the release: “This collaboration demonstrates how traditional financial institutions and on chain-native companies can work together to expand access to digital assets in a safe and compliant way.”

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Coinbase International focuses on expanding Coinbase’s institutional client base and introducing features and services expected by institutional investors, Tejpaul and Greg Tusar, head of institutional product at Coinbase, wrote in a January blog post.

When PNC and Coinbase announced their partnership in July, they said that in addition to allowing the bank’s clients to buy, hold and sell cryptocurrencies, PNC would add other crypto financial solutions for its clients and provide select banking services to Coinbase.

Demchak had said during the bank’s July earnings call that PNC would be adding solutions related to cryptocurrency and stablecoins.

“First off, you should expect to see from us announcements with respect to using our payment technology to help crypto companies,” Demchak said. “Now we are allowed to bank people in that business and just given our raw capabilities, you would expect that we’ll get some meaningful clients there.”

It was reported Wednesday (Dec. 3) that Coinbase CEO Brian Armstrong said his company is working with some of the biggest U.S. banks on pilot programs testing stablecoins, crypto custody and trading. Armstrong did not name the banks.

“The best banks are leaning into this as an opportunity,” Armstrong said at the New York Times DealBook Summit. “The ones who are fighting it are going to get left behind.”

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Bitcoin and other major cryptocurrencies are suddenly flying high on Tuesday, surging in value ahead of Wednesday's Federal Reserve meeting conclusion that's widely expected to bring a third interest rate cut. And that's led to a growing pile of short positions getting liquidated—a rarity of late.

Bitcoin was recently trading above $94,400, the highest price registered since mid-November, according to price aggregator CoinGecko. The price of the leading cryptocurrency had been hovering around the $90,000 mark prior to Tuesday morning's spike, with the coin now showing a 5% climb over the past 24 hours. It's now up about 4% on the week.

Altcoins are faring even better, however, with Ethereum extending its recent rebound with an 8% daily spike to a recent price of $3,359, pushing its weekly gain to more than 16%—the largest spike among the top 10 cryptocurrencies during that span.

XRP, meanwhile, is up about 5% on the day to $2.17, with Solana rising 6% to $144 and Dogecoin up 6% to $0.15.

Crypto traders betting on the future performance of top assets are being hit with liquidations on Tuesday, and while most of the major liquidation days in recent months have been focused on long positions hit by falling prices, it's mostly shorts getting pummeled on the day.

Over $376 million worth of positions have been liquidated over the last day, per data from CoinGlass, with shorts making up $297 million of those. Bitcoin currently dominates the crypto carnage, accounting for about $153 million worth of impacted positions, with Ethereum next up at $110 million.

What's driving Tuesday's price surge? The Federal Open Markets Committee (FOMC) began its latest meeting on Tuesday, with the gathering expected to produce the year's third rate cut when the meeting ends on Wednesday. According to CME FedWatch data, interest rate traders currently project a nearly 90% chance that the Fed issues another 25 bps rate cut.

Bitcoin and other risk assets typically perform well in a low interest rate environment, though Tuesday's crypto surge could mean that traders are buying the rumor—with plans to sell the news on Wednesday.

Users on Myriad—a prediction markets platform operated by Decrypt's parent company, Dastan—are increasingly bullish on the prospect of Bitcoin returning to a price of $100,000 sooner than it will crash to $69,000, giving the spike a nearly 80% chance as of this writing. That mark has climbed by 9% over the last day.

Daily Debrief NewsletterStart every day with the top news stories right now, plus original features, a podcast, videos and more.

PNC launches direct Bitcoin trading via Coinbase as charts mirror 2021 double top, hinting at possible $100,000 retest.

Tatevik Avetisyan2 min read

9 December 2025, 05:06 PM

PNC Bank’s move to plug direct Bitcoin trading into its private-bank platform lands on the same day chart analyst Ted Pillows maps a possible return toward the $100,000 area. Together, the bank’s partnership with Coinbase and the repeat of a 2021-style double-top pattern frame a market where Wall Street access is widening even as technicals hint at one more big swing before the next downturn.

PNC Launches Direct Bitcoin Trading Through Coinbase PartnershipPNC Bank opened direct Bitcoin trading for its private-bank clients today, becoming the first major U.S. bank to place spot BTC buying and selling inside its own platform. The bank switched on the feature on December 9, using Coinbase’s Crypto-as-a-Service infrastructure to route trades and handle custody.

PNC said the rollout gives eligible clients a way to buy, sell and hold Bitcoin without leaving the bank’s digital environment. The service sits inside PNC’s existing private-bank dashboard, so users can move between traditional accounts and Bitcoin balances in one place. The bank confirmed that Coinbase powers the trading engine on the back end.

The move follows a partnership the two companies announced earlier this year. At the time, PNC said it wanted to build crypto tools directly into its wealth-management business. Today’s launch marks the first major U.S. bank to offer this type of direct spot Bitcoin access rather than only ETFs or third-party referrals.

Bitcoin Repeats a 2021 Pattern as Chart Shows Double-Top and BounceMeanwhile, Bitcoin is tracing a structure that closely resembles its 2021 cycle, according to fresh weekly-chart analysis from market watcher Ted Pillows. His chart shows two rounded tops forming near record levels, followed by a sharp pullback and a quick rebound from support. The pattern mirrors the double-top sequence that shaped the market in late 2021 before the deeper decline of 2022.

Bitcoin Double Top Pattern. Source: TedPillows

The chart highlights how price recovered from the first drop and pushed back toward the prior peak. The same behavior appears on the current weekly candles, with Bitcoin bouncing from the mid-$80,000 support zone after a steep slide from the highs near $128,000. Ted notes that this rebound fits the same rhythm Bitcoin showed three years ago, when a brief rally followed the initial downturn.

He added that the repeated structure leaves room for one more push higher. His chart marks a potential path toward the $100,000 to $105,000 range before momentum fades again. The analysis points to the same shaded support area acting as the pivot in both cycles. In 2021, that level held once more before sellers regained control and drove price into the following year’s decline.

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Tatevik Avetisyan

Michael Saylor, the founder and executive chairman of Strategy, has revealed a major shift in traditional finance, where Wall Street’s largest banks are now providing credit backed by Bitcoin as collateral. 

According to Saylor, six banks that were crypto skeptics have flipped to active participants in just 12 months, far ahead of the 4–8 year timeline experts once predicted. The Bitcoin evangelist explained that Citi, JPMorgan, Wells Fargo, BNY Mellon, Charles Schwab, and Bank of America have all entered the crypto lending market in the last six months alone.

At the Binance Blockchain Week in Dubai, Saylor said that the top 10 US banks now facilitate crypto lending, up from zero in Q4 2024. This was driven by Basel III reforms that classified Bitcoin as a Tier 1 asset, as well as a rise in demand for BTC-backed credit facilities. 

According to data from a PwC report and Kaiko Research, $50 billion in new credit lines has been issued since September 2025. Banks captured 40% of the $150 billion annualized crypto lending market. 

Saylor emphasized lending as the “tipping point,” with banks offering loans at 50-70% loan-to-value (LTV) ratios on Bitcoin collateral at interest rates of 4-6%. This is lower than DeFi alternatives.

JPMorgan leads in BTC-backed lending
JPMorgan has been a leader in lending backed by BTC. CEO Jamie Dimon, once a Bitcoin skeptic, softened his stance on the crypto earlier this year. As reported by Cryptopolitan, the company launched a $10 billion credit facility against Bitcoin collateral in October. 

This extended its June 2025 policy, allowing clients to use spot Bitcoin ETFs (e.g., BlackRock’s IBIT) as collateral for loans across trading and wealth management.

According to reports, the company has announced plans for potential 2026 direct lending against BTC/ETH. This facility exemplifies Saylor’s point on banks issuing USD loans at low rates against BTC.

Wells Fargo joined the BTC lending wave in Q4 2025. It offers credit against Bitcoin ETFs and holdings following Basel III updates. It is now listed among the top banks facilitating crypto loans. Exploratory discussions on stablecoins have evolved into active BTC collateral programs. 

Saylor referenced Wells Fargo’s Q4 shift, noting it “followed suit” after JPMorgan’s facility, with internal blockchain tests upgraded for tokenized BTC deposits, enabling credit issuance.

BNY Mellon expanded Bitcoin custody to include lending in Q4 2025, holding BTC for ETFs and issuing credit against it. According to reports, the bank issued trials of blockchain deposits for $2.5 trillion in payments, tokenizing BTC holdings for instant settlement and collateral use. According to Saylor, BNY’s ETF custody is a gateway to $50 billion in new credit lines.

Citi, BOF, and Charles Schwab’s aggressive 2026 entry into BTC custody and credit
Other banks have outlined their plans for next year. Citi is actively preparing to launch Bitcoin custody and lending services in 2026.  A report made this month revealed Citi’s integration of CIDAP (Crypto Infrastructure for Digital Asset Platforms) to enable BTC-backed credit.

Additionally, at the beginning of Q4, Citi’s global head of partnerships confirmed that the bank has spent 2-3 years developing in-house and third-party custody solutions for native crypto coins like Bitcoin, targeting asset managers.

Bank of America will allow all of its affluent clients to invest 1% to 4% of their portfolios in crypto coins through Merrill and Private Bank, with an emphasis on Bitcoin ETFs as a collateralized form of investment, starting January 5, 2026.

Charles Schwab announced an aggressive 2026 entry into BTC custody and credit. The bank is set up for spot Bitcoin/Ethereum trading, as well as stablecoin issuance. CEO Rick Wurster confirmed that the $11.8 trillion platform will offer direct BTC trading in H1 2026, with lending against holdings via integrated brokerage. Saylor called it a “major change” for 37 million accounts.

Still, none of the six banks Michael Saylor mentioned hold Bitcoin or any other crypto coin directly on their own corporate balance sheets. US banking regulations and Basel III capital rules still make direct spot crypto ownership highly restrictive and capital-intensive for regulated banks.

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Bitcoin sits between two major liquidity blocks, creating a tight range that now anchors the broader market’s next move. At the same time, Ethereum’s ratio against Bitcoin is breaking its downtrend, adding a second signal that rotation and volatility may soon pick up.

ETHBTC Breaks Its Downtrend as Chart Shows First Clean Retest and LiftEthereum’s ratio against Bitcoin is showing its clearest bullish structure in months after breaking out of the descending channel that shaped the entire autumn move. The chart from BitBull highlights how price pushed above the upper trendline for the first time, paused on a clean retest and then turned higher again. That sequence often signals a shift in momentum as sellers lose control of the range.

ETHBTC Breakout Retest Pattern. Source: BitBull

The breakout followed weeks of lower highs inside the channel. Each attempt to recover stalled under the same diagonal resistance until this week’s close pushed through it. That move set the stage for the retest, where ETHBTC dipped back toward the trendline but held the level instead of sliding beneath it. The candles in that zone stayed tight, showing that buyers continued to absorb pressure.

Now the ratio is lifting off the retest area with a stronger push than earlier bounces. The candles forming above the trendline show the shift from defense to offense as the pair tries to build a higher structure. BitBull notes that this type of breakout–retest–continuation pattern often marks the early phase of a broader uptrend when market conditions support rotation into Ethereum.

Bitcoin Liquidity Map Shows Heavy Cluster at 93K–94K While Price Stays Range-BoundMeanwhile, Bitcoin’s latest liquidity heatmap points to a dense cluster of resting orders between 93,000 and 94,000 dollars, according to data shared by Daan Crypto Trades. The CoinGlass map shows thick bands of liquidity in that zone, suggesting many leveraged positions and pending orders sit just above the current range. That area now stands out as the nearest pocket where a sharp move could trigger larger liquidations.

Bitcoin Liquidity Heatmap 93K–94K Cluster. Source: Coinglass / Daan Crypto Trades

Below the market, the chart flags 87,000 dollars as the next important band, although the liquidity there appears thinner. The stripes around that level are less intense, which means there is still interest but not the same concentration seen higher up. If price moves down, the 87,000 region remains a reference point, yet it does not show the same weight of clustered orders as the overhead block.

Between these bands, Bitcoin continues to trade sideways, with candles sliding back and forth across the same intraday levels. The structure reflects a market that is still searching for direction while leverage builds around clear zones. As a result, traders watch the heatmap for confirmation of a breakout from the current range, since a decisive move into either cluster would likely release a new wave of volatility.

Bitcoin Treasuries Surpass 4 Million as Institutional Demand AcceleratesOn-chain data from Coin Bureau shows Bitcoin treasuries have surpassed 4 million BTC, one of the asset’s biggest milestones. 

Source: Coin BureauTherefore, this total reflects combined holdings across public and private companies, ETFs, governments, custodians, and emerging DeFi protocols now using Bitcoin as collateral.

The surge in institutional accumulation signals a major evolution in Bitcoin’s role within global finance. Once a niche digital experiment, Bitcoin has become a strategic reserve asset for leading corporations, with MicroStrategy and others reinforcing their balance sheets through long-term BTC holdings. 

At the same time, spot ETFs across the U.S., Europe, and Asia are accelerating mainstream adoption,providing regulated, accessible exposure that is drawing in both institutional capital and everyday investors.

Governments have also helped push Bitcoin past this historic milestone. El Salvador, the first country to adopt BTC as legal tender, continues to grow its reserves, while other nations quietly accumulate through strategic diversification or asset seizures. 

These rising state-level holdings underscore Bitcoin’s evolution from a speculative asset to a geopolitically relevant store of value.

Custodians and major asset managers have further accelerated this trend. As demand for secure, compliant BTC storage surges, institutional-grade custody solutions are enabling pension funds, hedge funds, and insurance firms to enter the market with confidence. This infrastructure boom has transformed Bitcoin from a niche technology into a fully integrated component of global financial portfolios.

Well, DeFi’s growing integration of Bitcoin marks a new frontier for the asset. Protocols now using BTC as collateral and liquidity are effectively bridging the gap between the world’s largest digital currency and decentralized finance, laying the groundwork for Bitcoin to function as a core layer of on-chain financial infrastructure.

Surpassing 4 million BTC in global treasuries signals more than aggressive accumulation, it reflects a structural realignment in modern finance. 

As corporations, governments, ETFs, and custodians embed Bitcoin into their balance sheets and product offerings, its identity is evolving from a speculative asset to a strategic institutional cornerstone. 

With only 21 million coins ever to exist, this accelerating adoption amplifies Bitcoin’s scarcity narrative and reinforces its long-term value proposition.

Top U.S. Bank CEOs to Meet Senators on December 11 to Shape Crypto Market StructureIn a notable shift for traditional finance, top U.S. bank CEOs have been called to a closed-door Senate meeting on December 11 to discuss the future of crypto market structure. 

According to analyst Diana, leaders from Citi, Bank of America, and Wells Fargo, long skeptical of digital assets, are now helping shape the regulatory framework they once resisted.

This comes at a pivotal moment for U.S. finance, as crypto adoption accelerates amid regulatory gaps and growing institutional demand for safer, clearer entry points. Engaging legacy banking leaders signals lawmakers’ push toward a more coordinated, mainstream framework for crypto oversight.

Banks may be driven by more than regulatory compliance. With crypto ETFs gaining traction, blockchain payment systems maturing, and tokenized assets entering institutional adoption, major banks risk losing relevance if they stay on the sidelines. Shaping regulatory frameworks could give them a strategic advantage as digital assets integrate with traditional finance.

For the crypto sector, the outcome is double-edged. Collaboration with banks and lawmakers could finally deliver regulatory clarity, attracting institutional capital and enhancing legitimacy. Yet critics warn that excessive bank influence may produce restrictive rules that favor incumbents and stifle innovation.

What does this show? Well, the symbolism is clear; institutions that once urged regulators to shun crypto are now invited to shape its future. December 11 could mark more than a policy discussion, it may be the moment Wall Street moves from observer to architect in the digital asset ecosystem.

ConclusionBitcoin crossing 4 million coins in institutional and sovereign treasuries marks more than a milestone, it signals a shift in global finance. As corporations, governments, and investment funds secure significant supply, Bitcoin is evolving from speculation to a strategic financial asset. 

With demand rising and supply tightening, it’s positioning itself as a key driver in economic policy, capital allocation, and long-term wealth preservation.

On the other hand, The December 11 meeting could mark a pivotal shift in the U.S. crypto landscape, as lawmakers and top banks collaborate to provide long-awaited clarity and structure. 

This convergence of traditional finance and digital assets may redefine regulatory frameworks and cement Wall Street’s role in building a secure, accessible, and innovative crypto ecosystem, potentially shaping the next era of mainstream cryptocurrency adoption.

ETH rallied above $3,300 after a mostly positive day for the crypto market. The token kept seeing inflows from whales, as well as another big purchase from Bitmine. 

ETH continues to see interest from large-scale players, including whales, in both spot and derivative markets. 

ETH rallied late on Tuesday, after a short squeeze liquidated positions above $3,300. | Source: Coingecko
ETH recovered above $3,200 after a short squeeze, following a day of rebuilding short liquidity. The token continued its expansion to $3,342.21. The last price move caused $36.3M in long liquidations for the past 24 hours, of which close to 50% were on Binance. 

The latest price moves showed a quick return to speculation, as traders opened new positions just as the token showed signs of a directional move. Open interest spiked within a short timespan, from $17.6B to $18.5B. However, traders opened new positions on the short side, suggesting the rally may be short-lived. 

Bitmine has $1B to buy more ETH
Bitmine revealed it had been buying more ETH in the past week, expanding its treasury to $12.05B. 

The treasury company has $1B remaining to make more purchases, after last week’s addition of over $138K ETH. Bitmine expanded its treasury by 13.8% in the past month, resuming more frequent purchases in December.

Treasury companies have slowed down their buying, but still added more ETH to their balance in December. BMNR shares responded by bouncing off their lows, rising to $38.60, around the middle of their range for the past few months. BMNR has secured its financing and is one of the predictable buyers of ETH. 

Hyperliquid whales go long on ETH
Hyperliquid whales also took high-profile positions in ETH, currently sitting on outsized unrealized gains. 

The 1011 whale, who was known for shorting BTC just before the October drop, expanded the unrealized gains from $3M to over $18M. The whale keeps paying fees of over $100,000 to retain the position, and has not closed to take profits. 

On-chain data shows whale currently holds the biggest long position on Hyperliquid, with a notional value of $269M. 

Hyperliquid whales are sitting on growing unrealized gains from their aggressive long positions. | Source: Coinglass
The second position was built by the ‘Anti-CZ’ whale, and is valued at $174M, with unrealized gains of over $6M. In the third spot is an older whale that quickly aped into ETH, with $1.6M in unrealized gains. Machi Big Brother, another notorious Hyperliquid trader, also increased his ETH long position. 

The latest climb erased most of the available ETH short liquidity, with few positions remaining up to $3,400. The short squeeze may be followed by a reversal, as ETH has accumulated long positions just above $3,000. At the current price range, ETH retains the support level at $3,000, in addition to the $2,800 range, which is the cost basis of multiple whales. 

The ETh fear and greed index rallied from 51 points to 66 points within a few hours, signaling a rapid shift in sentiment.

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Published: Dec 09, 2025 at 17:53

Voyager Token (VGX) is the native utility token of the Voyager cryptocurrency trading platform.

Voyager is a crypto brokerage app that enables users to trade a wide range of cryptocurrencies. VGX plays a central role in the Voyager ecosystem and offers various benefits and use cases for platform users. 

Voyager offers a loyalty program where VGX holders can earn rewards, cashback, and other benefits based on their VGX holdings.

Voyager Token (VGX) 

VGX was initially created as part of the Voyager Loyalty Program, where users can earn rewards for holding VGX. The more VGX you hold in your Voyager account, the higher your interest rate on your cryptocurrency balances.

Voyager offers interest on certain cryptocurrencies, and VGX holders can earn higher interest rates. The more VGX you hold, the more interest you can earn on your crypto.

Some exchanges and wallets support VGX staking, where users can lock up VGX to secure the network and receive rewards in return.

Disclaimer. This article is for informational purposes only and should not be viewed as an endorsement by Coinidol.com. The data provided is collected by the author and is not sponsored by any company or token developer. They are not a recommendation to buy or sell cryptocurrency. Readers should do their research before investing in funds.

Expert in finance, blockchain, NFT, metaverse, and web3 writer with great technical research proficiency and over 15 years of experience.

XRP (CRYPTO: XRP) and Ethereum (CRYPTO: ETH) surged 5% on Tuesday as a major Ethereum whale lifted a long position to $266 million.

XRP Breaks Its Downtrend And Retests The 200 EMA

Price Prediction for XRP (Source: TradingView)

XRP is up about 5% as price pushes above the descending trendline that has defined the entire decline since early November. 

Traders have monitored this level for weeks, and the clean breakout shows sellers losing control.

XRP price now trades above short-term EMAs, confirming early positive momentum. 

The next major level is the 200-day EMA near $2.19, where several prior rallies stalled. 

A close above that line would strengthen the case for a broader trend reversal.

Support has shifted upward to the $2.1–$2.12 band. 

Buyers repeatedly defended this region during the recent consolidation. 

Holding above it keeps $2.3 in focus and opens a path toward the larger resistance zone between $2.55 and $2.6.

The RSI sits near 66, showing strong demand without entering overbought territory. 

That combination often accompanies early breakouts rather than exhaustion phases.

Ethereum Clears Major Levels As Whale Expands $266M Long

ETH Price Analysis (Source: TradingView)

Ethereum is up more than 8% after breaking through the 0.618 Fibonacci retracement at $3,195 and approaching the $3,330–$3,350 resistance band. 

The move ends weeks of sideways price action marked by low volatility.

ETH now trades above all short EMAs and is holding above the 200-day EMA near $3,178. 

Reclaiming this level is significant because it capped upside attempts for nearly a month. 

A sustained hold would confirm that buyers have regained momentum.

Support now sits at $3,195 and at the EMA cluster around $3,130. 

A clear break above $3,350 would likely target $3,500, followed by a wider move toward $3,800.

RSI near 74 signals strong demand but not yet an immediate reversal warning. 

Whale Activity Shows Rising Conviction Behind EthereumA major Ethereum whale who correctly positioned ahead of the Oct. 10 market drop has now flipped aggressively long, increasing exposure from $218 million to roughly $266 million within days. 

The account added about $48 million in new size earlier today.

The position shows a return on equity of nearly 28% and carries no short exposure. 

The liquidation level sits around $2,117, far below spot, suggesting the holder is prepared to maintain the long position through volatility.

Unrealized profits jumped from about $3.37 million to nearly $14.9 million following the latest addition. 

Such concentrated positioning has drawn attention from traders who view whale behavior as a gauge of market sentiment.

This shift comes as the sector continues to digest Cardano's (CRYPTO: ADA) 11% rally today, which was driven by enthusiasm around the upcoming Midnight privacy network. 

The move helped lift activity across several large-cap assets and altcoins.

Read Next:

Ethereum Or Solana? The Real Winner Is One You’re Ignoring, Bitwise’s Matt Hougan Says
Image: Shutterstock

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NEOS Gold High Income ETF offers a covered call strategy on gold, targeting high monthly income and potential appreciation. IAUI delivers a 12.53% distribution rate, with approximately 85% of distributions classified as return of capital. The fund stands out due to its straightforward structure and is managed by a team with a strong track record in covered call ETFs.

Idorsia’s dual orexin receptor antagonist, the first and only drug of its kind approved in Europe for the treatment of insomnia disorder, has been awarded the inaugural Prix Galien Bridges Award in the category of “Best Biotechnology & Pharmaceutical Product”Inaugural winners are honored for breakthrough innovations in life sciences Allschwil, Switzerland – December 9, 2025
Idorsia Ltd (SIX: IDIA) announces that its novel treatment for insomnia disorder has been awarded the inaugural Prix Galien Bridges Award in the category of “Best Biotechnology & Pharmaceutical Product”. The award recognizes groundbreaking medicines, including biologics, gene therapies, and traditional pharmaceutical compounds, that advance patient care through scientific innovation.

Bettina Blosse, General Manager of Idorsia Nordics, commented:
"We are immensely proud to have been awarded the prestigious Prix Galien, particularly the first of its kind in the Nordics. The recognition from the jury is a wonderful endorsement of Idorsia's commitment to innovation in healthcare and the value that the new treatment brings to improving patient care for insomnia disorder. My team is working to make this medicine accessible to all patients in the Nordic region.”

Martine Clozel, MD and Chief Scientific Officer added:
“Our research team began work on the science of orexin and orexin receptors immediately after they were first described in 1998. Our initial work led to the understanding that antagonism of the orexin system induced a very physiological sleep. With a treatment of insomnia disorder in mind, the team set the target to design a dual orexin receptor antagonist that, among a number of criteria, would achieve a rapid onset of effect and a duration of action sufficient to cover the totality of the night at optimally effective doses, avoiding morning carry-over effects. It took us more than 10 years, and we had to synthesize and characterize more than 25,000 compounds to arrive at the molecule which has now been recognized with the Prix Galien Bridges Award – for improving not only the nights of patients with insomnia disorder, but also most importantly their daytime functioning.”

The Prix Galien Awards were created in 1970 by Roland Mehl in honor of Galien, the father of medical science and modern pharmacology, to recognize outstanding innovation and scientific advancement. With chapters in 16 countries and Africa, Prix Galien is regarded worldwide as the equivalent of the Nobel Prize for the life science industry.
For more information about the Foundation, visit: https://www.galienfoundation.org/
For more information about Prix Galien Bridges, visit: https://www.galienfoundation.org/prix-galien-bridges.

Notes to the editor

About The Galien Foundation
The Galien Foundation fosters, recognizes, and rewards excellence in scientific innovation to improve the state of human health. Our vision is to be the catalyst for the development of the next generation of innovative treatments and technologies that will impact the state of medical practice and save lives. The late Professor Elie Wiesel, 1986 Peace Nobel Laureate, is The Honorary Founding President of The Galien Foundation

The Foundation oversees and directs activities in the US for the Prix Galien, an international awards program dedicated to progress through innovative medicines development, with chapters in 14 countries, Africa and an inaugural chapter established in India in 2024. The Prix Galien was created in 1970 by Roland Mehl in honor of Galen, the father of medical science and modern pharmacology.

About insomnia disorder
Insomnia disorder is defined as difficulty initiating or maintaining sleep, causing clinically significant distress or impairment in important areas of daytime functioning. This impact on sleep quantity or quality should be present for at least three nights per week, over the period of at least three months, and occurs despite an adequate opportunity to sleep.1

Insomnia is a state of overactive wake signals and studies have shown that in patients with insomnia, brain regions associated with wakefulness remain more active during sleep.2,3 Insomnia disorder is a common problem with an estimated prevalence in Switzerland of 9.2% of the working-age population.4

Insomnia as a disorder is distinctly different from a short period of poor sleep and it can affect both physical and mental health.1,5 It is a persistent condition that has a negative impact on daytime performance.1 Idorsia's research has shown that poor sleep quality can affect many aspects of daily life, including the ability to concentrate, mood and energy levels.

The goal of treating insomnia is to improve sleep quality and quantity, as well as daytime performance, while avoiding side and after-effects the next morning. The currently recommended treatment for insomnia includes sleep hygiene, cognitive behavioral therapy and pharmacotherapy.4

About the orexin system
Wake and sleep signaling is regulated by intricate neural circuitry in the brain. One key component of this process is the orexin system, which helps promote wakefulness.6,7 There are two forms of orexin neuropeptides – small protein-like molecules used by nerve cells (neurons) to communicate with each other in the brain – orexin A and orexin B.6,8 Orexin promotes wakefulness through its receptors OX1R and OX2R. 6,8 Together, these neuropeptides and receptors make up the orexin system. The orexin system stimulates targeted neurons in the wake system – leading to the release of several chemicals (serotonin, histamine, acetylcholine, norepinephrine) – to promote wakefulness.9 Under normal circumstances, orexin levels rise throughout the day as wakefulness is promoted and then fall at night.10 Overactivity of the wake system is an important driver of insomnia.7

The Idorsia research team has been studying the science of orexin and orexin receptors since they were first described in 1998. The team's initial work led to the conclusion that antagonism of the orexin system is key to maintaining natural sleep architecture in patients with insomnia. With this goal in mind, the team developed dual antagonists with the aim of a rapid onset of action and a duration of action sufficient to bridge the night but short enough to minimize any negative residual activity the next morning at optimally effective doses.

References

The Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM–5; American Psychiatric Association, 2013).Buysse, D.J., et al. Drug Discov Today Dis Models. 2011;8(4):129-137.Levenson, J.C., et al. Chest. 2015;147(4):1179-1192.Hafner, Marco, et al., 2023. Santa Monica. CA: RAND Corporation.Wardle-Pinkston S., et al. Sleep Med Rev. 2019;48.Muehlan, C., et al. J Psychopharmacol. 2020;34(3):326-335.Boof, M.L., et al. Eur J Clin Pharmacol. 2019;75(2):195-205.Muehlan, C., et al. Expert Opin. Drug Metab. Toxicol. 2020;16(11):1063–1078.Clifford, B.S., et al. Trends Neurosci. 2001;24(12).726-31.Gotter, A.L., et al. BMC Neuroscience. 2013;14(1):14-19. About Idorsia
The purpose of Idorsia is to challenge accepted medical paradigms, answering the questions that matter most. To achieve this, we will discover, develop, and commercialize transformative medicines – either with in-house capabilities or together with partners – and evolve Idorsia into a leading biopharmaceutical company, with a strong scientific core.

Headquartered near Basel, Switzerland – a European biotech hub – Idorsia has a highly experienced team of dedicated professionals, covering all disciplines from bench to bedside; QUVIVIQ™ (daridorexant), a different kind of insomnia treatment with the potential to revolutionize this mounting public health concern; strong partners to maximize the value of our portfolio; a promising in-house development pipeline; and a specialized drug discovery engine focused on small-molecule drugs that can change the treatment paradigm for many patients. Idorsia is listed on the SIX Swiss Exchange (ticker symbol: IDIA).

For further information, please contact:
Investor & Media Relations
Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, CH-4123 Allschwil
+41 58 844 10 10
[email protected] – [email protected] – www.idorsia.com

The above information contains certain "forward-looking statements", relating to the company's business, which can be identified by the use of forward-looking terminology such as “intend”, "estimates", "believes", "expects", "may", "are expected to", "will", "will continue", "should", "would be", "seeks", "pending" or "anticipates" or similar expressions, or by discussions of strategy, plans or intentions. Such statements include descriptions of the company's investment and research and development programs, business development activities and anticipated expenditures in connection therewith, descriptions of new products expected to be introduced by the company and anticipated customer demand for such products and products in the company's existing portfolio. Such statements reflect the current views of the company with respect to future events and are subject to certain risks, uncertainties and assumptions. Many factors could cause the actual results, performance or achievements of the company to be materially different from any future results, performances or achievements that may be expressed or implied by such forward-looking statements. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those described herein as anticipated, believed, estimated or expected.

Press Release PDF

LUXEMBOURG--(BUSINESS WIRE)--Eurofins Scientific SE (EUFI.PA) has received various notifications of dealing from Persons Discharging Managerial Responsibilities (“PDMR”). The notification of Dealing Form for each PDMR can be found below. This notification is made in accordance with the European Market Abuse Regulation. NOTIFICATION AND PUBLIC DISCLOSURE OF TRANSACTIONS BY PERSONS DISCHARGING MANAGERIAL RESPONSIBILITIES AND PERSONS CLOSELY ASSOCIATED WITH THEM     1. Details of the person discha.

Key Takeaways KT-621 drove deep STAT6 degradation and strong biomarker reductions in KYMR's phase Ib BroADen study.KT-621 showed notable EASI and pruritus improvements, plus benefits in asthma and allergic rhinitis patients.KT-621 was well-tolerated, and KYMR has advanced it into a phase IIb study with data expected in 2027.
Shares of Kymera Therapeutics (KYMR - Free Report) were up 41.6% yesterday after the company announced positive data from the phase Ib BroADen study, which evaluated its lead pipeline candidate KT-621 for treating atopic dermatitis (AD), also known as eczema.

KT-621 is an investigational, first-in-class, once daily, oral degrader of STAT6, the specific transcription factor responsible for IL-4/IL-13 signaling and the central driver of type 2 inflammation.

Year to date, shares of Kymera have rallied 134.4% compared with the industry’s rise of 19.3%.

Image Source: Zacks Investment Research

More on the Data from KYMR’s BroADen StudyThe open-label, single-arm phase Ib BroADen study evaluated KT-621 across two doses (100 mg and 200 mg) in patients with moderate-to-severe AD.

Data from the study showed that treatment with KT-621 led to deep STAT6 degradation in both the 100 mg and 200 mg doses, with median reductions of 94% in the skin and 98% in the blood, showing that the candidate’s effects in healthy volunteers translated well to AD patients.

Treatment with KT-621 also led to strong reductions in disease-relevant type 2 biomarkers in blood, including Thymus and Activation-Regulated Chemokine (TARC) – median reduction of 74% in patients with baseline TARC levels comparable to Sanofi’s (SNY - Free Report) Dupixent (dupilumab) studies on AD, Eotaxin-3, IL-31, IgE, and in core type 2 inflammation and AD disease-relevant gene sets in skin lesions.

KT-621 demonstrated strong clinical activity across all measured endpoints in the phase Ib BroADen study, including a mean 63% reduction in Eczema Area and Severity Index (EASI) and a mean 40% reduction in peak pruritus Numerical Rating Scale (NRS).

Patients with asthma who received KT-621 experienced a median 56% reduction in FeNO along with improvements in asthma control. Also, patients with allergic rhinitis who received KT-621 experienced significant symptom relief and better quality of life.

Treatment with KT-621 was generally safe and well-tolerated, with no serious adverse side effects observed.

The positive phase Ib BroADen results highlight KT-621’s potential as a first-in-class, once-daily oral therapy for type 2 inflammatory diseases. Its week-4 outcomes were comparable to—and in some cases exceeded—published data for SNY’s blockbuster drug, Dupixent, which is approved for several types of inflammatory diseases, including moderate-to-severe AD.

KYMR’s Other Development ActivitiesKymera recently initiated dosing in the phase IIb study, BROADEN2, evaluating KT-621 in patients with moderate-to-severe AD. It expects to report data from the BROADEN2 trial by mid-2027.

Meanwhile, Kymera is on track to initiate a phase IIb study, BREADTH, in moderate-to-severe asthma patients in the first quarter of 2026.

Conducting parallel phase IIb studies in AD and asthma is expected to accelerate KT-621’s development and determine the appropriate dosing strategy for subsequent parallel phase III registrational programs spanning several type 2 dermatology, gastroenterology and respiratory conditions.

In the absence of a marketed product, the successful development of its pipeline candidates remains the key focus area for Kymera.

KYMR’s Zacks Rank & Stocks to ConsiderKymera currently carries a Zacks Rank #3 (Hold).

Some better-ranked stocks in the biotech sector are ANI Pharmaceuticals (ANIP - Free Report) and Castle Biosciences (CSTL - Free Report) , each sporting a Zacks Rank #1 (Strong Buy). You can see the complete list of today’s Zacks #1 Rank stocks here.

In the past 60 days, estimates for ANI Pharmaceuticals’ 2025 earnings per share (EPS) have increased from $7.28 to $7.54. EPS estimates for 2026 have moved up from $7.78 to $8.15 during the same period. ANIP stock has surged 47.2% year to date.

ANI Pharmaceuticals’ earnings beat estimates in each of the trailing four quarters, with the average surprise being 21.24%.

In the past 60 days, estimates for Castle Biosciences’ loss per share have narrowed from 65 cents to 23 cents for 2025. During the same time, loss per share estimates for 2026 have narrowed from $2.10 to $1.42. Year to date, shares of CSTL have rallied 43%.

Castle Biosciences’ earnings beat estimates in three of the trailing four quarters, while missing the same on the remaining occasion, the average surprise being 66.11%.

SailPoint, Inc. (SAIL) Q3 2026 Earnings Call December 9, 2025 8:30 AM EST

Company Participants

Scott Schmitz - Senior Vice President of Investor Relations
Mark McClain - Founder, CEO & Director
Brian Carolan - Chief Financial Officer
Matthew Mills - President

Conference Call Participants

Joseph Gallo - Jefferies LLC, Research Division
Robbie Owens - Piper Sandler & Co., Research Division
Gray Powell - BTIG, LLC, Research Division
Shaul Eyal - TD Cowen, Research Division
Peter Levine - Evercore ISI Institutional Equities, Research Division
Ryan Lountzis - Morgan Stanley, Research Division
Jonathan Ruykhaver - Cantor Fitzgerald & Co., Research Division
Shrenik Kothari - Robert W. Baird & Co. Incorporated, Research Division
Matthew Hedberg - RBC Capital Markets, Research Division
Junaid Siddiqui - Truist Securities, Inc., Research Division
Todd Weller - Stephens Inc., Research Division
Benjamin Bollin - Cleveland Research Company LLC
Joshua Tilton - Wolfe Research, LLC
Gregg Moskowitz - Mizuho Securities USA LLC, Research Division

Presentation

Operator

Thank you for standing by, and welcome to SailPoint's Third Quarter Fiscal Year 2026 Earnings Conference Call. [Operator Instructions]

I would now like to hand the call over to Scott Schmitz, VP of Investor Relations. Please go ahead.

Scott Schmitz
Senior Vice President of Investor Relations

Good morning, and thank you for joining us today to discuss SailPoint's fiscal third quarter 2026 financial results. Joining me today are SailPoint's Founder and CEO, Mark McClain; and our Chief Financial Officer, Brian Carolan. For the Q&A portion of today's call, we will also be joined by our President, Matt Mills.

Please note that today's call will include forward-looking statements. And because these statements are based on the company's current intent, expectations and projections, they are not guarantees of future performance, and a variety of factors could cause actual results to differ materially. This call will also include references to non-GAAP results, which excludes certain items that do not reflect our underlying business performance. Please reference this

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