Market Signal Briefing

IP price has dropped 48% over the past 5 days as investors booked profits after it hit a new all-time high over the weekend. A confirmed bearish pattern now points to more losses in the coming days.

Summary

IP price has dropped over 50% from its ATH hit earlier this month.
Profit-taking and the broader market downturn have muted the impact of recent project-related developments.
$5.4 stands as a key support level bulls must defend to stop further losses.

According to data from crypto.news, Story Protocol (IP) was trading at $7.59, down 24.5% over the past 24 hours and 48% below its new all-time high of $14.78 reached earlier on Sep. 21.

Notably, Story’s price rallied to its new record high amid renewed community discussion after the project announced it would host the Origin Summit, held on Sep. 23, 2025, in Seoul during Korea Blockchain Week.

The summit, which served as a landmark event at the intersection of AI, intellectual property, and blockchain, brought together speakers and executives from leading entertainment and IP companies such as HYBE and SM Entertainment, alongside major crypto and investment firms, including Polygon, Grayscale, and Animoca Brands, to discuss the tokenization goals of IP through Story’s infrastructure.

Hosting major events like this helps improve a project’s visibility and often draws investor attention, which can translate into stronger support and long-term interest.

Other major developments that supported the rally include the launch of the IP Vault, which helps secure IP data by storing it on-chain, and real-world adoption through high-profile IP partnerships.

Aria, an IP tokenization project built on Story, recently announced plans to tokenize $100 million worth of K-pop IP on the Story blockchain, a move widely seen by the community as a high-profile endorsement of the platform’s real-world potential. With landmark IPs like Pinkfong’s “Baby Shark” also joining the platform, investors likely see this as a sign that Story Protocol is actively powering the tokenization of some of the most recognizable content in global entertainment.

Although these developments helped fuel the rally, their impact was undercut as investors began booking profits. It is quite typical for cryptocurrencies to experience some pullback after strong rallies, especially after an asset hits a new all-time high, as is the case for IP. 

Some of the selling pressure also stemmed from the broader crypto market downturn, which followed a fresh wave of tariffs announced by U.S. President Donald Trump and growing uncertainty over whether the Federal Reserve will move ahead with additional rate cuts this year.

Bitcoin (BTC) and many other top altcoins recorded losses on the day, and the crypto fear and greed index fell deep into ‘fear’ territory.

Crypto traders are now awaiting cues from today’s PCE data release, the Fed’s preferred measure of inflation, which could offer clarity on the central bank’s next move.

Story price analysis
On the daily chart, IP price has dropped below the lower trendline of an ascending broadening wedge that has been forming since late August this year. In technical analysis, this bearish reversal pattern develops during an uptrend when an asset’s price records successive higher highs and higher lows within two diverging upward-sloping lines.

IP price has broken below an ascending broadening wedge on the daily chart — Sep. 26 | Source: crypto.news
Following the bearish breakout, Story’s price has dropped below the 50-day simple moving average as sellers began to dominate price action.

Momentum indicators like the MACD were also flashing bearish signals today, with the MACD line crossing below the signal line, which is another telling sign that sellers are currently the dominant force.

Based on these bearish signs, IP remains vulnerable to downside action in the upcoming sessions unless the border market sentiment improves or a major bullish catalyst emerges.

As of press time, the next key support level for IP lies at $5.4, 29% below the current level. If bulls fail to defend this support, it could lead to a deeper correction towards $2.4, which marks the token’s lowest point in June.

Disclosure: This article does not represent investment advice. The content and materials featured on this page are for educational purposes only.

Key Indicators to Watch in Q4: Bitcoin Seasonal Trends, XRP/BTC, Dollar Index, Nvidia, and MoreAs we approach the final quarter of 2025, key charts provide valuable insights to help crypto traders navigate the evolving market landscape.Updated Sep 26, 2025, 7:53 a.m. Published Sep 26, 2025, 7:25 a.m.

This is an analysis post by CoinDesk analyst and Chartered Market Technician Omkar Godbole.

As we approach the final quarter of 2025, the following key charts provide valuable insights to help crypto traders navigate the evolving market landscape.

STORY CONTINUES BELOW

Bullish seasonalitySeasonal trends suggest a bullish Q4 outlook for both BTC$109,697.73 and ETH$3,943.96, the top two cryptocurrencies by market capitalization.

Since 2013, BTC$109,697.73 has delivered an average return of 85% in the final quarter, according to data from Coinglass, making Q4 historically the strongest period for bulls.

Seasonality leans bullish for BTC and ETH. (Coinglass)

November stands out as the most bullish month, with an average gain of 46%, followed by October, which typically sees a 21% increase.

ETH$3,943.96 also tends to perform well in the last three months of the year, although its strongest historical returns have been in the first quarter since inception.

BTC's 50-week SMA supportBitcoin's price has dropped by 5% this week, consistent with the bearish technical signals and looks set to extend losses to late August lows near $107,300. If bulls fail to defend that, the focus will shift to the 200-day simple moving average at $104,200.

The ongoing price decline, combined with bitcoin's historical pattern of peaking approximately 16 to 18 months after a halving event, may scare bulls.

However, such concerns may be premature as long as prices remain above the 50-week simple moving average (SMA). This moving average has consistently acted as a support level, marking the end of corrective price pullbacks during the current bull run that began in early 2023.

BTC's weekly chart in candlesticks format. (TradingView/CoinDesk)

Traders, therefore, should closely watch the 50-week SMA, which is currently positioned around $98,900, as a key level for broader market direction.

XRP/BTC compressionXRP, often called the "U.S. government coin" by firms like Arca, has surged 32% this year. However, despite this strong rally, the payments-focused cryptocurrency remains confined within a prolonged sideways trading range against Bitcoin (XRP/BTC), showing limited relative strength.

The XRP/BTC pair has been confined within a narrow trading range since early 2021, resulting in over four years of low-volatility compression.

Prolonged range play in XRP/BTC. (TradingView/CoinDesk)

Recent price action near the upper boundary of this channel suggests that bulls are gradually gaining control. A breakout from such a prolonged consolidation could trigger a powerful rally in XRP relative to BTC, as the accumulated energy from this squeeze is released.

Now, let’s turn to charts that call for caution.

Breakout in Defiance Daily Target 2x Short MSTR ETF (SMST)The leveraged anti-Strategy ETF (SMST), which seeks to deliver daily investment results that are -200%, or minus 2x, the daily percentage change in bitcoin-holder Strategy's (MSTR) share price, is flashing bullish signals.

The ETF’s price climbed to a five-month high of $35.65, forming what appears to be an inverse head-and-shoulders pattern, characterized by a prominent trough (the head) flanked by two smaller, roughly equal troughs (the shoulders).

Defiance Daily Target 2x Short MSTR ETF (SMST). (TradingView/CoinDesk)

This pattern often signals a potential bullish reversal, suggesting the ETF may be gearing up for a significant upward move.

In other words, it's flashing a bearish signal for both BTC and Strategy, which is the largest publicly listed BTC holder with a coin stash of 639,835 BTC.

Dollar Index's double bottomLast week, I discussed the dollar's post-Fed rate cut resilience as a potential headwind for risk assets, including cryptocurrencies.

The dollar index has since gained ground, establishing a double bottom at around 96.30. It's a sign that bulls have successfully established the path of least resistance on the higher side.

Dollar Index. (DXY). (CoinDesk/TradingView)

A continued move beyond 100.26, the high of the interim recovery between the twin bottoms around 96.30, would confirm the so-called double bottom breakout, opening the door for a move to 104.00.

Watch out for the pattern failure below 96.00, as that could lead to increased risk-taking in financial markets.

NVDA topping?Nvidia (NVDA), the world's largest listed company by market value, and a bellwether for risk assets, continues to flirt with the upper end of the broadening channel identified by June 2024 and November 2024 highs and lows hit in August 2024 and April 2025.

NVDA's bull run has stalled at key resistance. (TradingView/CoinDesk)

The rally has stalled at the upper trendline since late July in a sign of bullish exhaustion. Should it decline from here, it could signal the onset of a risk-off period in global markets, including cryptocurrencies.

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Total Crypto Trading Volume Hits Yearly High of $9.72T

Sep 9, 2025

Combined spot and derivatives trading on centralized exchanges surged 7.58% to $9.72 trillion in August, marking the highest monthly volume of 2025

What to know:

Combined spot and derivatives trading on centralized exchanges surged 7.58% to $9.72 trillion in August, marking the highest monthly volume of 2025Gate exchange emerged as major player with 98.9% volume surge to $746 billion, overtaking Bitget to become fourth-largest platformOpen interest across centralized derivatives exchanges rose 4.92% to $187 billionView Full Report

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Near $30M Ether Wipeout on Hyperliquid Stands Out as Crypto Market Sees $1B in Liquidation

5 hours ago

A $29.1 million ETH-USD long hit was indicative of the growing role of decentralized perpetual exchanges in driving liquidations.

What to know:

Ether (ETH) trade on Hyperliquid marked the largest liquidation in 24 hours amid a $1.19 billion leveraged position wipeout.Nearly 90% of liquidations were long positions, highlighting market bullishness and affecting over 260,000 traders.Hyperliquid, a decentralized exchange, saw significant liquidations, indicating increased risk-taking in decentralized markets.Read full story

Pi Network has been developing for years with a mobile-first approach and a mining community, yet it struggles to gain significant market traction. Dogecoin, a meme coin with little real utility, continues to dominate in recognition and liquidity. DOGE trades at $0.227 with a market cap of $34.4 billion, while Pi sits at $0.263 with only $2.16 billion. Despite having far fewer coins and a more defined vision, Pi hasn’t been able to challenge Dogecoin’s market position.

Pi faces hurdles in transparency, decentralization, and exchange access. It has been delisted from some platforms, and speculated listings on Binance and Coinbase have not materialized. Limited partnerships and delayed decisions from the core team hinder its adoption and market confidence.

“How is it possible that a meme coin with 151 billion coins can hold $0.22, while Pi with 20x fewer coins and a real vision sits only slightly higher at $0.26?” one expert questioned on social media.

Pi Network has several advantages that Dogecoin does not. It has a large community that actively mined and earned the coin, a clear white paper with real-world goals, and ecosystem apps and use cases under development.

Despite this, Dogecoin continues to lead in global recognition and market confidence. DOGE benefits from momentum, liquidity, and transparency. Pi, on the other hand, remains limited by closed ecosystems, delays, and centralization within its core team.

ConclusionPi continues technical upgrades and community building, but without broader market adoption or improved transparency, its ability to surpass meme coins remains uncertain. Market dynamics show that fundamentals alone do not guarantee success in crypto.

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The cryptocurrency market faced another dip today as Bitcoin price movements dragged altcoins lower. Despite the decline, many analysts say these fluctuations are part of a broader Bitcoin trading range, not a market collapse. 

Investors often describe the process as “five steps forward, two steps back,” highlighting the cyclical nature of Bitcoin and crypto markets.

Bitcoin Liquidation Hints at Short-Term Sell-offIn two days, roughly $17.5 billion in Bitcoin options are set to expire, with a max pain point at $107,000. Historically, Bitcoin often moves toward max pain during large options expirations.

“$BTC usually bottoms in September. A big leg down may happen before a reversal, especially with this massive options expiry,” noted a crypto trader.

Recent market activity shows a Bitcoin liquidity sweep that liquidated over-leveraged longs between $109,000 and $111,000. The next cluster of liquidity lies around $107,000–$108,000, which could trigger further short-term volatility.

“Deeper liquidity sweeps often spark aggressive shorting but can set up a sharp reversal once cleared,” analysts warned.

This setup highlights the importance of monitoring Bitcoin liquidity levels and price reversal signals in September 2025.

Bitcoin Four-Year Cycle Extended to Five-Year Cycle – Raoul PalRaoul Pal, founder of Global Macro Investor, suggests that Bitcoin’s historic four-year cycle, driven by halving events, may now have stretched into a five-year Bitcoin market cycle.

“U.S. debt maturity extensions in 2021–22 pushed the average weighted maturity from four years to 5.4 years,” Pal said. “This could shift the Bitcoin cycle peak to Q2 2026 instead of 2025.”

This insight may help investors adjust strategies for long-term Bitcoin price cycles and anticipate future market highs.

Bitcoin Closely Follows ISM Business CyclePal emphasized Bitcoin’s tight correlation with the ISM Purchasing Managers’ Index (PMI), a major indicator of U.S. economic trends:

Above 50: Economic expansion
Below 50: Economic contraction“Currently, the ISM is below 50, marking the longest contraction streak in decades,” Pal said. “Periods when the ISM was below 50, like 2015–16 and 2019–20, historically preceded major Bitcoin bull runs.”

This means that Bitcoin price movements often mirror U.S. economic cycles, creating opportunities for strategic investment.

High Interest Rates Delay Bitcoin Recovery and Cycle ReboundThe Federal Reserve’s sustained high interest rate environment has put pressure on Main Street while Wall Street benefits from asset debasement. 

Pal noted, “Interest rates need to decline to roll over U.S. debt and restore economic expansion. Until then, Bitcoin tends to follow the ISM’s contractionary trend.”

Investors monitoring the Bitcoin market recovery under high interest rates should expect limited short-term upside until economic conditions improve.

Never Miss a Beat in the Crypto World!Stay ahead with breaking news, expert analysis, and real-time updates on the latest trends in Bitcoin, altcoins, DeFi, NFTs, and more.

FAQsWhy is the crypto market down today?

The market dipped due to a short-term sell-off, potentially influenced by a large $17.5 billion Bitcoin options expiry. This created volatility, liquidating over-leveraged positions.

How do interest rates affect Bitcoin’s price?

High interest rates slow economic growth, which can delay Bitcoin’s bull market. A sustained recovery often requires lower rates to stimulate expansion and risk-on investment.

Is Bitcoin’s bull run over?

Not necessarily. Current volatility is seen as a normal correction. Historical data links Bitcoin bull runs to economic recovery phases, which may be ahead, suggesting potential for future growth.

What is the Bitcoin price prediction for 2025-2026?

Analysis suggests the classic 4-year cycle may be extending. The next major peak could now be in Q2 2026, influenced by broader U.S. economic debt cycles.

A huge crypto selloff has shaken the market again, pushing Ethereum, the second-largest cryptocurrency, down to a two-month low, trading below $3,900. This has sparked concern among traders and investors alike, as Veteran crypto analyst Ted Pillows says ETH could drop even further, possibly reaching around $3,500 before it starts to recover.

Ethereum Leads the LiquidationThe latest selloff has been brutal. Nearly $1 billion in crypto liquidations have hit the market this week, with Ethereum taking the hardest blow. According to Coinglass data, Ethereum saw around $312 million wiped out, and most of it from long positions.

Adding to the pressure, reports reveal that BlackRock sold $25.6 million worth of ETH, sparking fears of further institutional exits. Even the Options market data also reflects bearish sentiment, with increased demand for put options indicating expectations of further downside.

According to Ted Pillows, Ethereum’s recent price action mirrors Bitcoin’s 2020 cycle, where a 25%–30% drop followed a breakout above $20,000. He suggests that ETH could decline another 10%–15%.

Ethereum Price Levels to WatchCurrently, Ethereum is approaching a key support zone around $3,800, which will be crucial in determining its short-term direction.

If the $3,800 level holds, Ethereum could find stability and prepare for a fresh rally.If it fails, the price might slide further toward the $3,500 region before finding stronger ground.Pillows’ chart highlights this battle zone clearly, showing how Ethereum’s next leg depends on whether bulls can defend the key support area.

ETH Long-Term Goal Eyeing $6998Despite the recent turbulence, Ethereum’s fundamentals are still strong. Big institutions are still interested, and the network continues to grow, showing long-term strength. 

Crypto analyst The House Of Crypto notes a Descending Broadening Wedge forming on Ethereum’s weekly chart, which could push ETH up to around $6,998 if it breaks out.

For now, however, traders are keeping a close watch on the $3,800 support level.

Journalist

Posted: September 26, 2025

Key Takeaways 
Why is 0G facing further downside risk?
Technical indicators like MFI at 30 and RSI below 50 suggest weakening momentum, signaling bearish pressure on 0G.

 Who is driving the recent 0G market decline?
Perpetual traders dominate the derivatives market, with $18.3 million exiting and a negative OI-Weighted Funding Rate of -0.0879%.

0G [0G] stumbled in the past 24 hours. The asset, which had been forming new highs, now faces the threat of further decline after losing 21%, at press time.

Trading volume also fell, dropping to around half a billion—precisely $512 million—showing that weak hands are exiting the market.

How this plays out for 0G remains uncertain, according to AMBCrypto’s analysis.

Support level reached
The 1-hour support level analysis shows that 0G has taken a sharp drop after recently setting a new high.

This drop does not necessarily mark the beginning or end of a broader decline, as the chart indicates it coincides with a key support zone.

Source: TradingView

This level has been instrumental in 0G’s previous rallies, with one of the latest instances leading to the $0.34 high on the 23rd of September.

If it holds, a possible push forward could occur, similar to past scenarios when the token traded along this level.

The big question: Will 0G maintain its bullish momentum and push higher from here?

Support level may be a trap
However, the support level could prove a trap for investors expecting a rebound, turning into a bull trap. Technical indicators lean bearish.

At press time, the Money Flow Index (MFI), which tracks liquidity flowing in and out of an asset, fell to 30, entering bearish territory below the neutral 50 mark. This drop indicates growing bearish sentiment among investors. 

The Relative Strength Index (RSI) also points to potential downside, slipping just below the bullish threshold to 49, signaling weakening momentum.

Source: TradingView

If both indicators continue trending lower, they would confirm that the support level may fail to spark an upward push, triggering liquidations for long traders.

Presently, liquidation data shows $2.87 million in long contracts closed compared to $874,000 in shorts—a clear sign the market is leaning bearish.

Blame the perpetual investors
If any group of investors is responsible for the recent drop, it is perpetual traders. Over the past days, $18.3 million worth of 0G exited the market, while Open Interest (OI) fell to $81.13 million, as of writing.

This decline in OI alone does not confirm whether bulls or bears control the market—it only shows a reduction in contractual value.

Source: CoinGlass

However, the OI-Weighted Funding Rate turning negative confirmed bearish dominance.

A rate of -0.0879% implies that most liquidity in the derivatives market comes from bears, suggesting the market may continue trending downward.

Find key trading signals and the next move. Read until the end to catch hidden Bitcoin targets most traders miss.

Bitcoin struggles near monthly lows after a wave of liquidations, with options expiry and U.S. inflation data fueling uncertainty.

Published:
September 26, 2025 │ 8:00 AM GMT

Created by Kornelija Poderskytė from DailyCoin

More than $1 billion in leveraged positions were wiped out this week as Bitcoin tumbled toward $109,000, setting the stage for one of the market’s most volatile periods of 2025.

With $22 billion in crypto options contracts expiring on Friday and a key U.S. inflation report due the same day, traders say Bitcoin is at a critical crossroads.

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On Thursday, Bitcoin (BTC) slid to $108.7K, its weakest level in nearly a month, before steadying just above $109K threshold. 

Ethereum (ETH) tumbled even more in 24 hours to around $3,800, extending its losses to 14.3% since last month’s record highs.

The declines triggered a broad leverage flush. Data from CoinGlass shows that more than $975 million in liquidations occurred, led by $312 million in wiped ETH longs and $247 million in BTC.

Source: CoinGlassCrypto equities mirrored the slump. MicroStrategy (MSTR), the largest corporate holder of Bitcoin, fell as much as 10% to a five-month low, erasing its 2025 gains. Shares of miners Marathon Digital (MARA) and Riot Platforms (RIOT), along with Ether treasury firms Bitmine (BMNR) and Sharplink Gaming (SBET), slid 7–8%.

The selloff comes just as the market braces for the expiration of $22.3 billion in crypto options contracts on Friday. According to Deribit, a crypto options exchange, this is one of the biggest quarter-end expiries.

🚨 Options Expiry Alert 🚨

At 08:00 UTC tomorrow, over $22.3B in crypto options expire on Deribit; one of the biggest quarter-end expiries. 🔥$BTC: Notional: $17.06B | Put/Call: 0.76 | Max Pain: $110K$ETH: Notional: $5.20B | Put/Call: 0.80 | Max Pain: $3,800

Q3’s largest… pic.twitter.com/FDT1tWomYH

— Deribit (@DeribitOfficial) September 25, 2025
More than $17 billion is tied to Bitcoin, with dealer positioning clustered around $108,000–$109,000. A decisive break lower could force hedging flows that accelerate losses toward $96,000.

Macro risk adds another layer. The U.S. Core PCE report, a key Federal Reserve inflation gauge, is expected to show a slight cooling, but an upside surprise could strengthen the dollar and deepen the selloff across risk assets.

Still, not all signals point bearish. Meanwhile, crypto traders urge investors to zoom out to higher timeframes, which they say remain “unequivocally bullish,” describing the current pullback as a normal, healthy correction in a broader context.

According to @CredibleCrypto, the decline should either hold above the $98,000 lows — a pattern known as a “running flat” — or briefly dip below them in what’s called an “expanded flat.” In both scenarios, he said, the higher-timeframe structure remains intact.

Zooming out to remind you all of where we are in the bigger picture so you don't get lost in the lower timeframes and panic un-necessarily:

High timeframes remain unequivocally bullish, and the current correction is considered normal/healthy in HTF context.

The idea shared… https://t.co/y1ydqUy3IG pic.twitter.com/uVBDN2iSFz

— CrediBULL Crypto (@CredibleCrypto) September 25, 2025
Why This MattersThe convergence of forced liquidations, record options expiry, and pivotal macro data threatens to break Bitcoin’s critical support, which could set the tone for crypto markets into the fourth quarter.

Read DailyCoin’s most popular crypto news:
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Bitcoin’s Calm Before the Storm? $105K Support Faces Test

People Also Ask:Why did Bitcoin’s price drop this week?

Bitcoin fell after a sharp selloff in crypto markets triggered more than $975 million in liquidations.

What are crypto liquidations?

Liquidations occur when leveraged traders can’t meet margin requirements. Exchanges automatically close their positions, which often amplifies price swings.

What is the options expiry, and why does it matter?

Options expiry refers to contracts reaching their settlement date. Large expiries can increase volatility as traders and dealers rebalance their positions.

What role does U.S. inflation data play in Bitcoin’s price?

The Core PCE inflation report influences Federal Reserve policy. A hotter reading could boost the dollar and pressure risk assets, including Bitcoin.

Are traders still bullish on Bitcoin long-term?

Yes. Some analysts see the pullback as a healthy correction within an intact bullish trend, expecting higher prices later in 2025.

This article is for information purposes only and should not be considered trading or investment advice. Nothing herein shall be construed as financial, legal, or tax advice. Trading forex, cryptocurrencies, and CFDs pose a considerable risk of loss.

15 minutes ago

Crypto sentiment gauge, the Crypto Fear & Greed Index, collapsed below 30/100 for the first time since mid-April, with Bitcoin trading $25,000 higher.

332

Key points:

The Crypto Fear & Greed Index is back at levels not seen since Bitcoin traded at $83,000.

Analysis wonders whether the BTC price “turning point” is already here.

Social media user behavior already suggests that a price rebound should take place next.

Bitcoin (BTC) sentiment collapsed overnight Thursday as the latest BTC price dip forced fresh liquidations.

Fresh data from the Crypto Fear & Greed Index shows that “fear” now drives the mood.

Bitcoin sentiment echoes April lowsBitcoin, nearing new monthly lows under $109,000, had a near-instant impact on market sentiment.

The Fear & Greed Index, which lags market movements, hit just 28/100 on Friday, marking its lowest levels since April 11. The index fell 16 points in a single day.

Crypto Fear & Greed Index (screenshot). Source: Alternative.me“MORE fear and a HIGHER price,” crypto YouTube channel host Michael Pizzino summarized in part of an X post on the topic.

Pizzino referred to the emerging divergence between price and sentiment.

The last time that the Fear & Greed Index was below 30/100, BTC/USD traded at around $83,000, days after its recovery from $75,000 lows, data from Cointelegraph Markets Pro and TradingView confirms.

BTC/USD one-day chart. Source: Cointelegraph/TradingView
As a result, accompanying analysis argues that the time is right for a market reversal.

“Could this be the turning point Bitcoin and Crypto has been waiting for? The analysis looks good, but it has not been confirmed,” Pizzino added.

BTC/USDT perpetual contract one-day chart with sentiment data. Source: Michael Pizzino/XFear & Greed has been no stranger to erratic moves in 2025. As Cointelegraph reported, in February, the Index collapsed to just 10/100 thanks to macroeconomic uncertainty focused on US trade tariffs.

“Impatience and bearishness” rule BTC price takesSome signals of an impending BTC price rebound emerged even before the latest dip.

On Tuesday, research platform Santiment showed that social media users were already convinced that lower prices would soon come.

“As usual, social media is vocal on where Bitcoin will head next. Historically, lower price predictions increase the likelihood, and higher predictions imply lower future prices,” it explained to X followers.

Santiment described a “high amount of impatience and bearishness emerging from the retail crowd.”

At the same time, data revealed that large-volume traders were adding exposure in recent days.

Bitcoin price social media activity data. Source: Santiment/XThis article does not contain investment advice or recommendations. Every investment and trading move involves risk, and readers should conduct their own research when making a decision.

OKB price surged nearly 10% in 24 hours with trading volume spiking 200%, signaling strong buyer conviction over speculation. Trading above its Super Trend line at $169.35, OKB shows bullish momentum with potential to test resistance at $196.84. A breakout could drive OKB toward $210, but profit-taking risks may trigger pullbacks to $173.69 or deeper to $169.35 support.OKB has emerged as one of the strongest performers in the market, climbing nearly 10% in the past 24 hours. This comes as Bitcoin and other leading digital assets trade lower, pushing the global crypto market cap down by 2%. 

On-chain data shows rising demand for OKB, and if this momentum holds, the altcoin could close September above the key $200 level.

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OKB Rally Builds Steam
OKB’s price rally comes amid a notable spike in demand, with its daily trading volume surging almost 200% in the past day. This totals $293 million at press time, suggesting that the rally is not driven by speculation.

For token TA and market updates: Want more token insights like this? Sign up for Editor Harsh Notariya’s Daily Crypto Newsletter here.

OKB Price/Trading Volume. Source: Santiment
When an asset’s price rises alongside a sharp increase in trading volume, it signals strong conviction among buyers rather than short-term hype. 

Higher volumes mean more market participants are involved in the move, lending credibility to OKB’s rally and reducing the risk of a quick reversal. If demand continues at this pace, the increased depth in the market could provide the support needed for OKB to test the $200 level. 

Further, readings from the daily chart show that OKB trades solidly above its Super Trend Line, reflecting a strong bullish tilt in market sentiment. At press time, this indicator forms dynamic support below OKB’s price at $169.35.

OKB Super Trend Indicator. Source: TradingViewSponsored

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The Super Trend indicator tracks the market’s direction by placing a line above or below the price chart based on the asset’s volatility. 

As with OKB, when an asset’s price trades above the Super Trend line, it signals a bullish trend. It highlights that the market is in an uptrend that may persist as buying pressure dominates.

OKB Bulls Target $210, Yet Profit-Taking Threatens a Pullback
As September nears its close, all eyes are now on whether this momentum will be enough to propel the token toward the $200 milestone. For that to happen, OKB must first break above its next major resistance, which lies at $196.84. 

A successful breach of this level could propel its price toward $210.57 in the near term.

OKB Price Analysis. Source: TradingView
However, a surge in profit-taking would invalidate this bullish outlook. In that scenario, OKB could shed some of its recent gains and test support at $173.69.

OKB could fall toward the dynamic support of its Super Trend line at $169.35 if this level gives way.

Disclaimer

In line with the Trust Project guidelines, this price analysis article is for informational purposes only and should not be considered financial or investment advice. BeInCrypto is committed to accurate, unbiased reporting, but market conditions are subject to change without notice. Always conduct your own research and consult with a professional before making any financial decisions. Please note that our Terms and Conditions, Privacy Policy, and Disclaimers have been updated.

I'm about to make the most accurate Bitcoin (BTC -2.03%) prediction you'll ever read: In 2035, Bitcoin will either be worth practically nothing or it'll be worth half a million dollars. Maybe more.

Yield Basis aims to unlock sustainable Bitcoin yield on-chain, starting with capped liquidity pools. Sep 26, 2025, 8:33 a.m.

Michael Egorov, founder of Curve Finance, has launched Yield Basis, a decentralized protocol built to provide sustainable BTC$109,658.51 yield while eliminating impermanent loss (IL), one of decentralized finance’s longest-running challenges.

Bitcoin holders have long faced limited opportunities for on-chain returns. Lending markets rarely offer more than a fraction of a percent, while automated market maker (AMM) pools have exposed users to IL — the risk of losing value when token prices diverge. Even in favorable conditions, yields rarely topped 1–2%.

STORY CONTINUES BELOW

Yield Basis tackles this by reengineering the AMM model. The protocol removes IL risk altogether, which Egorov says will enable deeper Bitcoin liquidity on-chain and more attractive yield opportunities for institutional and professional investors. To manage early growth, three pools launched with a $1 million deposit cap each.

The system borrows from Curve’s five years of infrastructure resilience, adopting a vote-escrow mechanism (veYB) for governance. Token holders must lock their YB to participate in governance and earn protocol fees, distributed in either Curve’s crvUSD stablecoin or wrapped Bitcoin. Unlike many DeFi projects, token emissions aren’t simply handed to liquidity providers; they are tied to position yield, a model Egorov calls “value-protecting.”

Yield Basis secured $5 million in early 2025 funding and is the first project to debut on the joint Legion and Kraken launchpad, where the community can access its token sale. While Bitcoin is the initial focus, Egorov says the protocol’s impermanent loss solution could extend to Ethereum, tokenized commodities or even stocks — potentially broadening the scope of yield-bearing assets on-chain.

AI Disclaimer: Parts of this article were generated with the assistance from AI tools and reviewed by our editorial team to ensure accuracy and adherence to our standards. For more information, see CoinDesk's full AI Policy.

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Stablecoin Market Could Reach $4 Trillion by 2030, Citi Says in Revised Forecast

14 hours ago

Bank tokens may ultimately surpass stablecoins in transaction volume, report said.

What to know:

Citi raises its 2030 stablecoin issuance forecast to a $1.9 trillion base case and a $4 trillion bull case.Stablecoins could support up to $200 trillion in transactions at scale.Bank tokens may overtake stablecoins as corporates seek regulatory safeguards.Read full story

BlackRock's global head of digital assets, Robbie Mitchnick, believes the institutional adoption of crypto exchange-traded funds is still in its early stages. During a Sept.

Sui price is testing support at $3.10 as rising trading volume and new partnerships hint at long-term strength.

Summary

SUI trades at $3.13, down 18% weekly, with $1.66B spot volume up 46% in 24h.
Futures volume rises 23% to $7.48B while open interest falls 4.4%, showing cautious positioning.
New deals with t’order, CUDIS Wellness, and Google AI highlight institutional and real-world adoption.

Sui is trading at $3.13 at press time, down 3.5% in the past 24 hours, as the token approaches key support levels. Over the past week, it has dropped 18%, while in the past 30 days, it is still down 10%.

Daily trading activity shows a surge in market interest, with $1.66 billion in spot volume recorded in the last 24 hours, a 45.9% jump compared to the previous day. On the derivatives side, CoinGlass data shows that Sui’s (SUI) open interest fell 4.4% to $1.69 billion, while futures volume rose 23% to $7.48 billion.

This combination implies that although traders are engaging more actively, many are closing out positions rather than opening new ones.

New partnerships drive long-term use cases
Despite the near-term pullback, Sui continues to expand its ecosystem with major partnerships that strengthen its institutional and real-world presence.

On Sept. 24, Sui announced a partnership with t’order, the leading table-ordering platform in South Korea, T’order processes $4.3 billion annually and serves 35 million users. Using Sui’s sub-0.5-second transaction speeds and Walrus storage for safe loyalty data, the partnership integrates a KRW-pegged stablecoin across 300,000 point-of-sale devices.

A day later, Sui partnered with CUDIS Wellness to bring AI-powered smart rings and health data management onchain. Through Walrus and SEAL, users will own and monetize encrypted biometric data, aligning Sui with the growing wellness sector.

Sui and Google AI also partnered to introduce the Agentic Payments Protocol earlier this month. This system opens up new use cases in DeFi, IoT, and enterprise automation by enabling AI agents to make payments on their own.

Sui price technical analysis
On the daily chart, SUI is trading close to the lower Bollinger band at $3.13, indicating oversold conditions. The relative strength index at 38 is near the oversold zone, while the Stochastic RSI and Williams %R both indicate possible buy conditions.

Sui daily chart. Credit: crypto.news
All of the major SMAs and EMAs, from the 10-day ($3.38) to the 200-day ($3.20), flash sell signals, a bearish sign. Momentum and MACD indicators also lean bearish, showing the trend is still weak.

In the short term, holding above $3.10 support is critical. The $2.90–$3.00 range might be the next target if there is a breakdown. On the upside, the first indication of a potential rebound would be the recovery of the 20-day SMA around $3.46.

, /PRNewswire/ -- Boeing [NYSE: BA] and Norwegian Group announced today that the airline group has placed an order for 30 737-8 airplanes as the airline looks to expand its service across Europe.

The agreement represents the group's first direct Boeing order since 2017 and increases their 737 MAX order book to 80 airplanes.

"This milestone aircraft order is on attractive terms and secures our fleet growth in a way that supports our planned growth and sustainability targets. By exercising the options and adjusting the delivery profile, we maintain flexibility while reinforcing our commitment to operating one of the most modern and fuel-efficient fleets in Europe," said Geir Karlsen, CEO of Norwegian. "These aircraft will not only lower emissions but also provide our customers with an even better travel experience. We are pleased to extend our solid long-term partnership with Boeing through this order."

Norwegian has predominantly operated Boeing single-aisle airplanes since placing its first order for the Next-Generation 737-800 in 2007. It was the first European airline to take delivery of the 737 MAX in 2017 and was also the first airline to operate the 737-8 model on transatlantic routes between Europe and the U.S.

In 2022, Norwegian restructured its order book, firming its commitment to 50 737-8s with options for an additional 30 airplanes.

"Norwegian's impressive performance over the past few years has demonstrated the strength of their network, business model and strategy. Today's agreement for an additional 30 737-8s will support their ambition to be the airline of choice in Scandinavia, providing flexibility to expand across Europe and beyond," said Brad McMullen, Boeing senior vice president of Commercial Sales and Marketing. "Norwegian has been a great partner to the 737 program, having placed over 200 orders for the 737 NG and MAX since 2007. We are honored that Norwegian continues to place its trust in our 737 team to grow its business."

The 737-8 model can carry up to 200 passengers depending on configuration, with a range of up to 3,500 nautical miles (6,480 km). The 737 MAX family is well-suited to support airline fleet modernization by reducing fuel use and carbon emissions by 20% compared to the airplanes they replace.

About Norwegian 
The Norwegian group is a leading Nordic aviation company, headquartered at Fornebu outside Oslo, Norway. The company has over 8,200 employees and owns two of the prominent airlines in the Nordics: Norwegian Air Shuttle and Widerøe's Flyveselskap. Widerøe was acquired by Norwegian in 2024, aiming to facilitate seamless air travel across the two airline's networks.

Norwegian Air Shuttle, the largest Norwegian airline with around 4,700 employees, operates an extensive route network connecting Nordic countries to key European destinations. In 2024, Norwegian carried 22,6 million passengers and maintained a fleet of 86 Boeing 737-800 and 737 MAX 8 aircraft.

About Boeing
As a leading global aerospace company, Boeing develops, manufactures and services commercial airplanes, defense products and space systems for customers in more than 150 countries. As a top U.S. exporter, the company leverages the talents of a global supplier base to advance economic opportunity, sustainability and community impact. Boeing's diverse team is committed to innovating for the future and living the company's core values of safety, quality and integrity. Learn more at www.boeing.com.

Contact:
Boeing Media Relations
[email protected]

SOURCE Boeing

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Rivian looks increasingly like it will be a successful EV start-up, but don't get overexcited by the Tesla similarities.

After Tesla (TSLA -4.29%) proved that a start-up electric car company could take on the traditional automakers, Wall Street jumped into action. That was when Rivian (RIVN -0.44%) came public, to much fanfare. Fast forward a few years to the current day, and Rivian's stock price has fallen some 90% from its all-time highs. Is this a diamond in the rough that could turn you into a millionaire in a Tesla-style success story, or should you have more modest expectations?

Rivian has done big things
To give credit where credit is due, Rivian has achieved a huge amount of success in a very short period of time. It basically went from an idea -- making electric vehicles (EVs) -- to an operating business with a well-respected EV truck and an EV delivery van used widely by retail powerhouse Amazon (AMZN -0.84%). That isn't something that could have been achieved if Rivian didn't have its act together.

Image source: Rivian.

Notably, in late 2024, Rivian hit a key milestone, achieving a modest gross profit for the first time. While a gross profit only means that it was able to generate more revenue from selling its vehicles than it cost to produce them, that is a key step toward positive earnings.

The modest gross profit came after Rivian hit another important goal, scaled production. It delivered more than 10,000 vehicles in the second quarter of 2025, which is a substantial number. It also has a new truck called the R2 coming out next year, which will be geared to the mass market. That should help to further increase volume, which will allow Rivian to spread its costs over even more vehicles.

In many ways, Rivian is following in Tesla's footsteps. Given the massive stock price advance Tesla has made over its history, some investors might see Rivian as a second chance to catch a little of the Tesla opportunity they might have missed. Don't get overly excited.

Rivian has a long way to go
With a well-respected product and key partners like tech giant Amazon and automaker Volkswagen (which has agreed to provide fresh capital to Rivian based on Rivian's ability to meet certain business goals), Rivian seems like it will establish itself as a sustainably profitable business. However, this goal is still likely to be at least a few years away, given the need to invest in the business and research and development right now. Rivian could help you reach a seven-figure net worth, but it isn't likely to do so quickly.

Moreover, the competition set today is much larger than it was when Tesla entered the auto market. At the time, Tesla was basically the only company making EVs. Today, there are a number of sizable EV makers. Virtually all of the traditional automakers are in the space, too. Even if Rivian is successful, it could still just produce a modest profit at the bottom of its income statement, thanks to the changed competitive landscape.

That said, even that outcome would require strong execution. Although Rivian has lived up to its goals, for the most part, so far, there's no guarantee that it will continue to do so in the future. If the company starts missing its targets, investors are likely to turn deeply negative on the stock.

How much more negative could they get after a 90% price decline? Well, the stock happens to be up nearly 23% over the past year, which is notably better than the nearly 17% gain of the S&P 500 index (^GSPC -0.50%). Even after a 90%+ decline, there's still ample room for a deep drawdown, as investors appear to have priced in a lot of good news in recent days.

Risk takers may find it attractive
It probably wouldn't be a great idea to bet your house on Rivian. But it has achieved a great deal in a short period of time, with material opportunity for more success in the future. The problem is that it could also fall short of its goals and flame out, like many upstart EV makers have already done. If you see the execution strength and want to add Rivian to a diversified portfolio, it could help you reach millionaire status. Just go in recognizing the risk, which is material, and the time period you need to consider, which is long.

That's why more conservative investors will probably want to sit on the sidelines for now. It makes a great deal of sense to wait at least until the R2 has been brought to market, so investors can assess how well the new car does with consumers.

Reuben Gregg Brewer has no position in any of the stocks mentioned. The Motley Fool has positions in and recommends Amazon and Tesla. The Motley Fool recommends Volkswagen Ag. The Motley Fool has a disclosure policy.

You don't need to be a billionaire to invest like Buffett.

Legendary investor Warren Buffett is in the final year of leading his mighty conglomerate, Berkshire Hathaway (BRK.A -0.04%) (BRK.B -0.27%). The Oracle of Omaha, now 95, plans to retire at the end of the year following a 60-year run that turned a downtrodden textile company into a hugely successful company valued at more than $1 trillion.

Buffett's investing principles are comparatively simple, but not many have been able to duplicate them. He believes in buying stock in companies with outstanding management, a great position in their industry, solid revenue and earnings, and often, a generous dividend. By buying dividend stocks in companies that pay investors to hold them, Buffett and Berkshire Hathaway have been able to build wealth even faster.

Berkshire Hathaway has long-term investments in dozens of companies, but three stand out right now as ideal companies for anyone wanting to start a buy-and-hold portfolio. And you don't have to be a billionaire to invest like Buffett -- you need less than $300 total to get a share of Bank of America (BAC 0.26%), Chevron (CVX 0.97%), and Kroger (KR -0.06%).

Image source: The Motley Fool.

Bank of America: Buffett's favorite bank stock
Buffett and Berkshire Hathaway have positions in several financial companies. Berkshire owns insurance companies Geico, General Re, and Berkshire Hathaway; stock in credit card companies American Express, Visa, and Mastercard; a stake in the the credit ratings and analytics company Moody's; and a small percentage of Jefferies Financial Group, the investment bank.

But Bank of America is by far the company's biggest bank stock, as Berkshire holds 605.2 million shares for a $31.3 billion stake. Bank of America makes up 10% of Berkshire's entire portfolio. The North Carolina–based financial institution has about 69 million customers and maintains 3,700 locations across the country, as well as a network of 15,000 ATMs and a robust digital presence.

The company has benefited from a period of elevated interest rates that brought in increased net interest income -- the company reported $14.7 billion in net interest income in the second quarter, up 7% from a year ago. And while the Federal Reserve is now starting to lower rates, Bank of America will still be just fine as people begin to take out new loans or refinance mortgages.

Bank of America is also attractive for its 15.2 price-to-earnings ratio and its 2.1% dividend yield.

Chevron: The energy powerhouse
Buffett and Berkshire Hathaway recognize the importance of energy and fossil fuels in today's economy, and the conglomerate has sizable investments in ExxonMobil, Chevron, and Occidental Petroleum.

I like Chevron here. Even though oil prices have been down this year, Chevron still generates a massive amount of free cash flow -- $4.9 billion in the second quarter, up from $2.3 billion a year ago.

The company recently completed its $55 billion acquisition of Hess, emerging victorious over ExxonMobil in a legal battle that saw it win access to the Guyana Stabroek Block that is purportedly the biggest oil discovery in decades with more than 11 billion barrels of oil.

Chevron already recorded record production in the second quarter for the Permian Basin, with 1 billion barrels of oil per day, and I expect production to increase following the Hess merger.

The company pays a generous dividend yield of 4.4%.

Kroger: The defensive pick
Even when spending tightens up and consumer confidence falls, people still need to eat. While consumer discretionary stocks can come under pressure, consumer staples stocks, such as grocery stores, often can be a safer place for investors to put their money. That's where Kroger comes in.

Kroger is the second-largest grocery store chain in the U.S., behind only Walmart. The company has more than 2,700 locations, 2,250 pharmacies, and 1,700 fuel locations scattered throughout 35 U.S. states and the District of Columbia.

The Cincinnati-based grocer reported $33.9 billion in sales in the second quarter, including fuel and specialty pharmacy sales. But without those items, sales were up 3.8% from last year, indicating that people are spending more money in Kroger's grocery stores.

Part of that comes from Kroger's increased emphasis on growing its own in-house brands of food products, which the company can offer at a lower price point and a greater profit than national brands.

Kroger still has a cheap valuation with a P/E ratio of 16.4, which is lower than that of Walmart (38.7), Costco Wholesale (53.5), or Sprouts Farmers Market (26.7). Coupled with a dividend yield of 2.1%, Kroger offers a compelling investment opportunity.

American Express is an advertising partner of Motley Fool Money. Bank of America is an advertising partner of Motley Fool Money. Patrick Sanders has no position in any of the stocks mentioned. The Motley Fool has positions in and recommends Berkshire Hathaway, Chevron, Costco Wholesale, Jefferies Financial Group, Mastercard, Moody's, Visa, and Walmart. The Motley Fool recommends Kroger, Occidental Petroleum, and Sprouts Farmers Market. The Motley Fool has a disclosure policy.

September 26, 2025 3:15 AM EDT | Source: Questcorp Mining Inc.
Vancouver, British Columbia--(Newsfile Corp. - September 26, 2025) - Questcorp Mining Inc. (CSE: QQQ) (OTCQB: QQCMF) (FSE: D910) (the "Company" or "Questcorp") is pleased to announce that it will offer (the "Offering") up to 17,500,000 units (each, a "Unit") by way of non-brokered private placement at a price of $0.20 per Unit for gross proceeds of up to $3,500,000. Each Unit will consist of one common share of the Company (each, a "Share") and one-half-of-one share purchase warrant (each whole warrant, a "Warrant"). Each Warrant will entitle the holder to acquire an additional common share of the Company at a price of $0.30 for a period of twenty-four months following closing of the Offering, subject to accelerated expiry in the event the closing price of the Shares is $0.50 or higher for ten consecutive trading days.

The Company expects to utilize the proceeds of the Offering for advancement of ongoing exploration and drill work at the La Union Gold and Silver Project, upcoming exploration work at its North Island Copper Property and for general working capital purposes.

In connection with completion of the Offering, the Company will pay finders' fees to eligible third-parties who have introduced subscribers to the Offering. All securities issued in connection with the Offering will be subject to restrictions on resale for a period of four-months-and-one-day in accordance with applicable securities laws. Completion of the Offering remains subject to receipt of regulatory approvals.

About Questcorp Mining Inc.

Questcorp Mining Inc. is engaged in the business of the acquisition and exploration of mineral properties in North America, with the objective of locating and developing economic precious and base metals properties of merit. The Company holds an option to acquire an undivided 100% interest in and to mineral claims totaling 1,168.09 hectares comprising the North Island Copper Property, on Vancouver Island, British Columbia, subject to a royalty obligation. The Company also holds an option to acquire an undivided 100% interest in and to mineral claims totaling 2,520.2 hectares comprising the La Union Project located in Sonora, Mexico, subject to a royalty obligation.

This news release includes certain "forward-looking statements" under applicable Canadian securities legislation. Forward-looking statements include, but are not limited to, statements with respect to the intended use of proceeds from the Offering. Forward-looking statements are necessarily based upon a number of estimates and assumptions that, while considered reasonable, are subject to known and unknown risks, uncertainties, and other factors which may cause the actual results and future events to differ materially from those expressed or implied by such forward-looking statements. Such factors include but are not limited to: the ability of Riverside to secure geophysical contractors to undertake orientation surveys and follow up detailed survey to confirm and enhance the drill targets as contemplated or at all, general business, economic, competitive, political and social uncertainties, uncertain capital markets; and delay or failure to receive board or regulatory approvals. There can be no assurance that the geophysical surveys will be completed as contemplated or at all and that such statements will prove to be accurate, as actual results and future events could differ materially from those anticipated in such statements. Accordingly, readers should not place undue reliance on forward-looking statements. The Company disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law.

To view the source version of this press release, please visit https://www.newsfilecorp.com/release/268095

By Reuters

September 26, 20257:26 AM UTCUpdated ago

A logo of BMW is seen inside a car dealer in Nijmegen, Netherlands February 26, 2025. REUTERS/Piroschka van de Wouw/File Photo Purchase Licensing Rights, opens new tab

CompaniesSept 26 (Reuters) - BMW

(BMWG.DE), opens new tab is recalling over 196,000 vehicles in the U.S. as the engine starter relay may corrode, leading to overheating and short circuit, increasing the risk of a fire, the U.S. National Highway Traffic Safety Administration said on Friday.

The issue affects multiple models including Toyota Supra and 2022 BMW 230i vehicles, the U.S. auto safety regulator said.

Sign up here.

BMW dealers will replace the engine starter, free of charge, NHTSA said in the notice.

Reporting by Ruchika Khanna in Bengaluru; Editing by Mrigank Dhaniwala

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September 26, 2025 01:00 ET

 | Source:

Addex Therapeutics

Geneva, Switzerland, September 26, 2025 - Addex Therapeutics (SIX/NASDAQ: ADXN), a clinical-stage biopharmaceutical company focused on developing a portfolio of novel small molecule allosteric modulators for neurological disorders, today announced that it will report its Half-Year and Second Quarter 2025 Financial Results on September 30, 2025 and host a conference call to discuss the results on October 1, 2025. Tim Dyer, CEO and Mikhail Kalinichev, Head of Translational Science, will provide a business update and review of the Addex product pipeline during a teleconference and webcast for investors, analysts and media at 16:00 CEST (15:00 BST / 10:00 EDT / 07:00 PDT) on October 1, 2025.

Title:   Addex Therapeutics Reports Half-Year 2025 Financial Results and Provides Corporate Update
Date: October 1, 2025
Time: 16:00 CEST (15:00 BST / 10:00 EDT / 07:00 PDT) 

Joining the Conference Call:

Participants are required to register in advance of the conference using the link provided below. Upon registering, each participant will be provided with Participant Dial-in numbers, and a unique Personal PIN.In the 10 minutes prior to the call’s start time, participants will need to use the conference access information provided in the e-mail received at the point of registering. Participants may also use the call me feature instead of dialing the nearest dial in number.
Webcast registration URL:

https://edge.media-server.com/mmc/p/vh6nhzwt

Conference call registration URL:

https://register-conf.media-server.com/register/BI403a5726888046a6a0645698cc9fdaec

About Addex Therapeutics

Addex is a clinical-stage biopharmaceutical company focused on developing a portfolio of novel small molecule allosteric modulators for neurological disorders. Addex’s lead drug candidate, dipraglurant (mGlu5 negative allosteric modulator or NAM), is under evaluation for future development in brain injury recovery, including post-stroke and traumatic brain injury recovery. Addex’s partner, Indivior, has selected a GABAB PAM drug candidate for development in substance use disorders and has successfully completed IND enabling studies. Addex is advancing an independent GABAB PAM program for chronic cough. Addex also holds a 20% equity interest in a private spin out company, Neurosterix LLC, which is advancing a portfolio of allosteric modulator programs, including M4 PAM for schizophrenia, mGlu7 NAM for mood disorders and mGlu2 NAM for mild neurocognitive disorders. Addex shares are listed on the SIX Swiss Exchange and American Depositary Shares representing its shares are listed on the NASDAQ Capital Market, and trade under the ticker symbol “ADXN” on each exchange. For more information, visit www.addextherapeutics.com

  Contacts: 

Addex Forward Looking Statements:

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including statements about the intended use of proceeds of the offering. The words “may,” “will,” “could,” “would,” “should,” “expect,” “plan,” “anticipate,” “intend,” “believe,” “estimate,” “predict,” “project,” “potential,” “continue,” “target” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements in this press release, are based on management's current expectations and beliefs and are subject to a number of risks, uncertainties and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation, uncertainties related to market conditions. These and other risks and uncertainties are described in greater detail in the section entitled “Risk Factors” in Addex Therapeutics’ Annual Report on Form 20-F, prospectus and other filings that Addex Therapeutics may make with the SEC in the future. Any forward-looking statements contained in this press release represent Addex Therapeutics’ views only as of the date hereof and should not be relied upon as representing its views as of any subsequent date. Addex Therapeutics explicitly disclaims any obligation to update any forward-looking statements.

Key data from PSMAddition has been selected for a Presidential session; data to showcase the efficacy and safety of PluvictoTM plus standard of care (SoC) versus SoC alone in PSMA+ mHSPCNATALEE five-year analysis of Kisqali® to provide further long-term insights into risk of recurrence reduction in a broad EBC patient population New data for Pluvicto in prostate cancer and Kisqali in breast cancer strengthen the profiles of both medicines, with promise for new SoC in earlier disease settings Basel, September 26, 2025 – Novartis will present new data from 34 abstracts across its oncology portfolio at the European Society for Medical Oncology (ESMO) Congress 2025 in Berlin (October 17-21, 2025).

“We look forward to sharing new clinical data that underscores how we are reimagining treatment for breast and prostate cancer, advancing highly effective therapies designed to improve quality of life, enable more personalized care and ultimately provide more time for cancer patients,” said Dushen Chetty, PhD, Global Head of Oncology Development, Novartis, Ad Interim. “Our ambition is to set new standards of care in some of the most prevalent cancers by pioneering novel technologies like radioligand therapy.”

Key highlights of data accepted by ESMO include:

MedicineAbstract titleAbstract Number/
Presentation Details   Pluvicto™ (lutetium (177Lu) vipivotide tetraxetan)Phase 3 trial of [177Lu]Lu-PSMA-617 combined with ADT + ARPI in patients with PSMA-positive metastatic hormone-sensitive prostate cancer (PSMAddition)#LBA6
Presidential Symposium 2 (Proffered Paper session)
October 19, 2025
16:30 – 18:15 CESTPluvicto™ (lutetium (177Lu) vipivotide tetraxetan)Associations between quantitative baseline 68Ga-PSMA-11 PET parameters and 177Lu-PSMA-617 efficacy in the PSMAfore Study#2390P
Poster Presentation
October 18, 2025
09:00 – 17:00 CESTPluvicto™ (lutetium (177Lu) vipivotide tetraxetan)Final analysis of patients treated with [177Lu]Lu-PSMA-617 in early access program in metastatic castration-resistant prostate cancer (mCRPC) in France#2389P
Poster Presentation
October 18, 2025
09:00 – 17:00 CEST[225Ac]-PSMA-617PSMAcTION trial-in-progress: a phase 2/3 randomized trial of [225Ac]Ac-PSMA-617 (225Ac-PSMA-617) versus standard of care in patients with PSMA-positive metastatic castration-resistant prostate cancer who progressed on or after [177Lu]Lu-PSMA therapy#2516TiP
Poster Presentation
October 18, 2025
09:00 – 17:00 CESTKisqali® (ribociclib)Adjuvant ribociclib (RIB) plus nonsteroidal aromatase inhibitor (NSAI) in patients (pts) with HR+/HER2− early breast cancer (EBC): NATALEE 5-year outcomes#LBA14
Proffered Paper session
October 17, 2025
14:00 – 15:30 CESTKisqali® (ribociclib)Impact of neoadjuvant chemotherapy (NACT) response on clinical outcomes with ribociclib (RIB) in HR+/HER2− EBC: a subgroup analysis from the phase 3 NATALEE trial#366P
Poster Presentation
October 20, 2025
09:00 – 17:00 CESTKisqali® (ribociclib)A NATALEE data–based machine learning (ML) model to predict distant recurrence (DR) and treatment (tx) effect in real-world (RW) patients (pts) with HR+/HER2– early breast cancer (EBC) without CDK4/6 inhibitor (CDK4/6i) tx#372P
Poster Presentation
October 20, 2025
09:00 – 17:00 CESTKisqali® (ribociclib)Real-world characteristics, treatments and outcomes of NATALEE and monarchE-eligible HR+/HER2- early breast cancer patients in the hospital district of Helsinki and Uusimaa (HUS), Finland#360P
Poster Presentation
October 20, 2025
09:00 – 17:00 CESTKisqali® (ribociclib)Risk of Recurrence (ROR) After Neoadjuvant Ribociclib Plus ET in Clinically High-Risk ER+/HER2− BC: Preliminary Analysis of the SOLTI-RIBOLARIS Trial #296O
Proffered Paper session
October 17, 2025
14:00 – 15:30 CEST Novartis in oncology
The Novartis oncology strategy focuses on people living with cancer and those who care for them, from loved ones to clinical care teams, including their providers. For the past 30+ years, the aim has been to extend and improve lives by discovering differentiated, innovative and practice-changing medicines for patients.

As Novartis reimagines medicine, it collaborates with a wide range of patient advocacy groups and supports education, early cancer screening and diagnosis. With approximately 35 research and development projects across solid tumors, hematology and radioligand therapy (RLT), Novartis is committed to using technology, leading science and patient-centered research to deliver pioneering cancer care for all those in need.

Disclaimer
This press release contains forward-looking statements within the meaning of the United States Private Securities Litigation Reform Act of 1995. Forward-looking statements can generally be identified by words such as “potential,” “can,” “will,” “plan,” “may,” “could,” “would,” “expect,” “anticipate,” “look forward,” “believe,” “committed,” “investigational,” “pipeline,” “launch,” or similar terms, or by express or implied discussions regarding potential marketing approvals, new indications or labeling for the investigational or approved products described in this press release, or regarding potential future revenues from such products. You should not place undue reliance on these statements. Such forward-looking statements are based on our current beliefs and expectations regarding future events, and are subject to significant known and unknown risks and uncertainties. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those set forth in the forward-looking statements. There can be no guarantee that the investigational or approved products described in this press release will be submitted or approved for sale or for any additional indications or labeling in any market, or at any particular time. Nor can there be any guarantee that such products will be commercially successful in the future. In particular, our expectations regarding such products could be affected by, among other things, the uncertainties inherent in research and development, including clinical trial results and additional analysis of existing clinical data; regulatory actions or delays or government regulation generally; global trends toward health care cost containment, including government, payor and general public pricing and reimbursement pressures and requirements for increased pricing transparency; our ability to obtain or maintain proprietary intellectual property protection; the particular prescribing preferences of physicians and patients; general political, economic and business conditions, including the effects of and efforts to mitigate pandemic diseases; safety, quality, data integrity or manufacturing issues; potential or actual data security and data privacy breaches, or disruptions of our information technology systems, and other risks and factors referred to in Novartis AG’s current Form 20-F on file with the US Securities and Exchange Commission. Novartis is providing the information in this press release as of this date and does not undertake any obligation to update any forward-looking statements contained in this press release as a result of new information, future events or otherwise.

About Novartis
Novartis is an innovative medicines company. Every day, we work to reimagine medicine to improve and extend people’s lives so that patients, healthcare professionals and societies are empowered in the face of serious disease. Our medicines reach nearly 300 million people worldwide.

Reimagine medicine with us: Visit us at https://www.novartis.com and connect with us on LinkedIn, Facebook, X/Twitter and Instagram.

# # #

Novartis Media Relations
E-mail: [email protected]

Novartis Investor Relations
Central investor relations line: +41 61 324 7944
E-mail: [email protected]

Analyst’s Disclosure:I/we have no stock, option or similar derivative position in any of the companies mentioned, and no plans to initiate any such positions within the next 72 hours. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it. I have no business relationship with any company whose stock is mentioned in this article.

This transcription was created from a CEF Insights podcast recorded in September 2025. For more information, please visit cefa.com. This material is not and is not intended as investment advice, an indication of trading intent or holdings or the prediction of investment performance. All fund-specific information is the latest publicly available information. All other information is current as of the date of this presentation. All opinions and forward-looking statements are subject to change at any time.
Western Asset Management disclaims any responsibility to update such views and/or information. This information is deemed to be from reliable sources; however, Western Asset does not warrant its completeness or accuracy. This presentation is not intended to, and does not constitute an offer or solicitation to sell or a solicitation of an offer to buy any security, product, investment advice or service (nor shall any security, product, investment advice or service be offered or sold) in any jurisdiction in which Western Asset is not licensed to conduct business, and/or an offer, solicitation, purchase or a sale would be unavailable or unlawful.

Seeking Alpha's Disclosure: Past performance is no guarantee of future results. No recommendation or advice is being given as to whether any investment is suitable for a particular investor. Any views or opinions expressed above may not reflect those of Seeking Alpha as a whole. Seeking Alpha is not a licensed securities dealer, broker or US investment adviser or investment bank. Our analysts are third party authors that include both professional investors and individual investors who may not be licensed or certified by any institute or regulatory body.

SummaryHubSpot remains a buy, driven by strong AI execution, rapid Core Seat adoption, and accelerating multi-hub usage.HUBS's AI strategy, including "The Loop" and Data Hub, positions customers for success in the evolving Agent Engine Optimization (AEO) landscape.The new seat-based pricing model increases user penetration and embeds HUBS deeper into organizations, fueling robust ARR growth. MoMo Productions/DigitalVision via Getty Images

Investment action I had a buy rating for HubSpot (NYSE:HUBS) previously, as I believed it was in a great position to grow robustly, with support from the shift to seat-based pricing and AI monetization. The latest updates, particularly from INBOUND 2025, reinforce my

Analyst’s Disclosure:I/we have no stock, option or similar derivative position in any of the companies mentioned, and no plans to initiate any such positions within the next 72 hours. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.

Seeking Alpha's Disclosure: Past performance is no guarantee of future results. No recommendation or advice is being given as to whether any investment is suitable for a particular investor. Any views or opinions expressed above may not reflect those of Seeking Alpha as a whole. Seeking Alpha is not a licensed securities dealer, broker or US investment adviser or investment bank. Our analysts are third party authors that include both professional investors and individual investors who may not be licensed or certified by any institute or regulatory body.

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Crinetics Pharmaceuticals, Inc. - Special Call

Company Participants

Gayathri Diwakar - Senior Director of Investor Relations
R. Struthers - Founder, President, CEO & Director
Dana Pizzuti - Chief Medical & Development Officer
Isabel Kalofonos - Chief Commercial Officer
Tobin Schilke - Chief Financial Officer
Alan Krasner - Chief Endocrinologist

Conference Call Participants

Joshua Schimmer - Cantor Fitzgerald & Co., Research Division
Yasmeen Rahimi - Piper Sandler & Co., Research Division
Gavin Clark-Gartner - Evercore ISI Institutional Equities, Research Division
Joseph Schwartz - Leerink Partners LLC, Research Division
Anthea Li - Jefferies LLC, Research Division
Catherine Okoukoni - Citizens JMP Securities, LLC, Research Division
Brian Skorney - Robert W. Baird & Co. Incorporated, Research Division
Cory Jubinville - LifeSci Capital, LLC, Research Division
Douglas Tsao - H.C. Wainwright & Co, LLC, Research Division
Catherine Novack - JonesTrading Institutional Services, LLC, Research Division

Presentation

Operator

Welcome to the Crinetics Pharmaceuticals PALSONIFY FDA Approval Conference Call. [Operator Instructions]

I will now turn the call over to Gayathri Diwakar, Head of Investor Relations. Please go ahead.

Gayathri Diwakar
Senior Director of Investor Relations

Thank you, operator. Good afternoon, everyone, and thank you for joining us to discuss the FDA approval of PALSONIFY. Today on the call, we have Dr. Scott Struthers, Founder and Chief Executive Officer; Dr. Dana Pizzuti, Chief Medical and Development Officer; and Isabel Kalofonos, Chief Commercial Officer. In addition, Tobin Schilke, Chief Financial Officer; and Dr. Alan Krasner, Chief Endocrinologist, will also be joining for the Q&A portion.

Please note, there is a slide deck for today's presentation, which is in the Events and Presentations section of the Investors page on the Crinetics website. In addition, a press release was issued earlier today and is also available on the corporate website.

Slide 2. As a reminder, we'll be making forward-looking statements, and I invite you to learn more about the risks and uncertainties associated with these

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